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PUBLICACIONES

 

 

spacerTrabajos Publicados por Francisco Escobar del Rey
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  1. Soriguer, F.; Santiago, P.; Vila, L.; Arena, J.M.; Delgado, E.; Díaz Cadórniga, F.; Donnay, S.; Fernández Soto, M.; González-Romero, S.; Martul, P.; Puig Domingo, M.; Ares, S.; Escobar del Rey, F.; Morreale de Escobar, G.; , . "Clinical dilemmas arising from the increased intake of iodine in the Spanish population and the recommendation for systematic prescription of potassium iodide in pregnant and lactating women (Consensus of the TDY Working Group of SEEN).". J. Endocrinol. Invest.. 32(2): 184-191. (2009). (PMID: 19411820).
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  2. de Escobar, G.M.; Ares, S.; Berbel, P.; Obregón, M.J.; del Rey, F.E. "The changing role of maternal thyroid hormone in fetal brain development.". Semin. Perinatol.. 32(6): 380-386. (2008). (PMID: 19007674).
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  3. Sánchez-Vega, J.; del Rey, F.E.; Fariñas-Seijas, H.; de Escobar, G.M. "Inadequate iodine nutrition of pregnant women from Extremadura (Spain).". Eur. J. Endocrinol.. 159(4): 439-445. (2008). (PMID: 18644824).
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  4. de Escobar, G.M.; Obregón, M.J.; del Rey, F.E. "Iodine deficiency and brain development in the first half of pregnancy.". Public Health Nutr. 10(12A): 1554-1570. (2007). (PMID: 18053280).
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  5. Berbel, P.; Obregón, M.J.; Bernal, J.; Escobar del Rey, F.; Morreale de Escobar, G. "Iodine supplementation during pregnancy: a public health challenge.". Trends Endocrinol. Metab.. 18(9): 338-343. (2007). (PMID: 17962037).
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  6. Morreale de Escobar, G.; Escobar del Rey, F. "Iodine nutrition--more is better.". N. Engl. J. Med.. 355(14): 1500-1; author reply 1501. (2006). (PMID: 17024741).
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  7. Pedraza, P.E.; Obregon, M.J.; Escobar-Morreale, H.F.; del Rey, F.E.; de Escobar, G.M. "Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man.". Endocrinology. 147(5): 2098-2108. (2006). (PMID: 16455775).
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  8. Escobar-Morreale, H.F.; Botella-Carretero, J.I.; Escobar del Rey, F.; Morreale de Escobar, G. "REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine.". J Clin Endocrinol Metab. 90(8): 4946-4954. (2005). (PMID: 15928247).
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  9. Obregon, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "The effects of iodine deficiency on thyroid hormone deiodination.". Thyroid. 15(8): 917-929. (2005). (PMID: 16131334).
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  10. Morreale de Escobar, G.; Obregon, M.J.; Escobar del Rey, F. "Role of thyroid hormone during early brain development.". Eur. J. Endocrinol.. 151 Suppl 3(): U25-37. (2004). (PMID: 15554884).
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  11. Martinez-Galan, J.R.; Escobar del Rey, F.; Morreale de Escobar, G.; Santacana, M.; Ruiz-Marcos, A. "Hypothyroidism alters the development of radial glial cells in the term fetal and postnatal neocortex of the rat.". Brain Res. Dev. Brain Res.. 153(1): 109-114. (2004). (PMID: 15464223).
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  12. de Escobar, G.M.; Obregón, M.J.; del Rey, F.E. "Maternal thyroid hormones early in pregnancy and fetal brain development.". Best Pract. Res. Clin. Endocrinol. Metab.. 18(2): 225-248. (2004). (PMID: 15157838).
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  13. Lavado-Autric, R.; Ausó, E.; García-Velasco, J.V.; Arufe, M.d.e.l. .C.; Escobar del Rey, F.; Berbel, P.; Morreale de Escobar, G. "Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny.". J. Clin. Invest.. 111(7): 1073-1082. (2003). (PMID: 12671057).
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  14. Morreale de Escobar, G.; Obregón, M.J.; Escobar del Rey, F. "Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?". J. Clin. Endocrinol. Metab.. 85(11): 3975-3987. (2000). (PMID: 11095417).
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  15. Morreale de Escobar, G.; Escobar del Rey, F. "[Iodine during pregnancy, lactation and infancy. Minimum and maximum doses: from micrograms to grams].". An. Esp. Pediatr.. 53(1): 1-5. (2000). (PMID: 10998395).
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  16. Escobar-Morreale, H.F.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. Which are the regulatory mechanisms?". Biochimie. 81(5): 453-462. (1999). (PMID: 10403175).
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  17. Calvo, R.M.; Forcen, R.; Obregon, M.J.; Escobar del Rey, F.; Morreale de Escobar, G.; Regadera, J. "Immunohistochemical and morphometric studies of the fetal pancreas in diabetic pregnant rats. Effects of insulin administration.". Anat. Rec.. 251(2): 173-180. (1998). (PMID: 9624446).
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  18. Escobar-Morreale, H.F.; Escobar del Rey, F.; Morreale de Escobar, G. "Thyroid hormones influence serum leptin concentrations in the rat.". Endocrinology. 138(10): 4485-4488. (1997). (PMID: 9322968).
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  19. Escobar-Morreale, H.F.; Obregón, M.J.; Hernandez, A.; Escobar del Rey, F.; Morreale de Escobar, G. "Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine.". Endocrinology. 138(6): 2559-2568. (1997). (PMID: 9165049).
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  20. Calvo, R.; Morreale de Escobar, G.; Escobar del Rey, F.; Obregón, M.J. "Maternal nonthyroidal illness and fetal thyroid hormone status, as studied in the streptozotocin-induced diabetes mellitus rat model.". Endocrinology. 138(3): 1159-1169. (1997). (PMID: 9048623).
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  21. Calvo, R.; Morreale de Escobar, G.; Escobar del Rey, F.; Obregón, M.J. "Maternal diabetes mellitus, a rat model for nonthyroidal illness: correction of hypothyroxinemia with thyroxine treatment does not improve fetal thyroid hormone status.". Thyroid. 7(1): 79-87. (1997). (PMID: 9086576).
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  22. Pedraza, P.; Calvo, R.; Obregón, M.J.; Asunción, M.; Escobar del Rey, F.; Morreale de Escobar, G.M. "Displacement of T4 from transthyretin by the synthetic flavonoid EMD 21388 results in increased production of T3 from T4 in rat dams and fetuses.". Endocrinology. 137(11): 4902-4914. (1996). (PMID: 8895363).
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  23. Obregón, M.J.; Calvo, R.; Hernández, A.; Escobar del Rey, F.; Morreale de Escobar, G. "Regulation of uncoupling protein messenger ribonucleic acid and 5'-deiodinase activity by thyroid hormones in fetal brown adipose tissue.". Endocrinology. 137(11): 4721-4729. (1996). (PMID: 8895339).
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  24. Escobar-Morreale, H.F.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.". J. Clin. Invest.. 96(6): 2828-2838. (1995). (PMID: 8675653).
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  25. Chapa, F.; Künnecke, B.; Calvo, R.; Escobar del Rey, F.; Morreale de Escobar, G.; Cerdán, S. "Adult-onset hypothyroidism and the cerebral metabolism of (1,2-13C2) acetate as detected by 13C nuclear magnetic resonance.". Endocrinology. 136(1): 296-305. (1995). (PMID: 7828544).
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  26. Guadaño Ferraz, A.; Escobar del Rey, F.; Morreale de Escobar, G.; Innocenti, G.M.; Berbel, P. "The development of the anterior commissure in normal and hypothyroid rats.". Brain Res. Dev. Brain Res.. 81(2): 293-308. (1994). (PMID: 7813049).
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  27. Ruiz-Marcos, A.; Cartagena-Abella, P.; Martinez-Galan, J.R.; Calvo, R.; Morreale de Escobar, G.; Escobar del Rey, F. "Thyroxine treatment and the recovery of pyramidal cells of the cerebral cortex from changes induced by juvenile-onset hypothyroidism.". J. Neurobiol.. 25(7): 808-818. (1994). (PMID: 8089658).
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  28. Morreale de Escobar, G.; Calvo, R.; Escobar del Rey, F.; Obregón, M.J. "Thyroid hormones in tissues from fetal and adult rats.". Endocrinology. 134(6): 2410-2415. (1994). (PMID: 8194467).
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  29. Morreale de Escobar, G.; Calvo, R.; Escobar del Rey, F.; Obregon, M.J. "Differential effects of thyroid hormones on growth and thyrotropic hormones in rat fetuses near term.". Endocrinology. 132(5): 2056-2064. (1993). (PMID: 8477656).
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  30. Morreale de Escobar, G.; Obregón, M.J.; Calvo, R.; Escobar del Rey, F. "Effects of iodine deficiency on thyroid hormone metabolism and the brain in fetal rats: the role of the maternal transfer of thyroxin.". Am. J. Clin. Nutr.. 57(2 Suppl): 280S-285S. (1993). (PMID: 8427205).
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  31. Morreale de Escobar, G.; Calvo, R.; Obregon, M.J.; Escobar del Rey, F. "Homeostasis of brain T3 in rat fetuses and their mothers: effects of thyroid status and iodine deficiency.". Acta Med. Austriaca. 19 Suppl 1(): 110-116. (1992). (PMID: 1519443).
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  32. Calvo, R.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status.". Endocrinology. 131(1): 357-365. (1992). (PMID: 1612015).
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  33. Gil-Garay, R.; Miralles-Flores, C.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G.; Delgado-Baeza, E. "Maternal hypothyroidism and fetal chondro-osseous development in rats.". Biol. Neonate. 60(6): 385-394. (1991). (PMID: 1797134).
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  34. Morreale de Escobar, G.; Obregón, M.J.; Calvo, R.; Escobar del Rey, F. "Maternal thyroid hormones during pregnancy: effects on the fetus in congenital hypothyroidism and in iodine deficiency.". Adv. Exp. Med. Biol.. 299(): 133-156. (1991). (PMID: 1810132).
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  35. Obregón, M.J.; Ruiz de Oña, C.; Calvo, R.; Escobar del Rey, F.; Morreale de Escobar, G. "Outer ring iodothyronine deiodinases and thyroid hormone economy: responses to iodine deficiency in the rat fetus and neonate.". Endocrinology. 129(5): 2663-2673. (1991). (PMID: 1935795).
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  36. Ruiz de Oña, C.; Morreale de Escobar, G.; Calvo, R.; Escobar del Rey, F.; Obregón, M.J. "Thyroid hormones and 5'-deiodinase in the rat fetus late in gestation: effects of maternal hypothyroidism.". Endocrinology. 128(1): 422-432. (1991). (PMID: 1986934).
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  37. Calvo, R.; Obregón, M.J.; Ruiz de Oña, C.; Escobar del Rey, F.; Morreale de Escobar, G. "Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain.". J. Clin. Invest.. 86(3): 889-899. (1990). (PMID: 2394838).
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  38. Calvo, R.; Obregon, M.J.; Ruiz de Oña, C.; Ferreiro, B.; Escobar Del Rey, E.; Morreale de Escobar, G. "Thyroid hormone economy in pregnant rats near term: a "physiological" animal model of nonthyroidal illness?". Endocrinology. 127(1): 10-16. (1990). (PMID: 2113860).
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  39. Morreale de Escobar, G.; Calvo, R.; Obregon, M.J.; Escobar Del Rey, F. "Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term.". Endocrinology. 126(5): 2765-2767. (1990). (PMID: 2328706).
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  40. Obregón, M.J.; Ruiz de Oña, C.; Hernandez, A.; Calvo, R.; Escobar del Rey, F.; Morreale de Escobar, G. "Thyroid hormones and 5'-deiodinase in rat brown adipose tissue during fetal life.". Am. J. Physiol.. 257(5 Pt 1): E625-31. (1989). (PMID: 2688435).
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  41. Escobar del Rey, F.; Ruiz de Oña, C.; Bernal, J.; Obregón, M.J.; Morreale de Escobar, G. "Generalized deficiency of 3,5,3'-triiodo-L-thyronine (T3) in tissues from rats on a low iodine intake, despite normal circulating T3 levels.". Acta Endocrinol.. 120(4): 490-498. (1989). (PMID: 2718701).
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  42. Morreale de Escobar, G.; Obregón, M.J.; Ruiz de Oña, C.; Escobar del Rey, F. "Comparison of maternal to fetal transfer of 3,5,3'-triiodothyronine versus thyroxine in rats, as assessed from 3,5,3'-triiodothyronine levels in fetal tissues.". Acta Endocrinol.. 120(1): 20-30. (1989). (PMID: 2911938).
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  43. Ruiz de Oña, C.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Developmental changes in rat brain 5'-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyroidism and maternal thyroid hormones.". Pediatr. Res.. 24(5): 588-594. (1988). (PMID: 3205610).
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  44. Morreale de Escobar, G.; Obregon, M.J.; Escobar del Rey, F. "Maternal-fetal thyroid hormone relationships and the fetal brain.". Acta Med. Austriaca. 15 Suppl 1(): 66-70. (1988). (PMID: 3176827).
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  45. Morreale de Escobar, G.; Obregon, M.J.; Ruiz de Oña, C.; Escobar del Rey, F. "Transfer of thyroxine from the mother to the rat fetus near term: effects on brain 3,5,3'-triiodothyronine deficiency.". Endocrinology. 122(4): 1521-1531. (1988). (PMID: 3345725).
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  46. Morreale de Escobar, G.; Obregon, M.J.; Escobar del Rey, F. "Fetal and maternal thyroid hormones.". Horm. Res.. 26(1-4): 12-27. (1987). (PMID: 3297961).
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  47. Morreale de Escobar, G.; Pastor, R.; Obregon, M.J.; Escobar del Rey, F. "Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function.". Endocrinology. 117(5): 1890-1900. (1985). (PMID: 4042969).
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  48. Obregón, M.J.; Santisteban, P.; Rodríguez-Peña, A.; Pascual, A.; Cartagena, P.; Ruiz-Marcos, A.; Lamas, L.; Escobar del Rey, F.; Morreale de Escobar, G. "Cerebral hypothyroidism in rats with adult-onset iodine deficiency.". Endocrinology. 115(2): 614-624. (1984). (PMID: 6745172).
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  49. Obregon, M.J.; Mallol, J.; Pastor, R.; Morreale de Escobar, G.; Escobar del Rey, F. "L-thyroxine and 3,5,3'-triiodo-L-thyronine in rat embryos before onset of fetal thyroid function.". Endocrinology. 114(1): 305-307. (1984). (PMID: 6690276).
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  50. Ruiz-Marcos, A.; Sanchez-Toscano, F.; Obregon, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Thyroxine treatment and recovery of hypothyroidism-induced pyramidal cell damage.". Brain Res.. 239(2): 559-574. (1982). (PMID: 7093702).
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  51. Escobar del Rey, F.; Gomez-Pan, A.; Obregon, M.J.; Mallol, J.; Arnao, M.D.; Aranda, A.; Morreale de Escobar, G. "A survey of schoolchildren from a severe endemic goitre area in Spain.". Q. J. Med.. 50(198): 233-246. (1981). (PMID: 7302120).
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  52. Obregon, M.J.; Mallol, J.; Escobar del Rey, F.; Morreale de Escobar, G. "Presence of L-thyroxine and 3,5,3'-triiodo-L-thyronine in tissues from thyroidectomized rats.". Endocrinology. 109(3): 908-913. (1981). (PMID: 7262025).
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  53. Padron, F.; Duran-Garcia, S.; Obregon, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Specific uptake of human growth hormone by the liver of severely hypothyroid rats.". J. Endocrinol. Invest.. 4(1): 119-123. (1981). (PMID: 6263964).
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  54. Durán-García, S.; Obregón, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Differential effects of hypothyroidism on the specific uptake of growth hormone and prolactin by the rat liver.". Endocrinology. 108(6): 2054-2059. (1981). (PMID: 7227295).
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  55. Obregon, M.J.; Pascual, A.; Mallol, J.; Morreale de Escobar, G.; Escobar del Rey, F. "Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque).". Endocrinology. 106(6): 1827-1836. (1980). (PMID: 7371594).
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  56. Duran-Garcia, S.; Gomez-Nieto, J.; Fouchereau-Peron, M.; Padron, V.F.; Obregon, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Effects of thyroid hormones on liver binding sites for human growth hormone, as studied in the rat.". Clin. Endocrinol. (Oxf). 11(3): 275-290. (1979). (PMID: 228880).
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  57. Obregon, M.J.; Pascual, A.; de Escobar, G.M.; Escobar del Rey, F. "Pituitary and plasma thyrotropin, thyroxine, and triiodothyronine after hyperthyroidism.". Endocrinology. 104(5): 1467-1473. (1979). (PMID: 108095).
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  58. Obregon, M.J.; Roelfsema, F.; Morreale de Escobar, G.; Escobar del Rey, F.; Querido, A. "Exchange of triiodothyronine derived from thyroxine with circulating triiodothyronine as studied in the rat.". Clin. Endocrinol. (Oxf). 10(3): 305-315. (1979). (PMID: 455743).
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  59. Obregon, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Concentrations of triiodo-L-thyronine in the plasma and tissues of normal rats, as determined by radioimmunoassay: comparison with results obtained by an isotopic equilibrium technique.". Endocrinology. 103(6): 2145-2153. (1978). (PMID: 748038).
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