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PUBLICACIONES

 

 

spacerTrabajos Publicados por José Manuel González Sancho
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  1. Bustamante-Madrid, P.; Barbáchano, A.; Albandea-Rodríguez, D.; Rodríguez-Cobos, J.; Rodríguez-Salas, N.; Prieto, I.; Burgos, A.; Martínez de Villarreal, J.; Real, F.X.; González-Sancho, J.M.; Larriba, M.J.; Lafarga, M.; Muñoz, A.; Fernández-Barral, A. "Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids.". Cell Death Dis. 15(4): 301. (2024). (PMID: 38684650).
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  2. Pereira, F.; Fernández-Barral, A.; Larriba, M.J.; Barbáchano, A.; González-Sancho, J.M. "From molecular basis to clinical insights: a challenging future for the vitamin D endocrine system in colorectal cancer.". FEBS J. (): . (2023). (PMID: 37699548).
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  3. Martinez-Perez, D.; Viñal, D.; Peña-Lopez, J.; Jimenez-Bou, D.; Ruiz-Gutierrez, I.; Martinez-Recio, S.; Alameda-Guijarro, M.; Rueda-Lara, A.; Martin-Montalvo, G.; Ghanem, I.; Custodio, A.B.; Trilla-Fuertes, L.; Gamez-Pozo, A.; Barbachano, A.; Rodriguez-Cobos, J.; Bustamante-Madrid, P.; Fernandez-Barral, A.; Burgos, A.; Prieto-Nieto, M.I.; Pastrian, L.G.; González-Sancho, J.M.; Muñoz, A.; Feliu, J.; Rodríguez-Salas, N. "Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience.". Cancers (Basel). 15(17): . (2023). (PMID: 37686518).
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  4. González-Sancho, J.M.; Larriba, M.J.; Muñoz, A. "Wnt and Vitamin D at the Crossroads in Solid Cancer.". Cancers (Basel). 12(11): . (2020). (PMID: 33227961).
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  5. Ferrer-Mayorga, G.; Niell, N.; Cantero, R.; González-Sancho, J.M.; Del Peso, L.; Muñoz, A.; Larriba, M.J. "Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts.". Sci Rep. 9(1): 8085. (2019). (PMID: 31147591).
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  6. Moreno-Marín, N.; Merino, J.M.; Alvarez-Barrientos, A.; Patel, D.P.; Takahashi, S.; González-Sancho, J.M.; Gandolfo, P.; Rios, R.M.; Muñoz, A.; Gonzalez, F.J.; Fernández-Salguero, P.M. "Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling.". iScience. 4(): 44-63. (2018). (PMID: 30240752).
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  7. Niell, N.; Larriba, M.J.; Ferrer-Mayorga, G.; Sánchez-Pérez, I.; Cantero, R.; Real, F.X.; Del Peso, L.; Muñoz, A.; González-Sancho, J.M. "The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts.". Int. J. Cancer. 142(4): 792-804. (2018). (PMID: 29044515).
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  8. Barbáchano, A.; Fernández-Barral, A.; Pereira, F.; Segura, M.F.; Ordóñez-Morán, P.; Carrillo-de Santa Pau, E.; González-Sancho, J.M.; Hanniford, D.; Martínez, N.; Costales-Carrera, A.; Real, F.X.; Pálmer, H.G.; Rojas, J.M.; Hernando, E.; Muñoz, A. "SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.". Oncogene. 35(23): 2991-3003. (2016). (PMID: 26455323).
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  9. Aguilera, Ó.; González-Sancho, J.M.; Zazo, S.; Rincón, R.; Fernández, A.F.; Tapia, O.; Canals, F.; Morte, B.; Calvanese, V.; Orgaz, J.L.; Niell, N.; Aguilar, S.; Freije, J.M.; Graña, O.; Pisano, D.G.; Borrero, A.; Martínez-Useros, J.; Jiménez, B.; Fraga, M.F.; García-Foncillas, J.; López-Otín, C.; Lafarga, M.; Rojo, F.; Muñoz, A. "Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.". Oncotarget. 6(8): 5903-5917. (2015). (PMID: 25788273).
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  10. Rada, P.; Rojo, A.I.; Offergeld, A.; Feng, G.J.; Velasco-Martín, J.P.; González-Sancho, J.M.; Valverde, Á.M.; Dale, T.; Regadera, J.; Cuadrado, A. "WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes.". Antioxid. Redox Signal.. 22(7): 555-571. (2015). (PMID: 25336178).
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  11. Larriba, M.J.; González-Sancho, J.M.; Bonilla, F.; Muñoz, A. "Interaction of vitamin D with membrane-based signaling pathways.". Front Physiol. 5(): 60. (2014). (PMID: 24600406).
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  12. Larriba, M.J.; González-Sancho, J.M.; Barbáchano, A.; Niell, N.; Ferrer-Mayorga, G.; Muñoz, A. "Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells.". Cancers (Basel). 5(4): 1242-1260. (2013). (PMID: 24202444).
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  13. González-Sancho, J.M.; Sánchez-Pacheco, A.; Lasa, M.; Molina, S.; Vara, F.; del Peso, L. "The use of an active learning approach to teach metabolism to students of nutrition and dietetics.". Biochem Mol Biol Educ. 41(3): 131-138. (2013). (PMID: 23483652).
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  14. Díaz, R.; González-Sancho, J.M.; Soldevilla, B.; Silva, J.; García, J.M.; García, V.; Peña, C.; Herrera, M.; Gómez, I.; Bonilla, F.; Domínguez, G. "Differential regulation of TP73 isoforms by 1α,25-dihydroxyvitamin D3 and survivin in human colon and breast carcinomas.". Genes Chromosomes Cancer. 49(12): 1135-1142. (2010). (PMID: 20842728).
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  15. Lara, E.; Calvanese, V.; Huidobro, C.; Fernández, A.F.; Moncada-Pazos, A.; Obaya, A.J.; Aguilera, O.; González-Sancho, J.M.; Sánchez, L.; Astudillo, A.; Muñoz, A.; López-Otín, C.; Esteller, M.; Fraga, M.F. "Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer.". Mol. Cancer. 9(): 170. (2010). (PMID: 20591152).
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  16. Navarro, D.; Agra, N.; Pestaña, A.; Alonso, J.; González-Sancho, J.M. "The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes beta-catenin/TCF-mediated transcription.". Carcinogenesis. 31(3): 394-401. (2010). (PMID: 20019092).
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  17. Pendás-Franco, N.; Aguilera, O.; Pereira, F.; González-Sancho, J.M.; Muñoz, A. "Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes.". Anticancer Res.. 28(5A): 2613-2623. (2008). (PMID: 19035286).
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  18. Pendás-Franco, N.; García, J.M.; Peña, C.; Valle, N.; Pálmer, H.G.; Heinäniemi, M.; Carlberg, C.; Jiménez, B.; Bonilla, F.; Muñoz, A.; González-Sancho, J.M. "DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3.". Oncogene. 27(32): 4467-4477. (2008). (PMID: 18408752).
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  19. Aguilera, O.; Peña, C.; García, J.M.; Larriba, M.J.; Ordóñez-Morán, P.; Navarro, D.; Barbáchano, A.; López de Silanes, I.; Ballestar, E.; Fraga, M.F.; Esteller, M.; Gamallo, C.; Bonilla, F.; González-Sancho, J.M.; Muñoz, A. "The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells.". Carcinogenesis. 28(9): 1877-1884. (2007). (PMID: 17449905).
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  20. Larriba, M.J.; Valle, N.; Pálmer, H.G.; Ordóñez-Morán, P.; Alvarez-Díaz, S.; Becker, K.F.; Gamallo, C.; de Herreros, A.G.; González-Sancho, J.M.; Muñoz, A. "The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells.". Endocr. Relat. Cancer. 14(1): 141-151. (2007). (PMID: 17395983).
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  21. Pendás-Franco, N.; González-Sancho, J.M.; Suárez, Y.; Aguilera, O.; Steinmeyer, A.; Gamallo, C.; Berciano, M.T.; Lafarga, M.; Muñoz, A. "Vitamin D regulates the phenotype of human breast cancer cells.". Differentiation. 75(3): 193-207. (2007). (PMID: 17288543).
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  22. González-Sancho, J.M.; Larriba, M.J.; Ordóñez-Morán, P.; Pálmer, H.G.; Muñoz, A. "Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells.". Anticancer Res.. 26(4A): 2669-2681. (2006). (PMID: 16886677).
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  23. Aguilera, O.; Fraga, M.F.; Ballestar, E.; Paz, M.F.; Herranz, M.; Espada, J.; García, J.M.; Muñoz, A.; Esteller, M.; González-Sancho, J.M. "Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.". Oncogene. 25(29): 4116-4121. (2006). (PMID: 16491118).
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  24. Ordonez-Moran, P.; Larriba, M.J.; Pendas-Franco, N.; Aguilera, O.; Gonzalez-Sancho, J.M.; Munoz, A. "Vitamin D and cancer: an update of in vitro and in vivo data.". Front. Biosci.. 10(): 2723-2749. (2005). (PMID: 15970529).
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  25. González-Sancho, J.M.; Aguilera, O.; García, J.M.; Pendás-Franco, N.; Peña, C.; Cal, S.; García de Herreros, A.; Bonilla, F.; Muñoz, A. "The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer.". Oncogene. 24(6): 1098-1103. (2005). (PMID: 15592505).
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  26. González-Sancho, J.M.; Brennan, K.R.; Castelo-Soccio, L.A.; Brown, A.M. "Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin.". Mol. Cell. Biol.. 24(11): 4757-4768. (2004). (PMID: 15143170).
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  27. González-Sancho, J.M.; García, V.; Bonilla, F.; Muñoz, A. "Thyroid hormone receptors/THR genes in human cancer.". Cancer Lett.. 192(2): 121-132. (2003). (PMID: 12668276).
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  28. Caelles, C.; Bruna, A.; Morales, M.; González-Sancho, J.M.; González, M.V.; Jiménez, B.; Muñoz, A. "Glucocorticoid receptor antagonism of AP-1 activity by inhibition of MAPK family.". Ernst Schering Res. Found. Workshop. (40): 131-152. (2002). (PMID: 12355714).
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  29. Silva, J.M.; Domínguez, G.; González-Sancho, J.M.; García, J.M.; Silva, J.; García-Andrade, C.; Navarro, A.; Muñoz, A.; Bonilla, F. "Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer.". Oncogene. 21(27): 4307-4316. (2002). (PMID: 12082618).
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  30. González-Sancho, J.M.; Figueroa, A.; López-Barahona, M.; López, E.; Beug, H.; Muñoz, A. "Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells.". Mol. Carcinog.. 34(1): 25-34. (2002). (PMID: 12112320).
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  31. Pálmer, H.G.; González-Sancho, J.M.; Espada, J.; Berciano, M.T.; Puig, I.; Baulida, J.; Quintanilla, M.; Cano, A.; de Herreros, A.G.; Lafarga, M.; Muñoz, A. "Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.". J. Cell Biol.. 154(2): 369-387. (2001). (PMID: 11470825).
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  32. González, M.V.; Jiménez, B.; Berciano, M.T.; González-Sancho, J.M.; Caelles, C.; Lafarga, M.; Muñoz, A. "Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution.". J. Cell Biol.. 150(5): 1199-1208. (2000). (PMID: 10974006).
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  33. González, M.V.; González-Sancho, J.M.; Caelles, C.; Munoz, A.; Jiménez, B. "Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells.". FEBS Lett.. 459(2): 272-276. (1999). (PMID: 10518034).
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  34. Alvarez-Dolado, M.; González-Sancho, J.M.; Navarro-Yubero, C.; García-Fernández, L.F.; Muñoz, A. "Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells.". J. Neurosci. Res.. 58(2): 293-300. (1999). (PMID: 10502285).
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  35. González-Sancho, J.M.; Alvarez-Dolado, M.; Caelles, C.; Muñoz, A. "Inhibition of tenascin-C expression in mammary epithelial cells by thyroid hormone.". Mol. Carcinog.. 24(2): 99-9107. (1999). (PMID: 10078937).
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  36. Alvarez-Dolado, M.; González-Sancho, J.M.; Bernal, J.; Muñoz, A. "Developmental expression of the tenascin-C is altered by hypothyroidism in the rat brain.". Neuroscience. 84(1): 309-322. (1998). (PMID: 9580330).
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  37. González-Sancho, J.M.; Alvarez-Dolado, M.; Muñoz, A. "1,25-Dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells.". FEBS Lett.. 426(2): 225-228. (1998). (PMID: 9599013).
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  38. Caelles, C.; González-Sancho, J.M.; Muñoz, A. "Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway.". Genes Dev.. 11(24): 3351-3364. (1997). (PMID: 9407028).
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  39. López-Barahona, M.; Fialka, I.; González-Sancho, J.M.; Asunción, M.; González, M.; Iglesias, T.; Bernal, J.; Beug, H.; Muñoz, A. "Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells.". EMBO J.. 14(6): 1145-1155. (1995). (PMID: 7720705).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
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