INVESTIGACIÓN

 
  • Grupos de Investigación
  • Unidades de Investigación
  • Memoria Cientifíca
  • Publicaciones
espacio

 

PUBLICACIONES

 

 

spacerTrabajos Publicados por Ricardo Escalante Hernández
spacer
  1. Antón-Esteban, L.; Tornero-Écija, A.; Vincent, O.; Escalante, R. "Methods to Assess Autophagic Activity in Dictyostelium.". Methods Mol Biol. 2814(): 97-9106. (2024). (PMID: 38954200).
    spacer

  2. Bueno-Arribas, M.; Cruz-Cuevas, C.; Navas, M.A.; Escalante, R.; Vincent, O. "Coiled-coil-mediated dimerization of Atg16 is required for binding to the PROPPIN Atg21.". Open Biol. 13(11): 230192. (2023). (PMID: 37989223).
    spacer

  3. Mollereau, B.; Hayflick, S.J.; Escalante, R.; Mauthe, M.; Papandreou, A.; Iuso, A.; Celle, M.; Aniorte, S.; Issa, A.R.; Lasserre, J.P.; Lesca, G.; Thobois, S.; Burger, P.; Walter, L. "A burning question from the first international BPAN symposium: is restoration of autophagy a promising therapeutic strategy for BPAN?". Autophagy. (): . (2023). (PMID: 37565733).
    spacer

  4. Tornero-Écija, A.; Zapata-Del-Baño, A.; Antón-Esteban, L.; Vincent, O.; Escalante, R. "The association of lipid transfer protein VPS13A with endosomes is mediated by sorting nexin SNX5.". Life Sci Alliance. 6(6): . (2023). (PMID: 36977596).
    spacer

  5. Tornero-Écija, A.R.; Navas, M.A.; Muñoz-Braceras, S.; Vincent, O.; Escalante, R. "Effect of rapamycin on lysosomal accumulation in a CRISPR/Cas9-based cellular model of VPS13A deficiency.". J Cell Mol Med. (): . (2023). (PMID: 37163371).
    spacer

  6. Vincent, O.; Antón-Esteban, L.; Bueno-Arribas, M.; Tornero-Écija, A.; Navas, M.Á.; Escalante, R. "The WIPI Gene Family and Neurodegenerative Diseases: Insights From Yeast and Dictyostelium Models.". Front Cell Dev Biol. 9(): 737071. (2021). (PMID: 34540850).
    spacer

  7. Bueno-Arribas, M.; Blanca, I.; Cruz-Cuevas, C.; Escalante, R.; Navas, M.A.; Vincent, O. "A conserved ATG2 binding site in WIPI4 and yeast Hsv2 is disrupted by mutations causing β-propeller protein-associated neurodegeneration.". Hum Mol Genet. (): . (2021). (PMID: 34368840).
    spacer

  8. Escalante, R. "Proteins in Autophagic Machinery.". Cells. 10(8): . (2021). (PMID: 34440756).
    spacer

  9. Tornero-Écija, A.; Tábara, L.C.; Bueno-Arribas, M.; Antón-Esteban, L.; Navarro-Gómez, C.; Sánchez, I.; Vincent, O.; Escalante, R. "A Dictyostelium model for BPAN disease reveals a functional relationship between the WDR45/WIPI4 homolog Wdr45l and Vmp1 in the regulation of autophagy-associated PtdIns3P and ER stress.". Autophagy. (): 1-17. (2021). (PMID: 34328055).
    spacer

  10. Klionsky, D.J.; [ .., ].; Bartolome, A.; [ .., ].; Cuadrado, A.; [ .., ].; Escalante, R.; [ .., ].; García-Sanz, P.; [ .., ].; Lastres-Becker, I.; [ .., ].; León, Y.; [ .., ].; Martin-Sanz, P.; [ .., ].; Pajares, M.; [ .., ].; Rojo, A.I.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Villalobo, A.; [ .., ].; Vincent, O.; [ .., ].; Tong, C.K. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).". Autophagy. (): 1-382. (2021). (PMID: 33634751).
    spacer

  11. Escalante, R.; Cardenal-Muñoz, E. "The Dictyostelium discoideum model system.". Int. J. Dev. Biol.. 63(8-9-10): 317-320. (2019). (PMID: 31840771).
    spacer

  12. Tábara, L.C.; Vincent, O.; Escalante, R. "Evidence for an evolutionary relationship between Vmp1 and bacterial DedA proteins.". Int. J. Dev. Biol.. 63(1-2): 67-71. (2019). (PMID: 30785211).
    spacer

  13. Muñoz-Braceras, S.; Tornero-Écija, A.R.; Vincent, O.; Escalante, R. "VPS13A is closely associated with mitochondria and is required for efficient lysosomal degradation.". Dis Model Mech. 12(2): . (2019). (PMID: 30709847).
    spacer

  14. Hernández-Elvira, M.; Torres-Quiroz, F.; Escamilla-Ayala, A.; Domínguez-Martin, E.; Escalante, R.; Kawasaki, L.; Ongay-Larios, L.; Coria, R. "The Unfolded Protein Response Pathway in the Yeast Kluyveromyces lactis. A Comparative View among Yeast Species.". Cells. 7(8): . (2018). (PMID: 30110882).
    spacer

  15. Tábara, L.C.; Vicente, J.J.; Biazik, J.; Eskelinen, E.L.; Vincent, O.; Escalante, R. "Vacuole membrane protein 1 marks endoplasmic reticulum subdomains enriched in phospholipid synthesizing enzymes and is required for phosphoinositide distribution.". Traffic. 19(8): 624-638. (2018). (PMID: 29761602).
    spacer

  16. Domínguez-Martín, E.; Hernández-Elvira, M.; Vincent, O.; Coria, R.; Escalante, R. "Unfolding the Endoplasmic Reticulum of a Social Amoeba: Dictyostelium discoideum as a New Model for the Study of Endoplasmic Reticulum Stress.". Cells. 7(6): . (2018). (PMID: 29890774).
    spacer

  17. Domínguez-Martín, E.; Ongay-Larios, L.; Kawasaki, L.; Vincent, O.; Coello, G.; Coria, R.; Escalante, R. "IreA controls endoplasmic reticulum stress-induced autophagy and survival through homeostasis recovery.". Mol. Cell. Biol.. (): . (2018). (PMID: 29632077).
    spacer

  18. Sheikh, S.; Thulin, M.; Cavender, J.C.; Escalante, R.; Kawakami, S.I.; Lado, C.; Landolt, J.C.; Nanjundiah, V.; Queller, D.C.; Strassmann, J.E.; Spiegel, F.W.; Stephenson, S.L.; Vadell, E.M.; Baldauf, S.L. "A New Classification of the Dictyostelids.". Protist. 169(1): 1-28. (2018). (PMID: 29367151).
    spacer

  19. Rzepnikowska, W.; Flis, K.; Muñoz-Braceras, S.; Menezes, R.; Escalante, R.; Zoladek, T. "Yeast and other lower eukaryotic organisms for studies of Vps13 proteins in health and disease.". Traffic. 18(11): 711-719. (2017). (PMID: 28846184).
    spacer

  20. Domínguez-Martín, E.; Cardenal-Muñoz, E.; King, J.S.; Soldati, T.; Coria, R.; Escalante, R. "Methods to Monitor and Quantify Autophagy in the Social Amoeba Dictyostelium discoideum.". Cells. 6(3): . (2017). (PMID: 28671610).
    spacer

  21. Mesquita, A.; Cardenal-Muñoz, E.; Dominguez, E.; Muñoz-Braceras, S.; Nuñez-Corcuera, B.; Phillips, B.A.; Tábara, L.C.; Xiong, Q.; Coria, R.; Eichinger, L.; Golstein, P.; King, J.S.; Soldati, T.; Vincent, O.; Escalante, R. "Autophagy in Dictyostelium: Mechanisms, regulation and disease in a simple biomedical model.". Autophagy. 13(1): 24-40. (2017). (PMID: 27715405).
    spacer

  22. Tábara, L.C.; Escalante, R. "VMP1 Establishes ER-Microdomains that Regulate Membrane Contact Sites and Autophagy.". PLoS ONE. 11(11): e0166499. (2016). (PMID: 27861594).
    spacer

  23. Klionsky, D.J.; [ .., ].; Bartolomé, A.; [ .., ].; Escalante, R.; [ .., ].; Magariños, M.; [ .., ].; Martín-Sanz, P.; [ .., ].; Sanchez-Prieto, R.; [ .., ].; Valverde, A.M.; [ .., ].; Varela-Nieto, I.; [ .., ].; Zughaier, S.M. "Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).". Autophagy. 12(1): 1-222. (2016). (PMID: 26799652).
    spacer

  24. Muñoz-Braceras, S.; Escalante, R. "Analysis of Relevant Parameters for Autophagic Flux Using HeLa Cells Expressing EGFP-LC3.". Methods Mol. Biol.. 1449(): 313-329. (2016). (PMID: 27613046).
    spacer

  25. Mesquita, A.; Tábara, L.C.; Martinez-Costa, O.; Santos-Rodrigo, N.; Vincent, O.; Escalante, R. "Dissecting the function of Atg1 complex in Dictyostelium autophagy reveals a connection with the pentose phosphate pathway enzyme transketolase.". Open Biol. 5(8): . (2015). (PMID: 26246495).
    spacer

  26. Muñoz-Braceras, S.; Calvo, R.; Escalante, R. "TipC and the chorea-acanthocytosis protein VPS13A regulate autophagy in Dictyostelium and human HeLa cells.". Autophagy. 11(6): 918-927. (2015). (PMID: 25996471).
    spacer

  27. Calvo-Garrido, J.; King, J.S.; Muñoz-Braceras, S.; Escalante, R. "Vmp1 regulates PtdIns3P signaling during autophagosome formation in Dictyostelium discoideum.". Traffic. 15(11): 1235-1246. (2014). (PMID: 25131297).
    spacer

  28. Mesquita, A.; Calvo-Garrido, J.; Carilla-Latorre, S.; Escalante, R. "Monitoring autophagy in Dictyostelium.". Methods Mol. Biol.. 983(): 461-470. (2013). (PMID: 23494324).
    spacer

  29. Carilla-Latorre, S.; Annesley, S.J.; Muñoz-Braceras, S.; Fisher, P.R.; Escalante, R. "Ndufaf5 deficiency in the Dictyostelium model: new roles in autophagy and development.". Mol. Biol. Cell. 24(10): 1519-1528. (2013). (PMID: 23536703).
    spacer

  30. Romeralo, M.; Escalante, R.; Baldauf, S.L. "Evolution and diversity of dictyostelid social amoebae.". Protist. 163(3): 327-343. (2012). (PMID: 22209334).
    spacer

  31. Klionsky, D.J.; [ .., ].; Calvo-Garrido, J.; [ .., ].; Escalante, R.; [ .., ].; Sánchez-Prieto, R.; [ .., ].; Zuckerbraun, B. "Guidelines for the use and interpretation of assays for monitoring autophagy.". Autophagy. 8(4): 445-544. (2012). (PMID: 22966490).
    spacer

  32. Calvo-Garrido, J.; Carilla-Latorre, S.; Mesquita, A.; Escalante, R. "A proteolytic cleavage assay to monitor autophagy in Dictyostelium discoideum.". Autophagy. 7(9): HASH(0xa6b74c8). (2011). (PMID: 21778822).
    spacer

  33. Calvo-Garrido, J.; Carilla-Latorre, S.; Mesquita, A.; Escalante, R. "A proteolytic cleavage assay to monitor autophagy in Dictyostelium discoideum.". Autophagy. 7(9): 1063-1068. (2011). (PMID: 21876387).
    spacer

  34. Escalante, R. "Dictyostelium as a model for human disease.". Semin. Cell Dev. Biol.. 22(1): 69. (2011). (PMID: 21145406).
    spacer

  35. Francione, L.M.; Annesley, S.J.; Carilla-Latorre, S.; Escalante, R.; Fisher, P.R. "The Dictyostelium model for mitochondrial disease.". Semin. Cell Dev. Biol.. 22(1): 120-130. (2011). (PMID: 21129494).
    spacer

  36. Linares, J.F.; Moreno, R.; Fajardo, A.; Martínez-Solano, L.; Escalante, R.; Rojo, F.; Martínez, J.L. "The global regulator Crc modulates metabolism, susceptibility to antibiotics and virulence in Pseudomonas aeruginosa.". Environ. Microbiol.. 12(12): 3196-3212. (2010). (PMID: 20626455).
    spacer

  37. Calvo-Garrido, J.; Carilla-Latorre, S.; Kubohara, Y.; Santos-Rodrigo, N.; Mesquita, A.; Soldati, T.; Golstein, P.; Escalante, R. "Autophagy in Dictyostelium: genes and pathways, cell death and infection.". Autophagy. 6(6): 686-701. (2010). (PMID: 20603609).
    spacer

  38. Carilla-Latorre, S.; Gallardo, M.E.; Annesley, S.J.; Calvo-Garrido, J.; Graña, O.; Accari, S.L.; Smith, P.K.; Valencia, A.; Garesse, R.; Fisher, P.R.; Escalante, R. "MidA is a putative methyltransferase that is required for mitochondrial complex I function.". J. Cell. Sci.. 123(Pt 10): 1674-1683. (2010). (PMID: 20406883).
    spacer

  39. Calvo-Garrido, J.; Escalante, R. "Autophagy dysfunction and ubiquitin-positive protein aggregates in Dictyostelium cells lacking Vmp1.". Autophagy. 6(1): 100-109. (2010). (PMID: 20009561).
    spacer

  40. Calvo-Garrido, J.; Carilla-Latorre, S.; Escalante, R. "Vacuole membrane protein 1, autophagy and much more.". Autophagy. 4(6): 835-837. (2008). (PMID: 18641456).
    spacer

  41. Calvo-Garrido, J.; Carilla-Latorre, S.; Lázaro-Diéguez, F.; Egea, G.; Escalante, R. "Vacuole membrane protein 1 is an endoplasmic reticulum protein required for organelle biogenesis, protein secretion, and development.". Mol. Biol. Cell. 19(8): 3442-3453. (2008). (PMID: 18550798).
    spacer

  42. Carilla-Latorre, S.; Calvo-Garrido, J.; Bloomfield, G.; Skelton, J.; Kay, R.R.; Ivens, A.; Martinez, J.L.; Escalante, R. "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains.". BMC Microbiol.. 8(): 109. (2008). (PMID: 18590548).
    spacer

  43. Vicente, J.J.; Galardi-Castilla, M.; Escalante, R.; Sastre, L. "Structural and functional studies of a family of Dictyostelium discoideum developmentally regulated, prestalk genes coding for small proteins.". BMC Microbiol.. 8(): 1. (2008). (PMID: 18173832).
    spacer

  44. Metcalf, T.; van der Wel, H.; Escalante, R.; Sastre, L.; West, C.M. "Role of SP65 in assembly of the Dictyostelium discoideum spore coat.". Eukaryotic Cell. 6(7): 1137-1149. (2007). (PMID: 17416892).
    spacer

  45. Romeralo, M.; Escalante, R.; Sastre, L.; Lado, C. "Molecular systematics of dictyostelids: 5.8S ribosomal DNA and internal transcribed spacer region analyses.". Eukaryotic Cell. 6(1): 110-116. (2007). (PMID: 17056743).
    spacer

  46. Escalante, R.; Sastre, L. "Investigating gene expression: in situ hybridization and reporter genes.". Methods Mol. Biol.. 346(): 247-260. (2006). (PMID: 16957295).
    spacer

  47. Torija, P.; Robles, A.; Escalante, R. "Optimization of a large-scale gene disruption protocol in Dictyostelium and analysis of conserved genes of unknown function.". BMC Microbiol.. 6(): 75. (2006). (PMID: 16945142).
    spacer

  48. Torija, P.; Vicente, J.J.; Rodrigues, T.B.; Robles, A.; Cerdán, S.; Sastre, L.; Calvo, R.M.; Escalante, R. "Functional genomics in Dictyostelium: MidA, a new conserved protein, is required for mitochondrial function and development.". J. Cell. Sci.. 119(Pt 6): 1154-1164. (2006). (PMID: 16507593).
    spacer

  49. Escalante, R.; Iranfar, N.; Sastre, L.; Loomis, W.F. "Identification of genes dependent on the MADS box transcription factor SrfA in Dictyostelium discoideum development.". Eukaryotic Cell. 3(2): 564-566. (2004). (PMID: 15075287).
    spacer

  50. Alonso, A.; Morales, G.; Escalante, R.; Campanario, E.; Sastre, L.; Martinez, J.L. "Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology.". J. Antimicrob. Chemother.. 53(3): 432-434. (2004). (PMID: 14739147).
    spacer

  51. Escalante, R.; Yamada, Y.; Cotter, D.; Sastre, L.; Sameshima, M. "The MADS-box transcription factor SrfA is required for actin cytoskeleton organization and spore coat stability during Dictyostelium sporulation.". Mech. Dev.. 121(1): 51-56. (2004). (PMID: 14706699).
    spacer

  52. Escalante, R.; Moreno, N.; Sastre, L. "Dictyostelium discoideum developmentally regulated genes whose expression is dependent on MADS box transcription factor SrfA.". Eukaryotic Cell. 2(6): 1327-1335. (2003). (PMID: 14665466).
    spacer

  53. Escalante, R.; Sastre, L. "Regulated expression of the MADS-box transcription factor SrfA mediates activation of gene expression by protein kinase A during Dictyostelium sporulation.". Mech. Dev.. 117(1-2): 201-208. (2002). (PMID: 12204259).
    spacer

  54. Escalante, R.; Sastre, L. "cAMP and DIF-1 repress the expression of the Dictyostelium MADS-box gene srfA at early stages of development.". Biochem. Biophys. Res. Commun.. 285(3): 820-824. (2001). (PMID: 11453666).
    spacer

  55. Escalante, R.; Vicente, J.J.; Moreno, N.; Sastre, L. "The MADS-box gene srfA is expressed in a complex pattern under the control of alternative promoters and is essential for different aspects of Dictyostelium development.". Dev. Biol.. 235(2): 314-329. (2001). (PMID: 11437439).
    spacer

  56. Escalante, R.; Vicente, J.J. "Dictyostelium discoideum: a model system for differentiation and patterning.". Int. J. Dev. Biol.. 44(8): 819-835. (2000). (PMID: 11206323).
    spacer

  57. Sáez, A.G.; Escalante, R.; Sastre, L. "High DNA sequence variability at the alpha 1 Na/K-ATPase locus of Artemia franciscana (brine shrimp): polymorphism in a gene for salt-resistance in a salt-resistant organism.". Mol. Biol. Evol.. 17(2): 235-250. (2000). (PMID: 10677846).
    spacer

  58. Escalante, R.; Sastre, L. "A Serum Response Factor homolog is required for spore differentiation in Dictyostelium.". Development. 125(19): 3801-3808. (1998). (PMID: 9729488).
    spacer

  59. Shaulsky, G.; Escalante, R.; Loomis, W.F. "Developmental signal transduction pathways uncovered by genetic suppressors.". Proc. Natl. Acad. Sci. U.S.A.. 93(26): 15260-15265. (1996). (PMID: 8986798).
    spacer

  60. Wang, N.; Shaulsky, G.; Escalante, R.; Loomis, W.F. "A two-component histidine kinase gene that functions in Dictyostelium development.". EMBO J.. 15(15): 3890-3898. (1996). (PMID: 8670894).
    spacer

  61. Escalante, R.; Sastre, L. "Tissue-specific expression of two Artemia franciscana sarco/endoplasmic reticulum Ca-ATPase isoforms.". J. Histochem. Cytochem.. 44(4): 321-325. (1996). (PMID: 8601691).
    spacer

  62. Escalante, R.; Sastre, L. "Tissue-specific alternative promoters regulate the expression of the two sarco/endoplasmic reticulum Ca-ATPase isoforms from Artemia franciscana.". DNA Cell Biol.. 14(10): 893-900. (1995). (PMID: 7546295).
    spacer

  63. Escalante, R.; Loomis, W.F. "Whole-mount in situ hybridization of cell-type-specific mRNAs in Dictyostelium.". Dev. Biol.. 171(1): 262-266. (1995). (PMID: 7556903).
    spacer

  64. Escalante, R.; García-Sáez, A.; Sastre, L. "In situ hybridization analyses of Na, K-ATPase alpha-subunit expression during early larval development of Artemia franciscana.". J. Histochem. Cytochem.. 43(4): 391-399. (1995). (PMID: 7897181).
    spacer

  65. Escalante, R.; García-Sáez, A.; Ortega, M.A.; Sastre, L. "Gene expression after resumption of development of Artemia franciscana cryptobiotic embryos.". Biochem. Cell Biol.. 72(3-4): 78-83. (1995). (PMID: 7818853).
    spacer

  66. Escalante, R.; Sastre, L. "Identification of an Artemia franciscana retropseudogene containing part of the last exons of the sarco/endoplasmic reticulum Ca-ATPase-encoding SERCA gene.". Gene. 149(2): 377-378. (1994). (PMID: 7959022).
    spacer

  67. Escalante, R.; Sastre, L. "Structure of Artemia franciscana sarco/endoplasmic reticulum Ca-ATPase gene.". J. Biol. Chem.. 269(17): 13005-13012. (1994). (PMID: 8175720).
    spacer

  68. Escalante, R.; Houdebine, L.M.; Pamblanco, M. "Transferrin gene expression in the mammary gland of the rat. The enhancing effect of 17 beta-oestradiol on the level of RNA is tissue-specific.". J. Mol. Endocrinol.. 11(2): 151-159. (1993). (PMID: 8297471).
    spacer

  69. Escalante, R.; Sastre, L. "Similar alternative splicing events generate two sarcoplasmic or endoplasmic reticulum Ca-ATPase isoforms in the crustacean Artemia franciscana and in vertebrates.". J. Biol. Chem.. 268(19): 14090-14095. (1993). (PMID: 8314776).
    spacer

 

 

 

 

 

Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
Tel +(34) 91 585 4400 // Fax +(34) 91 558 4401
Email:Info