INVESTIGACIÓN

 
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PUBLICACIONES

 

 

spacerTrabajos Publicados por Jesús Espada Regalado
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  1. Calvo-Sánchez, M.I.; Fernández-Martos, S.; Carrasco, E.; Moreno-Bueno, G.; Bernabéu, C.; Quintanilla, M.; Espada, J. "A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle.". J Mol Cell Biol. 11(1): 39-52. (2019). (PMID: 30239775).
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  2. Espada, J.; Martín-Pérez, J. "An Update on Src Family of Nonreceptor Tyrosine Kinases Biology.". Int Rev Cell Mol Biol. 331(): 83-8122. (2017). (PMID: 28325216).
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  3. Carrasco, E.; Blázquez-Castro, A.; Calvo, M.I.; Juarranz, Á.; Espada, J. "Switching on a transient endogenous ROS production in mammalian cells and tissues.". Methods. 109(): 180-189. (2016). (PMID: 27586523).
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  4. Carrasco, E.; Calvo, M.I.; Blázquez-Castro, A.; Vecchio, D.; Zamarrón, A.; de Almeida, I.J.; Stockert, J.C.; Hamblin, M.R.; Juarranz, Á.; Espada, J. "Photoactivation of ROS Production In Situ Transiently Activates Cell Proliferation in Mouse Skin and in the Hair Follicle Stem Cell Niche Promoting Hair Growth and Wound Healing.". J. Invest. Dermatol.. 135(11): 2611-2622. (2015). (PMID: 26134949).
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  5. Larcher, F.; Espada, J.; Díaz-Ley, B.; Jaén, P.; Juarranz, A.; Quintanilla, M. "New experimental models of skin homeostasis and diseases.". Actas Dermosifiliogr. 106(1): 17-28. (2014). (PMID: 24878038).
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  6. Espada, J.; Esteller, M. "Mouse models in epigenetics: insights in development and disease.". Brief Funct Genomics. 12(3): 279-287. (2013). (PMID: 23426092).
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  7. Blázquez-Castro, A.; Carrasco, E.; Calvo, M.I.; Jaén, P.; Stockert, J.C.; Juarranz, A.; Sánz-Rodríguez, F.; Espada, J. "Protoporphyrin IX-dependent photodynamic production of endogenous ROS stimulates cell proliferation.". Eur. J. Cell Biol.. 91(3): 216-223. (2012). (PMID: 22293959).
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  8. Espada, J. "Non-catalytic functions of DNMT1.". Epigenetics. 7(2): 115-118. (2012). (PMID: 22395459).
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  9. Espada, J.; Peinado, H.; Lopez-Serra, L.; Setién, F.; Lopez-Serra, P.; Portela, A.; Renart, J.; Carrasco, E.; Calvo, M.; Juarranz, A.; Cano, A.; Esteller, M. "Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context.". Nucleic Acids Res.. 39(21): 9194-9205. (2011). (PMID: 21846773).
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  10. Osorio, F.G.; Varela, I.; Lara, E.; Puente, X.S.; Espada, J.; Santoro, R.; Freije, J.M.; Fraga, M.F.; López-Otín, C. "Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease.". Aging Cell. 9(6): 947-957. (2010). (PMID: 20961378).
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  11. Espada, J.; Esteller, M. "DNA methylation and the functional organization of the nuclear compartment.". Semin. Cell Dev. Biol.. 21(2): 238-246. (2010). (PMID: 19892028).
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  12. Espada, J.; Calvo, M.B.; Díaz-Prado, S.; Medina, V. "Wnt signalling and cancer stem cells.". Clin Transl Oncol. 11(7): 411-427. (2009). (PMID: 19574199).
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  13. Medina, V.; Calvo, M.B.; Díaz-Prado, S.; Espada, J. "Hedgehog signalling as a target in cancer stem cells.". Clin Transl Oncol. 11(4): 199-207. (2009). (PMID: 19380296).
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  14. Espada, J.; Galaz, S.; Sanz-Rodríguez, F.; Blázquez-Castro, A.; Stockert, J.C.; Bagazgoitia, L.; Jaén, P.; González, S.; Cano, A.; Juarranz, A. "Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes.". J. Cell. Physiol.. 219(1): 84-93. (2009). (PMID: 19065634).
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  15. Fernandez, A.F.; Rosales, C.; Lopez-Nieva, P.; Graña, O.; Ballestar, E.; Ropero, S.; Espada, J.; Melo, S.A.; Lujambio, A.; Fraga, M.F.; Pino, I.; Javierre, B.; Carmona, F.J.; Acquadro, F.; Steenbergen, R.D.; Snijders, P.J.; Meijer, C.J.; Pineau, P.; Dejean, A.; Lloveras, B.; Capella, G.; Quer, J.; Buti, M.; Esteban, J.I.; Allende, H.; Rodriguez-Frias, F.; Castellsague, X.; Minarovits, J.; Ponce, J.; Capello, D.; Gaidano, G.; Cigudosa, J.C.; Gomez-Lopez, G.; Pisano, D.G.; Valencia, A.; Piris, M.A.; Bosch, F.X.; Cahir-McFarland, E.; Kieff, E.; Esteller, M. "The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer.". Genome Res.. 19(3): 438-451. (2009). (PMID: 19208682).
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  16. Espada, J.; Varela, I.; Flores, I.; Ugalde, A.P.; Cadiñanos, J.; Pendás, A.M.; Stewart, C.L.; Tryggvason, K.; Blasco, M.A.; Freije, J.M.; López-Otín, C. "Nuclear envelope defects cause stem cell dysfunction in premature-aging mice.". J. Cell Biol.. 181(1): 27-35. (2008). (PMID: 18378773).
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  17. Llamazares, M.; Obaya, A.J.; Moncada-Pazos, A.; Heljasvaara, R.; Espada, J.; López-Otín, C.; Cal, S. "The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway.". J. Cell. Sci.. 120(Pt 20): 3544-3552. (2007). (PMID: 17895370).
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  18. Espada, J.; Ballestar, E.; Santoro, R.; Fraga, M.F.; Villar-Garea, A.; Németh, A.; Lopez-Serra, L.; Ropero, S.; Aranda, A.; Orozco, H.; Moreno, V.; Juarranz, A.; Stockert, J.C.; Längst, G.; Grummt, I.; Bickmore, W.; Esteller, M. "Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells.". Nucleic Acids Res.. 35(7): 2191-2198. (2007). (PMID: 17355984).
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  19. Espada, J.; Esteller, M. "Epigenetic control of nuclear architecture.". Cell. Mol. Life Sci.. 64(4): 449-457. (2007). (PMID: 17221334).
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  20. Aguilera, O.; Fraga, M.F.; Ballestar, E.; Paz, M.F.; Herranz, M.; Espada, J.; García, J.M.; Muñoz, A.; Esteller, M.; González-Sancho, J.M. "Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.". Oncogene. 25(29): 4116-4121. (2006). (PMID: 16491118).
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  21. Agrelo, R.; Cheng, W.H.; Setien, F.; Ropero, S.; Espada, J.; Fraga, M.F.; Herranz, M.; Paz, M.F.; Sanchez-Cespedes, M.; Artiga, M.J.; Guerrero, D.; Castells, A.; von Kobbe, C.; Bohr, V.A.; Esteller, M. "Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer.". Proc. Natl. Acad. Sci. U.S.A.. 103(23): 8822-8827. (2006). (PMID: 16723399).
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  22. Boix-Chornet, M.; Fraga, M.F.; Villar-Garea, A.; Caballero, R.; Espada, J.; Nuñez, A.; Casado, J.; Largo, C.; Casal, J.I.; Cigudosa, J.C.; Franco, L.; Esteller, M.; Ballestar, E. "Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis.". J. Biol. Chem.. 281(19): 13540-13547. (2006). (PMID: 16531610).
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  23. Galaz, S.; Espada, J.; Stockert, J.C.; Pacheco, M.; Sanz-Rodríguez, F.; Arranz, R.; Rello, S.; Cañete, M.; Villanueva, A.; Esteller, M.; Juarranz, A. "Loss of E-cadherin mediated cell-cell adhesion as an early trigger of apoptosis induced by photodynamic treatment.". J. Cell. Physiol.. 205(1): 86-96. (2005). (PMID: 15880654).
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  24. Agrelo, R.; Setien, F.; Espada, J.; Artiga, M.J.; Rodriguez, M.; Pérez-Rosado, A.; Sanchez-Aguilera, A.; Fraga, M.F.; Piris, M.A.; Esteller, M. "Inactivation of the lamin A/C gene by CpG island promoter hypermethylation in hematologic malignancies, and its association with poor survival in nodal diffuse large B-cell lymphoma.". J. Clin. Oncol.. 23(17): 3940-3947. (2005). (PMID: 15867203).
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  25. Espada, J.; Peinado, H.; Esteller, M.; Cano, A. "Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase.". Exp. Cell Res.. 305(2): 409-417. (2005). (PMID: 15817165).
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  26. Fraga, M.F.; Ballestar, E.; Villar-Garea, A.; Boix-Chornet, M.; Espada, J.; Schotta, G.; Bonaldi, T.; Haydon, C.; Ropero, S.; Petrie, K.; Iyer, N.G.; Pérez-Rosado, A.; Calvo, E.; Lopez, J.A.; Cano, A.; Calasanz, M.J.; Colomer, D.; Piris, M.A.; Ahn, N.; Imhof, A.; Caldas, C.; Jenuwein, T.; Esteller, M. "Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.". Nat. Genet.. 37(4): 391-400. (2005). (PMID: 15765097).
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  27. Espada, J.; Juarranz, A.; Galaz, S.; Cañete, M.; Villanueva, A.; Pacheco, M.; Stockert, J.C. "Non-aqueous permanent mounting for immunofluorescence microscopy.". Histochem. Cell Biol.. 123(3): 329-334. (2005). (PMID: 15856278).
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  28. Ropero, S.; Setien, F.; Espada, J.; Fraga, M.F.; Herranz, M.; Asp, J.; Benassi, M.S.; Franchi, A.; Patiño, A.; Ward, L.S.; Bovee, J.; Cigudosa, J.C.; Wim, W.; Esteller, M. "Epigenetic loss of the familial tumor-suppressor gene exostosin-1 (EXT1) disrupts heparan sulfate synthesis in cancer cells.". Hum. Mol. Genet.. 13(22): 2753-2765. (2004). (PMID: 15385438).
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  29. Fraga, M.F.; Herranz, M.; Espada, J.; Ballestar, E.; Paz, M.F.; Ropero, S.; Erkek, E.; Bozdogan, O.; Peinado, H.; Niveleau, A.; Mao, J.H.; Balmain, A.; Cano, A.; Esteller, M. "A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors.". Cancer Res.. 64(16): 5527-5534. (2004). (PMID: 15313885).
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  30. Espada, J.; Ballestar, E.; Fraga, M.F.; Villar-Garea, A.; Juarranz, A.; Stockert, J.C.; Robertson, K.D.; Fuks, F.; Esteller, M. "Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.". J. Biol. Chem.. 279(35): 37175-37184. (2004). (PMID: 15220328).
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  31. Ballestar, E.; Paz, M.F.; Valle, L.; Wei, S.; Fraga, M.F.; Espada, J.; Cigudosa, J.C.; Huang, T.H.; Esteller, M. "Methyl-CpG binding proteins identify novel sites of epigenetic inactivation in human cancer.". EMBO J.. 22(23): 6335-6345. (2003). (PMID: 14633992).
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  32. Villar-Garea, A.; Fraga, M.F.; Espada, J.; Esteller, M. "Procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells.". Cancer Res.. 63(16): 4984-4989. (2003). (PMID: 12941824).
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  33. Espada, J.; Juarranz, A.; Villanueva, A.; Cañete, M.; Andrés, I.; Stockert, J.C. "Recycling cultured cells for immunofluorescent labeling.". Histochem. Cell Biol.. 116(1): 41-47. (2001). (PMID: 11479721).
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  34. Pálmer, H.G.; González-Sancho, J.M.; Espada, J.; Berciano, M.T.; Puig, I.; Baulida, J.; Quintanilla, M.; Cano, A.; de Herreros, A.G.; Lafarga, M.; Muñoz, A. "Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.". J. Cell Biol.. 154(2): 369-387. (2001). (PMID: 11470825).
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  35. Juarranz, A.; Espada, J.; Stockert, J.C.; Villanueva, A.; Polo, S.; Domínguez, V.; Cañete, M. "Photodamage induced by Zinc(II)-phthalocyanine to microtubules, actin, alpha-actinin and keratin of HeLa cells.". Photochem. Photobiol.. 73(3): 283-289. (2001). (PMID: 11281025).
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  36. Rozenberg, G.I.; Espada, J.; de Cidre, L.L.; Eiján, A.M.; Calvo, J.C.; Bertolesi, G.E. "Heparan sulfate, heparin, and heparinase activity detection on polyacrylamide gel electrophoresis using the fluorochrome tris(2,2'-bipyridine) ruthenium (II).". Electrophoresis. 22(1): 3-11. (2001). (PMID: 11197174).
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  37. Espada, J.; Pérez-Moreno, M.; Braga, V.M.; Rodriguez-Viciana, P.; Cano, A. "H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes.". J. Cell Biol.. 146(5): 967-980. (1999). (PMID: 10477752).
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  38. Apgar, J.M.; Juarranz, A.; Espada, J.; Villanueva, A.; Cañete, M.; Stockert, J.C. "Fluorescence microscopy of rat embryo sections stained with haematoxylin-eosin and Masson's trichrome method.". J Microsc. 191(Pt 1): 20-27. (1998). (PMID: 9723188).
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  39. Espada, J.; Horobin, R.W.; Stockert, J.C. "Fluorescent cytochemistry of acid phosphatase and demonstration of fluid-phase endocytosis using an azo dye method.". Histochem. Cell Biol.. 108(6): 481-487. (1997). (PMID: 9450630).
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  40. Stockert, J.C.; Pelling, C.; Espada, J. "New cationic fluorochromes from diaryloxazole scintillators: fluorescence of chromatin DNA induced by N-quaternary POPOP derivatives.". Acta Histochem.. 99(2): 195-205. (1997). (PMID: 9248577).
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  41. Bertolesi, G.E.; Trigoso, C.I.; Espada, J.; Stockert, J.C. "Cytochemical application of tris (2,2'-bipyridine) ruthenium (II): fluorescence reaction with sulfated polyanions of mast cell granules.". J. Histochem. Cytochem.. 43(5): 537-543. (1995). (PMID: 7730592).
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  42. Espada, J.; Bertolesi, G.E.; Trigoso, C.I.; Gamallo, C.; Stockert, J.C. "Fluorescence of mast cell granules in paraffin sections and cell smears induced by an N-quaternary oxazole scintillator.". Histochem. J.. 27(4): 318-322. (1995). (PMID: 7635764).
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  43. Pizarro, A.; Gamallo, C.; Castresana, J.S.; Gomez, L.; Palacios, J.; Benito, N.; Espada, J.; Fonseca, E.; Contreras, F. "p53 protein expression in viral warts from patients with epidermodysplasia verruciformis.". Br. J. Dermatol.. 132(4): 513-519. (1995). (PMID: 7748739).
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  44. Palacios, J.; Benito, N.; Pizarro, A.; Suárez, A.; Espada, J.; Cano, A.; Gamallo, C. "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features.". Am. J. Pathol.. 146(3): 605-612. (1995). (PMID: 7534041).
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  45. Espada, J.; Stockert, J.C. "Fluorescence of bisazo dye reaction products from the coupled tetrazonium method for proteins.". Acta Histochem.. 96(3): 315-324. (1994). (PMID: 7531933).
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  46. Espada, J.; Valverde, P.; Stockert, J.C. "Selective fluorescence of eosinophilic structures in grasshopper and mammalian testis stained with haematoxylin-eosin.". Histochemistry. 99(5): 385-390. (1993). (PMID: 7687595).
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