Gómez-Hurtado, N.; Domínguez-Rodríguez, A.; Mateo, P.; Fernandez-Velasco, M.; Val-Blasco, A.; Aizpún, R.; Sabourin, J.; Gómez, A.M.; Benitah, J.P.; Delgado, C. "Beneficial effects of leptin treatment in a setting of cardiac dysfunction induced by transverse aortic constriction in mouse.". J. Physiol. (Lond.). (): . (2017). (PMID: 28374413).
Val-Blasco, A.; Piedras, M.J.; Ruiz-Hurtado, G.; Suarez, N.; Prieto, P.; Gonzalez-Ramos, S.; Gómez-Hurtado, N.; Delgado, C.; Pereira, L.; Benito, G.; Zaragoza, C.; Domenech, N.; Crespo-Leiro, M.G.; Vasquez-Echeverri, D.; Nuñez, G.; Lopez-Collazo, E.; Boscá, L.; Fernández-Velasco, M. "Role of NOD1 in Heart Failure Progression via Regulation of Ca(2+) Handling.". J. Am. Coll. Cardiol.. 69(4): 423-433. (2017). (PMID: 28126160).
Delgado, C.; Ruiz-Hurtado, G.; Gómez-Hurtado, N.; González-Ramos, S.; Rueda, A.; Benito, G.; Prieto, P.; Zaragoza, C.; Delicado, E.G.; Pérez-Sen, R.; Miras-Portugal, M.T.; Núñez, G.; Boscá, L.; Fernández-Velasco, M. "NOD1, A new player in cardiac function and calcium handling.". Cardiovasc. Res.. (): . (2015). (PMID: 25824149).
CONCLUSION Our data provide the first evidence that NOD1 activation induces cardiac dysfunction associated with excitation-contraction coupling-impairment through NF-κB activation, and uncover a new proinflammatory player in the regulation of cardiovascular function.
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Gómez-Hurtado, N.; Fernández-Velasco, M.; Fernández-Alfonso, M.S.; Boscá, L.; Delgado, C. "Prolonged leptin treatment increases transient outward K⁺ current via upregulation of Kv4.2 and Kv4.3 channel subunits in adult rat ventricular myocytes.". Pflugers Arch.. 466(5): 903-914. (2014). (PMID: 24046152).
Guzmán-Ruiz, R.; Gómez-Hurtado, N.; Gil-Ortega, M.; Somoza, B.; González, M.C.; Aránguez, I.; Martín-Ramos, M.; González-Martín, C.; Delgado, C.; Fernández-Alfonso, M.; Ruiz-Gayo, M. "Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin.". Front Endocrinol (Lausanne). 4(): 175. (2013). (PMID: 24298268).
Ruiz-Hurtado, G.; Gómez-Hurtado, N.; Fernández-Velasco, M.; Calderón, E.; Smani, T.; Ordoñez, A.; Cachofeiro, V.; Boscá, L.; Díez, J.; Gómez, A.M.; Delgado, C. "Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.". Cardiovasc. Res.. 96(1): 81-89. (2012). (PMID: 22787135).
Martín, R.; Miana, M.; Jurado-López, R.; Martínez-Martínez, E.; Gómez-Hurtado, N.; Delgado, C.; Bartolomé, M.V.; San Román, J.A.; Cordova, C.; Lahera, V.; Nieto, M.L.; Cachofeiro, V. "DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.". PLoS ONE. 7(7): e41545. (2012). (PMID: 22844495).
Smani, T.; Calderón-Sanchez, E.; Gómez-Hurtado, N.; Fernández-Velasco, M.; Cachofeiro, V.; Lahera, V.; Ordoñez, A.; Delgado, C. "Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes.". Cardiovasc. Res.. 87(3): 459-466. (2010). (PMID: 20189952).
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