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PUBLICACIONES

 

 

spacerTrabajos Publicados por Manuel Izquierdo Pastor
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  1. Izquierdo, M.; Ruiz-Navarro, J.; Baldari, C.T.; Roda-Navarro, P. "Editorial: Structure and function of the immunological and redirecting artificial synapses and their clinical implications.". Front Immunol. 15(): 1497118. (2024). (PMID: 39421740).
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  2. Ruiz-Navarro, J.; Fernández-Hermira, S.; Sanz-Fernández, I.; Barbeito, P.; Navarro-Zapata, A.; Pérez-Martínez, A.; Garcia-Gonzalo, F.R.; Calvo, V.; Izquierdo Pastor, M. "Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes.". Elife. 13(): . (2024). (PMID: 39479958).
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  3. Martín-Antonio, B.; Blanco, B.; González-Murillo, Á.; Hidalgo, L.; Minguillón, J.; Pérez-Chacón, G.; , .; , .; , . "Newer generations of multi-target CAR and STAb-T immunotherapeutics: NEXT CART Consortium as a cooperative effort to overcome current limitations.". Front Immunol. 15(): 1386856. (2024). (PMID: 38779672).
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  4. Fernández-Hermira, S.; Sanz-Fernández, I.; Botas, M.; Calvo, V.; Izquierdo, M. "Analysis of centrosomal area actin reorganization and centrosome polarization upon lymphocyte activation at the immunological synapse.". Methods Cell Biol. 173(): 15-32. (2023). (PMID: 36653081).
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  5. Ruiz-Navarro, J.; Calvo, V.; Izquierdo, M. "Extracellular vesicles and microvilli in the immune synapse.". Front Immunol. 14(): 1324557. (2023). (PMID: 38268920).
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  6. Ibáñez-Navarro, M.; Fernández, A.; Escudero, A.; Esteso, G.; Campos-Silva, C.; Navarro-Aguadero, M.Á.; Leivas, A.; Caracuel, B.R.; Rodríguez-Antolín, C.; Ortiz, A.; Navarro-Zapata, A.; Mestre-Durán, C.; Izquierdo, M.; Balaguer-Pérez, M.; Ferreras, C.; Martínez-López, J.; Valés-Gómez, M.; Pérez-Martínez, A.; Fernández, L. "NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and in vivo but fail to eliminate leukemia initiating cells.". Front Immunol. 14(): 1187665. (2023). (PMID: 37928520).
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  7. Garcia-Martinez, I.; Alen, R.; Pereira, L.; Povo-Retana, A.; Astudillo, A.M.; Hitos, A.B.; Gomez-Hurtado, I.; Lopez-Collazo, E.; Boscá, L.; Francés, R.; Lizasoain, I.; Moro, M.Á.; Balsinde, J.; Izquierdo, M.; Valverde, Á.M. "Saturated fatty acid-enriched small extracellular vesicles mediate a crosstalk inducing liver inflammation and hepatocyte insulin resistance.". JHEP Rep. 5(8): 100756. (2023). (PMID: 37360906).
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  8. Gómez-Morón, Á.; Requena, S.; Pertusa, C.; Lozano-Prieto, M.; Calzada-Fraile, D.; Scagnetti, C.; Sánchez-García, I.; Calero-García, A.A.; Izquierdo, M.; Martín-Cófreces, N.B. "End-binding protein 1 regulates the metabolic fate of CD4+ T lymphoblasts and Jurkat T cells and the organization of the mitochondrial network.". Front Immunol. 14(): 1197289. (2023). (PMID: 37520527).
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  9. Cilleros-Rodriguez, D.; Martin-Morales, R.; Barbeito, P.; Deb Roy, A.; Loukil, A.; Sierra-Rodero, B.; Herranz, G.; Pampliega, O.; Redrejo-Rodriguez, M.; Goetz, S.C.; Izquierdo, M.; Inoue, T.; Garcia-Gonzalo, F.R. "Multiple ciliary localization signals control INPP5E ciliary targeting.". Elife. 11(): . (2022). (PMID: 36063381).
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  10. Calvo, V.; Izquierdo, M. "T Lymphocyte and CAR-T Cell-Derived Extracellular Vesicles and Their Applications in Cancer Therapy.". Cells. 11(5): . (2022). (PMID: 35269412).
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  11. Calvo, V.; Izquierdo, M. "Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse.". Front Cell Dev Biol. 9(): 629097. (2021). (PMID: 33614660).
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  12. Bello-Gamboa, A.; Velasco, M.; Moreno, S.; Herranz, G.; Ilie, R.; Huetos, S.; Dávila, S.; Sánchez, A.; Bernardino De La Serna, J.; Calvo, V.; Izquierdo, M. "Actin reorganization at the centrosomal area and the immune synapse regulates polarized secretory traffic of multivesicular bodies in T lymphocytes.". J Extracell Vesicles. 9(1): 1759926. (2020). (PMID: 32939232).
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  13. Calvo, V.; Izquierdo, M. "Inducible Polarized Secretion of Exosomes in T and B Lymphocytes.". Int J Mol Sci. 21(7): . (2020). (PMID: 32290050).
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  14. Bello-Gamboa, A.; Izquierdo, J.M.; Velasco, M.; Moreno, S.; Garrido, A.; Meyers, L.; Palomino, J.C.; Calvo, V.; Izquierdo, M. "Imaging the Human Immunological Synapse.". J Vis Exp. (154): . (2019). (PMID: 31929507).
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  15. Herranz, G.; Aguilera, P.; Dávila, S.; Sánchez, A.; Stancu, B.; Gómez, J.; Fernández-Moreno, D.; de Martín, R.; Quintanilla, M.; Fernández, T.; Rodríguez-Silvestre, P.; Márquez-Expósito, L.; Bello-Gamboa, A.; Fraile-Ramos, A.; Calvo, V.; Izquierdo, M. "Protein Kinase C δ Regulates the Depletion of Actin at the Immunological Synapse Required for Polarized Exosome Secretion by T Cells.". Frontiers in immunology. 10(): 851. (2019). (PMID: 31105694).
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  16. Bello-Morales, R.; Praena, B.; de la Nuez, C.; Rejas, M.T.; Guerra, M.; Galán-Ganga, M.; Izquierdo, M.; Calvo, V.; Krummenacher, C.; López-Guerrero, J.A. "Role of Microvesicles in the Spread of Herpes Simplex Virus 1 in Oligodendrocytic Cells.". J. Virol.. 92(10): . (2018). (PMID: 29514899).
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  17. Calvo, V.; Izquierdo, M. "Imaging Polarized Secretory Traffic at the Immune Synapse in Living T Lymphocytes.". Front Immunol. 9(): 684. (2018). (PMID: 29681902).
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  18. Cañas, J.A.; Sastre, B.; Mazzeo, C.; Fernández-Nieto, M.; Rodrigo-Muñoz, J.M.; González-Guerra, A.; Izquierdo, M.; Barranco, P.; Quirce, S.; Sastre, J.; Del Pozo, V. "Exosomes from eosinophils autoregulate and promote eosinophil functions.". J. Leukoc. Biol.. 101(5): 1191-1199. (2017). (PMID: 28096299).
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  19. Mazzeo, C.; Calvo, V.; Alonso, R.; Mérida, I.; Izquierdo, M. "Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes.". Cell Death Differ.. 23(1): 99-9109. (2016). (PMID: 26045048).
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  20. Mazzeo, C.; Cañas, J.A.; Zafra, M.P.; Rojas Marco, A.; Fernández-Nieto, M.; Sanz, V.; Mittelbrunn, M.; Izquierdo, M.; Baixaulli, F.; Sastre, J.; Del Pozo, V. "Exosome secretion by eosinophils: A possible role in asthma pathogenesis.". J. Allergy Clin. Immunol.. 135(6): 1603-1613. (2015). (PMID: 25617225).
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  21. Través, P.G.; Pimentel-Santillana, M.; Carrasquero, L.M.; Pérez-Sen, R.; Delicado, E.G.; Luque, A.; Izquierdo, M.; Martín-Sanz, P.; Miras-Portugal, M.T.; Boscá, L. "Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.". J. Immunol.. 190(8): 4226-4235. (2013). (PMID: 23479225).
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  22. Alonso, R.; Mazzeo, C.; Rodriguez, M.C.; Marsh, M.; Fraile-Ramos, A.; Calvo, V.; Avila-Flores, A.; Merida, I.; Izquierdo, M. "Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes.". Cell Death Differ.. 18(7): 1161-1173. (2011). (PMID: 21252909).
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  23. Alonso, R.; Mazzeo, C.; Mérida, I.; Izquierdo, M. "A new role of diacylglycerol kinase alpha on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes.". Biochimie. 89(2): 213-221. (2007). (PMID: 16989932).
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  24. Alonso, R.; Rodríguez, M.C.; Pindado, J.; Merino, E.; Mérida, I.; Izquierdo, M. "Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes.". J Biol Chem. 280(31): 28439-28450. (2005). (PMID: 15870081).
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  25. Robles, M.S.; Leonardo, E.; Criado, L.M.; Izquierdo, M.; Martínez-A, C. "Exacerbated inflammatory responses in transgenic mice expressing an inhibitor of apoptosis protein (OpIAP).". Cell Death Differ.. 10(11): 1226-1233. (2003). (PMID: 14576774).
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  26. Jambrina, E.; Alonso, R.; Alcalde, M.; del Carmen Rodríguez, M.; Serrano, A.; Martínez-A, C.; García-Sancho, J.; Izquierdo, M. "Calcium influx through receptor-operated channel induces mitochondria-triggered paraptotic cell death.". J. Biol. Chem.. 278(16): 14134-14145. (2003). (PMID: 12571238).
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  27. Del Prete, M.J.; Robles, M.S.; Guáo, A.; Martínez-A, C.; Izquierdo, M.; Garcia-Sanz, J.A. "Degradation of cellular mRNA is a general early apoptosis-induced event.". FASEB J.. 16(14): 2003-2005. (2002). (PMID: 12397088).
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  28. Robles, M.S.; Leonardo, E.; Criado, L.M.; Izquierdo, M.; Martínez-A, C. "Inhibitor of apoptosis protein from Orgyia pseudotsugata nuclear polyhedrosis virus provides a costimulatory signal required for optimal proliferation of developing thymocytes.". J. Immunol.. 168(4): 1770-1779. (2002). (PMID: 11823509).
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  29. Sanjuán, M.A.; Jones, D.R.; Izquierdo, M.; Mérida, I. "Role of diacylglycerol kinase alpha in the attenuation of receptor signaling.". J. Cell Biol.. 153(1): 207-220. (2001). (PMID: 11285286).
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  30. Ruiz-Ruiz, C.; Robledo, G.; Font, J.; Izquierdo, M.; López-Rivas, A. "Protein kinase C inhibits CD95 (Fas/APO-1)-mediated apoptosis by at least two different mechanisms in Jurkat T cells.". J. Immunol.. 163(9): 4737-4746. (1999). (PMID: 10528172).
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  31. Izquierdo, M.; Grandien, A.; Criado, L.M.; Robles, S.; Leonardo, E.; Albar, J.P.; de Buitrago, G.G.; Martínez-A, C. "Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor.". EMBO J.. 18(1): 156-166. (1999). (PMID: 9878059).
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  32. Zubiaur, M.; Izquierdo, M.; Terhorst, C.; Malavasi, F.; Sancho, J. "CD38 ligation results in activation of the Raf-1/mitogen-activated protein kinase and the CD3-zeta/zeta-associated protein-70 signaling pathways in Jurkat T lymphocytes.". J. Immunol.. 159(1): 193-205. (1997). (PMID: 9200455).
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  33. Ruiz-Ruiz, M.C.; Izquierdo, M.; de Murcia, G.; López-Rivas, A. "Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis.". Eur. J. Immunol.. 27(6): 1442-1450. (1997). (PMID: 9209497).
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  34. Izquierdo, M.; Ruiz-Ruiz, M.C.; López-Rivas, A. "Stimulation of phosphatidylinositol turnover is a key event for Fas-dependent, activation-induced apoptosis in human T lymphocytes.". J. Immunol.. 157(1): 21-28. (1996). (PMID: 8683117).
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  35. Ruiz-Ruiz, M.C.; Oliver, F.J.; Izquierdo, M.; López-Rivas, A. "Activation-induced apoptosis in Jurkat cells through a myc-independent mechanism.". Mol. Immunol.. 32(13): 947-955. (1995). (PMID: 7477000).
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  36. Pastor, M.I.; Woodrow, M.; Cantrell, D. "Regulation and function of p21ras in T lymphocytes.". Cancer Surv.. 22(): 75-83. (1995). (PMID: 7720060).
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  37. Izquierdo Pastor, M.; Reif, K.; Cantrell, D. "The regulation and function of p21ras during T-cell activation and growth.". Immunol. Today. 16(3): 159-164. (1995). (PMID: 7718090).
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  38. Cantrell, D.; Pastor, M.I.; Woodrow, M. "The regulation and function of p21ras in signal transduction by the T cell antigen receptor.". Adv. Exp. Med. Biol.. 365(): 73-79. (1994). (PMID: 7887315).
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  39. Cantrell, D.; Izquierdo-Pastor, M.; Reif, K.; Woodrow, M. "Signal transduction by the T-cell antigen receptor: regulation and function of p21ras and PtdIns-3 kinase.". Chem. Immunol.. 59(): 115-127. (1994). (PMID: 7945924).
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  40. Izquierdo, M.; Leevers, S.J.; Williams, D.H.; Marshall, C.J.; Weiss, A.; Cantrell, D. "The role of protein kinase C in the regulation of extracellular signal-regulated kinase by the T cell antigen receptor.". Eur. J. Immunol.. 24(10): 2462-2468. (1994). (PMID: 7925576).
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  41. Izquierdo, M.; Bowden, S.; Cantrell, D. "The role of Raf-1 in the regulation of extracellular signal-regulated kinase 2 by the T cell antigen receptor.". J. Exp. Med.. 180(1): 401-406. (1994). (PMID: 8006597).
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  42. Izquierdo, M.; Leevers, S.J.; Marshall, C.J.; Cantrell, D. "p21ras couples the T cell antigen receptor to extracellular signal-regulated kinase 2 in T lymphocytes.". J. Exp. Med.. 178(4): 1199-1208. (1993). (PMID: 8376929).
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  43. Cantrell, D.A.; Izquierdo, M.; Reif, K.; Woodrow, M. "Regulation of PtdIns-3-kinase and the guanine nucleotide binding proteins p21ras during signal transduction by the T cell antigen receptor and the interleukin-2 receptor.". Semin. Immunol.. 5(5): 319-326. (1993). (PMID: 8260648).
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  44. Izquierdo, M.; Cantrell, D.A. "Protein tyrosine kinases couple the interleukin-2 receptor to p21ras.". Eur. J. Immunol.. 23(1): 131-135. (1993). (PMID: 8419163).
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  45. Cantrell, D.A.; Graves, J.D.; Izquierdo, M.; Lucas, S.; Downward, J. "T lymphocyte activation signals.". Ciba Found. Symp.. 164(): 208-18; discussion 218-22. (1992). (PMID: 1395932).
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  46. Izquierdo, M.; Cantrell, D.A. "T-cell activation.". Trends Cell Biol.. 2(9): 268-271. (1992). (PMID: 14731519).
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  47. Izquierdo, M.; Downward, J.; Graves, J.D.; Cantrell, D.A. "Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells.". Mol. Cell. Biol.. 12(7): 3305-3312. (1992). (PMID: 1620132).
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  48. Graves, J.D.; Downward, J.; Izquierdo-Pastor, M.; Rayter, S.; Warne, P.H.; Cantrell, D.A. "The growth factor IL-2 activates p21ras proteins in normal human T lymphocytes.". J. Immunol.. 148(8): 2417-2422. (1992). (PMID: 1532814).
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  49. Balboa, M.A.; Izquierdo, M.; Sánchez-Madrid, F.; Fernández-Rañada, J.M.; López-Botet, M. "Analysis of different protein kinase C-dependent events in T cells from allogeneic bone marrow transplantation recipients.". Clin. Exp. Immunol.. 87(3): 478-484. (1992). (PMID: 1544233).
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  50. Izquierdo, M.; Downward, J.; Otani, H.; Leonard, W.J.; Cantrell, D.A. "Interleukin (IL)-2 activation of p21ras in murine myeloid cells transfected with human IL-2 receptor beta chain.". Eur. J. Immunol.. 22(3): 817-821. (1992). (PMID: 1547824).
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  51. Aramburu, J.; Balboa, M.A.; Izquierdo, M.; López-Botet, M. "A novel functional cell surface dimer (Kp43) expressed by natural killer cells and gamma/delta TCR+ T lymphocytes. II. Modulation of natural killer cytotoxicity by anti-Kp43 monoclonal antibody.". J. Immunol.. 147(2): 714-721. (1991). (PMID: 1830071).
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  52. Beyers, A.D.; Davis, S.J.; Cantrell, D.A.; Izquierdo, M.; Williams, A.F. "Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens.". EMBO J.. 10(2): 377-385. (1991). (PMID: 1671352).
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  53. Izquierdo, M.; Balboa, M.A.; Fernández-Rañada, J.M.; Figuera, A.; Torres, A.; Iriondo, A.; López-Botet, M. "Relation between the increase of circulating CD3+ CD57+ lymphocytes and T cell dysfunction in recipients of bone marrow transplantation.". Clin. Exp. Immunol.. 82(1): 145-150. (1990). (PMID: 1698579).
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  54. Izquierdo, M.; Redondo, J.M.; Balboa, M.A.; López-Rivas, A.; Cragoe, E.J.; Vázquez, L.; Fernández-Rañada, J.M.; López-Botet, M. "Deficient protein kinase C-dependent Na+/H+ exchanger activity in T cells from bone marrow transplantation recipients.". J. Immunol.. 143(7): 2185-2192. (1989). (PMID: 2550550).
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  55. Izquierdo, M.; Balboa, M.A.; Lamana, M.L.; López-Botet, M. "High toxic efficiency of ricin immunotoxins specific for the T-cell antigen receptor of a human leukemia T-cell line.". Int. J. Cancer. 43(4): 697-702. (1989). (PMID: 2467887).
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  56. Izquierdo, M.; Balboa, M.A.; Figuera, A.; López-Botet, M. "Selective T cell subset depletion with anti-CD4 and anti-CD8 intact ricin immunotoxins.". Clin. Exp. Immunol.. 74(2): 300-304. (1988). (PMID: 3265657).
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  57. López-Botet, M.; De Landazuri, M.O.; Izquierdo, M.; Ramirez, A.; Cámara, R.; Fernández-Rañada, J. "Defective interleukin 2 receptor expression is associated with the T cell disfunction subsequent to bone marrow transplantation.". Eur. J. Immunol.. 17(8): 1167-1174. (1987). (PMID: 3113980).
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