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PUBLICACIONES

 

 

spacerTrabajos Publicados por María Jesús Obregón Perea
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  1. Pescador, N.; Francisco, V.; Vázquez, P.; Esquinas, E.M.; González-Páramos, C.; Valdecantos, M.P.; García-Martínez, I.; Urrutia, A.A.; Ruiz, L.; Escalona-Garrido, C.; Foretz, M.; Viollet, B.; Fernández-Moreno, M.Á.; Calle-Pascual, A.L.; Obregón, M.J.; Aragonés, J.; Valverde, Á.M. "Metformin reduces macrophage HIF1α-dependent proinflammatory signaling to restore brown adipocyte function in vitro.". Redox Biol. 48(): 102171. (2021). (PMID: 34736121).
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  2. Escalona-Garrido, C.; Vázquez, P.; Mera, P.; Zagmutt, S.; García-Casarrubios, E.; Montero-Pedrazuela, A.; Rey-Stolle, F.; Guadaño-Ferraz, A.; Rupérez, F.J.; Serra, D.; Herrero, L.; Obregon, M.J.; Valverde, Á.M. "Moderate SIRT1 overexpression protects against inflammation of brown adipose tissue.". Mol Metab. (): 101097. (2020). (PMID: 33049408).
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  3. González-Ramos, S.; Paz-García, M.; Fernández-García, V.; Portune, K.J.; Acosta-Medina, E.F.; Sanz, Y.; Castrillo, A.; Martín-Sanz, P.; Obregon, M.J.; Boscá, L. "NOD1 deficiency promotes an imbalance of thyroid hormones and microbiota homeostasis in mice fed high fat diet.". Sci Rep. 10(1): 12317. (2020). (PMID: 32704052).
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  4. Corrales, P.; Vivas, Y.; Izquierdo-Lahuerta, A.; Horrillo, D.; Seoane-Collazo, P.; Velasco, I.; Torres, L.; Lopez, Y.; Martínez, C.; López, M.; Ros, M.; Obregon, M.J.; Medina-Gomez, G. "Long-term caloric restriction ameliorates deleterious effects of aging on white and brown adipose tissue plasticity.". Aging Cell. 18(3): e12948. (2019). (PMID: 30920127).
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  5. Sevillano, J.; Sánchez-Alonso, M.G.; Zapatería, B.; Calderón, M.; Alcalá, M.; Limones, M.; Pita, J.; Gramage, E.; Vicente-Rodríguez, M.; Horrillo, D.; Medina-Gómez, G.; Obregón, M.J.; Viana, M.; Valladolid-Acebes, I.; Herradón, G.; Ramos-Álvarez, M.P. "Pleiotrophin deletion alters glucose homeostasis, energy metabolism and brown fat thermogenic function in mice.". Diabetologia. (): . (2018). (PMID: 30327824).
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  6. Bárez-López, S.; Obregon, M.J.; Bernal, J.; Guadaño-Ferraz, A. "Thyroid Hormone Economy in the Perinatal Mouse Brain: Implications for Cerebral Cortex Development.". Cereb. Cortex. 28(5): 1783-1793. (2018). (PMID: 28407057).
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  7. Ridruejo, E.; Romero-Caími, G.; Obregón, M.J.; Kleiman de Pisarev, D.; Alvarez, L. "Potential Molecular Targets of Statins in the Prevention of Hepatocarcinogenesis.". Ann Hepatol. 17(3): 490-500. (2018). (PMID: 29735800).
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  8. Lucia, F.S.; Pacheco-Torres, J.; González-Granero, S.; Canals, S.; Obregón, M.J.; García-Verdugo, J.M.; Berbel, P. "Transient Hypothyroidism During Lactation Arrests Myelination in the Anterior Commissure of Rats. A Magnetic Resonance Image and Electron Microscope Study.". Front Neuroanat. 12(): 31. (2018). (PMID: 29755326).
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  9. Gil-Ibañez, P.; Belinchon, M.M.; Obregon, M.J.; Morte, B.; Bernal, J. "Is the intrinsic genomic activity of thyroxine relevant in vivo? Insight from the effects on gene expression in primary cerebrocortical and neuroblastoma cells.". Thyroid. (): . (2017). (PMID: 28605984).
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  10. García-Casarrubios, E.; de Moura, C.; Arroba, A.I.; Pescador, N.; Calderon-Dominguez, M.; Garcia, L.; Herrero, L.; Serra, D.; Cadenas, S.; Reis, F.; Carvalho, E.; Obregon, M.J.; Valverde, Á.M. "Rapamycin negatively impacts insulin signaling, glucose uptake and uncoupling protein-1 in brown adipocytes.". Biochim. Biophys. Acta. 1861(12 Pt A): 1929-1941. (2016). (PMID: 27686967).
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  11. Calderon-Dominguez, M.; Sebastián, D.; Fucho, R.; Weber, M.; Mir, J.F.; García-Casarrubios, E.; Obregón, M.J.; Zorzano, A.; Valverde, Á.M.; Serra, D.; Herrero, L. "Carnitine Palmitoyltransferase 1 Increases Lipolysis, UCP1 Protein Expression and Mitochondrial Activity in Brown Adipocytes.". PLoS ONE. 11(7): e0159399. (2016). (PMID: 27438137).
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  12. Martinez-deMena, R.; Calvo, R.M.; Garcia, L.; Obregon, M.J. "Effect of glucocorticoids on the activity, expression and proximal promoter of type II deiodinase in rat brown adipocytes.". Mol. Cell. Endocrinol.. 428(): 58-67. (2016). (PMID: 26994513).
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  13. Bárez-López, S.; Obregon, M.J.; Martínez-de-Mena, R.; Bernal, J.; Guadaño-Ferraz, A.; Morte, B. "Effect of Triiodothyroacetic Acid Treatment in Mct8 Deficiency: A Word of Caution.". Thyroid. 26(5): 618-626. (2016). (PMID: 26701289).
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  14. Martinez-deMena, R.; Anedda, A.; Cadenas, S.; Obregon, M.J. "TSH effects on thermogenesis in rat brown adipocytes.". Mol. Cell. Endocrinol.. 404(): 151-158. (2015). (PMID: 25662278).
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  15. Navarro, D.; Alvarado, M.; Navarrete, F.; Giner, M.; Obregon, M.J.; Manzanares, J.; Berbel, P. "Gestational and early postnatal hypothyroidism alters VGluT1 and VGAT bouton distribution in the neocortex and hippocampus, and behavior in rats.". Front Neuroanat. 9(): 9. (2015). (PMID: 25741243).
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  16. Gabrielsen, K.M.; Krokstad, J.S.; Villanger, G.D.; Blair, D.A.; Obregon, M.J.; Sonne, C.; Dietz, R.; Letcher, R.J.; Jenssen, B.M. "Thyroid hormones and deiodinase activity in plasma and tissues in relation to high levels of organohalogen contaminants in East Greenland polar bears (Ursus maritimus).". Environ. Res.. 136(): 413-423. (2015). (PMID: 25460663).
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  17. Obregon, M.J. "Adipose tissues and thyroid hormones.". Front Physiol. 5(): 479. (2014). (PMID: 25566082).
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  18. Bárez-López, S.; Bosch-García, D.; Gómez-Andrés, D.; Pulido-Valdeolivas, I.; Montero-Pedrazuela, A.; Obregon, M.J.; Guadaño-Ferraz, A. "Abnormal motor phenotype at adult stages in mice lacking type 2 deiodinase.". PLoS ONE. 9(8): e103857. (2014). (PMID: 25083788).
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  19. Núñez, B.; Martínez de Mena, R.; Obregon, M.J.; Font-Llitjós, M.; Nunes, V.; Palacín, M.; Dumitrescu, A.M.; Morte, B.; Bernal, J. "Cerebral cortex hyperthyroidism of newborn mct8-deficient mice transiently suppressed by lat2 inactivation.". PLoS ONE. 9(5): e96915. (2014). (PMID: 24819605).
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  20. Obregon, M.J. "Changing white into brite adipocytes. Focus on "BMP4 and BMP7 induce the white-to-brown transition of primary human adipose stem cells".". Am. J. Physiol., Cell Physiol.. 306(5): C425-7. (2014). (PMID: 24429067).
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  21. Selmi-Ruby, S.; Bouazza, L.; Obregon, M.J.; Conscience, A.; Flamant, F.; Samarut, J.; Borson-Chazot, F.; Rousset, B. "The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.". Endocrinology. 155(2): 635-646. (2014). (PMID: 24265449).
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  22. Bianco, A.C.; Anderson, G.; Forrest, D.; Galton, V.A.; Gereben, B.; Kim, B.W.; Kopp, P.A.; Liao, X.H.; Obregon, M.J.; Peeters, R.P.; Refetoff, S.; Sharlin, D.S.; Simonides, W.S.; Weiss, R.E.; Williams, G.R.; , . "American Thyroid Association Guide to investigating thyroid hormone economy and action in rodent and cell models.". Thyroid. 24(1): 88-8168. (2014). (PMID: 24001133).
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  23. Castro, I.; Quisenberry, L.; Calvo, R.M.; Obregon, M.J.; Lado-Abeal, J. "Septic shock non-thyroidal illness syndrome causes hypothyroidism and conditions for reduced sensitivity to thyroid hormone.". J. Mol. Endocrinol.. 50(2): 255-266. (2013). (PMID: 23296981).
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  24. Lavado-Autric, R.; Calvo, R.M.; de Mena, R.M.; de Escobar, G.M.; Obregon, M.J. "Deiodinase activities in thyroids and tissues of iodine-deficient female rats.". Endocrinology. 154(1): 529-536. (2013). (PMID: 23142811).
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  25. Garcia, B.; Martinez-de-Mena, R.; Obregon, M.J. "Arachidonic acid stimulates DNA synthesis in brown preadipocytes through the activation of protein kinase C and MAPK.". Biochim. Biophys. Acta. 1821(10): 1309-1315. (2012). (PMID: 22766489).
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  26. Tinahones, F.J.; Coín-Aragüez, L.; Mayas, M.D.; Garcia-Fuentes, E.; Hurtado-Del-Pozo, C.; Vendrell, J.; Cardona, F.; Calvo, R.M.; Obregon, M.J.; El Bekay, R. "Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels.". BMC Physiol.. 12(): 4. (2012). (PMID: 22471305).
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  27. Hurtado del Pozo, C.; Vesperinas-García, G.; Rubio, M.Á.; Corripio-Sánchez, R.; Torres-García, A.J.; Obregon, M.J.; Calvo, R.M. "ChREBP expression in the liver, adipose tissue and differentiated preadipocytes in human obesity.". Biochim. Biophys. Acta. 1811(12): 1194-1200. (2011). (PMID: 21840420).
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  28. Hernandez, A.; de Mena, R.M.; Martin, E.; Obregon, M.J. "Differences in the response of UCP1 mRNA to hormonal stimulation between rat and mouse primary cultures of brown adipocytes.". Cell. Physiol. Biochem.. 28(5): 969-980. (2011). (PMID: 22178948).
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  29. Negro, R.; Soldin, O.P.; Obregon, M.J.; Stagnaro-Green, A. "Hypothyroxinemia and pregnancy.". Endocr Pract. 17(3): 422-429. (2011). (PMID: 21247845).
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  30. Calvo, R.M.; Obregon, M.J. "Presence and regulation of D1 and D2 deiodinases in rat white adipose tissue.". Metab. Clin. Exp.. 60(9): 1207-1210. (2011). (PMID: 21397282).
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  31. del Pozo, C.H.; Calvo, R.M.; Vesperinas-García, G.; Gómez-Ambrosi, J.; Frühbeck, G.; Rubio, M.A.; Obregon, M.J. "Expression profile in omental and subcutaneous adipose tissue from lean and obese subjects. Repression of lipolytic and lipogenic genes.". Obes Surg. 21(5): 633-643. (2011). (PMID: 20686928).
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  32. Martinez de Mena, R.; Scanlan, T.S.; Obregon, M.J. "The T3 receptor beta1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes.". Endocrinology. 151(10): 5074-5083. (2010). (PMID: 20719854).
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  33. Obregon, M.J. "Maternal obesity results in offspring prone to metabolic syndrome.". Endocrinology. 151(8): 3475-3476. (2010). (PMID: 20660073).
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  34. Hurtado del Pozo, C.; Calvo, R.M.; Vesperinas-García, G.; Gómez-Ambrosi, J.; Frühbeck, G.; Corripio-Sánchez, R.; Rubio, M.A.; Obregon, M.J. "IPO8 and FBXL10: new reference genes for gene expression studies in human adipose tissue.". Obesity (Silver Spring). 18(5): 897-903. (2010). (PMID: 19876011).
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  35. Lado-Abeal, J.; Calvo, R.M.; Victoria, B.; Castro, I.; Obregon, M.J.; Araujo-Vilar, D. "Regional decrease of subcutaneous adipose tissue in patients with type 2 familial partial lipodystrophy is associated with changes in thyroid hormone metabolism.". Thyroid. 20(4): 419-424. (2010). (PMID: 20373986).
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  36. Calvo, R.M.; Obregon, M.J. "Tri-iodothyronine upregulates adiponutrin mRNA expression in rat and human adipocytes.". Mol. Cell. Endocrinol.. 311(1-2): 39-46. (2009). (PMID: 19619606).
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  37. Isorna, E.; Obregon, M.J.; Calvo, R.M.; Vázquez, R.; Pendón, C.; Falcón, J.; Muñoz-Cueto, J.A. "Iodothyronine deiodinases and thyroid hormone receptors regulation during flatfish (Solea senegalensis) metamorphosis.". J. Exp. Zool. B Mol. Dev. Evol.. 312B(3): 231-246. (2009). (PMID: 19306324).
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  38. de Escobar, G.M.; Ares, S.; Berbel, P.; Obregón, M.J.; del Rey, F.E. "The changing role of maternal thyroid hormone in fetal brain development.". Semin. Perinatol.. 32(6): 380-386. (2008). (PMID: 19007674).
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  39. Medina-Gomez, G.; Calvo, R.M.; Obregon, M.J. "Thermogenic effect of triiodothyroacetic acid at low doses in rat adipose tissue without adverse side effects in the thyroid axis.". Am. J. Physiol. Endocrinol. Metab.. 294(4): E688-97. (2008). (PMID: 18285526).
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  40. Simonides, W.S.; Mulcahey, M.A.; Redout, E.M.; Muller, A.; Zuidwijk, M.J.; Visser, T.J.; Wassen, F.W.; Crescenzi, A.; da-Silva, W.S.; Harney, J.; Engel, F.B.; Obregon, M.J.; Larsen, P.R.; Bianco, A.C.; Huang, S.A. "Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.". J. Clin. Invest.. 118(3): 975-983. (2008). (PMID: 18259611).
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  41. Obregon, M.J. "Thyroid hormone and adipocyte differentiation.". Thyroid. 18(2): 185-195. (2008). (PMID: 18279019).
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  42. Palos, F.; García-Rendueles, M.E.; Araujo-Vilar, D.; Obregon, M.J.; Calvo, R.M.; Cameselle-Teijeiro, J.; Bravo, S.B.; Perez-Guerra, O.; Loidi, L.; Czarnocka, B.; Alvarez, P.; Refetoff, S.; Dominguez-Gerpe, L.; Alvarez, C.V.; Lado-Abeal, J. "Pendred syndrome in two Galician families: insights into clinical phenotypes through cellular, genetic, and molecular studies.". J. Clin. Endocrinol. Metab.. 93(1): 267-277. (2008). (PMID: 17940114).
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  43. de Escobar, G.M.; Obregón, M.J.; del Rey, F.E. "Iodine deficiency and brain development in the first half of pregnancy.". Public Health Nutr. 10(12A): 1554-1570. (2007). (PMID: 18053280).
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  44. Berbel, P.; Obregón, M.J.; Bernal, J.; Escobar del Rey, F.; Morreale de Escobar, G. "Iodine supplementation during pregnancy: a public health challenge.". Trends Endocrinol. Metab.. 18(9): 338-343. (2007). (PMID: 17962037).
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  45. Obregon, M.J.; Calvo, R.M.; Del Rey, F.E.; de Escobar, G.M. "Ontogenesis of thyroid function and interactions with maternal function.". Endocr Dev. 10(): 86-98. (2007). (PMID: 17684391).
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  46. Hernandez, A.; Garcia, B.; Obregon, M.J. "Gene expression from the imprinted Dio3 locus is associated with cell proliferation of cultured brown adipocytes.". Endocrinology. 148(8): 3968-3976. (2007). (PMID: 17510246).
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  47. Pedraza, P.E.; Obregon, M.J.; Escobar-Morreale, H.F.; del Rey, F.E.; de Escobar, G.M. "Mechanisms of adaptation to iodine deficiency in rats: thyroid status is tissue specific. Its relevance for man.". Endocrinology. 147(5): 2098-2108. (2006). (PMID: 16455775).
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  48. Barrantes, I.d.e.l. .B.; Montero-Pedrazuela, A.; Guadaño-Ferraz, A.; Obregon, M.J.; Martinez de Mena, R.; Gailus-Durner, V.; Fuchs, H.; Franz, T.J.; Kalaydjiev, S.; Klempt, M.; Hölter, S.; Rathkolb, B.; Reinhard, C.; Morreale de Escobar, G.; Bernal, J.; Busch, D.H.; Wurst, W.; Wolf, E.; Schulz, H.; Shtrom, S.; Greiner, E.; Hrabé de Angelis, M.; Westphal, H.; Niehrs, C. "Generation and characterization of dickkopf3 mutant mice.". Mol. Cell. Biol.. 26(6): 2317-2326. (2006). (PMID: 16508007).
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  49. Obregon, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "The effects of iodine deficiency on thyroid hormone deiodination.". Thyroid. 15(8): 917-929. (2005). (PMID: 16131334).
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  50. Martinez-deMena, R.; Obregón, M.J. "Insulin increases the adrenergic stimulation of 5' deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K.". J Mol Endocrinol. 34(1): 139-151. (2005). (PMID: 15691884).
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  51. Alvarez, L.; Hernández, S.; Martinez-de-Mena, R.; Kolliker-Frers, R.; Obregón, M.J.; Kleiman de Pisarev, D.L. "The role of type I and type II 5' deiodinases on hexachlorobenzene-induced alteration of the hormonal thyroid status.". Toxicology. 207(3): 349-362. (2005). (PMID: 15664263).
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  52. Morreale de Escobar, G.; Obregon, M.J.; Escobar del Rey, F. "Role of thyroid hormone during early brain development.". Eur. J. Endocrinol.. 151 Suppl 3(): U25-37. (2004). (PMID: 15554884).
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  53. Kester, M.H.; Martinez de Mena, R.; Obregon, M.J.; Marinkovic, D.; Howatson, A.; Visser, T.J.; Hume, R.; Morreale de Escobar, G. "Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas.". J. Clin. Endocrinol. Metab.. 89(7): 3117-3128. (2004). (PMID: 15240580).
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  54. de Escobar, G.M.; Obregón, M.J.; del Rey, F.E. "Maternal thyroid hormones early in pregnancy and fetal brain development.". Best Pract. Res. Clin. Endocrinol. Metab.. 18(2): 225-248. (2004). (PMID: 15157838).
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  55. Medina-Gomez, G.; Calvo, R.M.; Obregón, M.J. "T3 and Triac inhibit leptin secretion and expression in brown and white rat adipocytes.". Biochim. Biophys. Acta. 1682(1-3): 38-47. (2004). (PMID: 15158754).
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  56. Pascual-Leone, A.M.; Ramos, S.; Goya, L.; Alvarez, C.; Escrivá, F.; Obregón, M.J. "Age-dependent adaptation of the liver thyroid status and recovery of serum levels and hepatic insulin-like growth factor-I expression in neonatal and adult diabetic rats.". Metab. Clin. Exp.. 52(9): 1117-1125. (2003). (PMID: 14506616).
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  57. Medina-Gomez, G.; Hernàndez, A.; Calvo, R.M.; Martin, E.; Obregón, M.J. "Potent thermogenic action of triiodothyroacetic acid in brown adipocytes.". Cell. Mol. Life Sci.. 60(9): 1957-1967. (2003). (PMID: 14523556).
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  58. Carmona, M.C.; Iglesias, R.; Obregón, M.J.; Darlington, G.J.; Villarroya, F.; Giralt, M. "Mitochondrial biogenesis and thyroid status maturation in brown fat require CCAAT/enhancer-binding protein alpha.". J. Biol. Chem.. 277(24): 21489-21498. (2002). (PMID: 11940593).
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  59. Martinez-deMena, R.; Hernández, A.; Obregón, M.J. "Triiodothyronine is required for the stimulation of type II 5'-deiodinase mRNA in rat brown adipocytes.". Am. J. Physiol. Endocrinol. Metab.. 282(5): E1119-27. (2002). (PMID: 11934678).
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  60. García, B.; Obregón, M.J. "Growth factor regulation of uncoupling protein-1 mRNA expression in brown adipocytes.". Am. J. Physiol., Cell Physiol.. 282(1): C105-12. (2002). (PMID: 11742803).
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  61. Aláez, C.; Calvo, R.; Obregón, M.J.; Alvarez, C.; Goya, L.; Escrivá, F.; Martín, M.A.; Pascual-Leone, A.M. "Influence of type II 5' deiodinase on TSH content in diabetic rats.". J. Physiol. Biochem.. 57(3): 221-230. (2001). (PMID: 11800284).
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  62. Schröder-van der Elst, J.P.; van der Heide, D.; Kastelijn, J.; Rousset, B.; Obregón, M.J. "The expression of the sodium/iodide symporter is up-regulated in the thyroid of fetuses of iodine-deficient rats.". Endocrinology. 142(9): 3736-3741. (2001). (PMID: 11517148).
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  63. Morreale de Escobar, G.; Obregón, M.J.; Escobar del Rey, F. "Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia?". J. Clin. Endocrinol. Metab.. 85(11): 3975-3987. (2000). (PMID: 11095417).
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  64. Hernández, A.; Obregón, M.J. "Triiodothyronine amplifies the adrenergic stimulation of uncoupling protein expression in rat brown adipocytes.". Am. J. Physiol. Endocrinol. Metab.. 278(5): E769-77. (2000). (PMID: 10780931).
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  65. Barroso, I.; Benito, B.; Garcí-Jiménez, C.; Hernández, A.; Obregón, M.J.; Santisteban, P. "Norepinephrine, tri-iodothyronine and insulin upregulate glyceraldehyde-3-phosphate dehydrogenase mRNA during Brown adipocyte differentiation.". Eur. J. Endocrinol.. 141(2): 169-179. (1999). (PMID: 10427161).
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  66. Escobar-Morreale, H.F.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Tissue-specific patterns of changes in 3,5,3'-triiodo-L-thyronine concentrations in thyroidectomized rats infused with increasing doses of the hormone. Which are the regulatory mechanisms?". Biochimie. 81(5): 453-462. (1999). (PMID: 10403175).
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  67. Calvo, R.M.; Roda, J.M.; Obregón, M.J.; Morreale de Escobar, G. "Thyroid hormones in human tumoral and normal nervous tissues.". Brain Res.. 801(1-2): 150-157. (1998). (PMID: 9729351).
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  68. Calvo, R.M.; Forcen, R.; Obregon, M.J.; Escobar del Rey, F.; Morreale de Escobar, G.; Regadera, J. "Immunohistochemical and morphometric studies of the fetal pancreas in diabetic pregnant rats. Effects of insulin administration.". Anat. Rec.. 251(2): 173-180. (1998). (PMID: 9624446).
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  69. Schröder-van der Elst, J.P.; van der Heide, D.; Morreale de Escobar, G.; Obregón, M.J. "Iodothyronine deiodinase activities in fetal rat tissues at several levels of iodine deficiency: a role for the skin in 3,5,3'-triiodothyronine economy?". Endocrinology. 139(5): 2229-2234. (1998). (PMID: 9564827).
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  70. Hernández, A.; St Germain, D.L.; Obregón, M.J. "Transcriptional activation of type III inner ring deiodinase by growth factors in cultured rat brown adipocytes.". Endocrinology. 139(2): 634-639. (1998). (PMID: 9449635).
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  71. García, B.; Obregón, M.J. "Norepinephrine potentiates the mitogenic effect of growth factors in quiescent brown preadipocytes: relationship with uncoupling protein messenger ribonucleic acid expression.". Endocrinology. 138(10): 4227-4233. (1997). (PMID: 9322934).
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  72. Guadaño-Ferraz, A.; Obregón, M.J.; St Germain, D.L.; Bernal, J. "The type 2 iodothyronine deiodinase is expressed primarily in glial cells in the neonatal rat brain.". Proc. Natl. Acad. Sci. U.S.A.. 94(19): 10391-10396. (1997). (PMID: 9294221).
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  73. Escobar-Morreale, H.F.; Obregón, M.J.; Hernandez, A.; Escobar del Rey, F.; Morreale de Escobar, G. "Regulation of iodothyronine deiodinase activity as studied in thyroidectomized rats infused with thyroxine or triiodothyronine.". Endocrinology. 138(6): 2559-2568. (1997). (PMID: 9165049).
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  74. Calvo, R.; Morreale de Escobar, G.; Escobar del Rey, F.; Obregón, M.J. "Maternal nonthyroidal illness and fetal thyroid hormone status, as studied in the streptozotocin-induced diabetes mellitus rat model.". Endocrinology. 138(3): 1159-1169. (1997). (PMID: 9048623).
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  75. Calvo, R.; Morreale de Escobar, G.; Escobar del Rey, F.; Obregón, M.J. "Maternal diabetes mellitus, a rat model for nonthyroidal illness: correction of hypothyroxinemia with thyroxine treatment does not improve fetal thyroid hormone status.". Thyroid. 7(1): 79-87. (1997). (PMID: 9086576).
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  76. Pedraza, P.; Calvo, R.; Obregón, M.J.; Asunción, M.; Escobar del Rey, F.; Morreale de Escobar, G.M. "Displacement of T4 from transthyretin by the synthetic flavonoid EMD 21388 results in increased production of T3 from T4 in rat dams and fetuses.". Endocrinology. 137(11): 4902-4914. (1996). (PMID: 8895363).
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  77. Obregón, M.J.; Calvo, R.; Hernández, A.; Escobar del Rey, F.; Morreale de Escobar, G. "Regulation of uncoupling protein messenger ribonucleic acid and 5'-deiodinase activity by thyroid hormones in fetal brown adipose tissue.". Endocrinology. 137(11): 4721-4729. (1996). (PMID: 8895339).
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  78. Hernández, A.; Obregón, M.J. "Presence and mRNA expression of T3 receptors in differentiating rat brown adipocytes.". Mol. Cell. Endocrinol.. 121(1): 37-46. (1996). (PMID: 8865164).
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  79. Hernández, A.; Obregón, M.J. "T3 potentiates the adrenergic stimulation of type II 5'-deiodinase activity in cultured rat brown adipocytes.". Am. J. Physiol.. 271(1 Pt 1): E15-23. (1996). (PMID: 8760076).
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  80. Escobar-Morreale, H.F.; del Rey, F.E.; Obregón, M.J.; de Escobar, G.M. "Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat.". Endocrinology. 137(6): 2490-2502. (1996). (PMID: 8641203).
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  81. Solé, E.; Calvo, R.; Obregón, M.J.; Meseguer, A. "Effects of thyroid hormone on the androgenic expression of KAP gene in mouse kidney.". Mol. Cell. Endocrinol.. 119(2): 147-159. (1996). (PMID: 8807634).
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  82. Obregón, M.J.; Cannon, B.; Nedergaard, J. "Postnatal selective suppression of lipoprotein lipase gene expression in brown adipose tissue (relative to the expression of the gene for the uncoupling protein) is not due to adrenergic insensitivity: a possible specific inhibitory effect of colostrum.". Biochem. J.. 314 ( Pt 1)(): 261-267. (1996). (PMID: 8660292).
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  83. Escobar-Morreale, H.F.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats.". J. Clin. Invest.. 96(6): 2828-2838. (1995). (PMID: 8675653).
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  84. Hernández, A.; Obregón, M.J. "Presence of growth factors-induced type III iodothyronine 5-deiodinase in cultured rat brown adipocytes.". Endocrinology. 136(10): 4543-4550. (1995). (PMID: 7664675).
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  85. Pascual-Leone, A.M.; Aláez, C.; Calvo, R.; Martín, M.A.; Obregón, M.J. "Effects of thyroid hormone deiodination on regulation of thyroid axis in undernourished rats.". Am. J. Physiol.. 267(6 Pt 1): E983-9. (1994). (PMID: 7810644).
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  86. Solé, E.; Calvo, R.; Obregón, M.J.; Meseguer, A. "Thyroid hormone controls the cell-specific expression of the kidney androgen-regulated protein gene in S3 mouse kidney cells.". Endocrinology. 135(5): 2120-2129. (1994). (PMID: 7956935).
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  87. Morreale de Escobar, G.; Calvo, R.; Escobar del Rey, F.; Obregón, M.J. "Thyroid hormones in tissues from fetal and adult rats.". Endocrinology. 134(6): 2410-2415. (1994). (PMID: 8194467).
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  88. Perez-Castillo, A.; Hernandez, A.; Pipaon, C.; Santos, A.; Obregon, M.J. "Multiple regulation of S14 gene expression during brown fat differentiation.". Endocrinology. 133(2): 545-552. (1993). (PMID: 8393767).
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  89. Hernandez, A.; Garcia-Jimenez, C.; Santisteban, P.; Obregon, M.J. "Regulation of malic-enzyme-gene expression by cAMP and retinoic acid in differentiating brown adipocytes.". Eur. J. Biochem.. 215(2): 285-290. (1993). (PMID: 8393790).
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  90. Morreale de Escobar, G.; Calvo, R.; Escobar del Rey, F.; Obregon, M.J. "Differential effects of thyroid hormones on growth and thyrotropic hormones in rat fetuses near term.". Endocrinology. 132(5): 2056-2064. (1993). (PMID: 8477656).
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  91. García-Jimenez, C.; Hernández, A.; Obregón, M.J.; Santisteban, P. "Malic enzyme gene expression in differentiating brown adipocytes: regulation by insulin and triiodothyronine.". Endocrinology. 132(4): 1537-1543. (1993). (PMID: 8462451).
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  92. Morreale de Escobar, G.; Obregón, M.J.; Calvo, R.; Escobar del Rey, F. "Effects of iodine deficiency on thyroid hormone metabolism and the brain in fetal rats: the role of the maternal transfer of thyroxin.". Am. J. Clin. Nutr.. 57(2 Suppl): 280S-285S. (1993). (PMID: 8427205).
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  93. Morreale de Escobar, G.; Calvo, R.; Obregon, M.J.; Escobar del Rey, F. "Homeostasis of brain T3 in rat fetuses and their mothers: effects of thyroid status and iodine deficiency.". Acta Med. Austriaca. 19 Suppl 1(): 110-116. (1992). (PMID: 1519443).
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  94. Calvo, R.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "The rat placenta and the transfer of thyroid hormones from the mother to the fetus. Effects of maternal thyroid status.". Endocrinology. 131(1): 357-365. (1992). (PMID: 1612015).
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  95. Aláez, C.; Calvo, R.; Obregón, M.J.; Pascual-Leone, A.M. "Thyroid hormones and 5'-deiodinase activity in neonatal undernourished rats.". Endocrinology. 130(2): 773-779. (1992). (PMID: 1733724).
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  96. Gil-Garay, R.; Miralles-Flores, C.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G.; Delgado-Baeza, E. "Maternal hypothyroidism and fetal chondro-osseous development in rats.". Biol. Neonate. 60(6): 385-394. (1991). (PMID: 1797134).
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  97. Morreale de Escobar, G.; Obregón, M.J.; Calvo, R.; Escobar del Rey, F. "Maternal thyroid hormones during pregnancy: effects on the fetus in congenital hypothyroidism and in iodine deficiency.". Adv. Exp. Med. Biol.. 299(): 133-156. (1991). (PMID: 1810132).
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  98. Obregón, M.J.; Ruiz de Oña, C.; Calvo, R.; Escobar del Rey, F.; Morreale de Escobar, G. "Outer ring iodothyronine deiodinases and thyroid hormone economy: responses to iodine deficiency in the rat fetus and neonate.". Endocrinology. 129(5): 2663-2673. (1991). (PMID: 1935795).
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  99. Ruiz de Oña, C.; Morreale de Escobar, G.; Calvo, R.; Escobar del Rey, F.; Obregón, M.J. "Thyroid hormones and 5'-deiodinase in the rat fetus late in gestation: effects of maternal hypothyroidism.". Endocrinology. 128(1): 422-432. (1991). (PMID: 1986934).
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  100. Calvo, R.; Obregón, M.J.; Ruiz de Oña, C.; Escobar del Rey, F.; Morreale de Escobar, G. "Congenital hypothyroidism, as studied in rats. Crucial role of maternal thyroxine but not of 3,5,3'-triiodothyronine in the protection of the fetal brain.". J. Clin. Invest.. 86(3): 889-899. (1990). (PMID: 2394838).
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  101. Calvo, R.; Obregon, M.J.; Ruiz de Oña, C.; Ferreiro, B.; Escobar Del Rey, E.; Morreale de Escobar, G. "Thyroid hormone economy in pregnant rats near term: a "physiological" animal model of nonthyroidal illness?". Endocrinology. 127(1): 10-16. (1990). (PMID: 2113860).
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  102. Morreale de Escobar, G.; Calvo, R.; Obregon, M.J.; Escobar Del Rey, F. "Contribution of maternal thyroxine to fetal thyroxine pools in normal rats near term.". Endocrinology. 126(5): 2765-2767. (1990). (PMID: 2328706).
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  103. Obregón, M.J.; Ruiz de Oña, C.; Hernandez, A.; Calvo, R.; Escobar del Rey, F.; Morreale de Escobar, G. "Thyroid hormones and 5'-deiodinase in rat brown adipose tissue during fetal life.". Am. J. Physiol.. 257(5 Pt 1): E625-31. (1989). (PMID: 2688435).
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  104. Rehnmark, S.; Kopecký, J.; Jacobsson, A.; Néchad, M.; Herron, D.; Nelson, B.D.; Obregon, M.J.; Nedergaard, J.; Cannon, B. "Brown adipocytes differentiated in vitro can express the gene for the uncoupling protein thermogenin: effects of hypothyroidism and norepinephrine.". Exp. Cell Res.. 182(1): 75-83. (1989). (PMID: 2497023).
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  105. Escobar del Rey, F.; Ruiz de Oña, C.; Bernal, J.; Obregón, M.J.; Morreale de Escobar, G. "Generalized deficiency of 3,5,3'-triiodo-L-thyronine (T3) in tissues from rats on a low iodine intake, despite normal circulating T3 levels.". Acta Endocrinol.. 120(4): 490-498. (1989). (PMID: 2718701).
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  106. Obregón, M.J.; Jacobsson, A.; Kirchgessner, T.; Schotz, M.C.; Cannon, B.; Nedergaard, J. "Postnatal recruitment of brown adipose tissue is induced by the cold stress experienced by the pups. An analysis of mRNA levels for thermogenin and lipoprotein lipase.". Biochem. J.. 259(2): 341-346. (1989). (PMID: 2497735).
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  107. Morreale de Escobar, G.; Obregón, M.J.; Ruiz de Oña, C.; Escobar del Rey, F. "Comparison of maternal to fetal transfer of 3,5,3'-triiodothyronine versus thyroxine in rats, as assessed from 3,5,3'-triiodothyronine levels in fetal tissues.". Acta Endocrinol.. 120(1): 20-30. (1989). (PMID: 2911938).
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  108. Ruiz de Oña, C.; Obregón, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Developmental changes in rat brain 5'-deiodinase and thyroid hormones during the fetal period: the effects of fetal hypothyroidism and maternal thyroid hormones.". Pediatr. Res.. 24(5): 588-594. (1988). (PMID: 3205610).
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  109. Morreale de Escobar, G.; Obregon, M.J.; Escobar del Rey, F. "Maternal-fetal thyroid hormone relationships and the fetal brain.". Acta Med. Austriaca. 15 Suppl 1(): 66-70. (1988). (PMID: 3176827).
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  110. Viñas, O.; Giralt, M.; Obregón, M.J.; Iglesias, R.; Villarroya, F.; Mampel, T. "Iodothyronine 5'-deiodinase activity and thyroid hormone content in brown adipose tissue during the breeding cycle of the rat.". Biochem. J.. 255(2): 457-461. (1988). (PMID: 3060112).
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  111. Morreale de Escobar, G.; Obregon, M.J.; Ruiz de Oña, C.; Escobar del Rey, F. "Transfer of thyroxine from the mother to the rat fetus near term: effects on brain 3,5,3'-triiodothyronine deficiency.". Endocrinology. 122(4): 1521-1531. (1988). (PMID: 3345725).
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  112. Obregon, M.J.; Pitamber, R.; Jacobsson, A.; Nedergaard, J.; Cannon, B. "Euthyroid status is essential for the perinatal increase in thermogenin mRNA in brown adipose tissue of rat pups.". Biochem. Biophys. Res. Commun.. 148(1): 9-14. (1987). (PMID: 3118877).
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  113. Morreale de Escobar, G.; Obregon, M.J.; Escobar del Rey, F. "Fetal and maternal thyroid hormones.". Horm. Res.. 26(1-4): 12-27. (1987). (PMID: 3297961).
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  114. Obregon, M.J.; Mills, I.; Silva, J.E.; Larsen, P.R. "Catecholamine stimulation of iodothyronine 5'-deiodinase activity in rat dispersed brown adipocytes.". Endocrinology. 120(3): 1069-1072. (1987). (PMID: 3803310).
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  115. Iglesias, R.; Fernandez, J.A.; Mampel, T.; Obregón, M.J.; Villarroya, F. "Iodothyronine 5'-deiodinase activity in rat brown adipose tissue during development.". Biochim. Biophys. Acta. 923(2): 233-240. (1987). (PMID: 3814615).
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  116. Obregon, M.J.; Larsen, P.R.; Silva, J.E. "The role of 3,3',5'-triiodothyronine in the regulation of type II iodothyronine 5'-deiodinase in the rat cerebral cortex.". Endocrinology. 119(5): 2186-2192. (1986). (PMID: 3769868).
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  117. Morreale de Escobar, G.; Pastor, R.; Obregon, M.J.; Escobar del Rey, F. "Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function.". Endocrinology. 117(5): 1890-1900. (1985). (PMID: 4042969).
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  118. Obregon, M.J.; Larsen, P.R.; Silva, J.E. "Plasma kinetics, tissue distribution, and cerebrocortical sources of reverse triiodothyronine in the rat.". Endocrinology. 116(6): 2192-2200. (1985). (PMID: 3996308).
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  119. Obregón, M.J.; Santisteban, P.; Rodríguez-Peña, A.; Pascual, A.; Cartagena, P.; Ruiz-Marcos, A.; Lamas, L.; Escobar del Rey, F.; Morreale de Escobar, G. "Cerebral hypothyroidism in rats with adult-onset iodine deficiency.". Endocrinology. 115(2): 614-624. (1984). (PMID: 6745172).
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  120. Ortiz-Caro, J.; Obregón, M.J.; Pascual, A.; Jolin, T. "Decreased T4 to T3 conversion in tissues of streptozotocin-diabetic rats.". Acta Endocrinol.. 106(1): 86-91. (1984). (PMID: 6328820).
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  121. Obregon, M.J.; Mallol, J.; Pastor, R.; Morreale de Escobar, G.; Escobar del Rey, F. "L-thyroxine and 3,5,3'-triiodo-L-thyronine in rat embryos before onset of fetal thyroid function.". Endocrinology. 114(1): 305-307. (1984). (PMID: 6690276).
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  122. Mallol, J.; Obregón, M.J.; Morreale de Escobar, G. "Analytical artifacts in radioimmunoassay of L-thyroxin in human milk.". Clin. Chem.. 28(6): 1277-1282. (1982). (PMID: 7074933).
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  123. Santisteban, P.; Obregon, M.J.; Rodriguez-Peña, A.; Lamas, L.; Del Rey, F.E.; De Escobar, G.M. "Are iodine-deficient rats euthyroid?". Endocrinology. 110(5): 1780-1789. (1982). (PMID: 6804212).
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  124. Lamas, L.; Couvreur, M.; Obregon, M.J.; van den Hove-Vandenbroucke, M.F. "Effect of chronic iodide supplements on thyroid secretion: the role of lysosomes.". Endocrinology. 110(5): 1804-1811. (1982). (PMID: 7075539).
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  125. van den Hove-Vandenbroucke, M.F.; Santisteban, P.; Couvreur, M.; Obregon, M.J.; Lamas, L. "Involution of rat iodoprive hyperplastic goiter: effect of iodide administration on thyroid function and lysosomal properties.". Endocrinology. 110(5): 1812-1818. (1982). (PMID: 6176441).
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  126. Ruiz-Marcos, A.; Sanchez-Toscano, F.; Obregon, M.J.; Escobar del Rey, F.; Morreale de Escobar, G. "Thyroxine treatment and recovery of hypothyroidism-induced pyramidal cell damage.". Brain Res.. 239(2): 559-574. (1982). (PMID: 7093702).
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  127. Obregón, M.J. "Thyroxine radioimmunoassay for population surveys using dried blood: modifications of a highly sensitive method.". Ann. Clin. Biochem.. 19(Pt 1): 29-34. (1982). (PMID: 7065631).
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  128. Escobar del Rey, F.; Gomez-Pan, A.; Obregon, M.J.; Mallol, J.; Arnao, M.D.; Aranda, A.; Morreale de Escobar, G. "A survey of schoolchildren from a severe endemic goitre area in Spain.". Q. J. Med.. 50(198): 233-246. (1981). (PMID: 7302120).
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  129. Obregon, M.J.; Mallol, J.; Escobar del Rey, F.; Morreale de Escobar, G. "Presence of L-thyroxine and 3,5,3'-triiodo-L-thyronine in tissues from thyroidectomized rats.". Endocrinology. 109(3): 908-913. (1981). (PMID: 7262025).
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  130. Padron, F.; Duran-Garcia, S.; Obregon, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Specific uptake of human growth hormone by the liver of severely hypothyroid rats.". J. Endocrinol. Invest.. 4(1): 119-123. (1981). (PMID: 6263964).
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  131. Durán-García, S.; Obregón, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Differential effects of hypothyroidism on the specific uptake of growth hormone and prolactin by the rat liver.". Endocrinology. 108(6): 2054-2059. (1981). (PMID: 7227295).
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  132. Obregon, M.J.; Kurtz, A.; Ekins, R.; Morreale de Escobar, G. "Evaluation of free and total L-thyroxine in serum by a commercial procedure.". Clin. Chem.. 27(1): 149-152. (1981). (PMID: 7449098).
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  133. Obregon, M.J.; Pascual, A.; Mallol, J.; Morreale de Escobar, G.; Escobar del Rey, F. "Evidence against a major role of L-thyroxine at the pituitary level: studies in rats treated with iopanoic acid (telepaque).". Endocrinology. 106(6): 1827-1836. (1980). (PMID: 7371594).
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  134. Duran-Garcia, S.; Gomez-Nieto, J.; Fouchereau-Peron, M.; Padron, V.F.; Obregon, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Effects of thyroid hormones on liver binding sites for human growth hormone, as studied in the rat.". Clin. Endocrinol. (Oxf). 11(3): 275-290. (1979). (PMID: 228880).
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  135. Pascual, A.; Obregon, M.J.; de Escobar, G.M. "Tyrosine hydroxylase and the conversion of L-thyroxine into 3',3,5-triiodo-L-thyronone in the rat.". Endocrinology. 104(6): 1574-1579. (1979). (PMID: 36273).
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  136. Obregon, M.J.; Pascual, A.; de Escobar, G.M.; Escobar del Rey, F. "Pituitary and plasma thyrotropin, thyroxine, and triiodothyronine after hyperthyroidism.". Endocrinology. 104(5): 1467-1473. (1979). (PMID: 108095).
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  137. Obregon, M.J.; Roelfsema, F.; Morreale de Escobar, G.; Escobar del Rey, F.; Querido, A. "Exchange of triiodothyronine derived from thyroxine with circulating triiodothyronine as studied in the rat.". Clin. Endocrinol. (Oxf). 10(3): 305-315. (1979). (PMID: 455743).
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  138. Obregon, M.J.; Morreale de Escobar, G.; Escobar del Rey, F. "Concentrations of triiodo-L-thyronine in the plasma and tissues of normal rats, as determined by radioimmunoassay: comparison with results obtained by an isotopic equilibrium technique.". Endocrinology. 103(6): 2145-2153. (1978). (PMID: 748038).
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  139. Bernal, J.; Obregón, M.J. "Thyroglobulin-like antigens in a goiter with impaired thyroglobulin biosynthesis.". J. Clin. Endocrinol. Metab.. 39(3): 592-595. (1974). (PMID: 4416644).
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