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PUBLICACIONES

 

 

spacerTrabajos Publicados por Margarita Díaz-Guerra González
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  1. Ugalde-Triviño, L.; Díaz-Guerra, M. "PSD-95: An Effective Target for Stroke Therapy Using Neuroprotective Peptides.". Int J Mol Sci. 22(22): . (2021). (PMID: 34830481).
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  2. Ayuso-Dolado, S.; Esteban-Ortega, G.M.; Vidaurre, Ó.G.; Díaz-Guerra, M. "A novel cell-penetrating peptide targeting calpain-cleavage of PSD-95 induced by excitotoxicity improves neurological outcome after stroke.". Theranostics. 11(14): 6746-6765. (2021). (PMID: 34093851).
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  3. Diaz-Guerra, M. "Excitotoxicity-induced endocytosis as a potential target for stroke neuroprotection.". Neural Regen Res. 16(2): 300-301. (2021). (PMID: 32859784).
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  4. Galán-Ganga, M.; Del Río, R.; Jiménez-Moreno, N.; Díaz-Guerra, M.; Lastres-Becker, I. "Cannabinoid CB2 Receptor Modulation by the Transcription Factor NRF2 is Specific in Microglial Cells.". Cell. Mol. Neurobiol.. (): . (2019). (PMID: 31385133).
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  5. López-Menéndez, C.; Simón-García, A.; Gamir-Morralla, A.; Pose-Utrilla, J.; Luján, R.; Mochizuki, N.; Díaz-Guerra, M.; Iglesias, T. "Excitotoxic targeting of Kidins220 to the Golgi apparatus precedes calpain cleavage of Rap1-activation complexes.". Cell Death Dis. 10(7): 535. (2019). (PMID: 31296845).
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  6. Tejeda, G.S.; Esteban-Ortega, G.M.; San Antonio, E.; Vidaurre, Ó.G.; Díaz-Guerra, M. "Prevention of excitotoxicity-induced processing of BDNF receptor TrkB-FL leads to stroke neuroprotection.". EMBO Mol Med. 11(7): e9950. (2019). (PMID: 31273936).
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  7. Tejeda, G.S.; Esteban-Ortega, G.M.; San Antonio, E.; Vidaurre, Ó.G.; Díaz-Guerra, M. "Prevention of excitotoxicity-induced processing of BDNF receptor TrkB-FL leads to stroke neuroprotection.". EMBO Mol Med. (): . (2019). (PMID: 31160342).
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  8. Tejeda, G.S.; Díaz-Guerra, M. "Integral Characterization of Defective BDNF/TrkB Signalling in Neurological and Psychiatric Disorders Leads the Way to New Therapies.". Int J Mol Sci. 18(2): . (2017). (PMID: 28134845).
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  9. Tejeda, G.S.; Ayuso-Dolado, S.; Arbeteta, R.; Esteban-Ortega, G.M.; Vidaurre, O.G.; Díaz-Guerra, M. "Brain ischaemia induces shedding of a BDNF-scavenger ectodomain from TrkB receptors by excitotoxicity-activation of metalloproteinases and γ-secretases.". J. Pathol.. (): . (2015). (PMID: 26712630).
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  10. Gamir-Morralla, A.; López-Menéndez, C.; Ayuso-Dolado, S.; Tejeda, G.S.; Montaner, J.; Rosell, A.; Iglesias, T.; Díaz-Guerra, M. "Development of a neuroprotective peptide that preserves survival pathways by preventing Kidins220/ARMS calpain processing induced by excitotoxicity.". Cell Death Dis. 6(): e1939. (2015). (PMID: 26492372).
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  11. López-Menéndez, C.; Gamir-Morralla, A.; Jurado-Arjona, J.; Higuero, A.M.; Campanero, M.R.; Ferrer, I.; Hernández, F.; Ávila, J.; Díaz-Guerra, M.; Iglesias, T. "Kidins220 accumulates with tau in human Alzheimer's disease and related models: modulation of its calpain-processing by GSK3β/PP1 imbalance.". Hum. Mol. Genet.. 22(3): 466-482. (2013). (PMID: 23118350).
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  12. Vidaurre, O.G.; Gascón, S.; Deogracias, R.; Sobrado, M.; Cuadrado, E.; Montaner, J.; Rodríguez-Peña, A.; Díaz-Guerra, M. "Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity.". Cell Death Dis. 3(): e256. (2012). (PMID: 22258407).
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  13. López-Menéndez, C.; Gascón, S.; Sobrado, M.; Vidaurre, O.G.; Higuero, A.M.; Rodríguez-Peña, A.; Iglesias, T.; Díaz-Guerra, M. "Kidins220/ARMS downregulation by excitotoxic activation of NMDARs reveals its involvement in neuronal survival and death pathways.". J. Cell. Sci.. 122(Pt 19): 3554-3565. (2009). (PMID: 19759287).
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  14. Gascón, S.; Paez-Gomez, J.A.; Díaz-Guerra, M.; Scheiffele, P.; Scholl, F.G. "Dual-promoter lentiviral vectors for constitutive and regulated gene expression in neurons.". J. Neurosci. Methods. 168(1): 104-112. (2008). (PMID: 17983662).
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  15. Gascón, S.; Sobrado, M.; Roda, J.M.; Rodríguez-Peña, A.; Díaz-Guerra, M. "Excitotoxicity and focal cerebral ischemia induce truncation of the NR2A and NR2B subunits of the NMDA receptor and cleavage of the scaffolding protein PSD-95.". Mol. Psychiatry. 13(1): 99-9114. (2008). (PMID: 17486105).
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  16. Gascón, S.; García-Gallo, M.; Renart, J.; Díaz-Guerra, M. "Endoplasmic reticulum-associated degradation of the NR1 but not the NR2 subunits of the N-methyl-D-aspartate receptor induced by inhibition of the N-glycosylation in cortical neurons.". J. Neurosci. Res.. 85(8): 1713-1723. (2007). (PMID: 17455306).
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  17. Gascón, S.; Deogracias, R.; Sobrado, M.; Roda, J.M.; Renart, J.; Rodríguez-Peña, A.; Díaz-Guerra, M. "Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia.". J. Biol. Chem.. 280(41): 35018-35027. (2005). (PMID: 16049015).
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  18. Fernández, A.; Suárez, P.; Castro, J.M.; Tabarés, E.; Díaz-Guerra, M. "Characterization of regions in the GP5 protein of porcine reproductive and respiratory syndrome virus required to induce apoptotic cell death.". Virus Res.. 83(1-2): 103-118. (2002). (PMID: 11864744).
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  19. García-Gallo, M.; Renart, J.; Díaz-Guerra, M. "The NR1 subunit of the N-methyl-D-aspartate receptor can be efficiently expressed alone in the cell surface of mammalian cells and is required for the transport of the NR2A subunit.". Biochem. J.. 356(Pt 2): 539-547. (2001). (PMID: 11368783).
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  20. Díaz-Guerra, M.; Rivas, C.; Esteban, M. "Full activation of RNaseL in animal cells requires binding of 2-5A within ankyrin repeats 6 to 9 of this interferon-inducible enzyme.". J. Interferon Cytokine Res.. 19(2): 113-119. (1999). (PMID: 10090396).
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  21. García-Gallo, M.; Behrens, M.M.; Renart, J.; Díaz-Guerra, M. "Expression of N-methyl-D-aspartate receptors using vaccinia virus causes excitotoxic death in human kidney cells.". J. Cell. Biochem.. 72(1): 135-144. (1999). (PMID: 10025674).
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  22. Rivas, C.; Gil, J.; Mĕlková, Z.; Esteban, M.; Díaz-Guerra, M. "Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme.". Virology. 243(2): 406-414. (1998). (PMID: 9568039).
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  23. Díaz-Guerra, M.; Rivas, C.; Esteban, M. "Activation of the IFN-inducible enzyme RNase L causes apoptosis of animal cells.". Virology. 236(2): 354-363. (1997). (PMID: 9325243).
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  24. Díaz-Guerra, M.; Esteban, M.; Martínez, J.L. "Growth of Escherichia coli in acetate as a sole carbon source is inhibited by ankyrin-like repeats present in the 2',5'-linked oligoadenylate-dependent human RNase L enzyme.". FEMS Microbiol. Lett.. 149(1): 107-113. (1997). (PMID: 9103982).
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  25. Díaz-Guerra, M.; Rivas, C.; Esteban, M. "Inducible expression of the 2-5A synthetase/RNase L system results in inhibition of vaccinia virus replication.". Virology. 227(1): 220-228. (1997). (PMID: 9007077).
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  26. Ortega, M.A.; Díaz-Guerra, M.; Sastre, L. "Actin gene structure in two Artemia species, A. franciscana and A. parthenogenetica.". J. Mol. Evol.. 43(3): 224-235. (1996). (PMID: 8703088).
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  27. Suárez, P.; Díaz-Guerra, M.; Prieto, C.; Esteban, M.; Castro, J.M.; Nieto, A.; Ortín, J. "Open reading frame 5 of porcine reproductive and respiratory syndrome virus as a cause of virus-induced apoptosis.". J. Virol.. 70(5): 2876-2882. (1996). (PMID: 8627762).
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  28. Franco, E.; Behrens, M.M.; Díaz-Guerra, M.; Renart, J. "Structure and expression of a polyubiquitin gene from the crustacean Artemia.". Gene Expr.. 4(1-2): 19-28. (1994). (PMID: 7841785).
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  29. Diaz-Guerra, M.; Esteban, M. "Vaccinia virus nucleoside triphosphate phosphohydrolase I controls early and late gene expression by regulating the rate of transcription.". J. Virol.. 67(12): 7561-7572. (1993). (PMID: 8230476).
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  30. Díaz-Guerra, M.; Kahn, J.S.; Esteban, M. "A mutation of the nucleoside triphosphate phosphohydrolase I (NPH-I) gene confers sensitivity of vaccinia virus to interferon.". Virology. 197(1): 485-491. (1993). (PMID: 8212591).
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  31. Larcher, F.; Bauluz, C.; Díaz-Guerra, M.; Quintanilla, M.; Conti, C.J.; Ballestín, C.; Jorcano, J.L. "Aberrant expression of the simple epithelial type II keratin 8 by mouse skin carcinomas but not papillomas.". Mol. Carcinog.. 6(2): 112-121. (1992). (PMID: 1382441).
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  32. Diaz-Guerra, M.; Haddow, S.; Bauluz, C.; Jorcano, J.L.; Cano, A.; Balmain, A.; Quintanilla, M. "Expression of simple epithelial cytokeratins in mouse epidermal keratinocytes harboring Harvey ras gene alterations.". Cancer Res.. 52(3): 680-687. (1992). (PMID: 1370649).
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  33. Cruces, J.; Díaz-Guerra, M.; Gil, I.; Renart, J. "The 5S rRNA-histone repeat in the crustacean Artemia: structure, polymorphism and variation of the 5S rRNA segment in different populations.". Nucleic Acids Res.. 17(15): 6283-6297. (1989). (PMID: 2570403).
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  34. Díaz-Guerra, M.; Quintanilla, M.; Palmero, I.; Sastre, L.; Renart, J. "Differential expression of a gene highly homologous to c-ras during the development of the brine shrimp Artemia.". Biochem. Biophys. Res. Commun.. 162(2): 802-808. (1989). (PMID: 2502981).
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  35. Gallego, M.E.; Díaz-Guerra, M.; Cruces, J.; Sebastián, J.; Renart, J. "Characterization of two types of rRNA gene repeat units from the crustacean Artemia.". Gene. 48(1): 175-182. (1986). (PMID: 3557126).
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  36. Cruces, J.; Wonenburger, M.L.; Díaz-Guerra, M.; Sebastián, J.; Renart, J. "Satellite DNA in the crustacean Artemia.". Gene. 44(2-3): 341-345. (1986). (PMID: 3023196).
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