INVESTIGACIÓN

 
  • Grupos de Investigación
  • Unidades de Investigación
  • Memoria Cientifíca
  • Publicaciones
espacio

 

PUBLICACIONES

 

 

spacerTrabajos Publicados por Rosario Perona Abellón
spacer
  1. Guerrero-López, R.; Manguán-García, C.; Carrascoso-Rubio, C.; Lozano, M.L.; Toldos-Torres, M.; García-Castro, L.; Sánchez-Dominguez, R.; Alberquilla, O.; Sánchez-Pérez, I.; Molina-Molina, M.; Bueren, J.A.; Guenechea, G.; Perona, R.; Sastre, L. "Premature ageing of lung alveoli and bone marrow cells from Terc deficient mice with different telomere lengths.". Sci Rep. 15(1): 6102. (2025). (PMID: 39971959).
    spacer

  2. Duminy-Luppi, D.; Alcaide-Aldeano, A.; Planas-Cerezales, L.; Bermudo, G.; Vicens-Zygmunt, V.; Luburich, P.; Del Río-Carrero, B.; Llatjós, R.; Pijuan, L.; Escobar, I.; Rivas, F.; Montes-Worboys, A.; Gutiérrez-Rodríguez, Y.; Rodríguez-Plaza, D.; Padró-Miquel, A.; Esteve-Garcia, A.; Fernández-Varas, B.; Flores, C.; Fuentes, M.; Dorca, J.; Santos, S.; Perona, R.; Günther, A.; Shull, J.; Molina-Molina, M. "Diagnostic and prognostic implications of family history of fibrotic interstitial lung diseases.". Respir Res. 25(1): 433. (2024). (PMID: 39695595).
    spacer

  3. Acero-Riaguas, L.; Griso-Acevedo, A.B.; SanLorenzo-Vaquero, A.; Ibáñez-Herrera, B.; Fernandez-Diaz, S.M.; Mascaraque, M.; Sánchez-Siles, R.; López-García, I.; Benítez-Buelga, C.; Bravo-Burguillos, E.R.; Castelo, B.; Cebrián-Carretero, J.L.; Perona, R.; Sastre, L.; Sastre-Perona, A. "DUSP1 and SOX2 expression determine squamous cell carcinoma of the salivary gland progression.". Sci Rep. 14(1): 15007. (2024). (PMID: 38951654).
    spacer

  4. Fernández-Varas, B.; Manguan-García, C.; Rodriguez-Centeno, J.; Mendoza-Lupiáñez, L.; Calatayud, J.; Perona, R.; Martín-Martínez, M.; Gutierrez-Rodriguez, M.; Benítez-Buelga, C.; Sastre, L. "Clinical mutations in the TERT and TERC genes coding for telomerase components induced oxidative stress, DNA damage at telomeres and cell apoptosis besides decreased telomerase activity.". Hum Mol Genet. 33(9): 818-834. (2024). (PMID: 38641551).
    spacer

  5. Melones-Herrero, J.; Alcalá, S.; Ruiz-Cañas, L.; Benítez-Buelga, C.; Batres-Ramos, S.; Calés, C.; Lorenzo, O.; Perona, R.; Quiroga, A.G.; Sainz, B.; Sánchez-Pérez, I. "Platinum iodido drugs show potential anti-tumor activity, affecting cancer cell metabolism and inducing ROS and senescence in gastrointestinal cancer cells.". Commun Biol. 7(1): 353. (2024). (PMID: 38519773).
    spacer

  6. Bargiela-Iparraguirre, J.; Herrero, J.M.; Pajuelo-Lozano, N.; Perez, M.; Perona, R.; Quiroga, A.G.; Calés, C.; Sanchez-Perez, I. "Regulatory effects of miR-19a on MAD2 expression and tumorigenesis in gastric cancer.". Genes Dis. 10(4): 1180-1182. (2023). (PMID: 37397556).
    spacer

  7. Lasaga, M.; Río, P.; Vilas-Zornoza, A.; Planell, N.; Navarro, S.; Alignani, D.; Fernández-Varas, B.; Mouzo, D.; Zubicaray, J.; Pujol, R.M.; Nicoletti, E.; Schwartz, J.D.; Sevilla, J.; Ainciburi, M.; Ullate-Agote, A.; Surrallés, J.; Perona, R.; Sastre, L.; Prosper, F.; Gomez-Cabrero, D.; Bueren, J.A. "Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia.". Haematologica. (): . (2023). (PMID: 37021532).
    spacer

  8. Retuerto, M.; Lledó, A.; Fernandez-Varas, B.; Guerrero-López, R.; Usategui, A.; Lalueza, A.; García-García, R.; Mancebo, E.; Paz-Artal, E.; Sastre, L.; Perona, R.; Pablos, J.L. "Shorter telomere length is associated with COVID-19 hospitalization and with persistence of radiographic lung abnormalities.". Immun Ageing. 19(1): 38. (2022). (PMID: 35996190).
    spacer

  9. Michel, M.; Benítez-Buelga, C.; Calvo, P.A.; Hanna, B.M.F.; Mortusewicz, O.; Masuyer, G.; Davies, J.; Wallner, O.; Sanjiv, K.; Albers, J.J.; Castañeda-Zegarra, S.; Jemth, A.S.; Visnes, T.; Sastre-Perona, A.; Danda, A.N.; Homan, E.J.; Marimuthu, K.; Zhenjun, Z.; Chi, C.N.; Sarno, A.; Wiita, E.; von Nicolai, C.; Komor, A.J.; Rajagopal, V.; Müller, S.; Hank, E.C.; Varga, M.; Scaletti, E.R.; Pandey, M.; Karsten, S.; Haslene-Hox, H.; Loevenich, S.; Marttila, P.; Rasti, A.; Mamonov, K.; Ortis, F.; Schömberg, F.; Loseva, O.; Stewart, J.; D'Arcy-Evans, N.; Koolmeister, T.; Henriksson, M.; Michel, D.; de Ory, A.; Acero, L.; Calvete, O.; Scobie, M.; Hertweck, C.; Vilotijevic, I.; Kalderén, C.; Osorio, A.; Perona, R.; Stolz, A.; Stenmark, P.; Berglund, U.W.; de Vega, M.; Helleday, T. "Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.". Science. 376(6600): 1471-1476. (2022). (PMID: 35737787).
    spacer

  10. Shull, J.G.; Planas-Cerezales, L.; Lara Compte, C.; Perona, R.; Molina-Molina, M. "Harnessing PM2.5 Exposure Data to Predict Progression of Fibrotic Interstitial Lung Diseases Based on Telomere Length.". Front Med (Lausanne). 9(): 871898. (2022). (PMID: 35646972).
    spacer

  11. Rodríguez-Fanjul, V.; Guerrero-López, R.; Fernández-Varas, B.; Perona, R.; Sastre-Perona, A.; Sastre, L. "Comparison of Colorectal Cancer Stem Cells and Oxaliplatin-Resistant Cells Unveils Functional Similarities.". Cells. 11(3): . (2022). (PMID: 35159320).
    spacer

  12. Usategui, A.; Municio, C.; Arias-Salgado, E.G.; Martín, M.; Fernández-Varas, B.; Del Rey, M.J.; Carreira, P.; González, A.; Criado, G.; Perona, R.; Pablos, J.L. "Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis.". Immun Ageing. 19(1): 7. (2022). (PMID: 35086525).
    spacer

  13. Planas-Cerezales, L.; Arias-Salgado, E.G.; Berastegui, C.; Montes-Worboys, A.; González-Montelongo, R.; Lorenzo-Salazar, J.M.; Vicens-Zygmunt, V.; Garcia-Moyano, M.; Dorca, J.; Flores, C.; Perona, R.; Román, A.; Molina-Molina, M. "Lung Transplant Improves Survival and Quality of Life Regardless of Telomere Dysfunction.". Front Med (Lausanne). 8(): 695919. (2021). (PMID: 34395476).
    spacer

  14. Francisco, S.; Arranz, A.; Merino, J.; Punzón, C.; Perona, R.; Fresno, M. "Early p38 Activation Regulated by MKP-1 Is Determinant for High Levels of IL-10 Expression Through TLR2 Activation.". Front Immunol. 12(): 660065. (2021). (PMID: 34234775).
    spacer

  15. Gálvez, E.; Vallespín, E.; Arias-Salgado, E.G.; Sánchez-Valdepeñas, C.; Giménez, Y.; Navarro, S.; Río, P.; Bogliolo, M.; Pujol, R.; Peiró, M.; Nevado, J.; Zubicaray, J.; Sebastián, E.; Catalá, A.; Beléndez, C.; Díaz de Heredia, C.; Galera, A.; Badell, I.; Madero, L.; Perona, R.; Sastre, L.; Surrallés, J.; Bueren, J.; Lapunzina, P.; Sevilla, J. "Next-generation Sequencing in Bone Marrow Failure Syndromes and Isolated Cytopenias: Experience of the Spanish Network on Bone Marrow Failure Syndromes.". Hemasphere. 5(4): e539. (2021). (PMID: 33718801).
    spacer

  16. Pintado-Berninches, L.; Montes-Worboys, A.; Manguan-García, C.; Arias-Salgado, E.G.; Serrano, A.; Fernandez-Varas, B.; Guerrero-López, R.; Iarriccio, L.; Planas, L.; Guenechea, G.; Egusquiaguirre, S.P.; Hernandez, R.M.; Igartua, M.; Luis Pedraz, J.; Cortijo, J.; Sastre, L.; Molina-Molina, M.; Perona, R. "GSE4-loaded nanoparticles a potential therapy for lung fibrosis that enhances pneumocyte growth, reduces apoptosis and DNA damage.". FASEB J. 35(3): e21422. (2021). (PMID: 33638895).
    spacer

  17. Carrascoso-Rubio, C.; Zittersteijn, H.A.; Pintado-Berninches, L.; Fernández-Varas, B.; Lozano, M.L.; Manguan-Garcia, C.; Sastre, L.; Bueren, J.A.; Perona, R.; Guenechea, G. "Generation of dyskeratosis congenita-like hematopoietic stem cells through the stable inhibition of DKC1.". Stem Cell Res Ther. 12(1): 92. (2021). (PMID: 33514435).
    spacer

  18. Perona, R. "The Different Roads to Maintain Telomeres in Cancer Cells.". Genes (Basel). 11(12): . (2020). (PMID: 33371195).
    spacer

  19. Pajuelo-Lozano, N.; Alcalá, S.; Sainz, B.; Perona, R.; Sanchez-Perez, I. "Targeting MAD2 modulates stemness and tumorigenesis in human Gastric Cancer cell lines.". Theranostics. 10(21): 9601-9618. (2020). (PMID: 32863948).
    spacer

  20. Aguirre, L.A.; Montalbán-Hernández, K.; Avendaño-Ortiz, J.; Marín, E.; Lozano, R.; Toledano, V.; Sánchez-Maroto, L.; Terrón, V.; Valentín, J.; Pulido, E.; Casalvilla, J.C.; Rubio, C.; Diekhorst, L.; Laso-García, F.; Del Fresno, C.; Collazo-Lorduy, A.; Jiménez-Munarriz, B.; Gómez-Campelo, P.; Llanos-González, E.; Fernández-Velasco, M.; Rodríguez-Antolín, C.; Pérez de Diego, R.; Cantero-Cid, R.; Hernádez-Jimenez, E.; Álvarez, E.; Rosas, R.; Dies López-Ayllón, B.; de Castro, J.; Wculek, S.K.; Cubillos-Zapata, C.; Ibáñez de Cáceres, I.; Díaz-Agero, P.; Gutiérrez Fernández, M.; Paz de Miguel, M.; Sancho, D.; Schulte, L.; Perona, R.; Belda-Iniesta, C.; Boscá, L.; López-Collazo, E. "Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells.". Oncoimmunology. 9(1): 1773204. (2020). (PMID: 32923132).
    spacer

  21. Rodriguez-Centeno, J.; Perona, R.; Sastre, L. "Dyskerin Mutations Present in Dyskeratosis Congenita Patients Increase Oxidative Stress and DNA Damage Signalling in Dictyostelium Discoideum.". Cells. 8(11): . (2019). (PMID: 31717312).
    spacer

  22. Rodriguez-Centeno, J.; Manguán-García, C.; Perona, R.; Sastre, L. "Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms.". PLoS ONE. 14(9): e0222909. (2019). (PMID: 31550289).
    spacer

  23. Iglesias, M.; Felix, D.A.; Gutiérrez-Gutiérrez, Ó.; De Miguel-Bonet, M.D.M.; Sahu, S.; Fernández-Varas, B.; Perona, R.; Aboobaker, A.A.; Flores, I.; González-Estévez, C. "Downregulation of mTOR Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians.". Stem Cell Reports. 13(2): 405-418. (2019). (PMID: 31353226).
    spacer

  24. Celaya, A.M.; Sánchez-Pérez, I.; Bermúdez-Muñoz, J.M.; Rodríguez-de la Rosa, L.; Pintado-Berninches, L.; Perona, R.; Murillo-Cuesta, S.; Varela-Nieto, I. "Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss.". Elife. 8(): . (2019). (PMID: 30938680).
    spacer

  25. Arias-Salgado, E.G.; Galvez, E.; Planas-Cerezales, L.; Pintado-Berninches, L.; Vallespin, E.; Martinez, P.; Carrillo, J.; Iarriccio, L.; Ruiz-Llobet, A.; Catalá, A.; Badell-Serra, I.; Gonzalez-Granado, L.I.; Martín-Nalda, A.; Martínez-Gallo, M.; Galera-Miñarro, A.; Rodríguez-Vigil, C.; Bastos-Oreiro, M.; Perez de Nanclares, G.; Leiro-Fernández, V.; Uria, M.L.; Diaz-Heredia, C.; Valenzuela, C.; Martín, S.; López-Muñiz, B.; Lapunzina, P.; Sevilla, J.; Molina-Molina, M.; Perona, R.; Sastre, L. "Genetic analyses of aplastic anemia and idiopathic pulmonary fibrosis patients with short telomeres, possible implication of DNA-repair genes.". Orphanet J Rare Dis. 14(1): 82. (2019). (PMID: 30995915).
    spacer

  26. Moncho-Amor, V.; Pintado-Berninches, L.; Ibañez de Cáceres, I.; Martín-Villar, E.; Quintanilla, M.; Chakravarty, P.; Cortes-Sempere, M.; Fernández-Varas, B.; Rodriguez-Antolín, C.; de Castro, J.; Sastre, L.; Perona, R. "Role of Dusp6 Phosphatase as a Tumor Suppressor in Non-Small Cell Lung Cancer.". Int J Mol Sci. 20(8): . (2019). (PMID: 31027181).
    spacer

  27. Baquero, J.M.; Benítez-Buelga, C.; Fernández, V.; Urioste, M.; García-Giménez, J.L.; Perona, R.; , .; Benítez, J.; Osorio, A. "A common SNP in the uracil-DNA glycosylase gene UNG decreases ovarian cancer risk in BRCA2 mutation carriers.". Mol Oncol. (): . (2019). (PMID: 30747491).
    spacer

  28. Planas-Cerezales, L.; Arias-Salgado, E.G.; Buendia-Roldán, I.; Montes-Worboys, A.; López, C.E.; Vicens-Zygmunt, V.; Hernaiz, P.L.; Sanuy, R.L.; Leiro-Fernandez, V.; Vilarnau, E.B.; Llinás, E.S.; Sargatal, J.D.; Abellón, R.P.; Selman, M.; Molina-Molina, M. "Predictive factors and prognostic effect of telomere shortening in pulmonary fibrosis.". Respirology. 24(2): 146-153. (2019). (PMID: 30320420).
    spacer

  29. Pintado-Berninches, L.; Fernandez-Varas, B.; Benitez-Buelga, C.; Manguan-Garcia, C.; Serrano-Benitez, A.; Iarriccio, L.; Carrillo, J.; Guenechea, G.; Egusquiaguirre, S.P.; Pedraz, J.L.; Hernández, R.M.; Igartua, M.; Arias-Salgado, E.G.; Cortés-Ledesma, F.; Sastre, L.; Perona, R. "GSE4 peptide suppresses oxidative and telomere deficiencies in ataxia telangiectasia patient cells.". Cell Death Differ.. (): . (2019). (PMID: 30670828).
    spacer

  30. Pajuelo-Lozano, N.; Bargiela-Iparraguirre, J.; Dominguez, G.; Quiroga, A.G.; Perona, R.; Sanchez-Perez, I. "XPA, XPC, and XPD Modulate Sensitivity in Gastric Cisplatin Resistance Cancer Cells.". Front Pharmacol. 9(): 1197. (2018). (PMID: 30386247).
    spacer

  31. Higgs, C.; Crow, Y.J.; Adams, D.M.; Chang, E.; Hayes, D.; Herbig, U.; Huang, J.N.; Himes, R.; Jajoo, K.; Johnson, F.B.; Reynolds, S.D.; Yonekawa, Y.; Armanios, M.; Boulad, F.; DiNardo, C.D.; Dufour, C.; Goldman, F.D.; Khan, S.; Kratz, C.; Myers, K.C.; Raghu, G.; Alter, B.P.; Aubert, G.; Bhala, S.; Cowen, E.W.; Dror, Y.; El-Youssef, M.; Friedman, B.; Giri, N.; Helms Guba, L.; Khincha, P.P.; Lin, T.F.; Longhurst, H.; McReynolds, L.J.; Nelson, A.; Olson, T.; Pariser, A.; Perona, R.; Sasa, G.; Schratz, K.; Simonetto, D.A.; Townsley, D.; Walsh, M.; Stevens, K.; Agarwal, S.; Bertuch, A.A.; Savage, S.A.; , . "Understanding the evolving phenotype of vascular complications in telomere biology disorders.". Angiogenesis. (): . (2018). (PMID: 30168024).
    spacer

  32. Montejano, R.; Stella-Ascariz, N.; Monge, S.; Bernardino, J.I.; Pérez-Valero, I.; Montes, M.L.; Valencia, E.; Martín-Carbonero, L.; Moreno, V.; González-Garcia, J.; Rodriguez-Centeno, J.; Rodes, B.; Esteban Cantos, A.; Alejos, B.; de Miguel, R.; Arnalich, F.; Perona, R.; Arribas, J.R. "Impact of Nucleos(t)ide Reverse Transcriptase Inhibitors on Blood Telomere Length Changes in a Prospective Cohort of Aviremic HIV-1 infected Adults.". J. Infect. Dis.. (): . (2018). (PMID: 29912427).
    spacer

  33. Molina-Molina, M.; Planas-Cerezales, L.; Perona, R. "Telomere Shortening in Idiopathic Pulmonary Fibrosis.". Arch. Bronconeumol.. 54(1): 3-4. (2018). (PMID: 28918867).
    spacer

  34. Arrizabalaga, O.; Moreno-Cugnon, L.; Auzmendi-Iriarte, J.; Aldaz, P.; de Cáceres, I.I.; Garros-Regulez, L.; Moncho-Amor, V.; Torres-Bayona, S.; Pernía, O.; Pintado-Berninches, L.; Carrasco-Ramirez, P.; Cortes-Sempere, M.; Rosas, R.; Sanchez-Gomez, P.; Ruiz, I.; Caren, H.; Pollard, S.; Garcia, I.; Sacido, A.A.; Lovell-Badge, R.; Belda-Iniesta, C.; Sampron, N.; Perona, R.; Matheu, A. "High expression of MKP1/DUSP1 counteracts glioma stem cell activity and mediates HDAC inhibitor response.". Oncogenesis. 6(12): 401. (2017). (PMID: 29284798).
    spacer

  35. Vera, O.; Jimenez, J.; Pernia, O.; Rodriguez-Antolin, C.; Rodriguez, C.; Sanchez Cabo, F.; Soto, J.; Rosas, R.; Lopez-Magallon, S.; Esteban Rodriguez, I.; Dopazo, A.; Rojo, F.; Belda, C.; Alvarez, R.; Valentin, J.; Benitez, J.; Perona, R.; De Castro, J.; Ibanez de Caceres, I. "DNA Methylation of miR-7 is a Mechanism Involved in Platinum Response through MAFG Overexpression in Cancer Cells.". Theranostics. 7(17): 4118-4134. (2017). (PMID: 29158814).
    spacer

  36. Montejano, R.; Stella-Ascariz, N.; Monge, S.; Bernardino, J.I.; Pérez-Valero, I.; Montes, M.L.; Valencia, E.; Martín-Carbonero, L.; Moreno, V.; González-García, J.; Arnalich, F.; Mingorance, J.; Pintado Berniches, L.; Perona, R.; Arribas, J.R. "Impact of Antiretroviral Treatment Containing Tenofovir Difumarate on the Telomere Length of Aviremic HIV-Infected Patients.". J Acquir Immune Defic Syndr. 76(1): 102-109. (2017). (PMID: 28418989).
    spacer

  37. Carrillo, J.; Calvete, O.; Pintado Berninches, L.; Manguan-García, C.; Sevilla Navarro, J.; Arias-Salgado, E.G.; Sastre, L.; Guenechea, G.; López Granados, E.; de Villartay, J.P.; Revy, P.; Benitez, J.; Perona, R. "Mutations in xlf/nhej1/cernunnos Gene Results In Downregulation of Telomerase Genes Expression and Telomere Shortening.". Hum. Mol. Genet.. (): . (2017). (PMID: 28369633).
    spacer

  38. Rincon, R.; Zazo, S.; Chamizo, C.; Manso, R.; González-Alonso, P.; Martin-Aparicio, E.; Cristobal, I.; Cañadas, C.; Perona, R.; Lluch, A.; Eroles, P.; Garcia-Foncillas, J.; Albanell, J.; Rovira, A.; Madoz-Gurpide, J.; Rojo, F. "c-Jun N-terminal kinase inactivation by mitogen-activated protein kinase phosphatase 1 determines resistance to taxanes and anthracyclines in breast cancer.". Mol. Cancer Ther.. (): . (2016). (PMID: 27599524).
    spacer

  39. García-Romero, N.; González-Tejedo, C.; Carrión-Navarro, J.; Esteban-Rubio, S.; Rackov, G.; Rodríguez-Fanjul, V.; Oliver-De La Cruz, J.; Prat-Acín, R.; Peris-Celda, M.; Blesa, D.; Ramírez-Jiménez, L.; Sánchez-Gómez, P.; Perona, R.; Escobedo-Lucea, C.; Belda-Iniesta, C.; Ayuso-Sacido, A. "Cancer stem cells from human glioblastoma resemble but do not mimic original tumors after in vitro passaging in serum-free media.". Oncotarget. (): . (2016). (PMID: 27589567).
    spacer

  40. Stella-Ascariz, N.; Montejano, R.; Pintado-Berninches, L.; Monge, S.; Bernardino, J.I.; Pérez-Valero, I.; Montes, M.L.; Mingorance, J.; Perona, R.; Arribas, J.R. "Differential effects of Tenofovir, Abacavir, Emtricitabine and Darunavir on telomerase activity in vitro.". J. Acquir. Immune Defic. Syndr.. (): . (2016). (PMID: 27552152).
    spacer

  41. Bargiela-Iparraguirre, J.; Prado-Marchal, L.; Fernandez-Fuente, M.; Gutierrez-González, A.; Moreno-Rubio, J.; Muñoz-Fernandez, M.; Sereno, M.; Sanchez-Prieto, R.; Perona, R.; Sanchez-Perez, I. "CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response.". Sci Rep. 6(): 21519. (2016). (PMID: 26867682).
    spacer

  42. Iarriccio, L.; Manguán-García, C.; Pintado-Berninches, L.; Mancheño, J.M.; Molina, A.; Perona, R.; Sastre, L. "GSE4, a Small Dyskerin- and GSE24.2-Related Peptide, Induces Telomerase Activity, Cell Proliferation and Reduces DNA Damage, Oxidative Stress and Cell Senescence in Dyskerin Mutant Cells.". PLoS ONE. 10(11): e0142980. (2015). (PMID: 26571381).
    spacer

  43. Calvete, O.; Martinez, P.; Garcia-Pavia, P.; Benitez-Buelga, C.; Paumard-Hernández, B.; Fernandez, V.; Dominguez, F.; Salas, C.; Romero-Laorden, N.; Garcia-Donas, J.; Carrillo, J.; Perona, R.; Triviño, J.C.; Andrés, R.; Cano, J.M.; Rivera, B.; Alonso-Pulpon, L.; Setien, F.; Esteller, M.; Rodriguez-Perales, S.; Bougeard, G.; Frebourg, T.; Urioste, M.; Blasco, M.A.; Benítez, J. "A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families.". Nat Commun. 6(): 8383. (2015). (PMID: 26403419).
    spacer

  44. Egusquiaguirre, S.P.; Manguán-García, C.; Pintado-Berninches, L.; Iarriccio, L.; Carbajo, D.; Albericio, F.; Royo, M.; Pedraz, J.L.; Hernández, R.M.; Perona, R.; Igartua, M. "Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: a promising approach for the treatment of defective telomerase disorders.". Eur J Pharm Biopharm. 91(): 91-9102. (2015). (PMID: 25660910).
    spacer

  45. López-Ayllón, B.D.; de Castro-Carpeño, J.; Rodriguez, C.; Pernía, O.; Ibañez de Cáceres, I.; Belda-Iniesta, C.; Perona, R.; Sastre, L. "Biomarkers of erlotinib response in non-small cell lung cancer tumors that do not harbor the more common epidermal growth factor receptor mutations.". Int J Clin Exp Pathol. 8(3): 2888-2898. (2015). (PMID: 26045797).
    spacer

  46. Benitez-Buelga, C.; Sanchez-Barroso, L.; Gallardo, M.; Apellániz-Ruiz, M.; Inglada-Pérez, L.; Yanowski, K.; Carrillo, J.; Garcia-Estevez, L.; Calvo, I.; Perona, R.; Urioste, M.; Osorio, A.; Blasco, M.A.; Rodriguez-Antona, C.; Benitez, J. "Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients.". Breast Cancer Res. Treat.. 149(2): 385-394. (2015). (PMID: 25528024).
    spacer

  47. Bargiela-Iparraguirre, J.; Prado-Marchal, L.; Pajuelo-Lozano, N.; Jiménez, B.; Perona, R.; Sánchez-Pérez, I. "Mad2 and BubR1 modulates tumourigenesis and paclitaxel response in MKN45 gastric cancer cells.". Cell Cycle. 13(22): 3590-3601. (2014). (PMID: 25483095).
    spacer

  48. Egusquiaguirre, S.P.; Manguán-García, C.; Perona, R.; Pedraz, J.L.; Hernández, R.M.; Igartua, M. "Development and validation of a rapid HPLC method for the quantification of GSE4 peptide in biodegradable PEI-PLGA nanoparticles.". J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.. 972(): 95-9101. (2014). (PMID: 25444543).
    spacer

  49. Lopez-Ayllon, B.D.; Moncho-Amor, V.; Abarrategi, A.; Ibañez de Cáceres, I.; Castro-Carpeño, J.; Belda-Iniesta, C.; Perona, R.; Sastre, L. "Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations.". Cancer Med. 3(5): 1099-1111. (2014). (PMID: 24961511).
    spacer

  50. Manguan-Garcia, C.; Pintado-Berninches, L.; Carrillo, J.; Machado-Pinilla, R.; Sastre, L.; Pérez-Quilis, C.; Esmoris, I.; Gimeno, A.; García-Giménez, J.L.; Pallardó, F.V.; Perona, R. "Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.". PLoS ONE. 9(7): e101424. (2014). (PMID: 24987982).
    spacer

  51. Carrillo, J.; González, A.; Manguán-García, C.; Pintado-Berninches, L.; Perona, R. "p53 pathway activation by telomere attrition in X-DC primary fibroblasts occurs in the absence of ribosome biogenesis failure and as a consequence of DNA damage.". Clin Transl Oncol. 16(6): 529-538. (2014). (PMID: 24065372).
    spacer

  52. Oliver-De La Cruz, J.; Carrión-Navarro, J.; García-Romero, N.; Gutiérrez-Martín, A.; Lázaro-Ibáñez, E.; Escobedo-Lucea, C.; Perona, R.; Belda-Iniesta, C.; Ayuso-Sacido, A. "SOX2+ cell population from normal human brain white matter is able to generate mature oligodendrocytes.". PLoS ONE. 9(6): e99253. (2014). (PMID: 24901457).
    spacer

  53. Cortés-Sempere, M.; de Miguel, M.P.; Pernía, O.; Rodriguez, C.; de Castro Carpeño, J.; Nistal, M.; Conde, E.; López-Ríos, F.; Belda-Iniesta, C.; Perona, R.; Ibanez de Caceres, I. "IGFBP-3 methylation-derived deficiency mediates the resistance to cisplatin through the activation of the IGFIR/Akt pathway in non-small cell lung cancer.". Oncogene. 32(10): 1274-1283. (2013). (PMID: 22543588).
    spacer

  54. Gutiérrez-González, A.; Belda-Iniesta, C.; Bargiela-Iparraguirre, J.; Dominguez, G.; García Alfonso, P.; Perona, R.; Sanchez-Perez, I. "Targeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair.". Apoptosis. 18(3): 347-360. (2013). (PMID: 23271172).
    spacer

  55. Machado-Pinilla, R.; Carrillo, J.; Manguan-Garcia, C.; Sastre, L.; Mentzer, A.; Gu, B.W.; Mason, P.J.; Perona, R. "Defects in mTR stability and telomerase activity produced by the Dkc1 A353V mutation in dyskeratosis congenita are rescued by a peptide from the dyskerin TruB domain.". Clin Transl Oncol. 14(10): 755-763. (2012). (PMID: 22855157).
    spacer

  56. Agostini, A.; Mondragón, L.; Bernardos, A.; Martínez-Máñez, R.; Marcos, M.D.; Sancenón, F.; Soto, J.; Costero, A.; Manguan-García, C.; Perona, R.; Moreno-Torres, M.; Aparicio-Sanchis, R.; Murguía, J.R. "Targeted cargo delivery in senescent cells using capped mesoporous silica nanoparticles.". Angew. Chem. Int. Ed. Engl.. 51(42): 10556-10560. (2012). (PMID: 22996839).
    spacer

  57. Ramírez de Molina, A.; de la Cueva, A.; Machado-Pinilla, R.; Rodriguez-Fanjul, V.; Gomez del Pulgar, T.; Cebrian, A.; Perona, R.; Lacal, J.C. "Acid ceramidase as a chemotherapeutic target to overcome resistance to the antitumoral effect of choline kinase α inhibition.". Curr Cancer Drug Targets. 12(6): 617-624. (2012). (PMID: 22515519).
    spacer

  58. Carrillo, J.; Martínez, P.; Solera, J.; Moratilla, C.; González, A.; Manguán-García, C.; Aymerich, M.; Canal, L.; Del Campo, M.; Dapena, J.L.; Escoda, L.; García-Sagredo, J.M.; Martín-Sala, S.; Rives, S.; Sevilla, J.; Sastre, L.; Perona, R. "High resolution melting analysis for the identification of novel mutations in DKC1 and TERT genes in patients with dyskeratosis congenita.". Blood Cells Mol. Dis.. 49(3-4): 140-146. (2012). (PMID: 22664374).
    spacer

  59. de Castro-Carpeño, J.; Perona, R.; Belda-Iniesta, C. "Treatment for ALK-mutated non-small-cell lung cancer: a new miracle in the research race.". Clin Transl Oncol. 13(11): 774-779. (2011). (PMID: 22082640).
    spacer

  60. Perona, R.; López-Ayllón, B.D.; de Castro Carpeño, J.; Belda-Iniesta, C. "A role for cancer stem cells in drug resistance and metastasis in non-small-cell lung cancer.". Clin Transl Oncol. 13(5): 289-293. (2011). (PMID: 21596655).
    spacer

  61. Moncho-Amor, V.; Galardi-Castilla, M.; Perona, R.; Sastre, L. "The dual-specificity protein phosphatase MkpB, homologous to mammalian MKP phosphatases, is required for D. discoideum post-aggregative development and cisplatin response.". Differentiation. 81(3): 199-207. (2011). (PMID: 21300429).
    spacer

  62. Moncho-Amor, V.; Ibañez de Cáceres, I.; Bandres, E.; Martínez-Poveda, B.; Orgaz, J.L.; Sánchez-Pérez, I.; Zazo, S.; Rovira, A.; Albanell, J.; Jiménez, B.; Rojo, F.; Belda-Iniesta, C.; García-Foncillas, J.; Perona, R. "DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer.". Oncogene. 30(6): 668-678. (2011). (PMID: 20890299).
    spacer

  63. Belda-Iniesta, C.; de Castro, J.; Perona, R. "Translational proteomics: what can you do for true patients?". J. Proteome Res.. 10(1): 101-104. (2011). (PMID: 20977278).
    spacer

  64. Perona, R. "The Nobel Prize in physiology or medicine 2009 "for telomere biology" and its relevance to cancer and related diseases.". Clin Transl Oncol. 12(10): 647-649. (2010). (PMID: 20947477).
    spacer

  65. Ibanez de Caceres, I.; Cortes-Sempere, M.; Moratilla, C.; Machado-Pinilla, R.; Rodriguez-Fanjul, V.; Manguán-García, C.; Cejas, P.; López-Ríos, F.; Paz-Ares, L.; de CastroCarpeño, J.; Nistal, M.; Belda-Iniesta, C.; Perona, R. "IGFBP-3 hypermethylation-derived deficiency mediates cisplatin resistance in non-small-cell lung cancer.". Oncogene. 29(11): 1681-1690. (2010). (PMID: 20023704).
    spacer

  66. Peralta-Sastre, A.; Manguan-Garcia, C.; de Luis, A.; Belda-Iniesta, C.; Moreno, S.; Perona, R.; Sanchez-Perez, I. "Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells.". Int. J. Biochem. Cell Biol.. 42(2): 318-328. (2010). (PMID: 19931410).
    spacer

  67. Ortín, I.; González, J.F.; Cuesta, E.d.e. .L.; Manguan-García, C.; Perona, R.; Avendaño, C. "Cytotoxicity mechanisms of pyrazino[1,2-b]isoquinoline-4-ones and SAR studies.". Bioorg. Med. Chem.. 17(23): 8040-8047. (2009). (PMID: 19875300).
    spacer

  68. Cortes-Sempere, M.; Chattopadhyay, S.; Rovira, A.; Rodriguez-Fanjul, V.; Belda-Iniesta, C.; Tapia, M.; Cejas, P.; Machado-Pinilla, R.; Manguan-García, C.; Sánchez-Pérez, I.; Nistal, M.; Moratilla, C.; de Castro-Carpeño, J.; Gonzalez-Barón, M.; Albanell, J.; Perona, R. "MKP1 repression is required for the chemosensitizing effects of NF-kappaB and PI3K inhibitors to cisplatin in non-small cell lung cancer.". Cancer Lett.. 286(2): 206-216. (2009). (PMID: 19553005).
    spacer

  69. Perona, R.; Machado-Pinilla, R.; Manguan, C.; Carrillo, J. "Telomerase deficiency and cancer susceptibility syndromes.". Clin Transl Oncol. 11(11): 711-714. (2009). (PMID: 19917533).
    spacer

  70. Sanchez-Perez, I.; Manguan-Garcia, C.; Menacho-Marquez, M.; Murguía, J.R.; Perona, R. "hCCR4/cNOT6 targets DNA-damage response proteins.". Cancer Lett.. 273(2): 281-291. (2009). (PMID: 18818012).
    spacer

  71. Ortín, I.; González, J.F.; Cuesta, E.d.e. .L.; Manguan-García, C.; Perona, R.; Avendaño, C. "Pyrazino[1,2-b]isoquinolines: synthesis and study of their cytostatic and cytotoxic properties.". Bioorg. Med. Chem.. 16(19): 9065-9078. (2008). (PMID: 18799316).
    spacer

  72. Perona, R.; Moncho-Amor, V.; Machado-Pinilla, R.; Belda-Iniesta, C.; Sánchez Pérez, I. "Role of CHK2 in cancer development.". Clin Transl Oncol. 10(9): 538-542. (2008). (PMID: 18796370).
    spacer

  73. Machado-Pinilla, R.; Sánchez-Pérez, I.; Murguía, J.R.; Sastre, L.; Perona, R. "A dyskerin motif reactivates telomerase activity in X-linked dyskeratosis congenita and in telomerase-deficient human cells.". Blood. 111(5): 2606-2614. (2008). (PMID: 18057229).
    spacer

  74. Cortés Sempere, M.; Rodríguez Fanjul, V.; Sánchez Pérez, I.; Perona, R. "The role of the NFkappaB signalling pathway in cancer.". Clin Transl Oncol. 10(3): 143-147. (2008). (PMID: 18321816).
    spacer

  75. Belda-Iniesta, C.; Perona, R.; Carpeño, J.d.e. .C.; Cejas, P.; Casado, E.; Manguan-García, C.; Ibanez de Caceres, I.; Sanchez-Perez, I.; Andreu, F.B.; Ferreira, J.A.; Aguilera, A.; de la Peña, J.; Perez-Sánchez, E.; Madero, R.; Feliu, J.; Sereno, M.; González-Barón, M. "Human recombinant erythropoietin does not promote cancer growth in presence of functional receptors expressed in cancer cells.". Cancer Biol. Ther.. 6(10): 1600-1605. (2007). (PMID: 17938574).
    spacer

  76. Perona, R.; Sánchez-Pérez, I. "Signalling pathways involved in clinical responses to chemotherapy.". Clin Transl Oncol. 9(10): 625-633. (2007). (PMID: 17974523).
    spacer

  77. Tapia, M.A.; González-Navarrete, I.; Dalmases, A.; Bosch, M.; Rodriguez-Fanjul, V.; Rolfe, M.; Ross, J.S.; Mezquita, J.; Mezquita, C.; Bachs, O.; Gascón, P.; Rojo, F.; Perona, R.; Rovira, A.; Albanell, J. "Inhibition of the canonical IKK/NF kappa B pathway sensitizes human cancer cells to doxorubicin.". Cell Cycle. 6(18): 2284-2292. (2007). (PMID: 17890907).
    spacer

  78. Belda-Iniesta, C.; de Castro Carpeño, J.; Casado Sáenz, E.; Cejas Guerrero, P.; Perona, R.; González Barón, M. "Molecular biology of malignant gliomas.". Clin Transl Oncol. 8(9): 635-641. (2006). (PMID: 17005465).
    spacer

  79. Belda-Iniesta, C.; Carpeño, J.d.e. .C.; Saenz, E.C.; Gutiérrez, M.; Perona, R.; Barón, M.G. "Long term responses with cetuximab therapy in glioblastoma multiforme.". Cancer Biol. Ther.. 5(8): 912-914. (2006). (PMID: 16929166).
    spacer

  80. Chattopadhyay, S.; Machado-Pinilla, R.; Manguan-García, C.; Belda-Iniesta, C.; Moratilla, C.; Cejas, P.; Fresno-Vara, J.A.; de Castro-Carpeño, J.; Casado, E.; Nistal, M.; Gonzalez-Barón, M.; Perona, R. "MKP1/CL100 controls tumor growth and sensitivity to cisplatin in non-small-cell lung cancer.". Oncogene. 25(23): 3335-3345. (2006). (PMID: 16462770).
    spacer

  81. Perona, R. "Cell signalling: growth factors and tyrosine kinase receptors.". Clin Transl Oncol. 8(2): 77-82. (2006). (PMID: 16632420).
    spacer

  82. Rojo, A.I.; Salinas, M.; Martín, D.; Perona, R.; Cuadrado, A. "Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB.". J. Neurosci.. 24(33): 7324-7334. (2004). (PMID: 15317858).
    spacer

  83. Ajenjo, N.; Cañón, E.; Sánchez-Pérez, I.; Matallanas, D.; León, J.; Perona, R.; Crespo, P. "Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.". J. Biol. Chem.. 279(31): 32813-32823. (2004). (PMID: 15173174).
    spacer

  84. Sanchez-Perez, I.; Rodriguez-Hernandez, C.J.; Manguan-García, C.; Torres, A.; Perona, R.; Murguía, J.R. "FK506 sensitizes mammalian cells to high osmolarity by modulating p38 MAP kinase activation.". Cell. Mol. Life Sci.. 61(6): 700-708. (2004). (PMID: 15052412).
    spacer

  85. Perona, R.; Sánchez-Pérez, I. "Control of oncogenesis and cancer therapy resistance.". Br. J. Cancer. 90(3): 573-577. (2004). (PMID: 14760366).
    spacer

  86. Domínguez, J.E.; Muñoz, M.C.; Zafra, D.; Sanchez-Perez, I.; Baqué, S.; Caron, M.; Mercurio, C.; Barberà, A.; Perona, R.; Gomis, R.; Guinovart, J.J. "The antidiabetic agent sodium tungstate activates glycogen synthesis through an insulin receptor-independent pathway.". J. Biol. Chem.. 278(44): 42785-42794. (2003). (PMID: 12925525).
    spacer

  87. Rodriguez-Hernandez, C.J.; Sanchez-Perez, I.; Gil-Mascarell, R.; Rodríguez-Afonso, A.; Torres, A.; Perona, R.; Murguia, J.R. "The immunosuppressant FK506 uncovers a positive regulatory cross-talk between the Hog1p and Gcn2p pathways.". J. Biol. Chem.. 278(36): 33887-33895. (2003). (PMID: 12813040).
    spacer

  88. Martínez-Piñeiro, L.; Rios, E.; Martínez-Gomariz, M.; Pastor, T.; de Cabo, M.; Picazo, M.L.; Palacios, J.; Perona, R. "Molecular staging of prostatic cancer with RT-PCR assay for prostate-specific antigen in peripheral blood and lymph nodes: comparison with standard histological staging and immunohistochemical assessment of occult regional lymph node metastases.". Eur. Urol.. 43(4): 342-350. (2003). (PMID: 12667714).
    spacer

  89. Madrid, O.; Varea, S.; Sanchez-Perez, I.; Gomez-Garcia, L.; De Miguel, E.; Gomez De Segura, I.A.; Perona, R. "Growth hormone protects against radiotherapy-induced cell death.". Eur. J. Endocrinol.. 147(4): 535-541. (2002). (PMID: 12370117).
    spacer

  90. Sánchez-Pérez, I.; Benitah, S.A.; Martínez-Gomariz, M.; Lacal, J.C.; Perona, R. "Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability.". Mol. Biol. Cell. 13(8): 2933-2945. (2002). (PMID: 12181357).
    spacer

  91. Aznar, S.; Valerón, P.F.; del Rincon, S.V.; Pérez, L.F.; Perona, R.; Lacal, J.C. "Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation.". Mol. Biol. Cell. 12(10): 3282-3294. (2001). (PMID: 11598209).
    spacer

  92. Sánchez-Pérez, I.; Martínez-Gomariz, M.; Williams, D.; Keyse, S.M.; Perona, R. "CL100/MKP-1 modulates JNK activation and apoptosis in response to cisplatin.". Oncogene. 19(45): 5142-5152. (2000). (PMID: 11064451).
    spacer

  93. Sánchez-Pérez, I.; Perona, R. "Lack of c-Jun activity increases survival to cisplatin.". FEBS Lett.. 453(1-2): 151-158. (1999). (PMID: 10403393).
    spacer

  94. Montaner, S.; Perona, R.; Saniger, L.; Lacal, J.C. "Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors.". J. Biol. Chem.. 274(13): 8506-8515. (1999). (PMID: 10085083).
    spacer

  95. Esteve, P.; Embade, N.; Perona, R.; Jiménez, B.; del Peso, L.; León, J.; Arends, M.; Miki, T.; Lacal, J.C. "Rho-regulated signals induce apoptosis in vitro and in vivo by a p53-independent, but Bcl2 dependent pathway.". Oncogene. 17(14): 1855-1869. (1998). (PMID: 9778052).
    spacer

  96. Montaner, S.; Perona, R.; Saniger, L.; Lacal, J.C. "Multiple signalling pathways lead to the activation of the nuclear factor kappaB by the Rho family of GTPases.". J. Biol. Chem.. 273(21): 12779-12785. (1998). (PMID: 9582304).
    spacer

  97. Sánchez-Perez, I.; Murguía, J.R.; Perona, R. "Cisplatin induces a persistent activation of JNK that is related to cell death.". Oncogene. 16(4): 533-540. (1998). (PMID: 9484843).
    spacer

  98. Perona, R.; Montaner, S.; Saniger, L.; Sánchez-Pérez, I.; Bravo, R.; Lacal, J.C. "Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins.". Genes Dev.. 11(4): 463-475. (1997). (PMID: 9042860).
    spacer

  99. Cosgaya, J.M.; Perona, R.; Aranda, A. "Retinoic acid induces secretion of transforming growth factors by PC12 pheochromocytoma cells.". Oncogene. 14(5): 579-587. (1997). (PMID: 9053856).
    spacer

  100. García-Sáez, A.; Perona, R.; Sastre, L. "Polymorphism and structure of the gene coding for the alpha 1 subunit of the Artemia franciscana Na/K-ATPase.". Biochem. J.. 321 ( Pt 2)(): 509-518. (1997). (PMID: 9020888).
    spacer

  101. Cosgaya, J.M.; Garcia-Villalba, P.; Perona, R.; Aranda, A. "Comparison of the effects of retinoic acid and nerve growth factor on PC12 cell proliferation, differentiation, and gene expression.". J. Neurochem.. 66(1): 89-98. (1996). (PMID: 8522994).
    spacer

  102. Perona, R.; Esteve, P.; Jiménez, B.; Ballestero, R.P.; Ramón y Cajal, S.; Lacal, J.C. "Tumorigenic activity of rho genes from Aplysia californica.". Oncogene. 8(5): 1285-1292. (1993). (PMID: 8479750).
    spacer

  103. Perona, R.; Bés, J.C.; Vallejo, C.G. "Degradation of yolk in the brine shrimp Artemia. Biochemical and morphological studies on the involvement of the lysosomal system.". Biol. Cell. 63(3): 361-366. (1988). (PMID: 3224215).
    spacer

  104. Perona, R.; Vallejo, C.G. "The lysosomal proteinase of Artemia. Purification and characterization.". Eur. J. Biochem.. 124(2): 357-362. (1982). (PMID: 7047162).
    spacer

  105. Garesse, R.; Perona, R.; Marco, R.; Vallejo, C.G. "The unmasking of proteolytic activity during the early development of Artemia salina. Identification of a precursor after hatching.". Eur. J. Biochem.. 106(1): 225-231. (1980). (PMID: 7042331).
    spacer

 

 

 

 

 

Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
Tel +(34) 91 585 4400 // Fax +(34) 91 558 4401
Email:Info