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PUBLICACIONES

 

 

spacerTrabajos Publicados por Amparo Cano García
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  1. Youssef, K.K.; Narwade, N.; Arcas, A.; Marquez-Galera, A.; Jiménez-Castaño, R.; Lopez-Blau, C.; Fazilaty, H.; García-Gutierrez, D.; Cano, A.; Galcerán, J.; Moreno-Bueno, G.; Lopez-Atalaya, J.P.; Nieto, M.A. "Two distinct epithelial-to-mesenchymal transition programs control invasion and inflammation in segregated tumor cell populations.". Nat Cancer. (): . (2024). (PMID: 39414946).
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  2. Morillo-Bernal, J.; Pizarro-García, P.; Moreno-Bueno, G.; Cano, A.; Mazón, M.J.; Eraso, P.; Portillo, F. "HuR (ELAVL1) Stabilizes SOX9 mRNA and Promotes Migration and Invasion in Breast Cancer Cells.". Cancers (Basel). 16(2): . (2024). (PMID: 38254873).
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  3. Cano, A.; Eraso, P.; Mazón, M.J.; Portillo, F. "LOXL2 in Cancer: A Two-Decade Perspective.". Int J Mol Sci. 24(18): . (2023). (PMID: 37762708).
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  4. Eraso, P.; Mazón, M.J.; Jiménez, V.; Pizarro-García, P.; Cuevas, E.P.; Majuelos-Melguizo, J.; Morillo-Bernal, J.; Cano, A.; Portillo, F. "New Functions of Intracellular LOXL2: Modulation of RNA-Binding Proteins.". Molecules. 28(11): . (2023). (PMID: 37298909).
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  5. Santamaría, P.G.; Dubus, P.; Bustos-Tauler, J.; Floristán, A.; Vázquez-Naharro, A.; Morales, S.; Cano, A.; Portillo, F. "Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.". Int J Mol Sci. 23(10): . (2022). (PMID: 35628534).
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  6. Alonso-Nocelo, M.; Ruiz-Cañas, L.; Sancho, P.; Görgülü, K.; Alcalá, S.; Pedrero, C.; Vallespinos, M.; López-Gil, J.C.; Ochando, M.; García-García, E.; David Trabulo, S.M.; Martinelli, P.; Sánchez-Tomero, P.; Sánchez-Palomo, C.; Gonzalez-Santamaría, P.; Yuste, L.; Wörmann, S.M.; Kabacaoğlu, D.; Earl, J.; Martin, A.; Salvador, F.; Valle, S.; Martin-Hijano, L.; Carrato, A.; Erkan, M.; García-Bermejo, L.; Hermann, P.C.; Algül, H.; Moreno-Bueno, G.; Heeschen, C.; Portillo, F.; Cano, A.; Sainz, B. "Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.". Gut. (): . (2022). (PMID: 35428659).
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  7. Vázquez-Naharro, A.; Bustos-Tauler, J.; Floristán, A.; Yuste, L.; Oltra, S.S.; Vinyals, A.; Moreno-Bueno, G.; Fabra, À.; Portillo, F.; Cano, A.; Santamaría, P.G. "Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival.". Cancers (Basel). 14(5): . (2022). (PMID: 35267510).
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  8. Yang, J.; Antin, P.; Berx, G.; Blanpain, C.; Brabletz, T.; Bronner, M.; Campbell, K.; Cano, A.; Casanova, J.; Christofori, G.; Dedhar, S.; Derynck, R.; Ford, H.L.; Fuxe, J.; García de Herreros, A.; Goodall, G.J.; Hadjantonakis, A.K.; Huang, R.Y.J.; Kalcheim, C.; Kalluri, R.; Kang, Y.; Khew-Goodall, Y.; Levine, H.; Liu, J.; Longmore, G.D.; Mani, S.A.; Massagué, J.; Mayor, R.; McClay, D.; Mostov, K.E.; Newgreen, D.F.; Nieto, M.A.; Puisieux, A.; Runyan, R.; Savagner, P.; Stanger, B.; Stemmler, M.P.; Takahashi, Y.; Takeichi, M.; Theveneau, E.; Thiery, J.P.; Thompson, E.W.; Weinberg, R.A.; Williams, E.D.; Xing, J.; Zhou, B.P.; Sheng, G.; , . "Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition.". Nat Rev Mol Cell Biol. (): . (2021). (PMID: 34654908).
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  9. López-Menéndez, C.; Vázquez-Naharro, A.; Santos, V.; Dubus, P.; Santamaría, P.G.; Martínez-Ramírez, Á.; Portillo, F.; Moreno-Bueno, G.; Faraldo, M.M.; Cano, A. "E2A modulates stemness, metastasis, and therapeutic resistance of breast cancer.". Cancer Res. (): . (2021). (PMID: 34145034).
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  10. Grilli, G.; Hermida-Prado, F.; Álvarez-Fernández, M.; Allonca, E.; Álvarez-González, M.; Astudillo, A.; Moreno-Bueno, G.; Cano, A.; García-Pedrero, J.M.; Rodrigo, J.P. "Impact of notch signaling on the prognosis of patients with head and neck squamous cell carcinoma.". Oral Oncol.. 110(): 105003. (2020). (PMID: 32932170).
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  11. Palacios-García, J.; Sanz-Flores, M.; Asensio, A.; Alvarado, R.; Rojo-Berciano, S.; Stamatakis, K.; Paramio, J.M.; Cano, A.; Nieto, M.Á.; García-Escudero, R.; Mayor, F.; Ribas, C. "G-protein-coupled receptor kinase 2 safeguards epithelial phenotype in head and neck squamous cell carcinomas.". Int. J. Cancer. 147(1): 218-229. (2020). (PMID: 31850518).
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  12. Yang, J.; Antin, P.; Berx, G.; Blanpain, C.; Brabletz, T.; Bronner, M.; Campbell, K.; Cano, A.; Casanova, J.; Christofori, G.; Dedhar, S.; Derynck, R.; Ford, H.L.; Fuxe, J.; García de Herreros, A.; Goodall, G.J.; Hadjantonakis, A.K.; Huang, R.J.Y.; Kalcheim, C.; Kalluri, R.; Kang, Y.; Khew-Goodall, Y.; Levine, H.; Liu, J.; Longmore, G.D.; Mani, S.A.; Massagué, J.; Mayor, R.; McClay, D.; Mostov, K.E.; Newgreen, D.F.; Nieto, M.A.; Puisieux, A.; Runyan, R.; Savagner, P.; Stanger, B.; Stemmler, M.P.; Takahashi, Y.; Takeichi, M.; Theveneau, E.; Thiery, J.P.; Thompson, E.W.; Weinberg, R.A.; Williams, E.D.; Xing, J.; Zhou, B.P.; Sheng, G.; , . "Guidelines and definitions for research on epithelial-mesenchymal transition.". Nat. Rev. Mol. Cell Biol.. (): . (2020). (PMID: 32300252).
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  13. Abreu, M.; Cabezas-Sainz, P.; Pereira-Veiga, T.; Falo, C.; Abalo, A.; Morilla, I.; Curiel, T.; Cueva, J.; Rodríguez, C.; Varela-Pose, V.; Lago-Lestón, R.; Mondelo, P.; Palacios, P.; Moreno-Bueno, G.; Cano, A.; García-Caballero, T.; Pujana, M.Á.; Sánchez-Piñón, L.; Costa, C.; López, R.; Muinelo-Romay, L. "Looking for a Better Characterization of Triple-Negative Breast Cancer by Means of Circulating Tumor Cells.". J Clin Med. 9(2): . (2020). (PMID: 32012729).
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  14. Tashkandi, M.; Ali, F.; Alsaqer, S.; Alhousami, T.; Cano, A.; Martin, A.; Salvador, F.; Portillo, F.; C Gerstenfeld, L.; Goldring, M.B.; Bais, M.V. "Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.". Int J Mol Sci. 20(19): . (2019). (PMID: 31569601).
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  15. Santamaría, P.G.; Moreno-Bueno, G.; Cano, A. "Contribution of Epithelial Plasticity to Therapy Resistance.". J Clin Med. 8(5): . (2019). (PMID: 31091749).
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  16. Molina-Crespo, Á.; Cadete, A.; Sarrio, D.; Gámez-Chiachio, M.; Martinez, L.; Chao, K.; Olivera, A.; Gonella, A.; Díaz, E.; Palacios, J.; Dhal, P.K.; Besev, M.; Rodríguez-Serrano, M.; García Bermejo, M.L.; Triviño, J.C.; Cano, A.; García-Fuentes, M.; Herzberg, O.; Torres, D.; Alonso, M.J.; Moreno-Bueno, G. "Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness.". Clin. Cancer Res.. (): . (2019). (PMID: 31064780).
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  17. Kober, K.I.; Cano, A.; Géraud, C.; Sipilä, K.; Mobasseri, S.A.; Philippeos, C.; Pisco, A.O.; Stannard, A.; Martin, A.; Salvador, F.; Santos, V.; Boutros, M.; Rognoni, E.; Watt, F.M. "Loxl2 is dispensable for dermal development, homeostasis and tumour stroma formation.". PLoS ONE. 13(6): e0199679. (2018). (PMID: 29953488).
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  18. Santamaría, P.G.; Floristán, A.; Fontanals-Cirera, B.; Vázquez-Naharro, A.; Santos, V.; Morales, S.; Yuste, L.; Peinado, H.; García-Gómez, A.; Portillo, F.; Hernando, E.; Cano, A. "Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.". Cell Death Differ.. 25(5): 935-950. (2018). (PMID: 29229995).
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  19. Salvador, F.; Martin, A.; López-Menéndez, C.; Moreno-Bueno, G.; Santos, V.; Vazquez-Naharro, A.; Santamaría, P.G.; Morales, S.; Dubus, P.; Muinelo-Romay, L.; López López, R.; Tung, J.C.; Weaver, V.M.; Portillo, F.; Cano, A. "Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer.". Cancer Res.. (): . (2017). (PMID: 28720577).
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  20. Santamaria, P.G.; Moreno-Bueno, G.; Portillo, F.; Cano, A. "EMT: Present and future in clinical oncology.". Mol Oncol. (): . (2017). (PMID: 28590039).
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  21. Cuevas, E.P.; Eraso, P.; Mazón, M.J.; Santos, V.; Moreno-Bueno, G.; Cano, A.; Portillo, F. "LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.". Sci Rep. 7(): 44988. (2017). (PMID: 28332555).
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  22. Hergueta-Redondo, M.; Sarrio, D.; Molina-Crespo, Á.; Vicario, R.; Bernadó-Morales, C.; Martínez, L.; Rojo-Sebastián, A.; Serra-Musach, J.; Mota, A.; Martínez-Ramírez, Á.; Castilla, M.Á.; González-Martin, A.; Pernas, S.; Cano, A.; Cortes, J.; Nuciforo, P.G.; Peg, V.; Palacios, J.; Pujana, M.Á.; Arribas, J.; Moreno-Bueno, G. "Gasdermin B expression predicts poor clinical outcome in HER2-positive breast cancer.". Oncotarget. (): . (2016). (PMID: 27462779).
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  23. Villarejo, A.; Molina-Ortiz, P.; Montenegro, Y.; Moreno-Bueno, G.; Morales, S.; Santos, V.; Gridley, T.; Pérez-Moreno, M.A.; Peinado, H.; Portillo, F.; Calés, C.; Cano, A. "Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.". Carcinogenesis. 36(5): 585-597. (2015). (PMID: 25784375).
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  24. Martin, A.; Salvador, F.; Moreno-Bueno, G.; Floristán, A.; Ruiz-Herguido, C.; Cuevas, E.P.; Morales, S.; Santos, V.; Csiszar, K.; Dubus, P.; Haigh, J.J.; Bigas, A.; Portillo, F.; Cano, A. "Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.". EMBO J.. 34(8): 1090-1109. (2015). (PMID: 25759215).
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  25. Canesin, G.; Cuevas, E.P.; Santos, V.; López-Menéndez, C.; Moreno-Bueno, G.; Huang, Y.; Csiszar, K.; Portillo, F.; Peinado, H.; Lyden, D.; Cano, A. "Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.". Oncogene. 34(8): 951-964. (2015). (PMID: 24632622).
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  26. Díaz-López, A.; Díaz-Martín, J.; Moreno-Bueno, G.; Cuevas, E.P.; Santos, V.; Olmeda, D.; Portillo, F.; Palacios, J.; Cano, A. "Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT.". Int. J. Cancer. 136(4): E62-73. (2015). (PMID: 25178837).
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  27. Díaz-López, A.; Moreno-Bueno, G.; Cano, A. "Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives.". Cancer Manag Res. 6(): 205-216. (2014). (PMID: 24812525).
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  28. Hergueta-Redondo, M.; Sarrió, D.; Molina-Crespo, Á.; Megias, D.; Mota, A.; Rojo-Sebastian, A.; García-Sanz, P.; Morales, S.; Abril, S.; Cano, A.; Peinado, H.; Moreno-Bueno, G. "Gasdermin-B promotes invasion and metastasis in breast cancer cells.". PLoS ONE. 9(3): e90099. (2014). (PMID: 24675552).
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  29. Cuevas, E.P.; Moreno-Bueno, G.; Canesin, G.; Santos, V.; Portillo, F.; Cano, A. "LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.". Biol Open. 3(2): 129-137. (2014). (PMID: 24414204).
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  30. Villarejo, A.; Cortés-Cabrera, A.; Molina-Ortíz, P.; Portillo, F.; Cano, A. "Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition.". J. Biol. Chem.. 289(2): 930-941. (2014). (PMID: 24297167).
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  31. Cubillo, E.; Diaz-Lopez, A.; Cuevas, E.P.; Moreno-Bueno, G.; Peinado, H.; Montes, A.; Santos, V.; Portillo, F.; Cano, A. "E47 and Id1 interplay in epithelial-mesenchymal transition.". PLoS ONE. 8(3): e59948. (2013). (PMID: 23555842).
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  32. Romero-Pérez, L.; Castilla, M.Á.; López-García, M.Á.; Díaz-Martín, J.; Biscuola, M.; Ramiro-Fuentes, S.; Oliva, E.; Matias-Guiu, X.; Prat, J.; Cano, A.; Moreno-Bueno, G.; Palacios, J. "Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis.". Hum. Pathol.. 44(2): 244-254. (2013). (PMID: 22974476).
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  33. Ocaña, O.H.; Córcoles, R.; Fabra, A.; Moreno-Bueno, G.; Acloque, H.; Vega, S.; Barrallo-Gimeno, A.; Cano, A.; Nieto, M.A. "Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.". Cancer Cell. 22(6): 709-724. (2012). (PMID: 23201163).
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  34. Nieto, M.A.; Cano, A. "The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity.". Semin. Cancer Biol.. 22(5-6): 361-368. (2012). (PMID: 22613485).
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  35. Cano, A.; Santamaría, P.G.; Moreno-Bueno, G. "LOXL2 in epithelial cell plasticity and tumor progression.". Future Oncol. 8(9): 1095-1108. (2012). (PMID: 23030485).
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  36. Molina-Ortiz, P.; Villarejo, A.; MacPherson, M.; Santos, V.; Montes, A.; Souchelnytskyi, S.; Portillo, F.; Cano, A. "Characterization of the SNAG and SLUG domains of Snail2 in the repression of E-cadherin and EMT induction: modulation by serine 4 phosphorylation.". PLoS ONE. 7(5): e36132. (2012). (PMID: 22567133).
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  37. Espada, J.; Peinado, H.; Lopez-Serra, L.; Setién, F.; Lopez-Serra, P.; Portela, A.; Renart, J.; Carrasco, E.; Calvo, M.; Juarranz, A.; Cano, A.; Esteller, M. "Regulation of SNAIL1 and E-cadherin function by DNMT1 in a DNA methylation-independent context.". Nucleic Acids Res.. 39(21): 9194-9205. (2011). (PMID: 21846773).
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  38. Moreno-Bueno, G.; Salvador, F.; Martín, A.; Floristán, A.; Cuevas, E.P.; Santos, V.; Montes, A.; Morales, S.; Castilla, M.A.; Rojo-Sebastián, A.; Martínez, A.; Hardisson, D.; Csiszar, K.; Portillo, F.; Peinado, H.; Palacios, J.; Cano, A. "Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.". EMBO Mol Med. 3(9): 528-544. (2011). (PMID: 21732535).
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  39. Castilla, M.Á.; Moreno-Bueno, G.; Romero-Pérez, L.; Van De Vijver, K.; Biscuola, M.; López-García, M.Á.; Prat, J.; Matías-Guiu, X.; Cano, A.; Oliva, E.; Palacios, J. "Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma.". J. Pathol.. 223(1): 72-80. (2011). (PMID: 21125666).
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  40. Raviña, M.; Cubillo, E.; Olmeda, D.; Novoa-Carballal, R.; Fernandez-Megia, E.; Riguera, R.; Sánchez, A.; Cano, A.; Alonso, M.J. "Hyaluronic acid/chitosan-g-poly(ethylene glycol) nanoparticles for gene therapy: an application for pDNA and siRNA delivery.". Pharm. Res.. 27(12): 2544-2555. (2010). (PMID: 20857179).
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  41. Castilla, M.A.; Moreno-Bueno, G.; Romero-Pérez, L.; De Vijver, K.V.; Biscuola, M.; López-García, M.A.; Prat, J.; Matías-Guiu, X.; Cano, A.; Oliva, E.; Palacios, J. "Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma.". J. Pathol.. (): . (2010). (PMID: 21038317).
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  42. Martin, A.; Cano, A. "Tumorigenesis: Twist1 links EMT to self-renewal.". Nat. Cell Biol.. 12(10): 924-925. (2010). (PMID: 20885418).
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  43. Santibáñez, J.F.; Kocić, J.; Fabra, A.; Cano, A.; Quintanilla, M. "Rac1 modulates TGF-beta1-mediated epithelial cell plasticity and MMP9 production in transformed keratinocytes.". FEBS Lett.. 584(11): 2305-2310. (2010). (PMID: 20353788).
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  44. Cano, A.; Portillo, F. "An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression.". Cell Adh Migr. 4(1): 56-60. (2010). (PMID: 20023376).
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  45. MacPherson, M.R.; Molina, P.; Souchelnytskyi, S.; Wernstedt, C.; Martin-Pérez, J.; Portillo, F.; Cano, A. "Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.". Mol. Biol. Cell. 21(2): 244-253. (2010). (PMID: 19923321).
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  46. Moreno-Bueno, G.; Peinado, H.; Molina, P.; Olmeda, D.; Cubillo, E.; Santos, V.; Palacios, J.; Portillo, F.; Cano, A. "The morphological and molecular features of the epithelial-to-mesenchymal transition.". Nat Protoc. 4(11): 1591-1613. (2009). (PMID: 19834475).
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  47. Espada, J.; Galaz, S.; Sanz-Rodríguez, F.; Blázquez-Castro, A.; Stockert, J.C.; Bagazgoitia, L.; Jaén, P.; González, S.; Cano, A.; Juarranz, A. "Oncogenic H-Ras and PI3K signaling can inhibit E-cadherin-dependent apoptosis and promote cell survival after photodynamic therapy in mouse keratinocytes.". J. Cell. Physiol.. 219(1): 84-93. (2009). (PMID: 19065634).
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  48. Sobrado, V.R.; Moreno-Bueno, G.; Cubillo, E.; Holt, L.J.; Nieto, M.A.; Portillo, F.; Cano, A. "The class I bHLH factors E2-2A and E2-2B regulate EMT.". J. Cell. Sci.. 122(Pt 7): 1014-1024. (2009). (PMID: 19295128).
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  49. Sarrió, D.; Palacios, J.; Hergueta-Redondo, M.; Gómez-López, G.; Cano, A.; Moreno-Bueno, G. "Functional characterization of E- and P-cadherin in invasive breast cancer cells.". BMC Cancer. 9(): 74. (2009). (PMID: 19257890).
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  50. Hergueta-Redondo, M.; Palacios, J.; Cano, A.; Moreno-Bueno, G. ""New" molecular taxonomy in breast cancer.". Clin Transl Oncol. 10(12): 777-785. (2008). (PMID: 19068448).
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  51. Fabre-Guillevin, E.; Malo, M.; Cartier-Michaud, A.; Peinado, H.; Moreno-Bueno, G.; Vallée, B.; Lawrence, D.A.; Palacios, J.; Cano, A.; Barlovatz-Meimon, G.; Charrière-Bertrand, C. "PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.". Breast Cancer Res.. 10(6): R100. (2008). (PMID: 19055748).
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  52. Thuault, S.; Tan, E.J.; Peinado, H.; Cano, A.; Heldin, C.H.; Moustakas, A. "HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition.". J. Biol. Chem.. 283(48): 33437-33446. (2008). (PMID: 18832382).
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  53. Moreno-Bueno, G.; Portillo, F.; Cano, A. "Transcriptional regulation of cell polarity in EMT and cancer.". Oncogene. 27(55): 6958-6969. (2008). (PMID: 19029937).
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  54. Cano, A.; Nieto, M.A. "Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition.". Trends Cell Biol.. 18(8): 357-359. (2008). (PMID: 18585040).
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  55. Olmeda, D.; Montes, A.; Moreno-Bueno, G.; Flores, J.M.; Portillo, F.; Cano, A. "Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines.". Oncogene. 27(34): 4690-4701. (2008). (PMID: 18408755).
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  56. Peinado, H.; Moreno-Bueno, G.; Hardisson, D.; Pérez-Gómez, E.; Santos, V.; Mendiola, M.; de Diego, J.I.; Nistal, M.; Quintanilla, M.; Portillo, F.; Cano, A. "Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.". Cancer Res.. 68(12): 4541-4550. (2008). (PMID: 18559498).
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  57. Malanchi, I.; Peinado, H.; Kassen, D.; Hussenet, T.; Metzger, D.; Chambon, P.; Huber, M.; Hohl, D.; Cano, A.; Birchmeier, W.; Huelsken, J. "Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.". Nature. 452(7187): 650-653. (2008). (PMID: 18385740).
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  58. Peinado, H.; Cano, A. "A hypoxic twist in metastasis.". Nat. Cell Biol.. 10(3): 253-254. (2008). (PMID: 18311179).
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  59. Sarrió, D.; Rodriguez-Pinilla, S.M.; Hardisson, D.; Cano, A.; Moreno-Bueno, G.; Palacios, J. "Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype.". Cancer Res.. 68(4): 989-997. (2008). (PMID: 18281472).
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  60. Olmeda, D.; Moreno-Bueno, G.; Flores, J.M.; Fabra, A.; Portillo, F.; Cano, A. "SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells.". Cancer Res.. 67(24): 11721-11731. (2007). (PMID: 18089802).
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  61. Jordà, M.; Vinyals, A.; Marazuela, A.; Cubillo, E.; Olmeda, D.; Valero, E.; Cano, A.; Fabra, A. "Id-1 is induced in MDCK epithelial cells by activated Erk/MAPK pathway in response to expression of the Snail and E47 transcription factors.". Exp. Cell Res.. 313(11): 2389-2403. (2007). (PMID: 17490644).
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  62. Peinado, H.; Olmeda, D.; Cano, A. "Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?". Nat. Rev. Cancer. 7(6): 415-428. (2007). (PMID: 17508028).
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  63. Faraldo, M.M.; Teulière, J.; Deugnier, M.A.; Birchmeier, W.; Huelsken, J.; Thiery, J.P.; Cano, A.; Glukhova, M.A. "beta-Catenin regulates P-cadherin expression in mammary basal epithelial cells.". FEBS Lett.. 581(5): 831-836. (2007). (PMID: 17292359).
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  64. Neria, F.; Caramelo, C.; Peinado, H.; González-Pacheco, F.R.; Deudero, J.J.; de Solis, A.J.; Fernández-Sánchez, R.; Peñate, S.; Cano, A.; Castilla, M.A. "Mechanisms of endothelial cell protection by blockade of the JAK2 pathway.". Am. J. Physiol., Cell Physiol.. 292(3): C1123-31. (2007). (PMID: 17035297).
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  65. Olmeda, D.; Jordá, M.; Peinado, H.; Fabra, A.; Cano, A. "Snail silencing effectively suppresses tumour growth and invasiveness.". Oncogene. 26(13): 1862-1874. (2007). (PMID: 17043660).
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  66. Peinado, H.; Cano, A. "New potential therapeutic targets to combat epithelial tumor invasion.". Clin Transl Oncol. 8(12): 851-857. (2006). (PMID: 17169758).
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  67. Moreno-Bueno, G.; Cubillo, E.; Sarrió, D.; Peinado, H.; Rodríguez-Pinilla, S.M.; Villa, S.; Bolós, V.; Jordá, M.; Fabra, A.; Portillo, F.; Palacios, J.; Cano, A. "Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.". Cancer Res.. 66(19): 9543-9556. (2006). (PMID: 17018611).
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  68. Robert, G.; Gaggioli, C.; Bailet, O.; Chavey, C.; Abbe, P.; Aberdam, E.; Sabatié, E.; Cano, A.; Garcia de Herreros, A.; Ballotti, R.; Tartare-Deckert, S. "SPARC represses E-cadherin and induces mesenchymal transition during melanoma development.". Cancer Res.. 66(15): 7516-7523. (2006). (PMID: 16885349).
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  69. Martínez-Estrada, O.M.; Cullerés, A.; Soriano, F.X.; Peinado, H.; Bolós, V.; Martínez, F.O.; Reina, M.; Cano, A.; Fabre, M.; Vilaró, S. "The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells.". Biochem. J.. 394(Pt 2): 449-457. (2006). (PMID: 16232121).
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  70. Millán, O.; Rico, D.; Peinado, H.; Zarich, N.; Stamatakis, K.; Pérez-Sala, D.; Rojas, J.M.; Cano, A.; Boscá, L. "Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis.". Carcinogenesis. 27(2): 328-336. (2006). (PMID: 16113051).
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  71. Peinado, H.; Portillo, F.; Cano, A. "Switching on-off Snail: LOXL2 versus GSK3beta.". Cell Cycle. 4(12): 1749-1752. (2005). (PMID: 16294032).
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  72. Peinado, H.; Del Carmen Iglesias-de la Cruz, M.; Olmeda, D.; Csiszar, K.; Fong, K.S.; Vega, S.; Nieto, M.A.; Cano, A.; Portillo, F. "A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.". EMBO J. 24(19): 3446-3458. (2005). (PMID: 16096638).
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  73. Jordà, M.; Olmeda, D.; Vinyals, A.; Valero, E.; Cubillo, E.; Llorens, A.; Cano, A.; Fabra, A. "Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor.". J Cell Sci. 118(Pt 15): 3371-3385. (2005). (PMID: 16079281).
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  74. Espada, J.; Peinado, H.; Esteller, M.; Cano, A. "Direct metabolic regulation of beta-catenin activity by the p85alpha regulatory subunit of phosphoinositide 3-OH kinase.". Exp. Cell Res.. 305(2): 409-417. (2005). (PMID: 15817165).
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  75. Fraga, M.F.; Ballestar, E.; Villar-Garea, A.; Boix-Chornet, M.; Espada, J.; Schotta, G.; Bonaldi, T.; Haydon, C.; Ropero, S.; Petrie, K.; Iyer, N.G.; Pérez-Rosado, A.; Calvo, E.; Lopez, J.A.; Cano, A.; Calasanz, M.J.; Colomer, D.; Piris, M.A.; Ahn, N.; Imhof, A.; Caldas, C.; Jenuwein, T.; Esteller, M. "Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer.". Nat. Genet.. 37(4): 391-400. (2005). (PMID: 15765097).
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  76. Peinado, H.; Portillo, F.; Cano, A. "Transcriptional regulation of cadherins during development and carcinogenesis.". Int. J. Dev. Biol.. 48(5-6): 365-375. (2004). (PMID: 15349812).
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  77. Fraga, M.F.; Herranz, M.; Espada, J.; Ballestar, E.; Paz, M.F.; Ropero, S.; Erkek, E.; Bozdogan, O.; Peinado, H.; Niveleau, A.; Mao, J.H.; Balmain, A.; Cano, A.; Esteller, M. "A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors.". Cancer Res.. 64(16): 5527-5534. (2004). (PMID: 15313885).
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  78. Peinado, H.; Marin, F.; Cubillo, E.; Stark, H.J.; Fusenig, N.; Nieto, M.A.; Cano, A. "Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo.". J. Cell. Sci.. 117(Pt 13): 2827-2839. (2004). (PMID: 15169839).
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  79. Sarrió, D.; Pérez-Mies, B.; Hardisson, D.; Moreno-Bueno, G.; Suárez, A.; Cano, A.; Martín-Pérez, J.; Gamallo, C.; Palacios, J. "Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions.". Oncogene. 23(19): 3272-3283. (2004). (PMID: 15077190).
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  80. Peinado, H.; Ballestar, E.; Esteller, M.; Cano, A. "Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex.". Mol. Cell. Biol.. 24(1): 306-319. (2004). (PMID: 14673164).
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  81. Olmeda, D.; Castel, S.; Vilaró, S.; Cano, A. "Beta-catenin regulation during the cell cycle: implications in G2/M and apoptosis.". Mol. Biol. Cell. 14(7): 2844-2860. (2003). (PMID: 12857869).
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  82. Peinado, H.; Quintanilla, M.; Cano, A. "Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.". J. Biol. Chem.. 278(23): 21113-21123. (2003). (PMID: 12665527).
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  83. Bolós, V.; Peinado, H.; Pérez-Moreno, M.A.; Fraga, M.F.; Esteller, M.; Cano, A. "The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors.". J. Cell. Sci.. 116(Pt 3): 499-511. (2003). (PMID: 12508111).
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  84. Blanco, M.J.; Moreno-Bueno, G.; Sarrio, D.; Locascio, A.; Cano, A.; Palacios, J.; Nieto, M.A. "Correlation of Snail expression with histological grade and lymph node status in breast carcinomas.". Oncogene. 21(20): 3241-3246. (2002). (PMID: 12082640).
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  85. Perez-Moreno, M.A.; Locascio, A.; Rodrigo, I.; Dhondt, G.; Portillo, F.; Nieto, M.A.; Cano, A. "A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.". J. Biol. Chem.. 276(29): 27424-27431. (2001). (PMID: 11309385).
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  86. Pálmer, H.G.; González-Sancho, J.M.; Espada, J.; Berciano, M.T.; Puig, I.; Baulida, J.; Quintanilla, M.; Cano, A.; de Herreros, A.G.; Lafarga, M.; Muñoz, A. "Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.". J. Cell Biol.. 154(2): 369-387. (2001). (PMID: 11470825).
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  87. Cano, A.; Pérez-Moreno, M.A.; Rodrigo, I.; Locascio, A.; Blanco, M.J.; del Barrio, M.G.; Portillo, F.; Nieto, M.A. "The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.". Nat. Cell Biol.. 2(2): 76-83. (2000). (PMID: 10655586).
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  88. Duque, P.M.; Alonso, C.; Sánchez-Prieto, R.; Lleonart, M.; Martínez, C.; de Buitrago, G.G.; Cano, A.; Quintanilla, M.; Ramon y Cajal, S. "Adenovirus lacking the 19-kDa and 55-kDa E1B genes exerts a marked cytotoxic effect in human malignant cells.". Cancer Gene Ther.. 6(6): 554-563. (2000). (PMID: 10608352).
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  89. Martin-Duque, P.; Sánchez-Prieto, R.; Romero, J.; Martinez-Lamparero, A.; Cebrian-Sagarriga, S.; Guinea-Viniegra, J.; Dominguez, C.; Lleonart, M.; Cano, A.; Quintanilla, M.; Ramón Y Cajal, S. "In vivo radiosensitizing effect of the adenovirus E1A gene in murine and human malignant tumors.". Int. J. Oncol.. 15(6): 1163-1168. (1999). (PMID: 10568823).
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  90. Cachón-González, M.B.; San-José, I.; Cano, A.; Vega, J.A.; García, N.; Freeman, T.; Schimmang, T.; Stoye, J.P. "The hairless gene of the mouse: relationship of phenotypic effects with expression profile and genotype.". Dev. Dyn.. 216(2): 113-126. (1999). (PMID: 10536052).
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  91. Espada, J.; Pérez-Moreno, M.; Braga, V.M.; Rodriguez-Viciana, P.; Cano, A. "H-Ras activation promotes cytoplasmic accumulation and phosphoinositide 3-OH kinase association of beta-catenin in epidermal keratinocytes.". J. Cell Biol.. 146(5): 967-980. (1999). (PMID: 10477752).
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  92. Rodrigo, I.; Cato, A.C.; Cano, A. "Regulation of E-cadherin gene expression during tumor progression: the role of a new Ets-binding site and the E-pal element.". Exp. Cell Res.. 248(2): 358-371. (1999). (PMID: 10222128).
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  93. Sanchez-Prieto, R.; Quintanilla, M.; Cano, A.; Lleonart, M.; Martin, P.; Ramon y Cajal, S. "In vivo tumor suppressor effect of retrovirus-mediated gene transfer of the adenovirus E1a gene.". Adv. Exp. Med. Biol.. 451(): 79-86. (1998). (PMID: 10026854).
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  94. Sánchez-Prieto, R.; Quintanilla, M.; Martín, P.; Lleonart, M.; Cano, A.; Dotto, G.P.; Ramón y Cajal, S. "In vivo antitumor effect of retrovirus-mediated gene transfer of the adenovirus E1a gene.". Cancer Gene Ther.. 5(4): 215-224. (1998). (PMID: 9694073).
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  95. Llorens, A.; Rodrigo, I.; López-Barcons, L.; Gonzalez-Garrigues, M.; Lozano, E.; Vinyals, A.; Quintanilla, M.; Cano, A.; Fabra, A. "Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression.". Lab. Invest.. 78(9): 1131-1142. (1998). (PMID: 9759657).
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  96. Lozano, E.; Cano, A. "Induction of mutual stabilization and retardation of tumor growth by coexpression of plakoglobin and E-cadherin in mouse skin spindle carcinoma cells.". Mol. Carcinog.. 21(4): 273-287. (1998). (PMID: 9585257).
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  97. Faraldo, M.L.; Rodrigo, I.; Behrens, J.; Birchmeier, W.; Cano, A. "Analysis of the E-cadherin and P-cadherin promoters in murine keratinocyte cell lines from different stages of mouse skin carcinogenesis.". Mol. Carcinog.. 20(1): 33-47. (1997). (PMID: 9328434).
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  98. Larcher, F.; Robles, A.I.; Duran, H.; Murillas, R.; Quintanilla, M.; Cano, A.; Conti, C.J.; Jorcano, J.L. "Up-regulation of vascular endothelial growth factor/vascular permeability factor in mouse skin carcinogenesis correlates with malignant progression state and activated H-ras expression levels.". Cancer Res.. 56(23): 5391-5396. (1996). (PMID: 8968091).
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  99. Sánchez-Prieto, R.; Quintanilla, M.; Cano, A.; Leonart, M.L.; Martin, P.; Anaya, A.; Ramón y Cajal, S. "Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene.". Oncogene. 13(5): 1083-1092. (1996). (PMID: 8806698).
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  100. Caulín, C.; López-Barcons, L.; Gonzáles-Garrigues, M.; Navarro, P.; Lozano, E.; Rodrigo, I.; Gamallo, C.; Cano, A.; Fabra, A.; Quintanilla, M. "Suppression of the metastatic phenotype of a mouse skin carcinoma cell line independent of E-cadherin expression and correlated with reduced Ha-ras oncogene products.". Mol. Carcinog.. 15(2): 104-114. (1996). (PMID: 8599577).
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  101. Cano, A.; Gamallo, C.; Kemp, C.J.; Benito, N.; Palacios, J.; Quintanilla, M.; Balmain, A. "Expression pattern of the cell adhesion molecules. E-cadherin, P-cadherin and alpha 6 beta 4 intergrin is altered in pre-malignant skin tumors of p53-deficient mice.". Int. J. Cancer. 65(2): 254-262. (1996). (PMID: 8567126).
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  102. Pizarro, A.; Gamallo, C.; Benito, N.; Palacios, J.; Quintanilla, M.; Cano, A.; Contreras, F. "Differential patterns of placental and epithelial cadherin expression in basal cell carcinoma and in the epidermis overlying tumours.". Br. J. Cancer. 72(2): 327-332. (1995). (PMID: 7640213).
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  103. Palacios, J.; Benito, N.; Pizarro, A.; Suárez, A.; Espada, J.; Cano, A.; Gamallo, C. "Anomalous expression of P-cadherin in breast carcinoma. Correlation with E-cadherin expression and pathological features.". Am. J. Pathol.. 146(3): 605-612. (1995). (PMID: 7534041).
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  105. Gamallo, C.; Palacios, J.; Suarez, A.; Pizarro, A.; Navarro, P.; Quintanilla, M.; Cano, A. "Correlation of E-cadherin expression with differentiation grade and histological type in breast carcinoma.". Am. J. Pathol.. 142(4): 987-993. (1993). (PMID: 7682767).
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  106. Caulín, C.; Bauluz, C.; Gandarillas, A.; Cano, A.; Quintanilla, M. "Changes in keratin expression during malignant progression of transformed mouse epidermal keratinocytes.". Exp. Cell Res.. 204(1): 11-21. (1993). (PMID: 7677983).
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  107. Gómez, M.; Navarro, P.; Quintanilla, M.; Cano, A. "Expression of alpha 6 beta 4 integrin increases during malignant conversion of mouse epidermal keratinocytes: association of beta 4 subunit to the cytokeratin fraction.". Exp. Cell Res.. 201(2): 250-261. (1992). (PMID: 1379191).
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  108. Inki, P.; Gomez, M.; Quintanilla, M.; Cano, A.; Jalkanen, M. "Expression of syndecan in transformed mouse keratinocytes.". Lab. Invest.. 67(2): 225-233. (1992). (PMID: 1501448).
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  109. Diaz-Guerra, M.; Haddow, S.; Bauluz, C.; Jorcano, J.L.; Cano, A.; Balmain, A.; Quintanilla, M. "Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.". Cancer Res.. 52(3): 680-687. (1992). (PMID: 1370649).
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  110. Navarro, P.; Gómez, M.; Pizarro, A.; Gamallo, C.; Quintanilla, M.; Cano, A. "A role for the E-cadherin cell-cell adhesion molecule during tumor progression of mouse epidermal carcinogenesis.". J. Cell Biol.. 115(2): 517-533. (1991). (PMID: 1918152).
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