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PUBLICACIONES

 

 

spacerTrabajos Publicados por Francisco Portillo Pérez
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  1. Morillo-Bernal, J.; Pizarro-García, P.; Moreno-Bueno, G.; Cano, A.; Mazón, M.J.; Eraso, P.; Portillo, F. "HuR (ELAVL1) Stabilizes SOX9 mRNA and Promotes Migration and Invasion in Breast Cancer Cells.". Cancers (Basel). 16(2): . (2024). (PMID: 38254873).
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  2. Cano, A.; Eraso, P.; Mazón, M.J.; Portillo, F. "LOXL2 in Cancer: A Two-Decade Perspective.". Int J Mol Sci. 24(18): . (2023). (PMID: 37762708).
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  3. Eraso, P.; Mazón, M.J.; Jiménez, V.; Pizarro-García, P.; Cuevas, E.P.; Majuelos-Melguizo, J.; Morillo-Bernal, J.; Cano, A.; Portillo, F. "New Functions of Intracellular LOXL2: Modulation of RNA-Binding Proteins.". Molecules. 28(11): . (2023). (PMID: 37298909).
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  4. Santamaría, P.G.; Dubus, P.; Bustos-Tauler, J.; Floristán, A.; Vázquez-Naharro, A.; Morales, S.; Cano, A.; Portillo, F. "Loxl2 and Loxl3 Paralogues Play Redundant Roles during Mouse Development.". Int J Mol Sci. 23(10): . (2022). (PMID: 35628534).
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  5. Alonso-Nocelo, M.; Ruiz-Cañas, L.; Sancho, P.; Görgülü, K.; Alcalá, S.; Pedrero, C.; Vallespinos, M.; López-Gil, J.C.; Ochando, M.; García-García, E.; David Trabulo, S.M.; Martinelli, P.; Sánchez-Tomero, P.; Sánchez-Palomo, C.; Gonzalez-Santamaría, P.; Yuste, L.; Wörmann, S.M.; Kabacaoğlu, D.; Earl, J.; Martin, A.; Salvador, F.; Valle, S.; Martin-Hijano, L.; Carrato, A.; Erkan, M.; García-Bermejo, L.; Hermann, P.C.; Algül, H.; Moreno-Bueno, G.; Heeschen, C.; Portillo, F.; Cano, A.; Sainz, B. "Macrophages direct cancer cells through a LOXL2-mediated metastatic cascade in pancreatic ductal adenocarcinoma.". Gut. (): . (2022). (PMID: 35428659).
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  6. Vázquez-Naharro, A.; Bustos-Tauler, J.; Floristán, A.; Yuste, L.; Oltra, S.S.; Vinyals, A.; Moreno-Bueno, G.; Fabra, À.; Portillo, F.; Cano, A.; Santamaría, P.G. "Loxl3 Promotes Melanoma Progression and Dissemination Influencing Cell Plasticity and Survival.". Cancers (Basel). 14(5): . (2022). (PMID: 35267510).
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  7. López-Menéndez, C.; Vázquez-Naharro, A.; Santos, V.; Dubus, P.; Santamaría, P.G.; Martínez-Ramírez, Á.; Portillo, F.; Moreno-Bueno, G.; Faraldo, M.M.; Cano, A. "E2A modulates stemness, metastasis, and therapeutic resistance of breast cancer.". Cancer Res. (): . (2021). (PMID: 34145034).
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  8. Portillo, F.; Vázquez, J.; Pajares, M.A. "Protein-protein interactions involving enzymes of the mammalian methionine and homocysteine metabolism.". Biochimie. (): . (2020). (PMID: 32105812).
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  9. Tashkandi, M.; Ali, F.; Alsaqer, S.; Alhousami, T.; Cano, A.; Martin, A.; Salvador, F.; Portillo, F.; C Gerstenfeld, L.; Goldring, M.B.; Bais, M.V. "Lysyl Oxidase-Like 2 Protects against Progressive and Aging Related Knee Joint Osteoarthritis in Mice.". Int J Mol Sci. 20(19): . (2019). (PMID: 31569601).
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  10. Santamaría, P.G.; Mazón, M.J.; Eraso, P.; Portillo, F. "UPR: An Upstream Signal to EMT Induction in Cancer.". J Clin Med. 8(5): . (2019). (PMID: 31071975).
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  11. Garrido, F.; Pacheco, M.; Vargas-Martínez, R.; Velasco-García, R.; Jorge, I.; Serrano, H.; Portillo, F.; Vázquez, J.; Pajares, M.Á. "Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase.". PLoS ONE. 13(6): e0199472. (2018). (PMID: 29924862).
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  12. Santamaría, P.G.; Floristán, A.; Fontanals-Cirera, B.; Vázquez-Naharro, A.; Santos, V.; Morales, S.; Yuste, L.; Peinado, H.; García-Gómez, A.; Portillo, F.; Hernando, E.; Cano, A. "Lysyl oxidase-like 3 is required for melanoma cell survival by maintaining genomic stability.". Cell Death Differ.. 25(5): 935-950. (2018). (PMID: 29229995).
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  13. Salvador, F.; Martin, A.; López-Menéndez, C.; Moreno-Bueno, G.; Santos, V.; Vazquez-Naharro, A.; Santamaría, P.G.; Morales, S.; Dubus, P.; Muinelo-Romay, L.; López López, R.; Tung, J.C.; Weaver, V.M.; Portillo, F.; Cano, A. "Lysyl oxidase-like protein LOXL2 promotes lung metastasis of breast cancer.". Cancer Res.. (): . (2017). (PMID: 28720577).
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  14. Santamaria, P.G.; Moreno-Bueno, G.; Portillo, F.; Cano, A. "EMT: Present and future in clinical oncology.". Mol Oncol. (): . (2017). (PMID: 28590039).
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  15. Cuevas, E.P.; Eraso, P.; Mazón, M.J.; Santos, V.; Moreno-Bueno, G.; Cano, A.; Portillo, F. "LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway.". Sci Rep. 7(): 44988. (2017). (PMID: 28332555).
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  16. Pérez, C.; Pérez-Zúñiga, F.J.; Garrido, F.; Reytor, E.; Portillo, F.; Pajares, M.A. "The Oncogene PDRG1 Is an Interaction Target of Methionine Adenosyltransferases.". PLoS ONE. 11(8): e0161672. (2016). (PMID: 27548429).
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  17. Mazón, M.J.; Eraso, P.; Portillo, F. "Specific phosphoantibodies reveal two phosphorylation sites in yeast Pma1 in response to glucose.". FEMS Yeast Res.. 15(5): . (2015). (PMID: 26019146).
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  18. Villarejo, A.; Molina-Ortiz, P.; Montenegro, Y.; Moreno-Bueno, G.; Morales, S.; Santos, V.; Gridley, T.; Pérez-Moreno, M.A.; Peinado, H.; Portillo, F.; Calés, C.; Cano, A. "Loss of Snail2 favors skin tumor progression by promoting the recruitment of myeloid progenitors.". Carcinogenesis. 36(5): 585-597. (2015). (PMID: 25784375).
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  19. Martin, A.; Salvador, F.; Moreno-Bueno, G.; Floristán, A.; Ruiz-Herguido, C.; Cuevas, E.P.; Morales, S.; Santos, V.; Csiszar, K.; Dubus, P.; Haigh, J.J.; Bigas, A.; Portillo, F.; Cano, A. "Lysyl oxidase-like 2 represses Notch1 expression in the skin to promote squamous cell carcinoma progression.". EMBO J.. 34(8): 1090-1109. (2015). (PMID: 25759215).
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  20. Canesin, G.; Cuevas, E.P.; Santos, V.; López-Menéndez, C.; Moreno-Bueno, G.; Huang, Y.; Csiszar, K.; Portillo, F.; Peinado, H.; Lyden, D.; Cano, A. "Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.". Oncogene. 34(8): 951-964. (2015). (PMID: 24632622).
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  21. Díaz-López, A.; Díaz-Martín, J.; Moreno-Bueno, G.; Cuevas, E.P.; Santos, V.; Olmeda, D.; Portillo, F.; Palacios, J.; Cano, A. "Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT.". Int. J. Cancer. 136(4): E62-73. (2015). (PMID: 25178837).
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  22. Garcia-Sanz, P.; Quintanilla, A.; Lafita, M.C.; Moreno-Bueno, G.; García-Gutierrez, L.; Tabor, V.; Varela, I.; Shiio, Y.; Larsson, L.G.; Portillo, F.; Leon, J. "Sin3b interacts with Myc and decreases Myc levels.". J. Biol. Chem.. 289(32): 22221-22236. (2014). (PMID: 24951594).
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  23. Cuevas, E.P.; Moreno-Bueno, G.; Canesin, G.; Santos, V.; Portillo, F.; Cano, A. "LOXL2 catalytically inactive mutants mediate epithelial-to-mesenchymal transition.". Biol Open. 3(2): 129-137. (2014). (PMID: 24414204).
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  24. Villarejo, A.; Cortés-Cabrera, A.; Molina-Ortíz, P.; Portillo, F.; Cano, A. "Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition.". J. Biol. Chem.. 289(2): 930-941. (2014). (PMID: 24297167).
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  25. Cubillo, E.; Diaz-Lopez, A.; Cuevas, E.P.; Moreno-Bueno, G.; Peinado, H.; Montes, A.; Santos, V.; Portillo, F.; Cano, A. "E47 and Id1 interplay in epithelial-mesenchymal transition.". PLoS ONE. 8(3): e59948. (2013). (PMID: 23555842).
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  26. Molina-Ortiz, P.; Villarejo, A.; MacPherson, M.; Santos, V.; Montes, A.; Souchelnytskyi, S.; Portillo, F.; Cano, A. "Characterization of the SNAG and SLUG domains of Snail2 in the repression of E-cadherin and EMT induction: modulation by serine 4 phosphorylation.". PLoS ONE. 7(5): e36132. (2012). (PMID: 22567133).
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  27. Mazón, M.J.; Barros, F.; De la Peña, P.; Quesada, J.F.; Escudero, A.; Cobo, A.M.; Pascual-Pascual, S.I.; Gutiérrez-Rivas, E.; Guillén, E.; Arpa, J.; Eraso, P.; Portillo, F.; Molano, J. "Screening for mutations in Spanish families with myotonia. Functional analysis of novel mutations in CLCN1 gene.". Neuromuscul. Disord.. 22(3): 231-243. (2012). (PMID: 22094069).
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  28. Moreno-Bueno, G.; Salvador, F.; Martín, A.; Floristán, A.; Cuevas, E.P.; Santos, V.; Montes, A.; Morales, S.; Castilla, M.A.; Rojo-Sebastián, A.; Martínez, A.; Hardisson, D.; Csiszar, K.; Portillo, F.; Peinado, H.; Palacios, J.; Cano, A. "Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas.". EMBO Mol Med. 3(9): 528-544. (2011). (PMID: 21732535).
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  29. Eraso, P.; Mazón, M.J.; Posas, F.; Portillo, F. "Gene expression profiling of yeasts overexpressing wild type or misfolded Pma1 variants reveals activation of the Hog1 MAPK pathway.". Mol. Microbiol.. 79(5): 1339-1352. (2011). (PMID: 21205016).
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  30. Alvaro-Benito, M.; de Abreu, M.; Portillo, F.; Sanz-Aparicio, J.; Fernández-Lobato, M. "New insights into the fructosyltransferase activity of Schwanniomyces occidentalis ß-fructofuranosidase, emerging from nonconventional codon usage and directed mutation.". Appl. Environ. Microbiol.. 76(22): 7491-7499. (2010). (PMID: 20851958).
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  31. Eraso, P.; Mazón, M.J.; Portillo, F. "A dominant negative mutant of PMA1 interferes with the folding of the wild type enzyme.". Traffic. 11(1): 37-47. (2010). (PMID: 19929866).
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  32. Cano, A.; Portillo, F. "An emerging role for class I bHLH E2-2 proteins in EMT regulation and tumor progression.". Cell Adh Migr. 4(1): 56-60. (2010). (PMID: 20023376).
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  33. Higuero, A.M.; Sánchez-Ruiloba, L.; Doglio, L.E.; Portillo, F.; Abad-Rodríguez, J.; Dotti, C.G.; Iglesias, T. "Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development.". J. Biol. Chem.. 285(2): 1343-1357. (2010). (PMID: 19903810).
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  34. MacPherson, M.R.; Molina, P.; Souchelnytskyi, S.; Wernstedt, C.; Martin-Pérez, J.; Portillo, F.; Cano, A. "Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.". Mol. Biol. Cell. 21(2): 244-253. (2010). (PMID: 19923321).
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  35. Moreno-Bueno, G.; Peinado, H.; Molina, P.; Olmeda, D.; Cubillo, E.; Santos, V.; Palacios, J.; Portillo, F.; Cano, A. "The morphological and molecular features of the epithelial-to-mesenchymal transition.". Nat Protoc. 4(11): 1591-1613. (2009). (PMID: 19834475).
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  36. Sobrado, V.R.; Moreno-Bueno, G.; Cubillo, E.; Holt, L.J.; Nieto, M.A.; Portillo, F.; Cano, A. "The class I bHLH factors E2-2A and E2-2B regulate EMT.". J. Cell. Sci.. 122(Pt 7): 1014-1024. (2009). (PMID: 19295128).
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  37. Moreno-Bueno, G.; Portillo, F.; Cano, A. "Transcriptional regulation of cell polarity in EMT and cancer.". Oncogene. 27(55): 6958-6969. (2008). (PMID: 19029937).
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  38. Olmeda, D.; Montes, A.; Moreno-Bueno, G.; Flores, J.M.; Portillo, F.; Cano, A. "Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines.". Oncogene. 27(34): 4690-4701. (2008). (PMID: 18408755).
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  39. Peinado, H.; Moreno-Bueno, G.; Hardisson, D.; Pérez-Gómez, E.; Santos, V.; Mendiola, M.; de Diego, J.I.; Nistal, M.; Quintanilla, M.; Portillo, F.; Cano, A. "Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas.". Cancer Res.. 68(12): 4541-4550. (2008). (PMID: 18559498).
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  40. Olmeda, D.; Moreno-Bueno, G.; Flores, J.M.; Fabra, A.; Portillo, F.; Cano, A. "SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells.". Cancer Res.. 67(24): 11721-11731. (2007). (PMID: 18089802).
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  41. Mazón, M.J.; Eraso, P.; Portillo, F. "Efficient degradation of misfolded mutant Pma1 by endoplasmic reticulum-associated degradation requires Atg19 and the Cvt/autophagy pathway.". Mol. Microbiol.. 63(4): 1069-1077. (2007). (PMID: 17238920).
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  42. Moreno-Bueno, G.; Cubillo, E.; Sarrió, D.; Peinado, H.; Rodríguez-Pinilla, S.M.; Villa, S.; Bolós, V.; Jordá, M.; Fabra, A.; Portillo, F.; Palacios, J.; Cano, A. "Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.". Cancer Res.. 66(19): 9543-9556. (2006). (PMID: 17018611).
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  43. Eraso, P.; Mazón, M.J.; Portillo, F. "Yeast protein kinase Ptk2 localizes at the plasma membrane and phosphorylates in vitro the C-terminal peptide of the H+-ATPase.". Biochim. Biophys. Acta. 1758(2): 164-170. (2006). (PMID: 16510118).
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  44. Peinado, H.; Portillo, F.; Cano, A. "Switching on-off Snail: LOXL2 versus GSK3beta.". Cell Cycle. 4(12): 1749-1752. (2005). (PMID: 16294032).
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  45. Peinado, H.; Del Carmen Iglesias-de la Cruz, M.; Olmeda, D.; Csiszar, K.; Fong, K.S.; Vega, S.; Nieto, M.A.; Cano, A.; Portillo, F. "A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.". EMBO J. 24(19): 3446-3458. (2005). (PMID: 16096638).
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  46. Marco-Ferreres, R.; Vivar, J.; Arredondo, J.J.; Portillo, F.; Cervera, M. "Co-operation between enhancers modulates quantitative expression from the Drosophila Paramyosin/miniparamyosin gene in different muscle types.". Mech. Dev.. 122(5): 681-694. (2005). (PMID: 15817225).
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  47. Portillo, F.; Mulet, J.M.; Serrano, R. "A role for the non-phosphorylated form of yeast Snf1: tolerance to toxic cations and activation of potassium transport.". FEBS Lett.. 579(2): 512-516. (2005). (PMID: 15642368).
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  48. Eraso, P.; Martínez-Burgos, M.; Falcón-Pérez, J.M.; Portillo, F.; Mazón, M.J. "Ycf1-dependent cadmium detoxification by yeast requires phosphorylation of residues Ser908 and Thr911.". FEBS Lett.. 577(3): 322-326. (2004). (PMID: 15556603).
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  49. Peinado, H.; Portillo, F.; Cano, A. "Transcriptional regulation of cadherins during development and carcinogenesis.". Int. J. Dev. Biol.. 48(5-6): 365-375. (2004). (PMID: 15349812).
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  50. Perez-Moreno, M.A.; Locascio, A.; Rodrigo, I.; Dhondt, G.; Portillo, F.; Nieto, M.A.; Cano, A. "A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions.". J. Biol. Chem.. 276(29): 27424-27431. (2001). (PMID: 11309385).
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  51. Gorgojo, B.; Portillo, F.; Martínez-Suárez, J.V. "Sequencing and heterologous expression in Saccharomyces cerevisiae of a Cryptococcus neoformans cDNA encoding a plasma membrane H(+)-ATPase.". Biochim. Biophys. Acta. 1509(1-2): 103-110. (2000). (PMID: 11118522).
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  52. de la Fuente, N.; Portillo, F. "The cell wall integrity/remodeling MAPK cascade is involved in glucose activation of the yeast plasma membrane H(+)-ATPase.". Biochim. Biophys. Acta. 1509(1-2): 189-194. (2000). (PMID: 11118530).
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  53. Goossens, A.; de La Fuente, N.; Forment, J.; Serrano, R.; Portillo, F. "Regulation of yeast H(+)-ATPase by protein kinases belonging to a family dedicated to activation of plasma membrane transporters.". Mol. Cell. Biol.. 20(20): 7654-7661. (2000). (PMID: 11003661).
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  54. Portillo, F. "Genetic characterization of the (534)DPPR motif of the yeast plasma membrane H(+)-ATPase.". Biochim. Biophys. Acta. 1468(1-2): 99-9106. (2000). (PMID: 11018655).
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  55. Portillo, F. "Regulation of plasma membrane H(+)-ATPase in fungi and plants.". Biochim. Biophys. Acta. 1469(1): 31-42. (2000). (PMID: 10692636).
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  56. Cano, A.; Pérez-Moreno, M.A.; Rodrigo, I.; Locascio, A.; Blanco, M.J.; del Barrio, M.G.; Portillo, F.; Nieto, M.A. "The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.". Nat. Cell Biol.. 2(2): 76-83. (2000). (PMID: 10655586).
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  57. Martín-Castillo, B.; Portillo, F. "Characterization of non-dominant lethal mutations in the yeast plasma membrane H+-ATPase gene.". Biochim. Biophys. Acta. 1417(1): 32-36. (1999). (PMID: 10076033).
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  58. Maldonado, A.M.; de la Fuente, N.; Portillo, F. "Characterization of an allele-nonspecific intragenic suppressor in the yeast plasma membrane H+-ATPase gene (Pma1).". Genetics. 150(1): 11-19. (1998). (PMID: 9725826).
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  59. de la Fuente, N.; Maldonado, A.M.; Portillo, F. "Yeast gene YOR137c is involved in the activation of the yeast plasma membrane H+-ATPase by glucose.". FEBS Lett.. 420(1): 17-19. (1997). (PMID: 9450541).
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  60. de la Fuente, N.; Maldonado, A.M.; Portillo, F. "Glucose activation of the yeast plasma membrane H+-ATPase requires the ubiquitin-proteasome proteolytic pathway.". FEBS Lett.. 411(2-3): 308-312. (1997). (PMID: 9271226).
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  61. Portillo, F. "Characterization of dominant lethal mutations in the yeast plasma membrane H+-ATPase gene.". FEBS Lett.. 402(2-3): 136-140. (1997). (PMID: 9037182).
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  62. Maldonado, A.M.; Portillo, F. "Genetic analysis of the fluorescein isothiocyanate binding site of the yeast plasma membrane H(+)-ATPase.". J. Biol. Chem.. 270(15): 8655-8659. (1995). (PMID: 7721767).
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  63. García-Arranz, M.; Maldonado, A.M.; Mazón, M.J.; Portillo, F. "Transcriptional control of yeast plasma membrane H(+)-ATPase by glucose. Cloning and characterization of a new gene involved in this regulation.". J. Biol. Chem.. 269(27): 18076-18082. (1994). (PMID: 8027068).
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  64. Eraso, P.; Portillo, F. "Molecular mechanism of regulation of yeast plasma membrane H(+)-ATPase by glucose. Interaction between domains and identification of new regulatory sites.". J. Biol. Chem.. 269(14): 10393-10399. (1994). (PMID: 8144622).
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  65. Gamo, F.J.; Portillo, F.; Gancedo, C. "Characterization of mutations that overcome the toxic effect of glucose on phosphoglucose isomerase less strains of Saccharomyces cerevisiae.". FEMS Microbiol. Lett.. 106(3): 233-237. (1993). (PMID: 8454188).
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  66. Portillo, F.; Gancedo, C. "Purification and properties of three intracellular proteinases from Candida albicans.". Biochim. Biophys. Acta. 881(2): 229-235. (1986). (PMID: 3513844).
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  67. Portillo, F.; Gancedo, C. "Mitochondrial resistance to miconazole in Saccharomyces cerevisiae.". Mol. Gen. Genet.. 199(3): 495-499. (1985). (PMID: 3162079).
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  68. Portillo, F.; Gancedo, C. "Mode of action of miconazole on yeasts: inhibition of the mitochondrial ATPase.". Eur. J. Biochem.. 143(2): 273-276. (1984). (PMID: 6236081).
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