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PUBLICACIONES

 

 

spacerTrabajos Publicados por Alberto Bartolomé Herranz
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  1. Suda, N.; Bartolomé, A.; Liang, J.; Son, J.; Yagishita, Y.; Siebel, C.; Accili, D.; Ding, H.; Pajvani, U.B. "β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice.". Mol Metab. (): 101894. (2024). (PMID: 38311286).
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  2. Bartolomé, A. "The Pancreatic Beta Cell: Editorial.". Biomolecules. 13(3): . (2023). (PMID: 36979430).
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  3. Kang, J.; Postigo-Fernandez, J.; Kim, K.; Zhu, C.; Yu, J.; Meroni, M.; Mayfield, B.; Bartolomé, A.; Dapito, D.H.; Ferrante, A.W.; Dongiovanni, P.; Valenti, L.; Creusot, R.J.; Pajvani, U.B. "Notch-mediated hepatocyte MCP-1 secretion causes liver fibrosis.". JCI Insight. 8(3): . (2023). (PMID: 36752206).
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  4. Bartolomé, A.; Ravusin, Y.; Yu, J.; Ferrante, A.W.; Pajvani, U.B. "An Overfeeding-Induced Obesity Mouse Model Reveals Necessity for Sin3a in Postnatal Peak β Cell Mass Acquisition.". Diabetes. (): . (2022). (PMID: 35944274).
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  5. Liang, J.; Chirikjian, M.; Pajvani, U.B.; Bartolomé, A. "MafA Regulation in β-Cells: From Transcriptional to Post-Translational Mechanisms.". Biomolecules. 12(4): . (2022). (PMID: 35454124).
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  6. Bartolomé, A.; Suda, N.; Yu, J.; Zhu, C.; Son, J.; Ding, H.; Califano, A.; Accili, D.; Pajvani, U.B. "Notch-mediated Ephrin signaling disrupts islet architecture and β cell function.". JCI Insight. 7(6): . (2022). (PMID: 35167496).
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  7. Bartolomé, A. "Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction.". Int J Mol Sci. 23(1): . (2022). (PMID: 35008927).
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  8. Yu, J.; Zhu, C.; Wang, X.; Kim, K.; Bartolome, A.; Dongiovanni, P.; Yates, K.P.; Valenti, L.; Carrer, M.; Sadowski, T.; Qiang, L.; Tabas, I.; Lavine, J.E.; Pajvani, U.B. "Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis.". Sci Transl Med. 13(599): . (2021). (PMID: 34162749).
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  9. Bartolomé, A.; Liang, J.; Wang, P.; Ho, D.D.; Pajvani, U.B. "Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex.". Sci Rep. 11(1): 9803. (2021). (PMID: 33963249).
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  10. Bartolomé, A.; Pajvani, U.B. "MTOR and Beta Cell Adaptation in T2D.". J Clin Endocrinol Metab. 106(3): e1466-e1467. (2021). (PMID: 33274365).
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  11. Zhu, C.; Ho, Y.J.; Salomao, M.A.; Dapito, D.H.; Bartolome, A.; Schwabe, R.F.; Lee, J.S.; Lowe, S.W.; Pajvani, U.B. "Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features.". J Hepatol. 74(3): 613-626. (2021). (PMID: 33038431).
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  12. Klionsky, D.J.; [ .., ].; Bartolome, A.; [ .., ].; Cuadrado, A.; [ .., ].; Escalante, R.; [ .., ].; García-Sanz, P.; [ .., ].; Lastres-Becker, I.; [ .., ].; León, Y.; [ .., ].; Martin-Sanz, P.; [ .., ].; Pajares, M.; [ .., ].; Rojo, A.I.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Villalobo, A.; [ .., ].; Vincent, O.; [ .., ].; Tong, C.K. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).". Autophagy. (): 1-382. (2021). (PMID: 33634751).
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  13. Bartolomé, A.; Liang, J.; Wang, P.; Ho, D.D.; Pajvani, U.B. "Angiotensin converting enzyme 2 is a novel target of the γ-secretase complex.". bioRxiv. (): . (2020). (PMID: 32908985).
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  14. Kanno, A.; Asahara, S.I.; Furubayashi, A.; Masuda, K.; Yoshitomi, R.; Suzuki, E.; Takai, T.; Kimura-Koyanagi, M.; Matsuda, T.; Bartolome, A.; Hirota, Y.; Yokoi, N.; Inaba, Y.; Inoue, H.; Matsumoto, M.; Inoue, K.; Abe, T.; Wei, F.Y.; Tomizawa, K.; Ogawa, W.; Seino, S.; Kasuga, M.; Kido, Y. "GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels.". JCI Insight. 5(9): . (2020). (PMID: 32376799).
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  15. Marqués, P.; Kamitz, A.; Bartolomé, A.; Burillo, J.; Martínez, H.; Jiménez, B.; Fernández-Rhodes, M.; Guillén, C.; Benito, M. "Essential role of glucokinase in the protection of pancreatic β cells to the glucose energetic status.". Cell Death Discov. 5(): 138. (2019). (PMID: 31583121).
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  16. Bartolome, A.; Zhu, C.; Sussel, L.; Pajvani, U.B. "Notch signaling dynamically regulates adult β cell proliferation and maturity.". J Clin Invest. 129(1): 268-280. (2019). (PMID: 30375986).
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  17. Zhu, C.; Kim, K.; Wang, X.; Bartolome, A.; Salomao, M.; Dongiovanni, P.; Meroni, M.; Graham, M.J.; Yates, K.P.; Diehl, A.M.; Schwabe, R.F.; Tabas, I.; Valenti, L.; Lavine, J.E.; Pajvani, U.B. "Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis.". Sci Transl Med. 10(468): . (2018). (PMID: 30463916).
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  18. Ravussin, Y.; Edwin, E.; Gallop, M.; Xu, L.; Bartolomé, A.; Kraakman, M.J.; LeDuc, C.A.; Ferrante, A.W. "Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding.". Cell Metab. 28(2): 289-299.e5. (2018). (PMID: 29937378).
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  19. Bartolomé, A.; García-Aguilar, A.; Asahara, S.I.; Kido, Y.; Guillén, C.; Pajvani, U.B.; Benito, M. "MTORC1 Regulates both General Autophagy and Mitophagy Induction after Oxidative Phosphorylation Uncoupling.". Mol Cell Biol. 37(23): . (2017). (PMID: 28894028).
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  20. Kawada, Y.; Asahara, S.I.; Sugiura, Y.; Sato, A.; Furubayashi, A.; Kawamura, M.; Bartolome, A.; Terashi-Suzuki, E.; Takai, T.; Kanno, A.; Koyanagi-Kimura, M.; Matsuda, T.; Hashimoto, N.; Kido, Y. "Histone deacetylase regulates insulin signaling via two pathways in pancreatic β cells.". PLoS One. 12(9): e0184435. (2017). (PMID: 28886131).
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  21. García-Aguilar, A.; Guillén, C.; Nellist, M.; Bartolomé, A.; Benito, M. "TSC2 N-terminal lysine acetylation status affects to its stability modulating mTORC1 signaling and autophagy.". Biochim Biophys Acta. 1863(11): 2658-2667. (2016). (PMID: 27542907).
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  22. Klionsky, D.J.; [ .., ].; Bartolomé, A.; [ .., ].; Escalante, R.; [ .., ].; Magariños, M.; [ .., ].; Martín-Sanz, P.; [ .., ].; Sanchez-Prieto, R.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Zughaier, S.M. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).". Autophagy. 12(1): 1-222. (2016). (PMID: 26799652).
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  23. Asahara, S.; Etoh, H.; Inoue, H.; Teruyama, K.; Shibutani, Y.; Ihara, Y.; Kawada, Y.; Bartolome, A.; Hashimoto, N.; Matsuda, T.; Koyanagi-Kimura, M.; Kanno, A.; Hirota, Y.; Hosooka, T.; Nagashima, K.; Nishimura, W.; Inoue, H.; Matsumoto, M.; Higgins, M.J.; Yasuda, K.; Inagaki, N.; Seino, S.; Kasuga, M.; Kido, Y. "Paternal allelic mutation at the Kcnq1 locus reduces pancreatic β-cell mass by epigenetic modification of Cdkn1c.". Proc Natl Acad Sci U S A. 112(27): 8332-8337. (2015). (PMID: 26100882).
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  24. Matsuda, T.; Takahashi, H.; Mieda, Y.; Shimizu, S.; Kawamoto, T.; Matsuura, Y.; Takai, T.; Suzuki, E.; Kanno, A.; Koyanagi-Kimura, M.; Asahara, S.; Bartolome, A.; Yokoi, N.; Inoue, H.; Ogawa, W.; Seino, S.; Kido, Y. "Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity.". PLoS One. 10(6): e0130757. (2015). (PMID: 26091000).
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  25. Bartolome, A.; Guillén, C. "Role of the mammalian target of rapamycin (mTOR) complexes in pancreatic β-cell mass regulation.". Vitam Horm. 95(): 425-469. (2014). (PMID: 24559928).
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  26. Bartolomé, A.; Kimura-Koyanagi, M.; Asahara, S.; Guillén, C.; Inoue, H.; Teruyama, K.; Shimizu, S.; Kanno, A.; García-Aguilar, A.; Koike, M.; Uchiyama, Y.; Benito, M.; Noda, T.; Kido, Y. "Pancreatic β-cell failure mediated by mTORC1 hyperactivity and autophagic impairment.". Diabetes. 63(9): 2996-3008. (2014). (PMID: 24740570).
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  27. Bartolomé, A.; López-Herradón, A.; Portal-Núñez, S.; García-Aguilar, A.; Esbrit, P.; Benito, M.; Guillén, C. "Autophagy impairment aggravates the inhibitory effects of high glucose on osteoblast viability and function.". Biochem J. 455(3): 329-337. (2013). (PMID: 23981124).
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  28. Guillen, C.; Bartolome, A.; Vila-Bedmar, R.; García-Aguilar, A.; Gomez-Hernandez, A.; Benito, M. "Concerted expression of the thermogenic and bioenergetic mitochondrial protein machinery in brown adipose tissue.". J Cell Biochem. 114(10): 2306-2313. (2013). (PMID: 23606415).
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  29. Bartolome, A.; Guillen, C.; Benito, M. "Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death.". Autophagy. 8(12): 1757-1768. (2012). (PMID: 22951927).
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  30. Shimizu, S.; Hosooka, T.; Matsuda, T.; Asahara, S.; Koyanagi-Kimura, M.; Kanno, A.; Bartolome, A.; Etoh, H.; Fuchita, M.; Teruyama, K.; Takahashi, H.; Inoue, H.; Mieda, Y.; Hashimoto, N.; Seino, S.; Kido, Y. "DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice.". J Mol Endocrinol. 49(2): 125-135. (2012). (PMID: 22822047).
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  31. Bartolomé, A.; Guillén, C.; Benito, M. "Role of the TSC1-TSC2 complex in the integration of insulin and glucose signaling involved in pancreatic beta-cell proliferation.". Endocrinology. 151(7): 3084-3094. (2010). (PMID: 20427478).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
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