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PUBLICACIONES

 

 

spacerTrabajos Publicados por Ana María Pérez Castillo
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  1. Herrera-Arozamena, C.; Estrada-Valencia, M.; García-Díez, G.; Pérez, C.; León, R.; Infantes, L.; Morales-García, J.A.; Pérez-Castillo, A.; Del Sastre, E.; López, M.G.; Rodríguez-Franco, M.I. "Discovery of a potent melatonin-based inhibitor of quinone reductase-2 with neuroprotective and neurogenic properties.". Eur J Med Chem. 277(): 116763. (2024). (PMID: 39146834).
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  2. Corral Nieto, Y.; Yakhine-Diop, S.M.S.; Moreno-Cruz, P.; Manrique García, L.; Gabrielly Pereira, A.; Morales-García, J.A.; Niso-Santano, M.; González-Polo, R.A.; Uribe-Carretero, E.; Durand, S.; Maiuri, M.C.; Paredes-Barquero, M.; Alegre-Cortés, E.; Canales-Cortés, S.; López de Munain, A.; Pérez-Tur, J.; Pérez-Castillo, A.; Kroemer, G.; Fuentes, J.M.; Bravo-San Pedro, J.M. "Changes in Liver Lipidomic Profile in G2019S-LRRK2 Mouse Model of Parkinson's Disease.". Cells. 12(5): . (2023). (PMID: 36899942).
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  3. Sierra-Magro, A.; Bartolome, F.; Lozano-Muñoz, D.; Alarcón-Gil, J.; Gine, E.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Cortes-Canteli, M.; Carro, E.; Pérez-Castillo, A.; Morales-García, J.A. "C/EBPβ Regulates TFAM Expression, Mitochondrial Function and Autophagy in Cellular Models of Parkinson's Disease.". Int J Mol Sci. 24(2): . (2023). (PMID: 36674978).
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  4. Toribio-Fernandez, R.; Ceron, C.; Tristão-Pereira, C.; Fernandez-Nueda, I.; Perez-Castillo, A.; Fernandez-Ferro, J.; Moro, M.A.; Ibañez, B.; Fuster, V.; Cortes-Canteli, M. "Oral anticoagulants: A plausible new treatment for Alzheimer's disease?". Br J Pharmacol. (): . (2023). (PMID: 36633908).
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  5. Alarcon-Gil, J.; Sierra-Magro, A.; Morales-Garcia, J.A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Cortes-Canteli, M.; Niso-Santano, M.; Martínez-Chacón, G.; Fuentes, J.M.; Santos, A.; Perez-Castillo, A. "Neuroprotective and Anti-Inflammatory Effects of Linoleic Acid in Models of Parkinson's Disease: The Implication of Lipid Droplets and Lipophagy.". Cells. 11(15): . (2022). (PMID: 35892594).
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  6. Herrera-Arozamena, C.; Estrada-Valencia, M.; López-Caballero, P.; Pérez, C.; Morales-García, J.A.; Pérez-Castillo, A.; Sastre, E.D.; Fernández-Mendívil, C.; Duarte, P.; Michalska, P.; Lombardía, J.; Senar, S.; León, R.; López, M.G.; Rodríguez-Franco, M.I. "Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative Cascades.". J Med Chem. (): . (2022). (PMID: 35245051).
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  7. Martínez-Chacón, G.; Paredes-Barquero, M.; Yakhine-Diop, S.M.S.; Uribe-Carretero, E.; Bargiela, A.; Sabater-Arcis, M.; Morales-García, J.; Alarcón-Gil, J.; Alegre-Cortés, E.; Canales-Cortés, S.; Rodríguez-Arribas, M.; Camello, P.J.; Pedro, J.M.B.; Perez-Castillo, A.; Artero, R.; Gonzalez-Polo, R.A.; Fuentes, J.M.; Niso-Santano, M. "Neuroprotective properties of queen bee acid by autophagy induction.". Cell Biol Toxicol. (): . (2021). (PMID: 34448959).
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  8. Yakhine-Diop, S.M.S.; Morales-García, J.A.; Niso-Santano, M.; González-Polo, R.A.; Uribe-Carretero, E.; Martinez-Chacon, G.; Durand, S.; Maiuri, M.C.; Aiastui, A.; Zulaica, M.; Ruíz-Martínez, J.; López de Munain, A.; Pérez-Tur, J.; Pérez-Castillo, A.; Kroemer, G.; Bravo-San Pedro, J.M.; Fuentes, J.M. "Metabolic alterations in plasma from patients with familial and idiopathic Parkinson's disease.". Aging (Albany NY). 12(): . (2020). (PMID: 32903216).
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  9. Morales-Garcia, J.A.; Calleja-Conde, J.; Lopez-Moreno, J.A.; Alonso-Gil, S.; Sanz-SanCristobal, M.; Riba, J.; Perez-Castillo, A. "N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo.". Transl Psychiatry. 10(1): 331. (2020). (PMID: 32989216).
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  10. Sethi, J.; Van Bulck, M.; Suhail, A.; Safarzadeh, M.; Perez-Castillo, A.; Pan, G. "Correction to: A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers.". Mikrochim Acta. 187(6): 338. (2020). (PMID: 32430539).
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  11. Sethi, J.; Van Bulck, M.; Suhail, A.; Safarzadeh, M.; Perez-Castillo, A.; Pan, G. "A label-free biosensor based on graphene and reduced graphene oxide dual-layer for electrochemical determination of beta-amyloid biomarkers.". Mikrochim Acta. 187(5): 288. (2020). (PMID: 32333119).
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  12. Herrera-Arozamena, C.; Estrada-Valencia, M.; Pérez, C.; Lagartera, L.; Morales-García, J.A.; Pérez-Castillo, A.; Franco-Gonzalez, J.F.; Michalska, P.; Duarte, P.; León, R.; López, M.G.; Mills, A.; Gago, F.; García-Yagüe, Á.J.; Fernández-Ginés, R.; Cuadrado, A.; Rodríguez-Franco, M.I. "Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.". Eur J Med Chem. 190(): 112090. (2020). (PMID: 32018096).
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  13. Estrada-Valencia, M.; Herrera-Arozamena, C.; Pérez, C.; Viña, D.; Morales-García, J.A.; Pérez-Castillo, A.; Ramos, E.; Romero, A.; Laurini, E.; Pricl, S.; Rodríguez-Franco, M.I. "New flavonoid - N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties.". J Enzyme Inhib Med Chem. 34(1): 712-727. (2019). (PMID: 31852270).
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  14. Morales-Garcia, J.A.; Alonso-Gil, S.; Santos, Á.; Perez-Castillo, A. "Phosphodiesterase 7 Regulation in Cellular and Rodent Models of Parkinson's Disease.". Mol. Neurobiol.. (): . (2019). (PMID: 31473904).
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  15. Van Bulck, M.; Sierra-Magro, A.; Alarcon-Gil, J.; Perez-Castillo, A.; Morales-Garcia, J.A. "Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease.". Int J Mol Sci. 20(3): . (2019). (PMID: 30743990).
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  16. Estrada Valencia, M.; Herrera-Arozamena, C.; de Andrés, L.; Pérez, C.; Morales-García, J.A.; Pérez-Castillo, A.; Ramos, E.; Romero, A.; Viña, D.; Yáñez, M.; Laurini, E.; Pricl, S.; Rodríguez-Franco, M.I. "Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.". Eur J Med Chem. 156(): 534-553. (2018). (PMID: 30025348).
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  17. Morales-Garcia, J.A.; Gine, E.; Hernandez-Encinas, E.; Aguilar-Morante, D.; Sierra-Magro, A.; Sanz-SanCristobal, M.; Alonso-Gil, S.; Sanchez-Lanzas, R.; Castaño, J.G.; Santos, A.; Perez-Castillo, A. "CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson's disease.". Sci Rep. 7(1): 13526. (2017). (PMID: 29051532).
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  18. Morales-Garcia, J.A.; Salado, I.G.; Sanz-San Cristobal, M.; Gil, C.; Pérez-Castillo, A.; Martínez, A.; Pérez, D.I. "Biological and Pharmacological Characterization of Benzothiazole-Based CK-1δ Inhibitors in Models of Parkinson's Disease.". ACS Omega. 2(8): 5215-5220. (2017). (PMID: 30023743).
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  19. Morales-García, J.A.; de la Fuente Revenga, M.; Alonso-Gil, S.; Rodríguez-Franco, M.I.; Feilding, A.; Perez-Castillo, A.; Riba, J. "The alkaloids of Banisteriopsis caapi, the plant source of the Amazonian hallucinogen Ayahuasca, stimulate adult neurogenesis in vitro.". Sci Rep. 7(1): 5309. (2017). (PMID: 28706205).
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  20. García, A.M.; Salado, I.G.; Perez, D.I.; Brea, J.; Morales-García, J.A.; González-García, A.; Cadavid, M.I.; Loza, M.I.; Luque, F.J.; Perez-Castillo, A.; Martinez, A.; Gil, C. "Pharmacological tools based on imidazole scaffold proved the utility of PDE10A inhibitors for Parkinson's disease.". Future Med Chem. (): . (2017). (PMID: 28485668).
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  21. Giné, E.; Echeverry-Alzate, V.; Lopez-Moreno, J.A.; Rodriguez de Fonseca, F.; Perez-Castillo, A.; Santos, A. "The CB1 receptor is required for the establishment of the hyperlocomotor phenotype in developmentally-induced hypothyroidism in mice.". Neuropharmacology. 116(): 132-141. (2017). (PMID: 28017790).
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  22. Morales-Garcia, J.A.; Echeverry-Alzate, V.; Alonso-Gil, S.; Sanz-SanCristobal, M.; Lopez-Moreno, J.A.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase7 Inhibition Activates Adult Neurogenesis in Hippocampus and Subventricular Zone In Vitro and In Vivo.". Stem Cells. 35(2): 458-472. (2017). (PMID: 27538853).
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  23. Hernandez-Encinas, E.; Aguilar-Morante, D.; Morales-Garcia, J.A.; Gine, E.; Sanz-SanCristobal, M.; Santos, A.; Perez-Castillo, A. "Complement component 3 (C3) expression in the hippocampus after excitotoxic injury: role of C/EBPβ.". J Neuroinflammation. 13(1): 276. (2016). (PMID: 27769255).
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  24. Estrada, M.; Herrera-Arozamena, C.; Pérez, C.; Viña, D.; Romero, A.; Morales-García, J.A.; Pérez-Castillo, A.; Rodríguez-Franco, M.I. "New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties.". Eur J Med Chem. 121(): 376-386. (2016). (PMID: 27267007).
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  25. Estrada, M.; Pérez, C.; Soriano, E.; Laurini, E.; Romano, M.; Pricl, S.; Morales-García, J.A.; Pérez-Castillo, A.; Rodríguez-Franco, M.I. "New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with σ-1 agonism and β-secretase inhibition.". Future Med Chem. 8(11): 1191-1207. (2016). (PMID: 27402296).
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  26. de la Fuente Revenga, M.; Pérez, C.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Caignard, D.H.; Yáñez, M.; Gamo, A.M.; Rodríguez-Franco, M.I. "Neurogenic Potential Assessment and Pharmacological Characterization of 6-Methoxy-1,2,3,4-tetrahydro-β-carboline (Pinoline) and Melatonin-Pinoline Hybrids.". ACS Chem Neurosci. 6(5): 800-810. (2015). (PMID: 25815906).
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  27. de la Fuente Revenga, M.; Fernández-Sáez, N.; Herrera-Arozamena, C.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Caignard, D.H.; Rivara, S.; Rodríguez-Franco, M.I. "Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of their Neurogenic Potential.". J. Med. Chem.. (): . (2015). (PMID: 26023814).
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  28. Mestre, L.; Redondo, M.; Carrillo-Salinas, F.J.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Gil, C.; Martínez, A.; Guaza, C. "Phosphodiesterase 7 inhibitor TC3.6 ameliorates symptomatology in a model of primary progressive multiple sclerosis.". Br. J. Pharmacol.. (): . (2015). (PMID: 25994655).
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  29. Morales-Garcia, J.A.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase 7 Inhibition Induces Dopaminergic Neurogenesis in Hemiparkinsonian Rats.". Stem Cells Transl Med. (): . (2015). (PMID: 25925836).
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  30. Aguilar-Morante, D.; Morales-Garcia, J.A.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein β induces motility and invasion of glioblastoma cells through transcriptional regulation of the calcium binding protein S100A4.". Oncotarget. 6(6): 4369-4384. (2015). (PMID: 25738360).
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  31. Morales-Garcia, J.A.; Aguilar-Morante, D.; Hernandez-Encinas, E.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Silencing phosphodiesterase 7B gene by lentiviral-shRNA interference attenuates neurodegeneration and motor deficits in hemiparkinsonian mice.". Neurobiol. Aging. 36(2): 1160-1173. (2015). (PMID: 25457552).
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  32. Hernandez-Encinas, E.; Aguilar-Morante, D.; Cortes-Canteli, M.; Morales-Garcia, J.A.; Gine, E.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein ß directly regulates the expression of the complement component 3 gene in neural cells: implications for the pro-inflammatory effects of this transcription factor.". J Neuroinflammation. 12(1): 14. (2015). (PMID: 25617152).
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  33. Prati, F.; De Simone, A.; Bisignano, P.; Armirotti, A.; Summa, M.; Pizzirani, D.; Scarpelli, R.; Perez, D.I.; Andrisano, V.; Perez-Castillo, A.; Monti, B.; Massenzio, F.; Polito, L.; Racchi, M.; Favia, A.D.; Bottegoni, G.; Martinez, A.; Bolognesi, M.L.; Cavalli, A. "Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.". Angew. Chem. Int. Ed. Engl.. 54(5): 1578-1582. (2015). (PMID: 25504761).
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  34. García, A.M.; Brea, J.; Morales-García, J.A.; Perez, D.I.; González, A.; Alonso-Gil, S.; Gracia-Rubio, I.; Ros-Simó, C.; Conde, S.; Cadavid, M.I.; Loza, M.I.; Perez-Castillo, A.; Valverde, O.; Martinez, A.; Gil, C. "Modulation of cAMP-specific PDE without emetogenic activity: new sulfide-like PDE7 inhibitors.". J. Med. Chem.. 57(20): 8590-8607. (2014). (PMID: 25264825).
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  35. López-Iglesias, B.; Pérez, C.; Morales-García, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Romero, A.; López, M.G.; Villarroya, M.; Conde, S.; Rodríguez-Franco, M.I. "New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.". J. Med. Chem.. 57(9): 3773-3785. (2014). (PMID: 24738476).
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  36. Morales-Garcia, J.A.; Palomo, V.; Redondo, M.; Alonso-Gil, S.; Gil, C.; Martinez, A.; Perez-Castillo, A. "Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders.". ACS Chem Neurosci. 5(3): 194-204. (2014). (PMID: 24437940).
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  37. Morales-García, J.A.; Susín, C.; Alonso-Gil, S.; Pérez, D.I.; Palomo, V.; Pérez, C.; Conde, S.; Santos, A.; Gil, C.; Martínez, A.; Pérez-Castillo, A. "Glycogen synthase kinase-3 inhibitors as potent therapeutic agents for the treatment of Parkinson disease.". ACS Chem Neurosci. 4(2): 350-360. (2013). (PMID: 23421686).
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  38. Giné, E.; Echeverry-Alzate, V.; López-Moreno, J.A.; López-Jimenez, A.; Torres-Romero, D.; Perez-Castillo, A.; Santos, A. "Developmentally-induced hypothyroidism alters the expression of Egr-1 and Arc genes and the sensitivity to cannabinoid agonists in the hippocampus. Possible implications for memory and learning.". Mol. Cell. Endocrinol.. 365(1): 119-128. (2013). (PMID: 23079472).
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  39. Chavarría, C.; Perez, D.I.; Pérez, C.; Morales Garcia, J.A.; Alonso-Gil, S.; Pérez-Castillo, A.; Gil, C.; Souza, J.M.; Porcal, W. "Microwave-assisted synthesis of hydroxyphenyl nitrones with protective action against oxidative stress.". Eur J Med Chem. 58(): 44-49. (2012). (PMID: 23085773).
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  40. Morales-Garcia, J.A.; Luna-Medina, R.; Alonso-Gil, S.; Sanz-Sancristobal, M.; Palomo, V.; Gil, C.; Santos, A.; Martinez, A.; Perez-Castillo, A. "Glycogen synthase kinase 3 inhibition promotes adult hippocampal neurogenesis in vitro and in vivo.". ACS Chem Neurosci. 3(11): 963-971. (2012). (PMID: 23173075).
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  41. Susín, C.; Morales-Garcia, J.A.; Aguilar-Morante, D.; Palomo, V.; Sanz-Sancristobal, M.; Alonso-Gil, S.; Gil, C.; Santos, A.; Martinez, A.; Perez-Castillo, A. "The new iminothiadiazole derivative VP1.14 ameliorates hippocampal damage after an excitotoxic injury.". J. Neurochem.. 122(6): 1193-1202. (2012). (PMID: 22774807).
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  42. Redondo, M.; Brea, J.; Perez, D.I.; Soteras, I.; Val, C.; Perez, C.; Morales-García, J.A.; Alonso-Gil, S.; Paul-Fernandez, N.; Martin-Alvarez, R.; Cadavid, M.I.; Loza, M.I.; Perez-Castillo, A.; Mengod, G.; Campillo, N.E.; Martinez, A.; Gil, C. "Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds.". J. Med. Chem.. 55(7): 3274-3284. (2012). (PMID: 22385507).
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  43. Palomo, V.; Perez, D.I.; Perez, C.; Morales-Garcia, J.A.; Soteras, I.; Alonso-Gil, S.; Encinas, A.; Castro, A.; Campillo, N.E.; Perez-Castillo, A.; Gil, C.; Martinez, A. "5-imino-1,2,4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3.". J. Med. Chem.. 55(4): 1645-1661. (2012). (PMID: 22257026).
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  44. Redondo, M.; Zarruk, J.G.; Ceballos, P.; Pérez, D.I.; Pérez, C.; Perez-Castillo, A.; Moro, M.A.; Brea, J.; Val, C.; Cadavid, M.I.; Loza, M.I.; Campillo, N.E.; Martínez, A.; Gil, C. "Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model.". Eur J Med Chem. 47(1): 175-185. (2012). (PMID: 22100138).
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  45. Cortes-Canteli, M.; Aguilar-Morante, D.; Sanz-Sancristobal, M.; Megias, D.; Santos, A.; Perez-Castillo, A. "Role of C/EBPβ transcription factor in adult hippocampal neurogenesis.". PLoS ONE. 6(10): e24842. (2011). (PMID: 22003384).
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  46. Aguilar-Morante, D.; Cortes-Canteli, M.; Sanz-Sancristobal, M.; Santos, A.; Perez-Castillo, A. "Decreased CCAAT/enhancer binding protein β expression inhibits the growth of glioblastoma cells.". Neuroscience. 176(): 110-119. (2011). (PMID: 21185356).
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  47. Morales-Garcia, J.A.; Luna-Medina, R.; Alfaro-Cervello, C.; Cortes-Canteli, M.; Santos, A.; Garcia-Verdugo, J.M.; Perez-Castillo, A. "Peroxisome proliferator-activated receptor γ ligands regulate neural stem cell proliferation and differentiation in vitro and in vivo.". Glia. 59(2): 293-307. (2011). (PMID: 21125653).
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  48. Morales-Garcia, J.A.; Redondo, M.; Alonso-Gil, S.; Gil, C.; Perez, C.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease.". PLoS ONE. 6(2): e17240. (2011). (PMID: 21390306).
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  49. Aguilar-Morante, D.; Morales-Garcia, J.A.; Sanz-SanCristobal, M.; Garcia-Cabezas, M.A.; Santos, A.; Perez-Castillo, A. "Inhibition of glioblastoma growth by the thiadiazolidinone compound TDZD-8.". PLoS ONE. 5(11): e13879. (2010). (PMID: 21079728).
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  50. Giné, E.; Morales-Garcia, J.A.; Perez-Castillo, A.; Santos, A. "Developmental hypothyroidism increases the expression of kainate receptors in the hippocampus and the sensitivity to kainic acid-induced seizures in the rat.". Endocrinology. 151(7): 3267-3276. (2010). (PMID: 20410204).
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  51. Morales-Garcia, J.A.; Luna-Medina, R.; Martinez, A.; Santos, A.; Perez-Castillo, A. "Anticonvulsant and neuroprotective effects of the novel calcium antagonist NP04634 on kainic acid-induced seizures in rats.". J. Neurosci. Res.. 87(16): 3687-3696. (2009). (PMID: 19565651).
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  52. Cocca, C.; Dorado, J.; Calvo, E.; López, J.A.; Santos, A.; Perez-Castillo, A. "15-Deoxi-Delta(12,14)-prostaglandin J2 is a tubulin-binding agent that destabilizes microtubules and induces mitotic arrest.". Biochem. Pharmacol.. 78(10): 1330-1339. (2009). (PMID: 19576185).
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  53. Martinez, B.; Rodrigues, T.B.; Gine, E.; Kaninda, J.P.; Perez-Castillo, A.; Santos, A. "Hypothyroidism decreases the biogenesis in free mitochondria and neuronal oxygen consumption in the cerebral cortex of developing rats.". Endocrinology. 150(8): 3953-3959. (2009). (PMID: 19389834).
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  54. Castaño, T.; Wang, H.; Campillo, N.E.; Ballester, S.; González-García, C.; Hernández, J.; Pérez, C.; Cuenca, J.; Pérez-Castillo, A.; Martínez, A.; Huertas, O.; Gelpí, J.L.; Luque, F.J.; Ke, H.; Gil, C. "Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors.". ChemMedChem. 4(5): 866-876. (2009). (PMID: 19350606).
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  55. Pérez Castillo, A.; Aguilar-Morante, D.; Morales-García, J.A.; Dorado, J. "Cancer stem cells and brain tumors.". Clin Transl Oncol. 10(5): 262-267. (2008). (PMID: 18490242).
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  56. Asúa, T.; Bilbao, A.; Gorriti, M.A.; Lopez-Moreno, J.A.; Del Mar Alvarez, M.; Navarro, M.; Rodríguez de Fonseca, F.; Perez-Castillo, A.; Santos, A. "Implication of the endocannabinoid system in the locomotor hyperactivity associated with congenital hypothyroidism.". Endocrinology. 149(5): 2657-2666. (2008). (PMID: 18218697).
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  57. Cortes-Canteli, M.; Luna-Medina, R.; Sanz-Sancristobal, M.; Alvarez-Barrientos, A.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer binding protein beta deficiency provides cerebral protection following excitotoxic injury.". J. Cell. Sci.. 121(Pt 8): 1224-1234. (2008). (PMID: 18388310).
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  58. Luna-Medina, R.; Cortes-Canteli, M.; Sanchez-Galiano, S.; Morales-Garcia, J.A.; Martinez, A.; Santos, A.; Perez-Castillo, A. "NP031112, a thiadiazolidinone compound, prevents inflammation and neurodegeneration under excitotoxic conditions: potential therapeutic role in brain disorders.". J. Neurosci.. 27(21): 5766-5776. (2007). (PMID: 17522320).
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  59. Sanchez-Rodriguez, J.; Kaninda-Tshilumbu, J.P.; Santos, A.; Perez-Castillo, A. "The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells.". Biochem J. 390(Pt 1): 57-65. (2005). (PMID: 15819613).
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  60. Luna-Medina, R.; Cortes-Canteli, M.; Alonso, M.; Santos, A.; Martínez, A.; Perez-Castillo, A. "Regulation of inflammatory response in neural cells in vitro by thiadiazolidinones derivatives through peroxisome proliferator-activated receptor gamma activation.". J. Biol. Chem.. 280(22): 21453-21462. (2005). (PMID: 15817469).
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  61. Martínez, B.; Pérez-Castillo, A.; Santos, A. "The mitochondrial respiratory complex I is a target for 15-deoxy-delta12,14-prostaglandin J2 action.". J. Lipid Res.. 46(4): 736-743. (2005). (PMID: 15654126).
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  62. Pignatelli, M.; Sánchez-Rodríguez, J.; Santos, A.; Perez-Castillo, A. "15-deoxy-Delta-12,14-prostaglandin J2 induces programmed cell death of breast cancer cells by a pleiotropic mechanism.". Carcinogenesis. 26(1): 81-92. (2005). (PMID: 15485993).
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  63. Alvarez, M.; Perez-Castillo, A.; Santos, A. "Thyroid hormone regulates Galphai1 gene expression in the rat cerebellar cortex during post-natal development.". J. Neurochem.. 92(2): 395-404. (2005). (PMID: 15663487).
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  64. Cortés-Canteli, M.; Wagner, M.; Ansorge, W.; Pérez-Castillo, A. "Microarray analysis supports a role for ccaat/enhancer-binding protein-beta in brain injury.". J. Biol. Chem.. 279(14): 14409-14417. (2004). (PMID: 14736879).
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  65. Pignatelli, M.; Cocca, C.; Santos, A.; Perez-Castillo, A. "Enhancement of BRCA1 gene expression by the peroxisome proliferator-activated receptor gamma in the MCF-7 breast cancer cell line.". Oncogene. 22(35): 5446-5450. (2003). (PMID: 12934104).
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  66. Pignatelli, M.; Luna-Medina, R.; Pérez-Rendón, A.; Santos, A.; Perez-Castillo, A. "The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells.". Biochem. J.. 373(Pt 3): 739-746. (2003). (PMID: 12755686).
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  67. Cortés-Canteli, M.; Pignatelli, M.; Santos, A.; Perez-Castillo, A. "CCAAT/enhancer-binding protein beta plays a regulatory role in differentiation and apoptosis of neuroblastoma cells.". J. Biol. Chem.. 277(7): 5460-5467. (2002). (PMID: 11733516).
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  68. Pignatelli, M.; Cortés-Canteli, M.; Lai, C.; Santos, A.; Perez-Castillo, A. "The peroxisome proliferator-activated receptor gamma is an inhibitor of ErbBs activity in human breast cancer cells.". J. Cell. Sci.. 114(Pt 22): 4117-4126. (2001). (PMID: 11739643).
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  69. Martinez, B.; del Hoyo, P.; Martin, M.A.; Arenas, J.; Perez-Castillo, A.; Santos, A. "Thyroid hormone regulates oxidative phosphorylation in the cerebral cortex and striatum of neonatal rats.". J. Neurochem.. 78(5): 1054-1063. (2001). (PMID: 11553679).
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  70. Menéndez-Hurtado, A.; Santos, A.; Pérez-Castillo, A. "Characterization of the promoter region of the rat CCAAT/enhancer-binding protein alpha gene and regulation by thyroid hormone in rat immortalized brown adipocytes.". Endocrinology. 141(11): 4164-4170. (2000). (PMID: 11089549).
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  71. Pignatelli, M.; Cortés-Canteli, M.; Santos, A.; Perez-Castillo, A. "Involvement of the NGFI-A gene in the differentiation of neuroblastoma cells.". FEBS Lett.. 461(1-2): 37-42. (1999). (PMID: 10561492).
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  72. Rodríguez-Manzaneque, J.C.; Pérez-Castillo, A.; Santos, A. "Control by thyroid hormone of NGFI-A gene expression in lung: regulation of NGFI-A promoter activity.". Mol. Cell. Endocrinol.. 141(1-2): 101-110. (1998). (PMID: 9723891).
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  73. Vega-Núñez, E.; Alvarez, A.M.; Menéndez-Hurtado, A.; Santos, A.; Perez-Castillo, A. "Neuronal mitochondrial morphology and transmembrane potential are severely altered by hypothyroidism during rat brain development.". Endocrinology. 138(9): 3771-3778. (1997). (PMID: 9275064).
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  74. Menéndez-Hurtado, A.; Vega-Núñez, E.; Santos, A.; Perez-Castillo, A. "Regulation by thyroid hormone and retinoic acid of the CCAAT/enhancer binding protein alpha and beta genes during liver development.". Biochem. Biophys. Res. Commun.. 234(3): 605-610. (1997). (PMID: 9175760).
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  75. Moreno, B.; Rodríguez-Manzaneque, J.C.; Pérez-Castillo, A.; Santos, A. "Thyroid hormone controls the expression of insulin-like growth factor I receptor gene at different levels in lung and heart of developing and adult rats.". Endocrinology. 138(3): 1194-1203. (1997). (PMID: 9048627).
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  76. Rodríguez-García, M.; Jolín, T.; Santos, A.; Pérez-Castillo, A. "Effect of perinatal hypothyroidism on the developmental regulation of rat pituitary growth hormone and thyrotropin genes.". Endocrinology. 136(10): 4339-4350. (1995). (PMID: 7664653).
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  77. Vega-Núñez, E.; Menéndez-Hurtado, A.; Garesse, R.; Santos, A.; Perez-Castillo, A. "Thyroid hormone-regulated brain mitochondrial genes revealed by differential cDNA cloning.". J. Clin. Invest.. 96(2): 893-899. (1995). (PMID: 7635984).
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  78. Garcia, I.; Pipaon, C.; Alemany, S.; Perez-Castillo, A. "Induction of NGFI-B gene expression during T cell activation. Role of protein phosphatases.". J. Immunol.. 153(8): 3417-3425. (1994). (PMID: 7930567).
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  79. Mellström, B.; Pipaón, C.; Naranjo, J.R.; Perez-Castillo, A.; Santos, A. "Differential effect of thyroid hormone on NGFI-A gene expression in developing rat brain.". Endocrinology. 135(2): 583-588. (1994). (PMID: 8033806).
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  80. Perez-Castillo, A.; Perez-Castillo, A.M.; Saez-Nieto, J.A. "Sequence of the penicillin-binding protein 2-encoding gene (penA) of Neisseria perflava/sicca.". Gene. 146(1): 91-93. (1994). (PMID: 8063111).
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  81. Castelló, A.; Rodríguez-Manzaneque, J.C.; Camps, M.; Pérez-Castillo, A.; Testar, X.; Palacín, M.; Santos, A.; Zorzano, A. "Perinatal hypothyroidism impairs the normal transition of GLUT4 and GLUT1 glucose transporters from fetal to neonatal levels in heart and brown adipose tissue. Evidence for tissue-specific regulation of GLUT4 expression by thyroid hormone.". J. Biol. Chem.. 269(8): 5905-5912. (1994). (PMID: 8119934).
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  82. Perez-Castillo, A.; Pipaón, C.; García, I.; Alemany, S. "NGFI-A gene expression is necessary for T lymphocyte proliferation.". J. Biol. Chem.. 268(26): 19445-19450. (1993). (PMID: 8366092).
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  83. Perez-Castillo, A.; Hernandez, A.; Pipaon, C.; Santos, A.; Obregon, M.J. "Multiple regulation of S14 gene expression during brown fat differentiation.". Endocrinology. 133(2): 545-552. (1993). (PMID: 8393767).
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  84. Garcia, I.; Perez-Castillo, A.; Moreno, J.; Alemany, S. "Beta-endorphin inhibits interleukin-2 release and expression of interleukin-2 receptors in concanavalin A-stimulated splenic lymphocytes.". Lymphokine Cytokine Res.. 11(6): 339-345. (1992). (PMID: 1477186).
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  85. Correa-Rotter, R.; Pérez-Castillo, A.; Chmielewski, D.; Rosenberg, M.E. "Relationship between renin, angiotensinogen and histone H2b messenger ribonucleic acid in the maturing rat kidney.". Nephron. 62(3): 322-327. (1992). (PMID: 1436346).
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  86. Pipaon, C.; Santos, A.; Perez-Castillo, A. "Thyroid hormone up-regulates NGFI-A gene expression in rat brain during development.". J. Biol. Chem.. 267(1): 21-23. (1992). (PMID: 1370444).
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  87. Muñoz, A.; Rodriguez-Peña, A.; Perez-Castillo, A.; Ferreiro, B.; Sutcliffe, J.G.; Bernal, J. "Effects of neonatal hypothyroidism on rat brain gene expression.". Mol. Endocrinol.. 5(2): 273-280. (1991). (PMID: 1710032).
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  88. Strait, K.A.; Schwartz, H.L.; Perez-Castillo, A.; Oppenheimer, J.H. "Relationship of c-erbA mRNA content to tissue triiodothyronine nuclear binding capacity and function in developing and adult rats.". J. Biol. Chem.. 265(18): 10514-10521. (1990). (PMID: 2162351).
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  89. Wong, N.C.; Perez-Castillo, A.M.; Sanders, M.M.; Schwartz, H.L.; Oppenheimer, J.H. "Thyroid hormone and circadian regulation of the binding activity of a liver-specific protein associated with the 5'-flanking region of the S14 gene.". J. Biol. Chem.. 264(8): 4466-4470. (1989). (PMID: 2925653).
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  90. Santos, A.; Perez-Castillo, A.; Wong, N.C.; Oppenheimer, J.H. "Labile proteins are necessary for T3 induction of growth hormone mRNA in normal rat pituitary and rat pituitary tumor cells.". J. Biol. Chem.. 262(35): 16880-16884. (1987). (PMID: 3680275).
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  91. Perez-Castillo, A.; Schwartz, H.L.; Oppenheimer, J.H. "Rat hepatic mRNA-S14 and lipogenic enzymes during weaning: role of S14 in lipogenesis.". Am. J. Physiol.. 253(5 Pt 1): E536-42. (1987). (PMID: 3688223).
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  92. Blázquez, E.; Perez Castillo, A.; de Diego, J.G. "Characterization of glucagon receptors in liver membranes and isolated hepatocytes during rat ontogenic development.". Mol. Cell. Endocrinol.. 49(2-3): 149-157. (1987). (PMID: 3030850).
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  93. Blázquez, E.; Perez Castillo, A.; Alvarez, E. "Characterization of insulin receptors in liver membranes and isolated hepatocytes during rat ontogenic development.". Horm. Metab. Res.. 18(10): 666-671. (1986). (PMID: 3536703).
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  94. Cabrer, B.; Brocas, H.; Perez-Castillo, A.; Pohl, V.; Navas, J.J.; Targovnik, H.; Centenera, J.A.; Vassart, G. "Normal level of thyroglobulin messenger ribonucleic acid in a human congenital goiter with thyroglobulin deficiency.". J. Clin. Endocrinol. Metab.. 63(4): 931-940. (1986). (PMID: 3745406).
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  95. Bernal, J.; Perez-Castillo, A. "Dissociation of the triiodothyronine receptor from the nucleus induced by cations: evidence for divalent cation sensitive and insensitive nuclear sites.". Acta Endocrinol.. 110(4): 510-514. (1985). (PMID: 3004087).
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  96. Perez Castillo, A.; Blazquez, E. "Evidence of glucagon biosynthesis involving protein intermediates in rat salivary glands.". Diabetologia. 27(4): 472-477. (1984). (PMID: 6510594).
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  97. Pérez-Castillo, A.; Blázquez, E. "Synthesis and release of glucagon by human salivary glands.". Diabetologia. 19(2): 123-129. (1980). (PMID: 6998816).
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