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PUBLICACIONES

 

 

spacerTrabajos Publicados por Cristina Manguán García
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  1. Guerrero-López, R.; Manguán-García, C.; Carrascoso-Rubio, C.; Lozano, M.L.; Toldos-Torres, M.; García-Castro, L.; Sánchez-Dominguez, R.; Alberquilla, O.; Sánchez-Pérez, I.; Molina-Molina, M.; Bueren, J.A.; Guenechea, G.; Perona, R.; Sastre, L. "Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths.". Sci Rep. 15(1): 6102. (2025). (PMID: 39971959).
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  2. Fernández-Varas, B.; Manguan-García, C.; Rodriguez-Centeno, J.; Mendoza-Lupiáñez, L.; Calatayud, J.; Perona, R.; Martín-Martínez, M.; Gutierrez-Rodriguez, M.; Benítez-Buelga, C.; Sastre, L. "Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity.". Hum Mol Genet. 33(9): 818-834. (2024). (PMID: 38641551).
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  3. Pintado-Berninches, L.; Montes-Worboys, A.; Manguan-García, C.; Arias-Salgado, E.G.; Serrano, A.; Fernandez-Varas, B.; Guerrero-López, R.; Iarriccio, L.; Planas, L.; Guenechea, G.; Egusquiaguirre, S.P.; Hernandez, R.M.; Igartua, M.; Luis Pedraz, J.; Cortijo, J.; Sastre, L.; Molina-Molina, M.; Perona, R. "GSE4-loaded nanoparticles a potential therapy for lung fibrosis that enhances pneumocyte growth, reduces apoptosis and DNA damage.". FASEB J. 35(3): e21422. (2021). (PMID: 33638895).
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  4. Carrascoso-Rubio, C.; Zittersteijn, H.A.; Pintado-Berninches, L.; Fernández-Varas, B.; Lozano, M.L.; Manguan-Garcia, C.; Sastre, L.; Bueren, J.A.; Perona, R.; Guenechea, G. "Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1.". Stem Cell Res Ther. 12(1): 92. (2021). (PMID: 33514435).
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  5. Rodriguez-Centeno, J.; Manguán-García, C.; Perona, R.; Sastre, L. "Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms.". PLoS ONE. 14(9): e0222909. (2019). (PMID: 31550289).
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  6. Pintado-Berninches, L.; Fernandez-Varas, B.; Benitez-Buelga, C.; Manguan-Garcia, C.; Serrano-Benitez, A.; Iarriccio, L.; Carrillo, J.; Guenechea, G.; Egusquiaguirre, S.P.; Pedraz, J.L.; Hernández, R.M.; Igartua, M.; Arias-Salgado, E.G.; Cortés-Ledesma, F.; Sastre, L.; Perona, R. "GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells.". Cell Death Differ.. (): . (2019). (PMID: 30670828).
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  7. Carrillo, J.; Calvete, O.; Pintado Berninches, L.; Manguan-García, C.; Sevilla Navarro, J.; Arias-Salgado, E.G.; Sastre, L.; Guenechea, G.; López Granados, E.; de Villartay, J.P.; Revy, P.; Benitez, J.; Perona, R. "Mutations in xlf/nhej1/cernunnos Gene Results In Downregulation of Telomerase Genes Expression and Telomere Shortening.". Hum. Mol. Genet.. (): . (2017). (PMID: 28369633).
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  8. Iarriccio, L.; Manguán-García, C.; Pintado-Berninches, L.; Mancheño, J.M.; Molina, A.; Perona, R.; Sastre, L. "GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells.". PLoS ONE. 10(11): e0142980. (2015). (PMID: 26571381).
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  9. Egusquiaguirre, S.P.; Manguán-García, C.; Pintado-Berninches, L.; Iarriccio, L.; Carbajo, D.; Albericio, F.; Royo, M.; Pedraz, J.L.; Hernández, R.M.; Perona, R.; Igartua, M. "Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders.". Eur J Pharm Biopharm. 91(): 91-9102. (2015). (PMID: 25660910).
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  10. Egusquiaguirre, S.P.; Manguán-García, C.; Perona, R.; Pedraz, J.L.; Hernández, R.M.; Igartua, M. "Development and validation of a rapid HPLC method for the quantification of GSE4 peptide in biodegradable PEI-PLGA nanoparticles.". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.. 972(): 95-9101. (2014). (PMID: 25444543).
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  11. Manguan-Garcia, C.; Pintado-Berninches, L.; Carrillo, J.; Machado-Pinilla, R.; Sastre, L.; Pérez-Quilis, C.; Esmoris, I.; Gimeno, A.; García-Giménez, J.L.; Pallardó, F.V.; Perona, R. "Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.". PLoS ONE. 9(7): e101424. (2014). (PMID: 24987982).
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  12. Carrillo, J.; González, A.; Manguán-García, C.; Pintado-Berninches, L.; Perona, R. "p53 pathway activation by telomere attrition in X-DC primary fibroblasts occurs in the absence of ribosome biogenesis failure and as a consequence of DNA damage.". Clin Transl Oncol. 16(6): 529-538. (2014). (PMID: 24065372).
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  13. Machado-Pinilla, R.; Carrillo, J.; Manguan-Garcia, C.; Sastre, L.; Mentzer, A.; Gu, B.W.; Mason, P.J.; Perona, R. "Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain.". Clin Transl Oncol. 14(10): 755-763. (2012). (PMID: 22855157).
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  14. Agostini, A.; Mondragón, L.; Bernardos, A.; Martínez-Máñez, R.; Marcos, M.D.; Sancenón, F.; Soto, J.; Costero, A.; Manguan-García, C.; Perona, R.; Moreno-Torres, M.; Aparicio-Sanchis, R.; Murguía, J.R. "Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles.". Angew. Chem. Int. Ed. Engl.. 51(42): 10556-10560. (2012). (PMID: 22996839).
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  15. Carrillo, J.; Martínez, P.; Solera, J.; Moratilla, C.; González, A.; Manguán-García, C.; Aymerich, M.; Canal, L.; Del Campo, M.; Dapena, J.L.; Escoda, L.; García-Sagredo, J.M.; Martín-Sala, S.; Rives, S.; Sevilla, J.; Sastre, L.; Perona, R. "High resolution melting analysis for the identification of novel mutations in DKC1 and TERT genes in patients with dyskeratosis congenita.". Blood Cells Mol. Dis.. 49(3-4): 140-146. (2012). (PMID: 22664374).
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  16. Ibanez de Caceres, I.; Cortes-Sempere, M.; Moratilla, C.; Machado-Pinilla, R.; Rodriguez-Fanjul, V.; Manguán-García, C.; Cejas, P.; López-Ríos, F.; Paz-Ares, L.; de CastroCarpeño, J.; Nistal, M.; Belda-Iniesta, C.; Perona, R. "IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer.". Oncogene. 29(11): 1681-1690. (2010). (PMID: 20023704).
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  17. Peralta-Sastre, A.; Manguan-Garcia, C.; de Luis, A.; Belda-Iniesta, C.; Moreno, S.; Perona, R.; Sanchez-Perez, I. "Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells.". Int. J. Biochem. Cell Biol.. 42(2): 318-328. (2010). (PMID: 19931410).
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  18. Ortín, I.; González, J.F.; Cuesta, E.d.e. .L.; Manguan-García, C.; Perona, R.; Avendaño, C. "Cytotoxicity mechanisms of pyrazino[1,2-b]isoquinoline-4-ones and SAR studies.". Bioorg. Med. Chem.. 17(23): 8040-8047. (2009). (PMID: 19875300).
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  19. Cortes-Sempere, M.; Chattopadhyay, S.; Rovira, A.; Rodriguez-Fanjul, V.; Belda-Iniesta, C.; Tapia, M.; Cejas, P.; Machado-Pinilla, R.; Manguan-García, C.; Sánchez-Pérez, I.; Nistal, M.; Moratilla, C.; de Castro-Carpeño, J.; Gonzalez-Barón, M.; Albanell, J.; Perona, R. "MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer.". Cancer Lett.. 286(2): 206-216. (2009). (PMID: 19553005).
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  20. Sanchez-Perez, I.; Manguan-Garcia, C.; Menacho-Marquez, M.; Murguía, J.R.; Perona, R. "hCCR4/cNOT6 targets DNA-damage response proteins.". Cancer Lett.. 273(2): 281-291. (2009). (PMID: 18818012).
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  21. Ortín, I.; González, J.F.; Cuesta, E.d.e. .L.; Manguan-García, C.; Perona, R.; Avendaño, C. "Pyrazino[1,2-b]isoquinolines: synthesis and study of their cytostatic and cytotoxic properties.". Bioorg. Med. Chem.. 16(19): 9065-9078. (2008). (PMID: 18799316).
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  22. Belda-Iniesta, C.; Perona, R.; Carpeño, J.d.e. .C.; Cejas, P.; Casado, E.; Manguan-García, C.; Ibanez de Caceres, I.; Sanchez-Perez, I.; Andreu, F.B.; Ferreira, J.A.; Aguilera, A.; de la Peña, J.; Perez-Sánchez, E.; Madero, R.; Feliu, J.; Sereno, M.; González-Barón, M. "Human recombinant erythropoietin does not promote cancer growth in presence of functional receptors expressed in cancer cells.". Cancer Biol. Ther.. 6(10): 1600-1605. (2007). (PMID: 17938574).
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  23. Chattopadhyay, S.; Machado-Pinilla, R.; Manguan-García, C.; Belda-Iniesta, C.; Moratilla, C.; Cejas, P.; Fresno-Vara, J.A.; de Castro-Carpeño, J.; Casado, E.; Nistal, M.; Gonzalez-Barón, M.; Perona, R. "MKP1/CL100 controls tumor growth and sensitivity to cisplatin in non-small-cell lung cancer.". Oncogene. 25(23): 3335-3345. (2006). (PMID: 16462770).
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  24. Sanchez-Perez, I.; Rodriguez-Hernandez, C.J.; Manguan-García, C.; Torres, A.; Perona, R.; Murguía, J.R. "FK506 sensitizes mammalian cells to high osmolarity by modulating p38 MAP kinase activation.". Cell. Mol. Life Sci.. 61(6): 700-708. (2004). (PMID: 15052412).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
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