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spacerTrabajos Publicados por Juan José Aragón Reyes
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  1. Mayoral-Varo, V.; Calcabrini, A.; Sánchez-Bailón, M.P.; Martínez-Costa, Ó.H.; González-Páramos, C.; Ciordia, S.; Hardisson, D.; Aragón, J.J.; Fernández-Moreno, M.Á.; Martín-Pérez, J. "c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells.". PLoS ONE. 15(7): e0235850. (2020). (PMID: 32673341).
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  2. Hermida, C.; Martínez-Costa, O.H.; Corrales, G.; Teruel, C.; Sánchez, V.; Sánchez, J.J.; Sarrión, D.; Ariza, M.J.; Codoceo, R.; Calvo, I.; Fernández-Mayoralas, A.; Aragón, J.J. "Improvement and validation of d-xylose determination in urine and serum as a new tool for the noninvasive evaluation of lactase activity in humans.". J. Clin. Lab. Anal.. 28(6): 478-486. (2014). (PMID: 24659338).
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  3. Aragón, J.J.; Hermida, C.; Martínez-Costa, O.H.; Sánchez, V.; Martín, I.; Sánchez, J.J.; Codoceo, R.; Cano, J.M.; Cano, A.; Crespo, L.; Torres, Y.; García, F.J.; Fernández-Mayoralas, A.; Solera, J.; Martínez, P. "Noninvasive diagnosis of hypolactasia with 4-Galactosylxylose (Gaxilose): a multicentre, open-label, phase IIB-III nonrandomized trial.". J. Clin. Gastroenterol.. 48(1): 29-36. (2014). (PMID: 23722657).
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  4. Hermida, C.; Guerra, P.; Martínez-Costa, O.H.; Sánchez, V.; Sánchez, J.J.; Solera, J.; Fernández-Mayoralas, A.; Codoceo, R.; Frías, J.; Aragón, J.J. "Phase I and phase IB clinical trials for the noninvasive evaluation of intestinal lactase with 4-galactosylxylose (gaxilose).". J. Clin. Gastroenterol.. 47(6): 501-508. (2013). (PMID: 23328304).
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  5. Martínez-Costa, O.H.; Sánchez, V.; Lázaro, A.; Hernández, E.D.; Tornheim, K.; Aragón, J.J. "Distinct functional roles of the two terminal halves of eukaryotic phosphofructokinase.". Biochem. J.. 445(2): 213-218. (2012). (PMID: 22530721).
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  6. Arechaga, I.; Martínez-Costa, O.H.; Ferreras, C.; Carrascosa, J.L.; Aragón, J.J. "Electron microscopy analysis of mammalian phosphofructokinase reveals an unusual 3-dimensional structure with significant implications for enzyme function.". FASEB J.. 24(12): 4960-4968. (2010). (PMID: 20732951).
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  7. Ferreras, C.; Hernández, E.D.; Martínez-Costa, O.H.; Aragón, J.J. "Subunit interactions and composition of the fructose 6-phosphate catalytic site and the fructose 2,6-bisphosphate allosteric site of mammalian phosphofructokinase.". J. Biol. Chem.. 284(14): 9124-9131. (2009). (PMID: 19218242).
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  8. Hermida, C.; Garcés, C.; de Oya, M.; Cano, B.; Martínez-Costa, O.H.; Rivero, S.; García-Ramírez, J.J.; Laborda, J.; Aragón, J.J. "The serum levels of the EGF-like homeotic protein dlk1 correlate with different metabolic parameters in two hormonally different children populations in Spain.". Clin. Endocrinol. (Oxf). 69(2): 216-224. (2008). (PMID: 18248640).
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  9. Adán, C.; Matsushima, Y.; Hernández-Sierra, R.; Marco-Ferreres, R.; Fernández-Moreno, M.A.; González-Vioque, E.; Calleja, M.; Aragón, J.J.; Kaguni, L.S.; Garesse, R. "Mitochondrial transcription factor B2 is essential for metabolic function in Drosophila melanogaster development.". J. Biol. Chem.. 283(18): 12333-12342. (2008). (PMID: 18308726).
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  10. Hermida, C.; Corrales, G.; Cañada, F.J.; Aragón, J.J.; Fernández-Mayoralas, A. "Optimizing the enzymatic synthesis of beta-D-galactopyranosyl-D-xyloses for their use in the evaluation of lactase activity in vivo.". Bioorg. Med. Chem.. 15(14): 4836-4840. (2007). (PMID: 17512743).
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  11. Martínez-Costa, O.H.; Sánchez-Martínez, C.; Sánchez, V.; Aragón, J.J. "Chimeric phosphofructokinases involving exchange of the N- and C-terminal halves of mammalian isozymes: implications for ligand binding sites.". FEBS Lett.. 581(16): 3033-3038. (2007). (PMID: 17544406).
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  12. Hermida, C.; Corrales, G.; Martínez-Costa, O.H.; Fernández-Mayoralas, A.; Aragón, J.J. "Noninvasive evaluation of intestinal lactase with 4-galactosylxylose: comparison with 3- and 2-galactosylxylose and optimization of the method in rats.". Clin Chem. 52(2): 270-277. (2006). (PMID: 16384892).
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  13. Flores, C.L.; Martínez-Costa, O.H.; Sánchez, V.; Gancedo, C.; Aragón, J.J. "The dimorphic yeast Yarrowia lipolytica possesses an atypical phosphofructokinase: characterization of the enzyme and its encoding gene.". Microbiology (Reading). 151(Pt 5): 1465-1474. (2005). (PMID: 15870456).
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  14. Marina, P.; Martínez-Costa, O.H.; Calderón, I.L.; Aragón, J.J. "Characterization of the aspartate kinase from Saccharomyces cerevisiae and of its interaction with threonine.". Biochem. Biophys. Res. Commun.. 321(3): 584-591. (2004). (PMID: 15358146).
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  15. Martínez-Costa, O.H.; Hermida, C.; Sánchez-Martínez, C.; Santamaría, B.; Aragón, J.J. "Identification of C-terminal motifs responsible for transmission of inhibition by ATP of mammalian phosphofructokinase, and their contribution to other allosteric effects.". Biochem. J.. 377(Pt 1): 77-84. (2004). (PMID: 12974670).
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  16. Sánchez-Martínez, C.; Estévez, A.M.; Aragón, J.J. "Phosphofructokinase C isozyme from ascites tumor cells: cloning, expression, and properties.". Biochem. Biophys. Res. Commun.. 271(3): 635-640. (2000). (PMID: 10814514).
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  17. Orosz, F.; Santamaría, B.; Ovádi, J.; Aragón, J.J. "Phosphofructokinase from Dictyostelium discoideum is a potent inhibitor of tubulin polymerization.". Biochemistry. 38(6): 1857-1865. (1999). (PMID: 10026266).
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  18. Sánchez-Martínez, C.; Aragón, J.J. "Analysis of phosphofructokinase subunits and isozymes in ascites tumor cells and its original tissue, murine mammary gland.". FEBS Lett.. 409(1): 86-90. (1997). (PMID: 9199509).
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  19. Aragón, J.J.; Cañada, F.J.; Fernández-Mayoralas, A.; López, R.; Martín-Lomas, M.; Villanueva, D. "A direct enzymatic synthesis of beta-D-galactopyranosyl-D-xylopyranosides and their use to evaluate rat intestinal lactase activity in vivo.". Carbohydr. Res.. 290(2): 209-216. (1996). (PMID: 8823908).
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  20. Estévez, A.M.; Heinisch, J.J.; Aragón, J.J. "Functional complementation of yeast phosphofructokinase mutants by the non-allosteric enzyme from Dictyostelium discoideum.". FEBS Lett.. 374(1): 100-104. (1995). (PMID: 7589492).
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  21. Aragón, J.J.; Sols, A. "Regulation of enzyme activity in the cell: effect of enzyme concentration.". FASEB J.. 5(14): 2945-2950. (1991). (PMID: 1752361).
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  22. Aragón, J.J.; Gómez, M.E.; Gancedo, C. "Identification of two forms of 6-phosphofructo-2-kinase in yeast.". FEBS Lett.. 226(1): 121-124. (1987). (PMID: 2961616).
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  23. Boscá, L.; Aragón, J.J.; Sols, A. "Modulation of muscle phosphofructokinase at physiological concentration of enzyme.". J. Biol. Chem.. 260(4): 2100-2107. (1985). (PMID: 2982809).
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  24. Boscá, L.; Aragón, J.J.; Sols, A. "Specific activation by fructose 2,6-bisphosphate and inhibition by P-enolpyruvate of ascites tumor phosphofructokinase.". Biochem. Biophys. Res. Commun.. 106(2): 486-491. (1982). (PMID: 6213231).
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