Biomedical and Biophysics MR

The Biomedical Magnetic Resonance and Biophysics Group focuses its research on the study of brain mechanisms underlying biomedical problems, using advanced imaging techniques (MRI, MRS, PET) combined with biophysical, metabolomic, and machine learning approaches. Our main research lines investigate the neurological changes associated with the development of metabolic diseases (such as obesity) and their treatment, as well as processes related to aging. Our aim is to understand how these conditions or their treatments modify brain structure and function, and to provide innovative tools for the standardization, analysis, and interpretation of neuroimaging data.

Research lines

  • Brain effects of anti-obesity drugs in animal models: studies in diet-induced obese mice, exploring modulators such as GLP-1 agonists or dual GLP-1-RA/GIP-RA, with a multidisciplinary approach (MRI, MRS, immunofluorescence, and systemic biomarkers).

  • Brain effects of pharmacological and surgical treatment in patients with obesity: longitudinal studies using MRI and MRS to characterize responses to GLP-1-RA/GIP-RA drugs and, in the medium term, compare them with bariatric surgery.

  • Biophysical models of the MRI signal: development and implementation of models, with a strong focus on diffusion imaging.

  • Standardization of MRI pre- and post-processing: optimization of neuroimaging workflows and data analysis through advanced statistical methods and machine learning.

  • Machine learning models applied to metabolomics and radiomics: integration of multiparametric biomarkers to characterize brain processes associated with obesity, metabolism and aging.

  • New biomarkers of obesity, metabolic dysfunction and aging processes: exploration of advanced MRI sequences to evaluate neuroinflammation and cerebral metabolism.

Group Coordinator

Adscribed Personnel