Mirasierra, M.; Fernández-Pérez, A.; Lizarbe, B.; Keiran, N.; Ruiz-Cañas, L.; Casarejos, M.J.; Cerdán, S.; Vendrell, J.; Fernández-Veledo, S.; Vallejo, M. "Alx3 deficiency disrupts energy homeostasis, alters body composition, and impairs hypothalamic regulation of food intake.". Cell Mol Life Sci. 81(1): 343. (2024). (PMID: 39129011).
Villanueva-Carmona, T.; Cedó, L.; Madeira, A.; Ceperuelo-Mallafré, V.; Rodríguez-Peña, M.M.; Núñez-Roa, C.; Maymó-Masip, E.; Repollés-de-Dalmau, M.; Badia, J.; Keiran, N.; Mirasierra, M.; Pimenta-Lopes, C.; Sabadell-Basallote, J.; Bosch, R.; Caubet, L.; Escolà-Gil, J.C.; Fernández-Real, J.M.; Vilarrasa, N.; Ventura, F.; Vallejo, M.; Vendrell, J.; Fernández-Veledo, S. "SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression.". Cell Metab. (): . (2023). (PMID: 36977414).
Grajales, D.; Vázquez, P.; Ruíz-Rosario, M.; Tudurí, E.; Mirasierra, M.; Ferreira, V.; Hitos, A.B.; Koller, D.; Zubiaur, P.; Cigudosa, J.C.; Abad-Santos, F.; Vallejo, M.; Quesada, I.; Tirosh, B.; Leibowitz, G.; Valverde, Á.M. "The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.". Diabetologia. (): . (2021). (PMID: 34932133).
Arcones, A.C.; Vila-Bedmar, R.; Mirasierra, M.; Cruces-Sande, M.; Vallejo, M.; Jones, B.; Tomas, A.; Mayor, F.; Murga, C. "GRK2 regulates GLP-1R-mediated early phase insulin secretion in vivo.". BMC Biol. 19(1): 40. (2021). (PMID: 33658023).
Castaño, C.; Mirasierra, M.; Vallejo, M.; Novials, A.; Párrizas, M. "Delivery of muscle-derived exosomal miRNAs induced by HIIT improves insulin sensitivity through down-regulation of hepatic FoxO1 in mice.". Proc Natl Acad Sci U S A. (): . (2020). (PMID: 33199621).
García-Sanz, P.; Mirasierra, M.; Moratalla, R.; Vallejo, M. "Embryonic defence mechanisms against glucose-dependent oxidative stress require enhanced expression of Alx3 to prevent malformations during diabetic pregnancy.". Sci Rep. 7(1): 389. (2017). (PMID: 28341857).
Mallarino, R.; Henegar, C.; Mirasierra, M.; Manceau, M.; Schradin, C.; Vallejo, M.; Beronja, S.; Barsh, G.S.; Hoekstra, H.E. "Developmental mechanisms of stripe patterns in rodents.". Nature. 539(7630): 518-523. (2016). (PMID: 27806375).
Mirasierra, M.; Vallejo, M. "Glucose-dependent downregulation of glucagon gene expression mediated by selective interactions between ALX3 and PAX6 in mouse alpha cells.". Diabetologia. 59(4): 766-775. (2016). (PMID: 26739814).
González-Rodríguez, A.; Más-Gutierrez, J.A.; Mirasierra, M.; Fernandez-Pérez, A.; Lee, Y.J.; Ko, H.J.; Kim, J.K.; Romanos, E.; Carrascosa, J.M.; Ros, M.; Vallejo, M.; Rondinone, C.M.; Valverde, A.M. "Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.". Aging Cell. 11(2): 284-296. (2012). (PMID: 22221695).
Mirasierra, M.; Fernández-Pérez, A.; Díaz-Prieto, N.; Vallejo, M. "Alx3-deficient mice exhibit decreased insulin in beta cells, altered glucose homeostasis and increased apoptosis in pancreatic islets.". Diabetologia. 54(2): 403-414. (2011). (PMID: 21104068).
Mirasierra, M.; Vallejo, M. "The homeoprotein Alx3 expressed in pancreatic beta-cells regulates insulin gene transcription by interacting with the basic helix-loop-helix protein E47.". Mol. Endocrinol.. 20(11): 2876-2889. (2006). (PMID: 16825292).
Pérez-Villamil, B.; Mirasierra, M.; Vallejo, M. "The homeoprotein Alx3 contains discrete functional domains and exhibits cell-specific and selective monomeric binding and transactivation.". J. Biol. Chem.. 279(36): 38062-38071. (2004). (PMID: 15226305).
Instituto de Investigaciones Biomédicas "Alberto Sols"
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