INVESTIGACIÓN

 
  • Grupos de Investigación
  • Unidades de Investigación
  • Memoria Cientifíca
  • Publicaciones
espacio

 

PUBLICACIONES

 

 

spacerTrabajos Publicados por Carmen Delgado Canencia
spacer
  1. Sánchez-García, S.; Jaén, R.I.; Fernández-Velasco, M.; Delgado, C.; Boscá, L.; Prieto, P. "Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond.". Pharmacol Res. 197(): 106982. (2023). (PMID: 37925045).
    spacer

  2. Povo-Retana, A.; Sánchez-García, S.; Alvarez-Lucena, C.; Landauro-Vera, R.; Prieto, P.; Delgado, C.; Martín-Sanz, P.; Boscá, L. "Crosstalk between P2Y receptors and cyclooxygenase activity in inflammation and tissue repair.". Purinergic Signal. (): . (2023). (PMID: 37052777).
    spacer

  3. Paz-García, M.; Povo-Retana, A.; Jaén, R.I.; Prieto, P.; Peraza, D.A.; Zaragoza, C.; Hernandez-Jimenez, M.; Pineiro, D.; Regadera, J.; García-Bermejo, M.L.; Rodríguez-Serrano, E.M.; Sánchez-García, S.; Moro, M.A.; Lizasoaín, I.; Delgado, C.; Valenzuela, C.; Boscá, L. "Beneficial effect of TLR4 blockade by a specific aptamer antagonist after acute myocardial infarction.". Biomed Pharmacother. 158(): 114214. (2023). (PMID: 36916435).
    spacer

  4. Fernández-García, V.; González-Ramos, S.; Avendaño-Ortiz, J.; Martín-Sanz, P.; Gómez-Coronado, D.; Delgado, C.; Castrillo, A.; Boscá, L. "High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice.". Cell Mol Life Sci. 79(8): 396. (2022). (PMID: 35789437).
    spacer

  5. Val-Blasco, A.; Prieto, P.; Jaén, R.I.; Gil-Fernández, M.; Pajares, M.; Domenech, N.; Terrón, V.; Tamayo, M.; Jorge, I.; Vázquez, J.; Bueno-Sen, A.; Vallejo-Cremades, M.T.; Pombo-Otero, J.; Sanchez-García, S.; Ruiz-Hurtado, G.; Gómez, A.M.; Zaragoza, C.; Crespo-Leiro, M.G.; López-Collazo, E.; Cuadrado, A.; Delgado, C.; Boscá, L.; Fernández-Velasco, M. "Specialized Proresolving Mediators Protect Against Experimental Autoimmune Myocarditis by Modulating Ca2+ Handling and NRF2 Activation.". JACC Basic Transl Sci. 7(6): 544-560. (2022). (PMID: 35818504).
    spacer

  6. Tamayo, M.; Martín-Nunes, L.; Piedras, M.J.; Martin-Calvo, M.; Martí-Morente, D.; Gil-Fernández, M.; Gómez-Hurtado, N.; Moro, M.Á.; Bosca, L.; Fernández-Velasco, M.; Delgado, C. "The Aryl Hydrocarbon Receptor Ligand FICZ Improves Left Ventricular Remodeling and Cardiac Function at the Onset of Pressure Overload-Induced Heart Failure in Mice.". Int J Mol Sci. 23(10): . (2022). (PMID: 35628213).
    spacer

  7. Fernández-García, V.; González-Ramos, S.; Avendaño-Ortiz, J.; Martín-Sanz, P.; Delgado, C.; Castrillo, A.; Boscá, L. "NOD1 splenic activation confers ferroptosis protection and reduces macrophage recruitment under pro-atherogenic conditions.". Biomed Pharmacother. 148(): 112769. (2022). (PMID: 35247718).
    spacer

  8. Navarro-García, J.A.; Salguero-Bodes, R.; González-Lafuente, L.; Martín-Nunes, L.; Rodríguez-Sánchez, E.; Bada-Bosch, T.; Hernández, E.; Mérida-Herrero, E.; Praga, M.; Solís, J.; Arribas, F.; Bueno, H.; Kuro-O, M.; Fernández-Velasco, M.; Ruilope, L.M.; Delgado, C.; Ruiz-Hurtado, G. "The anti-aging factor Klotho protects against acquired long QT syndrome induced by uremia and promoted by fibroblast growth factor 23.". BMC Med. 20(1): 14. (2022). (PMID: 35042527).
    spacer

  9. Val-Blasco, A.; Gil-Fernández, M.; Rueda, A.; Pereira, L.; Delgado, C.; Smani, T.; Ruiz Hurtado, G.; Fernández-Velasco, M. "Ca2+ mishandling in heart failure: potential targets.". Acta Physiol (Oxf). (): e13691. (2021). (PMID: 34022101).
    spacer

  10. Gil-Fernández, M.; Navarro-García, J.A.; Val-Blasco, A.; González-Lafuente, L.; Martínez, J.C.; Rueda, A.; Tamayo, M.; Morgado, J.L.; Zaragoza, C.; Ruilope, L.M.; Delgado, C.; Ruiz-Hurtado, G.; Fernández-Velasco, M. "Genetic Deletion of NOD1 Prevents Cardiac Ca2+ Mishandling Induced by Experimental Chronic Kidney Disease.". Int J Mol Sci. 21(22): . (2020). (PMID: 33238586).
    spacer

  11. Tamayo, M.; Martín-Nunes, L.; Val-Blasco, A.; G M-Piedras, M.J.; Navarro-García, J.A.; Lage, E.; Prieto, P.; Ruiz-Hurtado, G.; Fernández-Velasco, M.; Delgado, C. "Beneficial effects of paricalcitol on cardiac dysfunction and remodelling in a model of established heart failure.". Br. J. Pharmacol.. 177(14): 3273-3290. (2020). (PMID: 32154912).
    spacer

  12. Jaén, R.I.; Val-Blasco, A.; Prieto, P.; Gil-Fernández, M.; Smani, T.; López-Sendón, J.L.; Delgado, C.; Boscá, L.; Fernández-Velasco, M. "Innate Immune Receptors, Key Actors in Cardiovascular Diseases.". JACC Basic Transl Sci. 5(7): 735-749. (2020). (PMID: 32760860).
    spacer

  13. Tamayo, M.; Fulgencio-Covián, A.; Navarro-García, J.A.; Val-Blasco, A.; Ruiz-Hurtado, G.; Gil-Fernández, M.; Martín-Nunes, L.; Lopez, J.A.; Desviat, L.R.; Delgado, C.; Richard, E.; Fernández-Velasco, M. "Intracellular calcium mishandling leads to cardiac dysfunction and ventricular arrhythmias in a mouse model of propionic acidemia.". Biochim Biophys Acta Mol Basis Dis. 1866(1): 165586. (2020). (PMID: 31678161).
    spacer

  14. Delgado, C.; Gomez, A.M.; Samia El Hayek, M.; Ruiz-Hurtado, G.; Pereira, L. "Gender-Dependent Alteration of Ca2+ and TNFα Signaling in db/db Mice, an Obesity-Linked Type 2 Diabetic Model.". Front Physiol. 10(): 40. (2019). (PMID: 30792662).
    spacer

  15. Navarro-García, J.A.; Delgado, C.; Fernández-Velasco, M.; Val-Blasco, A.; Rodríguez-Sánchez, E.; Aceves-Ripoll, J.; Gómez-Hurtado, N.; Bada-Bosch, T.; Mérida-Herrero, E.; Hernández, E.; Praga, M.; Salguero, R.; Solís, J.; Arribas, F.; Delgado, J.F.; Bueno, H.; Kuro-O, M.; Ruilope, L.M.; Ruiz-Hurtado, G. "Fibroblast growth factor-23 promotes rhythm alterations and contractile dysfunction in adult ventricular cardiomyocytes.". Nephrol. Dial. Transplant.. (): . (2019). (PMID: 30629224).
    spacer

  16. Tamayo, M.; Martin-Nunes, L.; Val-Blasco, A.; Piedras, M.J.; Larriba, M.J.; Gómez-Hurtado, N.; Fernández-Velasco, M.; Delgado, C. "Calcitriol, the Bioactive Metabolite of Vitamin D, Increases Ventricular K+ Currents in Isolated Mouse Cardiomyocytes.". Front Physiol. 9(): 1186. (2018). (PMID: 30197603).
    spacer

  17. Val-Blasco, A.; Navarro-García, J.A.; Tamayo, M.; Piedras, M.J.; Prieto, P.; Delgado, C.; Ruiz-Hurtado, G.; Rozas-Romero, L.; Gil-Fernández, M.; Zaragoza, C.; Boscá, L.; Fernández-Velasco, M. "Deficiency of NOD1 Improves the β-Adrenergic Modulation of Ca2+ Handling in a Mouse Model of Heart Failure.". Front Physiol. 9(): 702. (2018). (PMID: 29962957).
    spacer

  18. Navarro-García, J.A.; Fernández-Velasco, M.; Delgado, C.; Delgado, J.F.; Kuro-O, M.; Ruilope, L.M.; Ruiz-Hurtado, G. "PTH, vitamin D, and the FGF-23-klotho axis and heart: Going beyond the confines of nephrology.". Eur. J. Clin. Invest.. 48(4): . (2018). (PMID: 29394451).
    spacer

  19. Gómez-Hurtado, N.; Domínguez-Rodríguez, A.; Mateo, P.; Fernandez-Velasco, M.; Val-Blasco, A.; Aizpún, R.; Sabourin, J.; Gómez, A.M.; Benitah, J.P.; Delgado, C. "Beneficial effects of leptin treatment in a setting of cardiac dysfunction induced by transverse aortic constriction in mouse.". J. Physiol. (Lond.). (): . (2017). (PMID: 28374413).
    spacer

  20. Tamayo, M.; Manzanares, E.; Bas, M.; Martín-Nunes, L.; Val-Blasco, A.; Jesús Larriba, M.; Fernández-Velasco, M.; Delgado, C. "Calcitriol (1,25-dihydroxyvitamin D3) increases L-type calcium current via protein kinase A signaling and modulates calcium cycling and contractility in isolated mouse ventricular myocytes.". Heart Rhythm. 14(3): 432-439. (2017). (PMID: 27989685).
    spacer

  21. Val-Blasco, A.; Prieto, P.; Gonzalez-Ramos, S.; Benito, G.; Vallejo-Cremades, M.T.; Pacheco, I.; González-Peramato, P.; Agra, N.; Terrón, V.; Delgado, C.; Martín-Sanz, P.; Boscá, L.; Fernández-Velasco, M. "NOD1 activation in cardiac fibroblasts induces myocardial fibrosis in a murine model of type 2 diabetes.". Biochem. J.. 474(3): 399-410. (2017). (PMID: 27803247).
    spacer

  22. Val-Blasco, A.; Piedras, M.J.; Ruiz-Hurtado, G.; Suarez, N.; Prieto, P.; Gonzalez-Ramos, S.; Gómez-Hurtado, N.; Delgado, C.; Pereira, L.; Benito, G.; Zaragoza, C.; Domenech, N.; Crespo-Leiro, M.G.; Vasquez-Echeverri, D.; Nuñez, G.; Lopez-Collazo, E.; Boscá, L.; Fernández-Velasco, M. "Role of NOD1 in Heart Failure Progression via Regulation of Ca(2+) Handling.". J. Am. Coll. Cardiol.. 69(4): 423-433. (2017). (PMID: 28126160).
    spacer

  23. Delgado, C.; Ruiz-Hurtado, G.; Gómez-Hurtado, N.; González-Ramos, S.; Rueda, A.; Benito, G.; Prieto, P.; Zaragoza, C.; Delicado, E.G.; Pérez-Sen, R.; Miras-Portugal, M.T.; Núñez, G.; Boscá, L.; Fernández-Velasco, M. "NOD1, A new player in cardiac function and calcium handling.". Cardiovasc. Res.. (): . (2015). (PMID: 25824149).
    spacer

    CONCLUSION
    Our data provide the first evidence that NOD1 activation induces cardiac dysfunction associated with excitation-contraction coupling-impairment through NF-κB activation, and uncover a new proinflammatory player in the regulation of cardiovascular function.

    ')" value="Abstract">

  24. Prieto, P.; Vallejo-Cremades, M.T.; Benito, G.; González-Peramato, P.; Francés, D.; Agra, N.; Terrón, V.; Gónzalez-Ramos, S.; Delgado, C.; Ruiz-Gayo, M.; Pacheco, I.; Velasco-Martín, J.P.; Regadera, J.; Martín-Sanz, P.; López-Collazo, E.; Boscá, L.; Fernández-Velasco, M. "NOD1 receptor is up-regulated in diabetic human and murine myocardium.". Clin. Sci.. 127(12): 665-677. (2014). (PMID: 24934088).
    spacer

  25. Gómez-Hurtado, N.; Fernández-Velasco, M.; Fernández-Alfonso, M.S.; Boscá, L.; Delgado, C. "Prolonged leptin treatment increases transient outward K⁺ current via upregulation of Kv4.2 and Kv4.3 channel subunits in adult rat ventricular myocytes.". Pflugers Arch.. 466(5): 903-914. (2014). (PMID: 24046152).
    spacer

  26. Guzmán-Ruiz, R.; Gómez-Hurtado, N.; Gil-Ortega, M.; Somoza, B.; González, M.C.; Aránguez, I.; Martín-Ramos, M.; González-Martín, C.; Delgado, C.; Fernández-Alfonso, M.; Ruiz-Gayo, M. "Remodeling of energy metabolism and absence of electrophysiological changes in the heart of obese hyperleptinemic mice. New insights into the pleiotropic role of leptin.". Front Endocrinol (Lausanne). 4(): 175. (2013). (PMID: 24298268).
    spacer

  27. Ruiz-Hurtado, G.; Gómez-Hurtado, N.; Fernández-Velasco, M.; Calderón, E.; Smani, T.; Ordoñez, A.; Cachofeiro, V.; Boscá, L.; Díez, J.; Gómez, A.M.; Delgado, C. "Cardiotrophin-1 induces sarcoplasmic reticulum Ca(2+) leak and arrhythmogenesis in adult rat ventricular myocytes.". Cardiovasc. Res.. 96(1): 81-89. (2012). (PMID: 22787135).
    spacer

  28. Fernández-Velasco, M.; Prieto, P.; Terrón, V.; Benito, G.; Flores, J.M.; Delgado, C.; Zaragoza, C.; Lavin, B.; Gómez-Parrizas, M.; López-Collazo, E.; Martín-Sanz, P.; Boscá, L. "NOD1 activation induces cardiac dysfunction and modulates cardiac fibrosis and cardiomyocyte apoptosis.". PLoS ONE. 7(9): e45260. (2012). (PMID: 23028889).
    spacer

  29. Martín, R.; Miana, M.; Jurado-López, R.; Martínez-Martínez, E.; Gómez-Hurtado, N.; Delgado, C.; Bartolomé, M.V.; San Román, J.A.; Cordova, C.; Lahera, V.; Nieto, M.L.; Cachofeiro, V. "DIOL triterpenes block profibrotic effects of angiotensin II and protect from cardiac hypertrophy.". PLoS ONE. 7(7): e41545. (2012). (PMID: 22844495).
    spacer

  30. Calderón-Sánchez, E.M.; Ruiz-Hurtado, G.; Smani, T.; Delgado, C.; Benitah, J.P.; Gómez, A.M.; Ordóñez, A. "Cardioprotective action of urocortin in postconditioning involves recovery of intracellular calcium handling.". Cell Calcium. 50(1): 84-90. (2011). (PMID: 21663963).
    spacer

  31. Fernández-Velasco, M.; Ruiz-Hurtado, G.; Rueda, A.; Neco, P.; Mercado-Morales, M.; Delgado, C.; Napolitano, C.; Priori, S.G.; Richard, S.; Gómez, A.M.; Benitah, J.P. "RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.". PLoS ONE. 6(6): e20863. (2011). (PMID: 21673970).
    spacer

  32. Martín-Fernández, B.; de las Heras, N.; Miana, M.; Ballesteros, S.; Delgado, C.; Song, S.; Hintze, T.; Cachofeiro, V.; Lahera, V. "Structural, functional, and molecular alterations produced by aldosterone plus salt in rat heart: association with enhanced serum and glucocorticoid-regulated kinase-1 expression.". J. Cardiovasc. Pharmacol.. 57(1): 114-121. (2011). (PMID: 20980916).
    spacer

  33. Ruiz-Hurtado, G.; Delgado, C. "Nitric oxide pathway in hypertrophied heart: new therapeutic uses of nitric oxide donors.". J. Hypertens.. 28 Suppl 1(): S56-61. (2010). (PMID: 20823718).
    spacer

  34. Smani, T.; Calderón-Sanchez, E.; Gómez-Hurtado, N.; Fernández-Velasco, M.; Cachofeiro, V.; Lahera, V.; Ordoñez, A.; Delgado, C. "Mechanisms underlying the activation of L-type calcium channels by urocortin in rat ventricular myocytes.". Cardiovasc. Res.. 87(3): 459-466. (2010). (PMID: 20189952).
    spacer

  35. Calderón-Sanchez, E.; Delgado, C.; Ruiz-Hurtado, G.; Domínguez-Rodríguez, A.; Cachofeiro, V.; Rodríguez-Moyano, M.; Gomez, A.M.; Ordóñez, A.; Smani, T. "Urocortin induces positive inotropic effect in rat heart.". Cardiovasc. Res.. 83(4): 717-725. (2009). (PMID: 19460778).
    spacer

  36. Martin-Fernandez, B.; Miana, M.; De Las Heras, N.; Ruiz-Hurtado, G.; Fernandez-Velasco, M.; Bas, M.; Ballesteros, S.; Lahera, V.; Cachofeiro, V.; Delgado, C. "Cardiac L-type calcium current is increased in a model of hyperaldosteronism in the rat.". Exp. Physiol.. 94(6): 675-683. (2009). (PMID: 19395659).
    spacer

  37. Ruiz-Hurtado, G.; Fernández-Velasco, M.; Mourelle, M.; Delgado, C. "LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation.". Hypertension. 50(6): 1049-1056. (2007). (PMID: 17984372).
    spacer

  38. Fernández-Velasco, M.; Ruiz-Hurtado, G.; Hurtado, O.; Moro, M.A.; Delgado, C. "TNF-alpha downregulates transient outward potassium current in rat ventricular myocytes through iNOS overexpression and oxidant species generation.". Am. J. Physiol. Heart Circ. Physiol.. 293(1): H238-45. (2007). (PMID: 17337591).
    spacer

  39. Fernández-Velasco, M.; Ruiz-Hurtado, G.; Delgado, C. "I K1 and I f in ventricular myocytes isolated from control and hypertrophied rat hearts.". Pflugers Arch.. 452(2): 146-154. (2006). (PMID: 16395601).
    spacer

  40. Heredia, M.d.e.l. .P.; Delgado, C.; Pereira, L.; Perrier, R.; Richard, S.; Vassort, G.; Bénitah, J.P.; Gómez, A.M. "Neuropeptide Y rapidly enhances [Ca2+]i transients and Ca2+ sparks in adult rat ventricular myocytes through Y1 receptor and PLC activation.". J. Mol. Cell. Cardiol.. 38(1): 205-212. (2005). (PMID: 15623437).
    spacer

  41. Fernández-Velasco, M.; Goren, N.; Benito, G.; Blanco-Rivero, J.; Boscá, L.; Delgado, C. "Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts.". J. Physiol. (Lond.). 553(Pt 2): 395-405. (2003). (PMID: 14514868).
    spacer

  42. Heredia, M.P.; Fernández-Velasco, M.; Benito, G.; Delgado, C. "Neuropeptide Y increases 4-aminopyridine-sensitive transient outward potassium current in rat ventricular myocytes.". Br. J. Pharmacol.. 135(7): 1701-1706. (2002). (PMID: 11934810).
    spacer

  43. Martínez, M.L.; Delgado, C. "Methoxamine inhibits transient outward potassium current through alpha1A-adrenoceptors in rat ventricular myocytes.". J. Cardiovasc. Pharmacol.. 35(2): 212-218. (2000). (PMID: 10672852).
    spacer

  44. Delgado, C.; Artiles, A.; Gómez, A.M.; Vassort, G. "Frequency-dependent increase in cardiac Ca2+ current is due to reduced Ca2+ release by the sarcoplasmic reticulum.". J. Mol. Cell. Cardiol.. 31(10): 1783-1793. (1999). (PMID: 10525417).
    spacer

  45. Martínez, M.L.; Fernández-Tomé, P.; López-Miranda, V.; Colado, M.I.; Delgado, C. "Modulation of adrenergic receptors during left ventricular hypertrophy development and after regression by captopril.". J. Cardiovasc. Pharmacol.. 34(4): 505-511. (1999). (PMID: 10511124).
    spacer

  46. Martínez, M.L.; Heredia, M.P.; Delgado, C. "Expression of T-type Ca(2+) channels in ventricular cells from hypertrophied rat hearts.". J. Mol. Cell. Cardiol.. 31(9): 1617-1625. (1999). (PMID: 10471346).
    spacer

  47. Bénitah, J.P.; Gómez, A.M.; Delgado, C.; Lorente, P.; Lederer, W.J. "A chloride current component induced by hypertrophy in rat ventricular myocytes.". Am. J. Physiol.. 272(5 Pt 2): H2500-6. (1997). (PMID: 9176322).
    spacer

  48. Gómez, A.M.; Benitah, J.P.; Henzel, D.; Vinet, A.; Lorente, P.; Delgado, C. "Modulation of electrical heterogeneity by compensated hypertrophy in rat left ventricle.". Am. J. Physiol.. 272(3 Pt 2): H1078-86. (1997). (PMID: 9087578).
    spacer

  49. Bénitah, J.P.; Gomez, A.M.; Bailly, P.; Da Ponte, J.P.; Berson, G.; Delgado, C.; Lorente, P. "Heterogeneity of the early outward current in ventricular cells isolated from normal and hypertrophied rat hearts.". J. Physiol. (Lond.). 469(): 111-138. (1993). (PMID: 7505822).
    spacer

  50. Delgado, C.; Tamargo, J.; Henzel, D.; Lorente, P. "Effects of propafenone on calcium current in guinea-pig ventricular myocytes.". Br. J. Pharmacol.. 108(3): 721-727. (1993). (PMID: 8385535).
    spacer

  51. Lorente, P.; Delgado, C.; Delmar, M.; Jalife, J. "Analytical modeling of the hysteresis phenomenon in guinea pig ventricular myocytes.". Acta Biotheor.. 40(2-3): 177-193. (1992). (PMID: 1462735).
    spacer

  52. Bénitah, J.P.; Bailly, P.; D'Agrosa, M.C.; Da Ponte, J.P.; Delgado, C.; Lorente, P. "Slow inward current in single cells isolated from adult human ventricles.". Pflugers Arch.. 421(2-3): 176-187. (1992). (PMID: 1356263).
    spacer

  53. Lorente, P.; Delgado, C.; Delmar, M.; Henzel, D.; Jalife, J. "Hysteresis in the excitability of isolated guinea pig ventricular myocytes.". Circ. Res.. 69(5): 1301-1315. (1991). (PMID: 1718624).
    spacer

  54. Tejerina, T.; Sesin, J.; Delgado, C.; Gonzalez, P.; Tamargo, J. "Effects of pimobendan and UD-CG-212 CL on calcium exchange and contraction in isolated rabbit aorta.". Arch Int Pharmacodyn Ther. 305(): 69-85. (1990). (PMID: 2241431).
    spacer

  55. Delgado, C.; Steinhaus, B.; Delmar, M.; Chialvo, D.R.; Jalife, J. "Directional differences in excitability and margin of safety for propagation in sheep ventricular epicardial muscle.". Circ. Res.. 67(1): 97-9110. (1990). (PMID: 2364498).
    spacer

  56. Manzanares, J.; Valenzuela, C.; Delgado, C.; Tamargo, J. "Comparison of six new antidepressants on isolated rat atria.". Arzneimittelforschung. 38(6): 805-809. (1988). (PMID: 3178921).
    spacer

  57. Tejerina, T.; Sesin, J.; Delgado, C.; Tamargo, J. "Effect of milrinone on contractility and 45Ca movements in the isolated rabbit aorta.". Eur. J. Pharmacol.. 148(2): 239-246. (1988). (PMID: 3378573).
    spacer

  58. Valenzuela, C.; Delgado, C.; Tamargo, J. "Electrophysiological effects of 5-hydroxypropafenone on guinea pig ventricular muscle fibers.". J. Cardiovasc. Pharmacol.. 10(5): 523-529. (1987). (PMID: 2447400).
    spacer

  59. Tejerina, T.; Delgado, C.; Valenzuela, C.; Tamargo, J. "Comparative effects of oxodipine and nifedipine in the isolated guinea-pig heart.". Arch Int Pharmacodyn Ther. 288(2): 186-199. (1987). (PMID: 3675081).
    spacer

  60. Delgado, C.; Tamargo, J.; Tejerina, T.; Valenzuela, C. "Effects of 5-hydroxy-propafenone in guinea-pig atrial fibres.". Br. J. Pharmacol.. 90(3): 575-582. (1987). (PMID: 2882804).
    spacer

  61. Delgado, C.; Manzanares, J.; Tamargo, J.; Valenzuela, C. "Electrophysiological effects of amoxapine in untreated and in amoxapine-pretreated rat atria.". Br. J. Pharmacol.. 87(2): 317-325. (1986). (PMID: 3955303).
    spacer

  62. Delgado, C.; Tamargo, J.; Tejerina, T. "Electrophysiological effects of propafenone in untreated and propafenone-pretreated guinea-pig atrial and ventricular muscle fibres.". Br. J. Pharmacol.. 86(4): 765-775. (1985). (PMID: 4075015).
    spacer

  63. Tamargo, J.; Delgado, C. "Electrophysiological effects of propafenone on isolated guinea-pig ventricular muscle and sheep Purkinje fibres.". Eur. J. Pharmacol.. 118(3): 331-340. (1985). (PMID: 4085559).
    spacer

  64. Tamargo, J.; Tejerina, T.; Delgado, C.; Barrigon, S. "Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles.". Eur. J. Pharmacol.. 109(2): 219-227. (1985). (PMID: 3996472).
    spacer

  65. Tejerina, M.T.; Delgado, C.; Diez, J.; Tamargo, J. "Inotropic and electrophysiological effects of PY 108-068 on isolated cardiac preparations.". Arch Int Pharmacodyn Ther. 271(1): 64-80. (1984). (PMID: 6497511).
    spacer

  66. Barrigon, S.; Tejerina, T.; Delgado, C.; Tamargo, J. "Effects of chlorbutol on 45Ca movements and contractile responses of rat aorta and its relevance to the actions of Syntocinon.". J. Pharm. Pharmacol.. 36(8): 521-526. (1984). (PMID: 6148394).
    spacer

  67. Diez, J.; Delgado, C.; Tamargo, J. "An analysis of the positive inotropic effect of AR-L 115 BS on isolated rat atria.". Arch Int Pharmacodyn Ther. 269(1): 70-82. (1984). (PMID: 6466008).
    spacer

  68. Barrigón, S.; Delgado, C.; Tejerina, T.; Tamargo, J. "Effects of bunaphtine on 45Ca movements in rat aortic smooth muscle.". Experientia. 39(7): 761-763. (1983). (PMID: 6861966).
    spacer

 

 

 

 

 

Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
Tel +(34) 91 585 4400 // Fax +(34) 91 558 4401
Email:Info