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PUBLICACIONES

 

 

spacerTrabajos Publicados por Piero Crespo Baraja
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  1. Agudo-Ibáñez, L.; Morante, M.; García-Gutiérrez, L.; Quintanilla, A.; Rodríguez, J.; Muñoz, A.; León, J.; Crespo, P. "ERK2 stimulates MYC transcription by anchoring CDK9 to the MYC promoter in a kinase activity-independent manner.". Sci Signal. 16(794): eadg4193. (2023). (PMID: 37463244).
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  2. Zaballos, M.A.; Acuña-Ruiz, A.; Morante, M.; Riesco-Eizaguirre, G.; Crespo, P.; Santisteban, P. "Inhibiting ERK dimerization ameliorates BRAF-driven anaplastic thyroid cancer.". Cell Mol Life Sci. 79(9): 504. (2022). (PMID: 36056964).
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  3. García-Ibáñez, Y.; Riesco-Eizaguirre, G.; Santisteban, P.; Casar, B.; Crespo, P. "RAS Subcellular Localization Inversely Regulates Thyroid Tumor Growth and Dissemination.". Cancers (Basel). 12(9): . (2020). (PMID: 32927904).
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  4. Zaballos, M.A.; Acuña-Ruiz, A.; Morante, M.; Crespo, P.; Santisteban, P. "Regulators of the RAS-ERK pathway as therapeutic targets in thyroid cancer.". Endocr. Relat. Cancer. 26(6): R319-R344. (2019). (PMID: 30978703).
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  5. Ferrer-Mayorga, G.; Larriba, M.J.; Crespo, P.; Muñoz, A. "Mechanisms of action of vitamin D in colon cancer.". J. Steroid Biochem. Mol. Biol.. 185(): 1-6. (2019). (PMID: 29981368).
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  6. Anta, B.; Pérez-Rodríguez, A.; Castro, J.; García-Domínguez, C.A.; Ibiza, S.; Martínez, N.; Durá, L.M.; Hernández, S.; Gragera, T.; Peña-Jiménez, D.; Yunta, M.; Zarich, N.; Crespo, P.; Serrador, J.M.; Santos, E.; Muñoz, A.; Oliva, J.L.; Rojas-Cabañeros, J.M. "PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes.". Cell Death Dis. 7(7): e2311. (2016). (PMID: 27468687).
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  7. Peregrin, S.; Jurado-Pueyo, M.; Campos, P.M.; Sanz-Moreno, V.; Ruiz-Gomez, A.; Crespo, P.; Mayor, F.; Murga, C. "Phosphorylation of p38 by GRK2 at the docking groove unveils a novel mechanism for inactivating p38MAPK.". Curr. Biol.. 16(20): 2042-2047. (2006). (PMID: 17055984).
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  8. Bernal, J.; Crespo, P. "Analysis of Rhes activation state and effector function.". Meth. Enzymol.. 407(): 535-542. (2006). (PMID: 16757351).
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  9. Matallanas, D.; Sanz-Moreno, V.; Arozarena, I.; Calvo, F.; Agudo-Ibáñez, L.; Santos, E.; Berciano, M.T.; Crespo, P. "Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.". Mol. Cell. Biol.. 26(1): 100-116. (2006). (PMID: 16354683).
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  10. Vaqué, J.P.; Navascues, J.; Shiio, Y.; Laiho, M.; Ajenjo, N.; Mauleon, I.; Matallanas, D.; Crespo, P.; León, J. "Myc antagonizes Ras-mediated growth arrest in leukemia cells through the inhibition of the Ras-ERK-p21Cip1 pathway.". J. Biol. Chem.. 280(2): 1112-1122. (2005). (PMID: 15528212).
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  11. Ajenjo, N.; Cañón, E.; Sánchez-Pérez, I.; Matallanas, D.; León, J.; Perona, R.; Crespo, P. "Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.". J. Biol. Chem.. 279(31): 32813-32823. (2004). (PMID: 15173174).
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  12. Crespo, P.; Gutkind, J.S. "Activation of MAPKs by G protein-coupled receptors.". Methods Mol. Biol.. 250(): 203-210. (2004). (PMID: 14755090).
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  13. Arozarena, I.; Matallanas, D.; Berciano, M.T.; Sanz-Moreno, V.; Calvo, F.; Muñoz, M.T.; Egea, G.; Lafarga, M.; Crespo, P. "Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.". Mol. Cell. Biol.. 24(4): 1516-1530. (2004). (PMID: 14749369).
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  14. Vargiu, P.; De Abajo, R.; Garcia-Ranea, J.A.; Valencia, A.; Santisteban, P.; Crespo, P.; Bernal, J. "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors.". Oncogene. 23(2): 559-568. (2004). (PMID: 14724584).
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  15. Caloca, M.J.; Zugaza, J.L.; Matallanas, D.; Crespo, P.; Bustelo, X.R. "Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1.". EMBO J.. 22(13): 3326-3336. (2003). (PMID: 12839994).
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  16. Sanz-Moreno, V.; Casar, B.; Crespo, P. "p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels.". Mol. Cell. Biol.. 23(9): 3079-3090. (2003). (PMID: 12697810).
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  17. Matallanas, D.; Arozarena, I.; Berciano, M.T.; Aaronson, D.S.; Pellicer, A.; Lafarga, M.; Crespo, P. "Differences on the inhibitory specificities of H-Ras, K-Ras, and N-Ras (N17) dominant negative mutants are related to their membrane microlocalization.". J. Biol. Chem.. 278(7): 4572-4581. (2003). (PMID: 12458225).
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  18. Bustelo, X.R.; Crespo, P. "Walking pathways at Heidelberg. Conference on oncogenes and growth control.". EMBO Rep.. 3(11): 1023-1028. (2002). (PMID: 12429611).
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  19. Esparís-Ogando, A.; Díaz-Rodríguez, E.; Montero, J.C.; Yuste, L.; Crespo, P.; Pandiella, A. "Erk5 participates in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.". Mol. Cell. Biol.. 22(1): 270-285. (2002). (PMID: 11739740).
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  20. Arozarena, I.; Matallanas, D.; Crespo, P. "Maintenance of CDC42 GDP-bound state by Rho-GDI inhibits MAP kinase activation by the exchange factor Ras-GRF. evidence for Ras-GRF function being inhibited by Cdc42-GDP but unaffected by CDC42-GTP.". J. Biol. Chem.. 276(24): 21878-21884. (2001). (PMID: 11285260).
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  21. Du Villard, J.A.; Wicker, R.; Crespo, P.; Russo, D.; Filetti, S.; Gutkind, J.S.; Sarasin, A.; Suárez, H.G. "Role of the cAMP and MAPK pathways in the transformation of mouse 3T3 fibroblasts by a TSHR gene constitutively activated by point mutation.". Oncogene. 19(42): 4896-4905. (2000). (PMID: 11039907).
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  22. Arozarena, I.; Aaronson, D.S.; Matallanas, D.; Sanz, V.; Ajenjo, N.; Tenbaum, S.P.; Teramoto, H.; Ighishi, T.; Zabala, J.C.; Gutkind, J.S.; Crespo, P. "The Rho family GTPase Cdc42 regulates the activation of Ras/MAP kinase by the exchange factor Ras-GRF.". J. Biol. Chem.. 275(34): 26441-26448. (2000). (PMID: 10840034).
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  23. Sanz, V.; Arozarena, I.; Crespo, P. "Distinct carboxy-termini confer divergent characteristics to the mitogen-activated protein kinase p38alpha and its splice isoform Mxi2.". FEBS Lett.. 474(2-3): 169-174. (2000). (PMID: 10838079).
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  24. Pena, E.; Berciano, M.T.; Fernandez, R.; Crespo, P.; Lafarga, M. "Stress-induced activation of c-Jun N-terminal kinase in sensory ganglion neurons: accumulation in nuclear domains enriched in splicing factors and distribution in perichromatin fibrils.". Exp. Cell Res.. 256(1): 179-191. (2000). (PMID: 10739665).
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  25. Ajenjo, N.; Aaronson, D.S.; Ceballos, E.; Richard, C.; León, J.; Crespo, P. "Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation.". J. Biol. Chem.. 275(10): 7189-7197. (2000). (PMID: 10702288).
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  26. Delgado, M.D.; Vaqué, J.P.; Arozarena, I.; López-Ilasaca, M.A.; Martínez, C.; Crespo, P.; León, J. "H-, K- and N-Ras inhibit myeloid leukemia cell proliferation by a p21WAF1-dependent mechanism.". Oncogene. 19(6): 783-790. (2000). (PMID: 10698496).
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  27. Movilla, N.; Crespo, P.; Bustelo, X.R. "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins.". Oncogene. 18(43): 5860-5869. (1999). (PMID: 10557073).
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  28. Lerga, A.; Crespo, P.; Berciano, M.; Delgado, M.D.; Cañelles, M.; Calés, C.; Richard, C.; Ceballos, E.; Gutierrez, P.; Ajenjo, N.; Gutkind, S.; León, J. "Regulation of c-Myc and Max in megakaryocytic and monocytic-macrophagic differentiation of K562 cells induced by protein kinase C modifiers: c-Myc is down-regulated but does not inhibit differentiation.". Cell Growth Differ.. 10(9): 639-654. (1999). (PMID: 10511314).
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  29. Freije, J.M.; Blay, P.; Pendás, A.M.; Cadiñanos, J.; Crespo, P.; López-Otín, C. "Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins.". Genomics. 58(3): 270-280. (1999). (PMID: 10373325).
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  30. Lopez-Ilasaca, M.; Crespo, P.; Pellici, P.G.; Gutkind, J.S.; Wetzker, R. "Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma.". Science. 275(5298): 394-397. (1997). (PMID: 8994038).
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  31. Crespo, P.; Schuebel, K.E.; Ostrom, A.A.; Gutkind, J.S.; Bustelo, X.R. "Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product.". Nature. 385(6612): 169-172. (1997). (PMID: 8990121).
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  32. Coso, O.A.; Chiariello, M.; Yu, J.C.; Teramoto, H.; Crespo, P.; Xu, N.; Miki, T.; Gutkind, J.S. "The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway.". Cell. 81(7): 1137-1146. (1995). (PMID: 7600581).
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  33. Crespo, P.; Xu, N.; Simonds, W.F.; Gutkind, J.S. "Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.". Nature. 369(6479): 418-420. (1994). (PMID: 8196770).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
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