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PUBLICACIONES

 

 

spacerTrabajos Publicados por Alejandro Samhan Arias
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  1. Lopes, J.; Marques-da-Silva, D.; Videira, P.A.; Samhan-Arias, A.K.; Lagoa, R. "Cardiolipin Membranes Promote Cytochrome c Transformation of Polycyclic Aromatic Hydrocarbons and Their In Vivo Metabolites.". Molecules. 29(5): . (2024). (PMID: 38474641).
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  2. Samhan-Arias, A.K.; Poejo, J.; Marques-da-Silva, D.; Martínez-Costa, O.H.; Gutierrez-Merino, C. "Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?". Molecules. 28(23): . (2023). (PMID: 38067638).
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  3. Salazar, J.; Samhan-Arias, A.K.; Gutierrez-Merino, C. "Hexa-Histidine, a Peptide with Versatile Applications in the Study of Amyloid-β(1-42) Molecular Mechanisms of Action.". Molecules. 28(20): . (2023). (PMID: 37894616).
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  4. Gorospe, B.; Moura, J.J.G.; Gutierrez-Merino, C.; Samhan-Arias, A.K. "Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol.". Int J Mol Sci. 23(23): . (2022). (PMID: 36499524).
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  5. Martínez-Costa, O.H.; Rodrigues-Miranda, L.; Clemente, S.M.; Parola, A.J.; Basilio, N.; Samhan-Arias, A.K. "The Use of Flavylium Salts as Dynamic Inhibitor Moieties for Human Cb5R.". Molecules. 28(1): . (2022). (PMID: 36615312).
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  6. Salazar, J.; Poejo, J.; Mata, A.M.; Samhan-Arias, A.K.; Gutierrez-Merino, C. "Design and Experimental Evaluation of a Peptide Antagonist against Amyloid β(1-42) Interactions with Calmodulin and Calbindin-D28k.". Int J Mol Sci. 23(4): . (2022). (PMID: 35216403).
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  7. Gutiérrez-Merino, C.; Martínez-Costa, O.H.; Monsalve, M.; Samhan-Arias, A.K. "Structural Features of Cytochrome b5-Cytochrome b5 Reductase Complex Formation and Implications for the Intramolecular Dynamics of Cytochrome b5 Reductase.". Int J Mol Sci. 23(1): . (2021). (PMID: 35008543).
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  8. Doblado, L.; Lueck, C.; Rey, C.; Samhan-Arias, A.K.; Prieto, I.; Stacchiotti, A.; Monsalve, M. "Mitophagy in Human Diseases.". Int J Mol Sci. 22(8): . (2021). (PMID: 33918863).
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  9. Clemente, S.M.; Martínez-Costa, O.H.; Monsalve, M.; Samhan-Arias, A.K. "Targeting Lipid Peroxidation for Cancer Treatment.". Molecules. 25(21): . (2020). (PMID: 33167334).
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  10. Valério, G.N.; Gutiérrez-Merino, C.; Nogueira, F.; Moura, I.; Moura, J.J.G.; Samhan-Arias, A.K. "Human erythrocytes exposure to juglone leads to an increase of superoxide anion production associated with cytochrome b5 reductase uncoupling.". Biochim Biophys Acta Bioenerg. 1861(2): 148134. (2020). (PMID: 31825806).
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  11. Samhan-Arias, A.K.; Cordas, C.M.; Carepo, M.S.; Maia, L.B.; Gutierrez-Merino, C.; Moura, I.; Moura, J.J.G. "Ligand accessibility to heme cytochrome b5 coordinating sphere and enzymatic activity enhancement upon tyrosine ionization.". J Biol Inorg Chem. 24(3): 317-330. (2019). (PMID: 30838452).
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  12. Samhan-Arias, A.K.; Fortalezas, S.; Cordas, C.M.; Moura, I.; Moura, J.J.G.; Gutierrez-Merino, C. "Cytochrome b5 reductase is the component from neuronal synaptic plasma membrane vesicles that generates superoxide anion upon stimulation by cytochrome c.". Redox Biol. 15(): 109-114. (2018). (PMID: 29227865).
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  13. Mohammadyani, D.; Yanamala, N.; Samhan-Arias, A.K.; Kapralov, A.A.; Stepanov, G.; Nuar, N.; Planas-Iglesias, J.; Sanghera, N.; Kagan, V.E.; Klein-Seetharaman, J. "Structural characterization of cardiolipin-driven activation of cytochrome c into a peroxidase and membrane perturbation.". Biochim Biophys Acta Biomembr. 1860(5): 1057-1068. (2018). (PMID: 29317202).
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  14. Samhan-Arias, A.K.; Maia, L.B.; Cordas, C.M.; Moura, I.; Gutierrez-Merino, C.; Moura, J.J.G. "Peroxidase-like activity of cytochrome b5 is triggered upon hemichrome formation in alkaline pH.". Biochim Biophys Acta Proteins Proteom. 1866(2): 373-378. (2018). (PMID: 28958890).
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  15. Samhan-Arias, A.K.; Almeida, R.M.; Ramos, S.; Cordas, C.M.; Moura, I.; Gutierrez-Merino, C.; Moura, J.J.G. "Topography of human cytochrome b5/cytochrome b5 reductase interacting domain and redox alterations upon complex formation.". Biochim Biophys Acta Bioenerg. 1859(2): 78-87. (2018). (PMID: 29111436).
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  16. Lagoa, R.; Samhan-Arias, A.K.; Gutierrez-Merino, C. "Correlation between the potency of flavonoids for cytochrome c reduction and inhibition of cardiolipin-induced peroxidase activity.". Biofactors. 43(3): 451-468. (2017). (PMID: 28317253).
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  17. Samhan-Arias, A.K.; López-Sánchez, C.; Marques-da-Silva, D.; Lagoa, R.; Garcia-Lopez, V.; García-Martínez, V.; Gutierrez-Merino, C. "High expression of cytochrome b 5 reductase isoform 3/cytochrome b 5 system in the cerebellum and pyramidal neurons of adult rat brain.". Brain Struct Funct. 221(4): 2147-2162. (2016). (PMID: 25850901).
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  18. Samhan-Arias, A.K.; Gutierrez-Merino, C. "Purified NADH-cytochrome b5 reductase is a novel superoxide anion source inhibited by apocynin: sensitivity to nitric oxide and peroxynitrite.". Free Radic Biol Med. 73(): 174-189. (2014). (PMID: 24816293).
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  19. Ji, J.; Kline, A.E.; Amoscato, A.; Samhan-Arias, A.K.; Sparvero, L.J.; Tyurin, V.A.; Tyurina, Y.Y.; Fink, B.; Manole, M.D.; Puccio, A.M.; Okonkwo, D.O.; Cheng, J.P.; Alexander, H.; Clark, R.S.; Kochanek, P.M.; Wipf, P.; Kagan, V.E.; Bayır, H. "Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury.". Nat Neurosci. 15(10): 1407-1413. (2012). (PMID: 22922784).
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  20. Samhan-Arias, A.K.; Ji, J.; Demidova, O.M.; Sparvero, L.J.; Feng, W.; Tyurin, V.; Tyurina, Y.Y.; Epperly, M.W.; Shvedova, A.A.; Greenberger, J.S.; Bayır, H.; Kagan, V.E.; Amoscato, A.A. "Oxidized phospholipids as biomarkers of tissue and cell damage with a focus on cardiolipin.". Biochim Biophys Acta. 1818(10): 2413-2423. (2012). (PMID: 22464971).
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  21. Samhan-Arias, A.K.; Marques-da-Silva, D.; Yanamala, N.; Gutierrez-Merino, C. "Stimulation and clustering of cytochrome b5 reductase in caveolin-rich lipid microdomains is an early event in oxidative stress-mediated apoptosis of cerebellar granule neurons.". J Proteomics. 75(10): 2934-2949. (2012). (PMID: 22200675).
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  22. Atkinson, J.; Kapralov, A.A.; Yanamala, N.; Tyurina, Y.Y.; Amoscato, A.A.; Pearce, L.; Peterson, J.; Huang, Z.; Jiang, J.; Samhan-Arias, A.K.; Maeda, A.; Feng, W.; Wasserloos, K.; Belikova, N.A.; Tyurin, V.A.; Wang, H.; Fletcher, J.; Wang, Y.; Vlasova, I.I.; Klein-Seetharaman, J.; Stoyanovsky, D.A.; Bayîr, H.; Pitt, B.R.; Epperly, M.W.; Greenberger, J.S.; Kagan, V.E. "A mitochondria-targeted inhibitor of cytochrome c peroxidase mitigates radiation-induced death.". Nat Commun. 2(): 497. (2011). (PMID: 21988913).
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  23. Tyurina, Y.Y.; Kisin, E.R.; Murray, A.; Tyurin, V.A.; Kapralova, V.I.; Sparvero, L.J.; Amoscato, A.A.; Samhan-Arias, A.K.; Swedin, L.; Lahesmaa, R.; Fadeel, B.; Shvedova, A.A.; Kagan, V.E. "Global phospholipidomics analysis reveals selective pulmonary peroxidation profiles upon inhalation of single-walled carbon nanotubes.". ACS Nano. 5(9): 7342-7353. (2011). (PMID: 21800898).
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  24. Kapralov, A.A.; Yanamala, N.; Tyurina, Y.Y.; Castro, L.; Samhan-Arias, A.; Vladimirov, Y.A.; Maeda, A.; Weitz, A.A.; Peterson, J.; Mylnikov, D.; Demicheli, V.; Tortora, V.; Klein-Seetharaman, J.; Radi, R.; Kagan, V.E. "Topography of tyrosine residues and their involvement in peroxidation of polyunsaturated cardiolipin in cytochrome c/cardiolipin peroxidase complexes.". Biochim Biophys Acta. 1808(9): 2147-2155. (2011). (PMID: 21550335).
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  25. Gutierrez-Merino, C.; Lopez-Sanchez, C.; Lagoa, R.; Samhan-Arias, A.K.; Bueno, C.; Garcia-Martinez, V. "Neuroprotective actions of flavonoids.". Curr Med Chem. 18(8): 1195-1212. (2011). (PMID: 21291366).
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  26. Tiago, T.; Marques-da-Silva, D.; Samhan-Arias, A.K.; Aureliano, M.; Gutierrez-Merino, C. "Early disruption of the actin cytoskeleton in cultured cerebellar granule neurons exposed to 3-morpholinosydnonimine-oxidative stress is linked to alterations of the cytosolic calcium concentration.". Cell Calcium. 49(3): 174-183. (2011). (PMID: 21356558).
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  27. Samhan-Arias, A.K.; Tyurina, Y.Y.; Kagan, V.E. "Lipid antioxidants: free radical scavenging versus regulation of enzymatic lipid peroxidation.". J Clin Biochem Nutr. 48(1): 91-95. (2011). (PMID: 21297919).
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  28. Pecina, P.; Borisenko, G.G.; Belikova, N.A.; Tyurina, Y.Y.; Pecinova, A.; Lee, I.; Samhan-Arias, A.K.; Przyklenk, K.; Kagan, V.E.; Hüttemann, M. "Phosphomimetic substitution of cytochrome C tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation.". Biochemistry. 49(31): 6705-6714. (2010). (PMID: 20586425).
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  29. Hiona, A.; Sanz, A.; Kujoth, G.C.; Pamplona, R.; Seo, A.Y.; Hofer, T.; Someya, S.; Miyakawa, T.; Nakayama, C.; Samhan-Arias, A.K.; Servais, S.; Barger, J.L.; Portero-Otín, M.; Tanokura, M.; Prolla, T.A.; Leeuwenburgh, C. "Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice.". PLoS One. 5(7): e11468. (2010). (PMID: 20628647).
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  30. Marques-da-Silva, D.; Samhan-Arias, A.K.; Tiago, T.; Gutierrez-Merino, C. "L-type calcium channels and cytochrome b5 reductase are components of protein complexes tightly associated with lipid rafts microdomains of the neuronal plasma membrane.". J Proteomics. 73(8): 1502-1510. (2010). (PMID: 20188223).
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  31. Kagan, V.E.; Wipf, P.; Stoyanovsky, D.; Greenberger, J.S.; Borisenko, G.; Belikova, N.A.; Yanamala, N.; Samhan Arias, A.K.; Tungekar, M.A.; Jiang, J.; Tyurina, Y.Y.; Ji, J.; Klein-Seetharaman, J.; Pitt, B.R.; Shvedova, A.A.; Bayir, H. "Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions.". Adv Drug Deliv Rev. 61(14): 1375-1385. (2009). (PMID: 19716396).
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  32. Samhan-Arias, A.K.; Garcia-Bereguiain, M.A.; Gutierrez-Merino, C. "Hydrogen sulfide is a reversible inhibitor of the NADH oxidase activity of synaptic plasma membranes.". Biochem Biophys Res Commun. 388(4): 718-722. (2009). (PMID: 19695225).
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  33. Lagoa, R.; Lopez-Sanchez, C.; Samhan-Arias, A.K.; Gañan, C.M.; Garcia-Martinez, V.; Gutierrez-Merino, C. "Kaempferol protects against rat striatal degeneration induced by 3-nitropropionic acid.". J Neurochem. 111(2): 473-487. (2009). (PMID: 19682208).
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  34. Belikova, N.A.; Tyurina, Y.Y.; Borisenko, G.; Tyurin, V.; Samhan Arias, A.K.; Yanamala, N.; Furtmüller, P.G.; Klein-Seetharaman, J.; Obinger, C.; Kagan, V.E. "Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria.". J Am Chem Soc. 131(32): 11288-11289. (2009). (PMID: 19627079).
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  35. Samhan-Arias, A.K.; Garcia-Bereguiain, M.A.; Martin-Romero, F.J.; Gutierrez-Merino, C. "Clustering of plasma membrane-bound cytochrome b5 reductase within 'lipid raft' microdomains of the neuronal plasma membrane.". Mol Cell Neurosci. 40(1): 14-26. (2009). (PMID: 18973815).
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  36. García-Bereguiaín, M.A.; Samhan-Arias, A.K.; Martín-Romero, F.J.; Gutiérrez-Merino, C. "Hydrogen sulfide raises cytosolic calcium in neurons through activation of L-type Ca2+ channels.". Antioxid Redox Signal. 10(1): 31-42. (2008). (PMID: 17956188).
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  37. Samhan-Arias, A.K.; Duarte, R.O.; Martín-Romero, F.J.; Moura, J.J.; Gutiérrez-Merino, C. "Reduction of ascorbate free radical by the plasma membrane of synaptic terminals from rat brain.". Arch Biochem Biophys. 469(2): 243-254. (2008). (PMID: 17963686).
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  38. López-Sánchez, C.; Martín-Romero, F.J.; Sun, F.; Luis, L.; Samhan-Arias, A.K.; García-Martínez, V.; Gutiérrez-Merino, C. "Blood micromolar concentrations of kaempferol afford protection against ischemia/reperfusion-induced damage in rat brain.". Brain Res. 1182(): 123-137. (2007). (PMID: 17950707).
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  39. Samhan-Arias, A.K.; García-Bereguiaín, M.A.; Martín-Romero, F.J.; Gutiérrez-Merino, C. "Regionalization of plasma membrane-bound flavoproteins of cerebellar granule neurons in culture by fluorescence energy transfer imaging.". J Fluoresc. 16(3): 393-401. (2006). (PMID: 16538396).
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  40. Samhan-Arias, A.K.; Martín-Romero, F.J.; Gutiérrez-Merino, C. "Kaempferol blocks oxidative stress in cerebellar granule cells and reveals a key role for reactive oxygen species production at the plasma membrane in the commitment to apoptosis.". Free Radic Biol Med. 37(1): 48-61. (2004). (PMID: 15183194).
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