INVESTIGACIÓN

 
  • Grupos de Investigación
  • Unidades de Investigación
  • Memoria Cientifíca
  • Publicaciones
espacio

 

PUBLICACIONES

 

 

spacerTrabajos Publicados por Alberto Muñoz Terol
spacer
  1. García-Martínez, J.M.; Chocarro-Calvo, A.; Martínez-Useros, J.; Regueira-Acebedo, N.; Fernández-Aceñero, M.J.; Muñoz, A.; Larriba, M.J.; García-Jiménez, C. "SIRT1 Mediates the Antagonism of Wnt/β-Catenin Pathway by Vitamin D in Colon Carcinoma Cells.". Int J Biol Sci. 20(14): 5495-5509. (2024). (PMID: 39494323).
    spacer

  2. Bustamante-Madrid, P.; Barbáchano, A.; Albandea-Rodríguez, D.; Rodríguez-Cobos, J.; Rodríguez-Salas, N.; Prieto, I.; Burgos, A.; Martínez de Villarreal, J.; Real, F.X.; González-Sancho, J.M.; Larriba, M.J.; Lafarga, M.; Muñoz, A.; Fernández-Barral, A. "Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids.". Cell Death Dis. 15(4): 301. (2024). (PMID: 38684650).
    spacer

  3. Montero, J.C.; Del Carmen, S.; Abad, M.; Sayagués, J.M.; Barbáchano, A.; Fernández-Barral, A.; Muñoz, A.; Pandiella, A. "An amino acid transporter subunit as an antibody-drug conjugate target in colorectal cancer.". J Exp Clin Cancer Res. 42(1): 200. (2023). (PMID: 37559159).
    spacer

  4. Martinez-Perez, D.; Viñal, D.; Peña-Lopez, J.; Jimenez-Bou, D.; Ruiz-Gutierrez, I.; Martinez-Recio, S.; Alameda-Guijarro, M.; Rueda-Lara, A.; Martin-Montalvo, G.; Ghanem, I.; Custodio, A.B.; Trilla-Fuertes, L.; Gamez-Pozo, A.; Barbachano, A.; Rodriguez-Cobos, J.; Bustamante-Madrid, P.; Fernandez-Barral, A.; Burgos, A.; Prieto-Nieto, M.I.; Pastrian, L.G.; González-Sancho, J.M.; Muñoz, A.; Feliu, J.; Rodríguez-Salas, N. "Clinico-Pathological Features, Outcomes and Impacts of COVID-19 Pandemic on Patients with Early-Onset Colorectal Cancer: A Single-Institution Experience.". Cancers (Basel). 15(17): . (2023). (PMID: 37686518).
    spacer

  5. García-Martínez, J.M.; Chocarro-Calvo, A.; Martínez-Useros, J.; Fernández-Aceñero, M.J.; Fiuza, M.C.; Cáceres-Rentero, J.; De la Vieja, A.; Barbáchano, A.; Muñoz, A.; Larriba, M.J.; García Jiménez, C. "Vitamin D induces SIRT1 activation through K610 deacetylation in colon cancer.". Elife. 12(): . (2023). (PMID: 37530744).
    spacer

  6. Agudo-Ibáñez, L.; Morante, M.; García-Gutiérrez, L.; Quintanilla, A.; Rodríguez, J.; Muñoz, A.; León, J.; Crespo, P. "ERK2 stimulates MYC transcription by anchoring CDK9 to the MYC promoter in a kinase activity-independent manner.". Sci Signal. 16(794): eadg4193. (2023). (PMID: 37463244).
    spacer

  7. Martínez, N.; Gragera, T.; de Lucas, M.P.; Cámara, A.B.; Ballester, A.; Anta, B.; Fernández-Medarde, A.; López-Briones, T.; Ortega, J.; Peña-Jiménez, D.; Barbáchano, A.; Montero-Calle, A.; Cordero, V.; Barderas, R.; Iglesias, T.; Yunta, M.; Oliva, J.L.; Muñoz, A.; Santos, E.; Zarich, N.; Rojas-Cabañeros, J.M. "PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability.". Oncogenesis. 12(1): 20. (2023). (PMID: 37045830).
    spacer

  8. Prieto, I.; Barbáchano, A.; Rodríguez-Salas, N.; Viñal, D.; Cortés-Guiral, D.; Muñoz, A.; Fernández-Barral, A. "Tailored chemotherapy for colorectal cancer peritoneal metastases based on a drug-screening platform in patient-derived organoids: a case report.". J Gastrointest Oncol. 14(1): 442-449. (2023). (PMID: 36915469).
    spacer

  9. Fajardo, P.; Taskova, M.; Martín-Serrano, M.A.; Hansen, J.; Slott, S.; Jakobsen, A.K.; Wibom, M.L.; Salegi, B.; Muñoz, A.; Barbachano, A.; Sharma, A.; Gubatan, J.M.; Habtezion, A.; Sanz-Ezquerro, J.J.; Astakhova, K.; Cuenda, A. "p38γ and p38δ as biomarkers in the interplay of colon cancer and inflammatory bowel diseases.". Cancer Commun (Lond). (): . (2022). (PMID: 35796643).
    spacer

  10. Solé, L.; Lobo-Jarne, T.; Álvarez-Villanueva, D.; Alonso-Marañón, J.; Guillén, Y.; Guix, M.; Sangrador, I.; Rozalén, C.; Vert, A.; Barbachano, A.; Lop, J.; Salido, M.; Bellosillo, B.; García-Romero, R.; Garrido, M.; González, J.; Martínez-Iniesta, M.; López-Arribillaga, E.; Salazar, R.; Montagut, C.; Torres, F.; Iglesias, M.; Celià-Terrassa, T.; Muñoz, A.; Villanueva, A.; Bigas, A.; Espinosa, L. "p53 wild-type colorectal cancer cells that express a fetal gene signature are associated with metastasis and poor prognosis.". Nat Commun. 13(1): 2866. (2022). (PMID: 35606354).
    spacer

  11. Muñoz, A.; Grant, W.B. "Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms.". Nutrients. 14(7): . (2022). (PMID: 35406059).
    spacer

  12. Carlberg, C.; Muñoz, A. "An update on vitamin D signaling and cancer.". Semin Cancer Biol. (): . (2022). (PMID: 32485310).
    spacer

  13. Barbáchano, A.; Fernández-Barral, A.; Bustamante-Madrid, P.; Prieto, I.; Rodríguez-Salas, N.; Larriba, M.J.; Muñoz, A. "Organoids and Colorectal Cancer.". Cancers (Basel). 13(11): . (2021). (PMID: 34071313).
    spacer

  14. Zamudio-Martinez, E.; Herrera-Campos, A.B.; Muñoz, A.; Rodríguez-Vargas, J.M.; Oliver, F.J. "Tankyrases as modulators of pro-tumoral functions: molecular insights and therapeutic opportunities.". J Exp Clin Cancer Res. 40(1): 144. (2021). (PMID: 33910596).
    spacer

  15. González-Sancho, J.M.; Larriba, M.J.; Muñoz, A. "Wnt and Vitamin D at the Crossroads in Solid Cancer.". Cancers (Basel). 12(11): . (2020). (PMID: 33227961).
    spacer

  16. Costales-Carrera, A.; Fernández-Barral, A.; Bustamante-Madrid, P.; Domínguez, O.; Guerra-Pastrián, L.; Cantero, R.; Del Peso, L.; Burgos, A.; Barbáchano, A.; Muñoz, A. "Comparative Study of Organoids from Patient-Derived Normal and Tumor Colon and Rectal Tissue.". Cancers (Basel). 12(8): . (2020). (PMID: 32824266).
    spacer

  17. Fernández-Barral, A.; Bustamante-Madrid, P.; Ferrer-Mayorga, G.; Barbáchano, A.; Larriba, M.J.; Muñoz, A. "Vitamin D Effects on Cell Differentiation and Stemness in Cancer.". Cancers (Basel). 12(9): . (2020). (PMID: 32854355).
    spacer

  18. Fernández-Barral, A.; Costales-Carrera, A.; Buira, S.P.; Jung, P.; Ferrer-Mayorga, G.; Larriba, M.J.; Bustamante-Madrid, P.; Domínguez, O.; Real, F.X.; Guerra-Pastrián, L.; Lafarga, M.; García-Olmo, D.; Cantero, R.; Del Peso, L.; Batlle, E.; Rojo, F.; Muñoz, A.; Barbáchano, A. "Vitamin D differentially regulates colon stem cells in patient-derived normal and tumor organoids.". FEBS J.. 287(1): 53-72. (2020). (PMID: 31306552).
    spacer

  19. Galindo-Pumariño, C.; Herrera, A.; Muñoz, A.; Carrato, A.; Herrera, M.; Peña, C. "Fibroblast-Derived 3D Matrix System Applicable to Endothelial Tube Formation Assay.". J Vis Exp. (154): . (2019). (PMID: 31929503).
    spacer

  20. Costales-Carrera, A.; Fernández-Barral, A.; Bustamante-Madrid, P.; Guerra, L.; Cantero, R.; Barbáchano, A.; Muñoz, A. "Plocabulin Displays Strong Cytotoxic Activity in a Personalized Colon Cancer Patient-Derived 3D Organoid Assay.". Mar Drugs. 17(11): . (2019). (PMID: 31752287).
    spacer

  21. Santos, C.P.; Lapi, E.; Martínez de Villarreal, J.; Álvaro-Espinosa, L.; Fernández-Barral, A.; Barbáchano, A.; Domínguez, O.; Laughney, A.M.; Megías, D.; Muñoz, A.; Real, F.X. "Urothelial organoids originating from Cd49fhigh mouse stem cells display Notch-dependent differentiation capacity.". Nat Commun. 10(1): 4407. (2019). (PMID: 31562298).
    spacer

  22. Ferrer-Mayorga, G.; Niell, N.; Cantero, R.; González-Sancho, J.M.; Del Peso, L.; Muñoz, A.; Larriba, M.J. "Vitamin D and Wnt3A have additive and partially overlapping modulatory effects on gene expression and phenotype in human colon fibroblasts.". Sci Rep. 9(1): 8085. (2019). (PMID: 31147591).
    spacer

  23. Ferrer-Mayorga, G.; Larriba, M.J.; Crespo, P.; Muñoz, A. "Mechanisms of action of vitamin D in colon cancer.". J. Steroid Biochem. Mol. Biol.. 185(): 1-6. (2019). (PMID: 29981368).
    spacer

  24. Herrera, A.; Herrera, M.; Guerra-Perez, N.; Galindo-Pumariño, C.; Larriba, M.J.; García-Barberán, V.; Gil, B.; Giménez-Moyano, S.; Ferreiro-Monteagudo, R.; Veguillas, P.; Candia, A.; Peña, R.; Pinto, J.; García-Bermejo, M.L.; Muñoz, A.; García de Herreros, A.; Bonilla, F.; Carrato, A.; Peña, C. "Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1.". Oncogenesis. 7(9): 76. (2018). (PMID: 30250018).
    spacer

  25. Moreno-Marín, N.; Merino, J.M.; Alvarez-Barrientos, A.; Patel, D.P.; Takahashi, S.; González-Sancho, J.M.; Gandolfo, P.; Rios, R.M.; Muñoz, A.; Gonzalez, F.J.; Fernández-Salguero, P.M. "Aryl Hydrocarbon Receptor Promotes Liver Polyploidization and Inhibits PI3K, ERK, and Wnt/β-Catenin Signaling.". iScience. 4(): 44-63. (2018). (PMID: 30240752).
    spacer

  26. Niell, N.; Larriba, M.J.; Ferrer-Mayorga, G.; Sánchez-Pérez, I.; Cantero, R.; Real, F.X.; Del Peso, L.; Muñoz, A.; González-Sancho, J.M. "The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts.". Int. J. Cancer. 142(4): 792-804. (2018). (PMID: 29044515).
    spacer

  27. Barbáchano, A.; Fernández-Barral, A.; Ferrer-Mayorga, G.; Costales-Carrera, A.; Larriba, M.J.; Muñoz, A. "The endocrine vitamin D system in the gut.". Mol. Cell. Endocrinol.. 453(): 79-87. (2017). (PMID: 27913273).
    spacer

  28. Ferrer-Mayorga, G.; Gómez-López, G.; Barbáchano, A.; Fernández-Barral, A.; Peña, C.; Pisano, D.G.; Cantero, R.; Rojo, F.; Muñoz, A.; Larriba, M.J. "Vitamin D receptor expression and associated gene signature in tumour stromal fibroblasts predict clinical outcome in colorectal cancer.". Gut. 66(8): 1449-1462. (2017). (PMID: 27053631).
    spacer

  29. García-Palmero, I.; Torres, S.; Bartolomé, R.A.; Peláez-García, A.; Larriba, M.J.; Lopez-Lucendo, M.; Peña, C.; Escudero-Paniagua, B.; Muñoz, A.; Casal, J.I. "Twist1-induced activation of human fibroblasts promotes matrix stiffness by upregulating palladin and collagen α1(VI).". Oncogene. 35(40): 5224-5236. (2016). (PMID: 26973246).
    spacer

  30. Anta, B.; Pérez-Rodríguez, A.; Castro, J.; García-Domínguez, C.A.; Ibiza, S.; Martínez, N.; Durá, L.M.; Hernández, S.; Gragera, T.; Peña-Jiménez, D.; Yunta, M.; Zarich, N.; Crespo, P.; Serrador, J.M.; Santos, E.; Muñoz, A.; Oliva, J.L.; Rojas-Cabañeros, J.M. "PGA1-induced apoptosis involves specific activation of H-Ras and N-Ras in cellular endomembranes.". Cell Death Dis. 7(7): e2311. (2016). (PMID: 27468687).
    spacer

  31. Barbáchano, A.; Fernández-Barral, A.; Pereira, F.; Segura, M.F.; Ordóñez-Morán, P.; Carrillo-de Santa Pau, E.; González-Sancho, J.M.; Hanniford, D.; Martínez, N.; Costales-Carrera, A.; Real, F.X.; Pálmer, H.G.; Rojas, J.M.; Hernando, E.; Muñoz, A. "SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150.". Oncogene. 35(23): 2991-3003. (2016). (PMID: 26455323).
    spacer

  32. Larriba, M.J.; García de Herreros, A.; Muñoz, A. "Vitamin D and the Epithelial to Mesenchymal Transition.". Stem Cells Int. 2016(): 6213872. (2016). (PMID: 26880977).
    spacer

  33. Ferrer-Mayorga, G.; Alvarez-Diaz, S.; Valle, N.; De Las Rivas, J.; Mendes, M.; Barderas, R.; Canals, F.; Tapia, O.; Casal, J.I.; Lafarga, M.; Munoz, A. "Cystatin D Locates in the Nucleus at Sites of Active Transcription and Modulates Gene and Protein Expression.". J. Biol. Chem.. (): . (2015). (PMID: 26364852).
    spacer

  34. Aguilera, Ó.; González-Sancho, J.M.; Zazo, S.; Rincón, R.; Fernández, A.F.; Tapia, O.; Canals, F.; Morte, B.; Calvanese, V.; Orgaz, J.L.; Niell, N.; Aguilar, S.; Freije, J.M.; Graña, O.; Pisano, D.G.; Borrero, A.; Martínez-Useros, J.; Jiménez, B.; Fraga, M.F.; García-Foncillas, J.; López-Otín, C.; Lafarga, M.; Rojo, F.; Muñoz, A. "Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.". Oncotarget. 6(8): 5903-5917. (2015). (PMID: 25788273).
    spacer

  35. Alba-Castellón, L.; Batlle, R.; Francí, C.; Fernández-Aceñero, M.J.; Mazzolini, R.; Peña, R.; Loubat, J.; Alameda, F.; Rodríguez, R.; Curto, J.; Albanell, J.; Muñoz, A.; Bonilla, F.; Ignacio Casal, J.; Rojo, F.; García de Herreros, A. "Snail1 expression is required for sarcomagenesis.". Neoplasia. 16(5): 413-421. (2014). (PMID: 24947186).
    spacer

  36. Ordóñez-Morán, P.; Irmisch, A.; Barbáchano, A.; Chicote, I.; Tenbaum, S.; Landolfi, S.; Tabernero, J.; Huelsken, J.; Muñoz, A.; Pálmer, H.G. "SPROUTY2 is a β-catenin and FOXO3a target gene indicative of poor prognosis in colon cancer.". Oncogene. 33(15): 1975-1985. (2014). (PMID: 23624922).
    spacer

  37. Larriba, M.J.; González-Sancho, J.M.; Bonilla, F.; Muñoz, A. "Interaction of vitamin D with membrane-based signaling pathways.". Front Physiol. 5(): 60. (2014). (PMID: 24600406).
    spacer

  38. Larriba, M.J.; González-Sancho, J.M.; Barbáchano, A.; Niell, N.; Ferrer-Mayorga, G.; Muñoz, A. "Vitamin D Is a Multilevel Repressor of Wnt/b-Catenin Signaling in Cancer Cells.". Cancers (Basel). 5(4): 1242-1260. (2013). (PMID: 24202444).
    spacer

  39. Muñoz-Alonso, M.J.; Álvarez, E.; Guillén-Navarro, M.J.; Pollán, M.; Avilés, P.; Galmarini, C.M.; Muñoz, A. "c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity.". Mar Drugs. 11(5): 1677-1692. (2013). (PMID: 23697951).
    spacer

  40. Amaral, A.F.; Méndez-Pertuz, M.; Muñoz, A.; Silverman, D.T.; Allory, Y.; Kogevinas, M.; Lloreta, J.; Rothman, N.; Carrato, A.; Rivas del Fresno, M.; Real, F.X.; Malats, N.; , . "Plasma 25-hydroxyvitamin D(3) and bladder cancer risk according to tumor stage and FGFR3 status: a mechanism-based epidemiological study.". J. Natl. Cancer Inst.. 104(24): 1897-1904. (2012). (PMID: 23108201).
    spacer

  41. Carballa, D.M.; Seoane, S.; Zacconi, F.; Pérez, X.; Rumbo, A.; Alvarez-Díaz, S.; Larriba, M.J.; Pérez-Fernández, R.; Muñoz, A.; Maestro, M.; Mouriño, A.; Torneiro, M. "Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D₃ analogues with a long side chain at C12 and short C17 side chains.". J. Med. Chem.. 55(20): 8642-8656. (2012). (PMID: 22989379).
    spacer

  42. Pereira, F.; Larriba, M.J.; Muñoz, A. "Vitamin D and colon cancer.". Endocr. Relat. Cancer. 19(3): R51-71. (2012). (PMID: 22383428).
    spacer

  43. Tenbaum, S.P.; Ordóñez-Morán, P.; Puig, I.; Chicote, I.; Arqués, O.; Landolfi, S.; Fernández, Y.; Herance, J.R.; Gispert, J.D.; Mendizabal, L.; Aguilar, S.; Ramón y Cajal, S.; Schwartz, S.; Vivancos, A.; Espín, E.; Rojas, S.; Baselga, J.; Tabernero, J.; Muñoz, A.; Palmer, H.G. "β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer.". Nat. Med.. 18(6): 892-901. (2012). (PMID: 22610277).
    spacer

  44. Alvarez-Díaz, S.; Valle, N.; Ferrer-Mayorga, G.; Lombardía, L.; Herrera, M.; Domínguez, O.; Segura, M.F.; Bonilla, F.; Hernando, E.; Muñoz, A. "MicroRNA-22 is induced by vitamin D and contributes to its antiproliferative, antimigratory and gene regulatory effects in colon cancer cells.". Hum. Mol. Genet.. 21(10): 2157-2165. (2012). (PMID: 22328083).
    spacer

  45. Pereira, F.; Barbáchano, A.; Singh, P.K.; Campbell, M.J.; Muñoz, A.; Larriba, M.J. "Vitamin D has wide regulatory effects on histone demethylase genes.". Cell Cycle. 11(6): 1081-1089. (2012). (PMID: 22370479).
    spacer

  46. Fraga, R.; Zacconi, F.; Sussman, F.; Ordóñez-Morán, P.; Muñoz, A.; Huet, T.; Molnár, F.; Moras, D.; Rochel, N.; Maestro, M.; Mouriño, A. "Design, synthesis, evaluation, and structure of vitamin D analogues with furan side chains.". Chemistry. 18(2): 603-612. (2012). (PMID: 22162241).
    spacer

  47. Pereira, F.; Barbáchano, A.; Silva, J.; Bonilla, F.; Campbell, M.J.; Muñoz, A.; Larriba, M.J. "KDM6B/JMJD3 histone demethylase is induced by vitamin D and modulates its effects in colon cancer cells.". Hum. Mol. Genet.. 20(23): 4655-4665. (2011). (PMID: 21890490).
    spacer

  48. Cristobo, I.; Larriba, M.J.; de los Ríos, V.; García, F.; Muñoz, A.; Casal, J.I. "Proteomic analysis of 1α,25-dihydroxyvitamin D3 action on human colon cancer cells reveals a link to splicing regulation.". J Proteomics. 75(2): 384-397. (2011). (PMID: 21864731).
    spacer

  49. Larriba, M.J.; Ordóñez-Morán, P.; Chicote, I.; Martín-Fernández, G.; Puig, I.; Muñoz, A.; Pálmer, H.G. "Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer.". PLoS ONE. 6(8): e23524. (2011). (PMID: 21858154).
    spacer

  50. Regueira, M.A.; Samanta, S.; Malloy, P.J.; Ordonez-Moran, P.; Resende, D.; Sussman, F.; Munoz, A.; Mourino, A.; Feldman, D.; Torneiro, M. "Synthesis and biological evaluation of 1α,25-dihydroxyvitamin D(3) analogues hydroxymethylated at C-26.". J. Med. Chem.. 54(11): 3950-3962. (2011). (PMID: 21524075).
    spacer

  51. Verlinden, L.; Verstuyf, A.; Eelen, G.; Bouillon, R.; Ordóñez-Morán, P.; Larriba, M.J.; Muñoz, A.; Rochel, N.; Sato, Y.; Moras, D.; Maestro, M.; Seoane, S.; Dominguez, F.; Eduardo-Canosa, S.; Nicoletti, D.; Moman, E.; Mouriño, A. "Synthesis, structure, and biological activity of des-side chain analogues of 1α,25-dihydroxyvitamin D3 with substituents at C18.". ChemMedChem. 6(5): 788-793. (2011). (PMID: 21520419).
    spacer

  52. Céspedes, M.V.; Larriba, M.J.; Pavón, M.A.; Alamo, P.; Casanova, I.; Parreño, M.; Feliu, A.; Sancho, F.J.; Muñoz, A.; Mangues, R. "Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model.". Am. J. Pathol.. 177(4): 2067-2079. (2010). (PMID: 20813963).
    spacer

  53. Barbáchano, A.; Ordóñez-Morán, P.; García, J.M.; Sánchez, A.; Pereira, F.; Larriba, M.J.; Martínez, N.; Hernández, J.; Landolfi, S.; Bonilla, F.; Pálmer, H.G.; Rojas, J.M.; Muñoz, A. "SPROUTY-2 and E-cadherin regulate reciprocally and dictate colon cancer cell tumourigenicity.". Oncogene. 29(34): 4800-4813. (2010). (PMID: 20543868).
    spacer

  54. Eelen, G.; Verlinden, L.; Bouillon, R.; De Clercq, P.; Muñoz, A.; Verstuyf, A. "CD-ring modified vitamin D3 analogs and their superagonistic action.". J. Steroid Biochem. Mol. Biol.. 121(1-2): 417-419. (2010). (PMID: 20132886).
    spacer

  55. Aguilera, O.; Fernández, A.F.; Muñoz, A.; Fraga, M.F. "Epigenetics and environment: a complex relationship.". J. Appl. Physiol.. 109(1): 243-251. (2010). (PMID: 20378707).
    spacer

  56. Ordóñez-Morán, P.; Alvarez-Díaz, S.; Valle, N.; Larriba, M.J.; Bonilla, F.; Muñoz, A. "The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling.". J. Steroid Biochem. Mol. Biol.. 121(1-2): 355-361. (2010). (PMID: 20223287).
    spacer

  57. Larriba, M.J.; Bonilla, F.; Muñoz, A. "The transcription factors Snail1 and Snail2 repress vitamin D receptor during colon cancer progression.". J. Steroid Biochem. Mol. Biol.. 121(1-2): 106-109. (2010). (PMID: 20138990).
    spacer

  58. Lara, E.; Calvanese, V.; Huidobro, C.; Fernández, A.F.; Moncada-Pazos, A.; Obaya, A.J.; Aguilera, O.; González-Sancho, J.M.; Sánchez, L.; Astudillo, A.; Muñoz, A.; López-Otín, C.; Esteller, M.; Fraga, M.F. "Epigenetic repression of ROR2 has a Wnt-mediated, pro-tumourigenic role in colon cancer.". Mol. Cancer. 9(): 170. (2010). (PMID: 20591152).
    spacer

  59. Larriba, M.J.; Casado-Vela, J.; Pendás-Franco, N.; Peña, R.; García de Herreros, A.; Berciano, M.T.; Lafarga, M.; Casal, J.I.; Muñoz, A. "Novel snail1 target proteins in human colon cancer identified by proteomic analysis.". PLoS ONE. 5(4): e10221. (2010). (PMID: 20421926).
    spacer

  60. Alvarez-Díaz, S.; Larriba, M.J.; López-Otín, C.; Muñoz, A. "Vitamin D: Proteases, protease inhibitors and cancer.". Cell Cycle. 9(1): 32-37. (2010). (PMID: 20016282).
    spacer

  61. Peña, C.; García, J.M.; Larriba, M.J.; Barderas, R.; Gómez, I.; Herrera, M.; García, V.; Silva, J.; Domínguez, G.; Rodríguez, R.; Cuevas, J.; de Herreros, A.G.; Casal, J.I.; Muñoz, A.; Bonilla, F. "SNAI1 expression in colon cancer related with CDH1 and VDR downregulation in normal adjacent tissue.". Oncogene. 28(49): 4375-4385. (2009). (PMID: 19802011).
    spacer

  62. Alvarez-Díaz, S.; Valle, N.; García, J.M.; Peña, C.; Freije, J.M.; Quesada, V.; Astudillo, A.; Bonilla, F.; López-Otín, C.; Muñoz, A. "Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.". J. Clin. Invest.. 119(8): 2343-2358. (2009). (PMID: 19662683).
    spacer

  63. Larriba, M.J.; Martín-Villar, E.; García, J.M.; Pereira, F.; Peña, C.; de Herreros, A.G.; Bonilla, F.; Muñoz, A. "Snail2 cooperates with Snail1 in the repression of vitamin D receptor in colon cancer.". Carcinogenesis. 30(8): 1459-1468. (2009). (PMID: 19502595).
    spacer

  64. Ordóñez-Morán, P.; Muñoz, A. "Nuclear receptors: genomic and non-genomic effects converge.". Cell Cycle. 8(11): 1675-1680. (2009). (PMID: 19448403).
    spacer

  65. Muñoz-Alonso, M.J.; González-Santiago, L.; Martínez, T.; Losada, A.; Galmarini, C.M.; Muñoz, A. "The mechanism of action of plitidepsin.". Curr Opin Investig Drugs. 10(6): 536-542. (2009). (PMID: 19513942).
    spacer

  66. Fernández-Contreras, M.E.; Sánchez-Hernández, J.J.; González, E.; Herráez, B.; Domínguez, I.; Lozano, M.; García De Paredes, M.L.; Muñoz, A.; Gamallo, C. "Combination of polymorphisms within 5' and 3' untranslated regions of thymidylate synthase gene modulates survival in 5 fluorouracil-treated colorectal cancer patients.". Int. J. Oncol.. 34(1): 219-229. (2009). (PMID: 19082493).
    spacer

  67. Pendás-Franco, N.; Aguilera, O.; Pereira, F.; González-Sancho, J.M.; Muñoz, A. "Vitamin D and Wnt/beta-catenin pathway in colon cancer: role and regulation of DICKKOPF genes.". Anticancer Res.. 28(5A): 2613-2623. (2008). (PMID: 19035286).
    spacer

  68. Ordóñez-Morán, P.; Larriba, M.J.; Pálmer, H.G.; Valero, R.A.; Barbáchano, A.; Duñach, M.; de Herreros, A.G.; Villalobos, C.; Berciano, M.T.; Lafarga, M.; Muñoz, A. "RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells.". J. Cell Biol.. 183(4): 697-710. (2008). (PMID: 19015318).
    spacer

  69. Eelen, G.; Valle, N.; Sato, Y.; Rochel, N.; Verlinden, L.; De Clercq, P.; Moras, D.; Bouillon, R.; Muñoz, A.; Verstuyf, A. "Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.". Chem. Biol.. 15(10): 1029-1034. (2008). (PMID: 18940664).
    spacer

  70. Pendás-Franco, N.; García, J.M.; Peña, C.; Valle, N.; Pálmer, H.G.; Heinäniemi, M.; Carlberg, C.; Jiménez, B.; Bonilla, F.; Muñoz, A.; González-Sancho, J.M. "DICKKOPF-4 is induced by TCF/beta-catenin and upregulated in human colon cancer, promotes tumour cell invasion and angiogenesis and is repressed by 1alpha,25-dihydroxyvitamin D3.". Oncogene. 27(32): 4467-4477. (2008). (PMID: 18408752).
    spacer

  71. Solanas, G.; Porta-de-la-Riva, M.; Agustí, C.; Casagolda, D.; Sánchez-Aguilera, F.; Larriba, M.J.; Pons, F.; Peiró, S.; Escrivà, M.; Muñoz, A.; Duñach, M.; de Herreros, A.G.; Baulida, J. "E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression.". J. Cell. Sci.. 121(Pt 13): 2224-2234. (2008). (PMID: 18565826).
    spacer

  72. Larriba, M.J.; Valle, N.; Alvarez, S.; Muñoz, A. "Vitamin D3 and colorectal cancer.". Adv. Exp. Med. Biol.. 617(): 271-280. (2008). (PMID: 18497050).
    spacer

  73. Muñoz-Alonso, M.J.; González-Santiago, L.; Zarich, N.; Martínez, T.; Alvarez, E.; Rojas, J.M.; Muñoz, A. "Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via Rac1/c-Jun NH2-terminal kinase activation in human melanoma cells.". J. Pharmacol. Exp. Ther.. 324(3): 1093-1101. (2008). (PMID: 18089842).
    spacer

  74. Aguilera, O.; Peña, C.; García, J.M.; Larriba, M.J.; Ordóñez-Morán, P.; Navarro, D.; Barbáchano, A.; López de Silanes, I.; Ballestar, E.; Fraga, M.F.; Esteller, M.; Gamallo, C.; Bonilla, F.; González-Sancho, J.M.; Muñoz, A. "The Wnt antagonist DICKKOPF-1 gene is induced by 1alpha,25-dihydroxyvitamin D3 associated to the differentiation of human colon cancer cells.". Carcinogenesis. 28(9): 1877-1884. (2007). (PMID: 17449905).
    spacer

  75. González-Santiago, L.; Alfonso, P.; Suárez, Y.; Núñez, A.; García-Fernández, L.F.; Alvarez, E.; Muñoz, A.; Casal, J.I. "Proteomic analysis of the resistance to aplidin in human cancer cells.". J. Proteome Res.. 6(4): 1286-1294. (2007). (PMID: 17338558).
    spacer

  76. Aguilera, O.; Muñoz, A.; Esteller, M.; Fraga, M.F. "Epigenetic alterations of the Wnt/beta-catenin pathway in human disease.". Endocr Metab Immune Disord Drug Targets. 7(1): 13-21. (2007). (PMID: 17346200).
    spacer

  77. Larriba, M.J.; Valle, N.; Pálmer, H.G.; Ordóñez-Morán, P.; Alvarez-Díaz, S.; Becker, K.F.; Gamallo, C.; de Herreros, A.G.; González-Sancho, J.M.; Muñoz, A. "The inhibition of Wnt/beta-catenin signalling by 1alpha,25-dihydroxyvitamin D3 is abrogated by Snail1 in human colon cancer cells.". Endocr. Relat. Cancer. 14(1): 141-151. (2007). (PMID: 17395983).
    spacer

  78. Pendás-Franco, N.; González-Sancho, J.M.; Suárez, Y.; Aguilera, O.; Steinmeyer, A.; Gamallo, C.; Berciano, M.T.; Lafarga, M.; Muñoz, A. "Vitamin D regulates the phenotype of human breast cancer cells.". Differentiation. 75(3): 193-207. (2007). (PMID: 17288543).
    spacer

  79. González-Santiago, L.; Suárez, Y.; Zarich, N.; Muñoz-Alonso, M.J.; Cuadrado, A.; Martínez, T.; Goya, L.; Iradi, A.; Sáez-Tormo, G.; Maier, J.V.; Moorthy, A.; Cato, A.C.; Rojas, J.M.; Muñoz, A. "Aplidin induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation.". Cell Death Differ.. 13(11): 1968-1981. (2006). (PMID: 16543941).
    spacer

  80. Suárez, Y.; González-Santiago, L.; Zarich, N.; Dávalos, A.; Aranda, J.F.; Alonso, M.A.; Lasunción, M.A.; Rojas, J.M.; Muñoz, A. "Plitidepsin cellular binding and Rac1/JNK pathway activation depend on membrane cholesterol content.". Mol. Pharmacol.. 70(5): 1654-1663. (2006). (PMID: 16928956).
    spacer

  81. Peña, C.; García, J.M.; García, V.; Silva, J.; Domínguez, G.; Rodríguez, R.; Maximiano, C.; García de Herreros, A.; Muñoz, A.; Bonilla, F. "The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas.". Int. J. Cancer. 119(9): 2098-2104. (2006). (PMID: 16804902).
    spacer

  82. González-Sancho, J.M.; Larriba, M.J.; Ordóñez-Morán, P.; Pálmer, H.G.; Muñoz, A. "Effects of 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells.". Anticancer Res.. 26(4A): 2669-2681. (2006). (PMID: 16886677).
    spacer

  83. Aguilera, O.; Fraga, M.F.; Ballestar, E.; Paz, M.F.; Herranz, M.; Espada, J.; García, J.M.; Muñoz, A.; Esteller, M.; González-Sancho, J.M. "Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer.". Oncogene. 25(29): 4116-4121. (2006). (PMID: 16491118).
    spacer

  84. Peiró, S.; Escrivà, M.; Puig, I.; Barberà, M.J.; Dave, N.; Herranz, N.; Larriba, M.J.; Takkunen, M.; Francí, C.; Muñoz, A.; Virtanen, I.; Baulida, J.; García de Herreros, A. "Snail1 transcriptional repressor binds to its own promoter and controls its expression.". Nucleic Acids Res.. 34(7): 2077-2084. (2006). (PMID: 16617148).
    spacer

  85. Peña, C.; García, J.M.; Silva, J.; García, V.; Rodríguez, R.; Alonso, I.; Millán, I.; Salas, C.; de Herreros, A.G.; Muñoz, A.; Bonilla, F. "E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations.". Hum Mol Genet. 14(22): 3361-3370. (2005). (PMID: 16203744).
    spacer

  86. Fernandez-Garcia, N.I.; Palmer, H.G.; Garcia, M.; Gonzalez-Martin, A.; del Rio, M.; Barettino, D.; Volpert, O.; Muñoz, A.; Jimenez, B. "1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells.". Oncogene. 24(43): 6533-6544. (2005). (PMID: 16007183).
    spacer

  87. Ordonez-Moran, P.; Larriba, M.J.; Pendas-Franco, N.; Aguilera, O.; Gonzalez-Sancho, J.M.; Munoz, A. "Vitamin D and cancer: an update of in vitro and in vivo data.". Front. Biosci.. 10(): 2723-2749. (2005). (PMID: 15970529).
    spacer

  88. Fu, M.; Wang, C.; Rao, M.; Wu, X.; Bouras, T.; Zhang, X.; Li, Z.; Jiao, X.; Yang, J.; Li, A.; Perkins, N.D.; Thimmapaya, B.; Kung, A.L.; Munoz, A.; Giordano, A.; Lisanti, M.P.; Pestell, R.G. "Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism.". J Biol Chem. 280(33): 29728-29742. (2005). (PMID: 15951563).
    spacer

  89. Pinazo-Durán, M.D.; Iborra, F.J.; Pons, S.; Sevilla-Romero, E.; Gallego-Pinazo, R.; Muñoz, A. "Postnatal thyroid hormone supplementation rescues developmental abnormalities induced by congenital-neonatal hypothyroidism in the rat retina.". Ophthalmic Res.. 37(4): 225-234. (2005). (PMID: 16006782).
    spacer

  90. Larriba, M.J.; Muñoz, A. "SNAIL vs vitamin D receptor expression in colon cancer: therapeutics implications.". Br. J. Cancer. 92(6): 985-989. (2005). (PMID: 15770204).
    spacer

  91. González-Sancho, J.M.; Aguilera, O.; García, J.M.; Pendás-Franco, N.; Peña, C.; Cal, S.; García de Herreros, A.; Bonilla, F.; Muñoz, A. "The Wnt antagonist DICKKOPF-1 gene is a downstream target of beta-catenin/TCF and is downregulated in human colon cancer.". Oncogene. 24(6): 1098-1103. (2005). (PMID: 15592505).
    spacer

  92. Pálmer, H.G.; Larriba, M.J.; García, J.M.; Ordóñez-Morán, P.; Peña, C.; Peiró, S.; Puig, I.; Rodríguez, R.; de la Fuente, R.; Bernad, A.; Pollán, M.; Bonilla, F.; Gamallo, C.; de Herreros, A.G.; Muñoz, A. "The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer.". Nat. Med.. 10(9): 917-919. (2004). (PMID: 15322538).
    spacer

  93. Cuadrado, A.; González, L.; Suárez, Y.; Martínez, T.; Muñoz, A. "JNK activation is critical for Aplidin-induced apoptosis.". Oncogene. 23(27): 4673-4680. (2004). (PMID: 15122339).
    spacer

  94. Navarro-Yubero, C.; Cuadrado, A.; Sonderegger, P.; Muñoz, A. "Neuroserpin is post-transcriptionally regulated by thyroid hormone.". Brain Res. Mol. Brain Res.. 123(1-2): 56-65. (2004). (PMID: 15046866).
    spacer

  95. Eckey, M.; Tenbaum, S.P.; Muñoz, A.; Baniahmad, A. "Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors.". Mol. Cell. Endocrinol.. 213(1): 71-78. (2003). (PMID: 15062575).
    spacer

  96. Pálmer, H.G.; Sánchez-Carbayo, M.; Ordóñez-Morán, P.; Larriba, M.J.; Cordón-Cardó, C.; Muñoz, A. "Genetic signatures of differentiation induced by 1alpha,25-dihydroxyvitamin D3 in human colon cancer cells.". Cancer Res.. 63(22): 7799-7806. (2003). (PMID: 14633706).
    spacer

  97. Bruna, A.; Nicolàs, M.; Muñoz, A.; Kyriakis, J.M.; Caelles, C. "Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids.". EMBO J.. 22(22): 6035-6044. (2003). (PMID: 14609950).
    spacer

  98. Pérez-García, X.; Rumbo, A.; Larriba, M.J.; Ordóñez, P.; Muñoz, A.; Mouriño, A. "The first locked side-chain analogues of calcitriol (1alpha,25-dihydroxyvitamin D3) induce vitamin D receptor transcriptional activity.". Org. Lett.. 5(22): 4033-4036. (2003). (PMID: 14572242).
    spacer

  99. Suárez, Y.; González, L.; Cuadrado, A.; Berciano, M.; Lafarga, M.; Muñoz, A. "Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells.". Mol. Cancer Ther.. 2(9): 863-872. (2003). (PMID: 14555705).
    spacer

  100. Cuadrado, A.; Navarro-Yubero, C.; Furneaux, H.; Muñoz, A. "Neuronal HuD gene encoding a mRNA stability regulator is transcriptionally repressed by thyroid hormone.". J. Neurochem.. 86(3): 763-773. (2003). (PMID: 12859688).
    spacer

  101. Figueroa, A.; Cuadrado, A.; Fan, J.; Atasoy, U.; Muscat, G.E.; Muñoz-Canoves, P.; Gorospe, M.; Muñoz, A. "Role of HuR in skeletal myogenesis through coordinate regulation of muscle differentiation genes.". Mol. Cell. Biol.. 23(14): 4991-5004. (2003). (PMID: 12832484).
    spacer

  102. González-Sancho, J.M.; García, V.; Bonilla, F.; Muñoz, A. "Thyroid hormone receptors/THR genes in human cancer.". Cancer Lett.. 192(2): 121-132. (2003). (PMID: 12668276).
    spacer

  103. Tenbaum, S.P.; Juenemann, S.; Schlitt, T.; Bernal, J.; Renkawitz, R.; Muñoz, A.; Baniahmad, A. "Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain.". Dev. Biol.. 254(1): 149-160. (2003). (PMID: 12606288).
    spacer

  104. Cuadrado, A.; Garcia-Fernandez, L.F.; Gonzalez, L.; Suarez, Y.; Losada, A.; Alcaide, V.; Martinez, T.; Fernandez-Sousa, J.M.; Sanchez-Puelles, J.M.; Munoz, A. "Aplidin induces apoptosis in human cancer cells via glutathione depletion and sustained activation of the epidermal growth factor receptor, Src, JNK, and p38 MAPK.". J. Biol. Chem.. 278(1): 241-250. (2003). (PMID: 12414812).
    spacer

  105. Sevilla-Romero, E.; Muñoz, A.; Pinazo-Durán, M.D. "Low thyroid hormone levels impair the perinatal development of the rat retina.". Ophthalmic Res.. 34(4): 181-191. (2002). (PMID: 12297689).
    spacer

  106. García-Fernández, L.F.; Losada, A.; Alcaide, V.; Alvarez, A.M.; Cuadrado, A.; González, L.; Nakayama, K.; Nakayama, K.I.; Fernández-Sousa, J.M.; Muñoz, A.; Sánchez-Puelles, J.M. "Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta.". Oncogene. 21(49): 7533-7544. (2002). (PMID: 12386816).
    spacer

  107. Caelles, C.; Bruna, A.; Morales, M.; González-Sancho, J.M.; González, M.V.; Jiménez, B.; Muñoz, A. "Glucocorticoid receptor antagonism of AP-1 activity by inhibition of MAPK family.". Ernst Schering Res. Found. Workshop. (40): 131-152. (2002). (PMID: 12355714).
    spacer

  108. Silva, J.M.; Domínguez, G.; González-Sancho, J.M.; García, J.M.; Silva, J.; García-Andrade, C.; Navarro, A.; Muñoz, A.; Bonilla, F. "Expression of thyroid hormone receptor/erbA genes is altered in human breast cancer.". Oncogene. 21(27): 4307-4316. (2002). (PMID: 12082618).
    spacer

  109. Cuadrado, A.; García-Fernández, L.F.; Imai, T.; Okano, H.; Muñoz, A. "Regulation of tau RNA maturation by thyroid hormone is mediated by the neural RNA-binding protein musashi-1.". Mol. Cell. Neurosci.. 20(2): 198-210. (2002). (PMID: 12093154).
    spacer

  110. Cuadrado, A.; Navarro-Yubero, C.; Furneaux, H.; Kinter, J.; Sonderegger, P.; Muñoz, A. "HuD binds to three AU-rich sequences in the 3'-UTR of neuroserpin mRNA and promotes the accumulation of neuroserpin mRNA and protein.". Nucleic Acids Res.. 30(10): 2202-2211. (2002). (PMID: 12000840).
    spacer

  111. González-Sancho, J.M.; Figueroa, A.; López-Barahona, M.; López, E.; Beug, H.; Muñoz, A. "Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells.". Mol. Carcinog.. 34(1): 25-34. (2002). (PMID: 12112320).
    spacer

  112. Gamborino, M.J.; Sevilla-Romero, E.; Muñoz, A.; Hernández-Yago, J.; Renau-Piqueras, J.; Pinazo-Durán, M.D. "Role of thyroid hormone in craniofacial and eye development using a rat model.". Ophthalmic Res.. 33(5): 283-291. (2001). (PMID: 11586062).
    spacer

  113. Alvarez-Dolado, M.; Figueroa, A.; Kozlov, S.; Sonderegger, P.; Furley, A.J.; Muñoz, A. "Thyroid hormone regulates TAG-1 expression in the developing rat brain.". Eur. J. Neurosci.. 14(8): 1209-1218. (2001). (PMID: 11703450).
    spacer

  114. Pálmer, H.G.; González-Sancho, J.M.; Espada, J.; Berciano, M.T.; Puig, I.; Baulida, J.; Quintanilla, M.; Cano, A.; de Herreros, A.G.; Lafarga, M.; Muñoz, A. "Vitamin D(3) promotes the differentiation of colon carcinoma cells by the induction of E-cadherin and the inhibition of beta-catenin signaling.". J. Cell Biol.. 154(2): 369-387. (2001). (PMID: 11470825).
    spacer

  115. Jiménez, B.; Volpert, O.V.; Reiher, F.; Chang, L.; Muñoz, A.; Karin, M.; Bouck, N. "c-Jun N-terminal kinase activation is required for the inhibition of neovascularization by thrombospondin-1.". Oncogene. 20(26): 3443-3448. (2001). (PMID: 11423995).
    spacer

  116. Koritschoner, N.P.; Alvarez-Dolado, M.; Kurz, S.M.; Heikenwälder, M.F.; Hacker, C.; Vogel, F.; Muñoz, A.; Zenke, M. "Thyroid hormone regulates the obesity gene tub.". EMBO Rep.. 2(6): 499-504. (2001). (PMID: 11415982).
    spacer

  117. Penela, P.; Barradas, M.; Alvarez-Dolado, M.; Muñoz, A.; Mayor, F. "Effect of hypothyroidism on G protein-coupled receptor kinase 2 expression levels in rat liver, lung, and heart.". Endocrinology. 142(3): 987-991. (2001). (PMID: 11181510).
    spacer

  118. Alvarez-Dolado, M.; Cuadrado, A.; Navarro-Yubero, C.; Sonderegger, P.; Furley, A.J.; Bernal, J.; Muñoz, A. "Regulation of the L1 cell adhesion molecule by thyroid hormone in the developing brain.". Mol. Cell. Neurosci.. 16(4): 499-514. (2000). (PMID: 11085884).
    spacer

  119. González, M.V.; Jiménez, B.; Berciano, M.T.; González-Sancho, J.M.; Caelles, C.; Lafarga, M.; Muñoz, A. "Glucocorticoids antagonize AP-1 by inhibiting the Activation/phosphorylation of JNK without affecting its subcellular distribution.". J. Cell Biol.. 150(5): 1199-1208. (2000). (PMID: 10974006).
    spacer

  120. García-Fernández, L.F.; Iñiguez, M.A.; Eguchi, N.; Fresno, M.; Urade, Y.; Muñoz, A. "Dexamethasone induces lipocalin-type prostaglandin D synthase gene expression in mouse neuronal cells.". J. Neurochem.. 75(2): 460-470. (2000). (PMID: 10899920).
    spacer

  121. Penela, P.; Alvarez-Dolado, M.; Muñoz, A.; Mayor, F. "Expression patterns of the regulatory proteins G protein-coupled receptor kinase 2 and beta-arrestin 1 during rat postnatal brain development: effect of hypothyroidism.". Eur. J. Biochem.. 267(14): 4390-4396. (2000). (PMID: 10880962).
    spacer

  122. Alvarez-Dolado, M.; González-Moreno, M.; Valencia, A.; Zenke, M.; Bernal, J.; Muñoz, A. "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions.". J. Neurochem.. 73(6): 2240-2249. (1999). (PMID: 10582581).
    spacer

  123. González, M.V.; González-Sancho, J.M.; Caelles, C.; Munoz, A.; Jiménez, B. "Hormone-activated nuclear receptors inhibit the stimulation of the JNK and ERK signalling pathways in endothelial cells.". FEBS Lett.. 459(2): 272-276. (1999). (PMID: 10518034).
    spacer

  124. Alvarez-Dolado, M.; González-Sancho, J.M.; Navarro-Yubero, C.; García-Fernández, L.F.; Muñoz, A. "Retinoic acid and 1,25-dihydroxyvitamin D3 inhibit tenascin-C expression in rat glioma C6 cells.". J. Neurosci. Res.. 58(2): 293-300. (1999). (PMID: 10502285).
    spacer

  125. Cuadrado, A.; Bernal, J.; Muñoz, A. "Identification of the mammalian homolog of the splicing regulator Suppressor-of-white-apricot as a thyroid hormone regulated gene.". Brain Res. Mol. Brain Res.. 71(2): 332-340. (1999). (PMID: 10521587).
    spacer

  126. Alvarez-Dolado, M.; Ruiz, M.; Del Río, J.A.; Alcántara, S.; Burgaya, F.; Sheldon, M.; Nakajima, K.; Bernal, J.; Howell, B.W.; Curran, T.; Soriano, E.; Muñoz, A. "Thyroid hormone regulates reelin and dab1 expression during brain development.". J. Neurosci.. 19(16): 6979-6993. (1999). (PMID: 10436054).
    spacer

  127. González-Sancho, J.M.; Alvarez-Dolado, M.; Caelles, C.; Muñoz, A. "Inhibition of tenascin-C expression in mammary epithelial cells by thyroid hormone.". Mol. Carcinog.. 24(2): 99-9107. (1999). (PMID: 10078937).
    spacer

  128. Casado, M.; Martin, M.; Muñoz, A.; Bernal, J. "Vitamin D3 inhibits proliferation and increases c-myc expression in fibroblasts from psoriatic patients.". J. Endocrinol. Invest.. 21(8): 520-525. (1998). (PMID: 9801993).
    spacer

  129. Llanos, S.; Caelles, C.; Azorín, I.; Renau-Piqueras, J.; Fernández-Luna, J.L.; Boscá, L.; Muñoz, A. "The c-erbA alpha protooncogene induces apoptosis in glial cells via a protein kinase C- and bcl-2-suppressible mechanism.". J. Neurochem.. 70(6): 2315-2326. (1998). (PMID: 9603196).
    spacer

  130. Alvarez-Dolado, M.; González-Sancho, J.M.; Bernal, J.; Muñoz, A. "Developmental expression of the tenascin-C is altered by hypothyroidism in the rat brain.". Neuroscience. 84(1): 309-322. (1998). (PMID: 9580330).
    spacer

  131. González-Sancho, J.M.; Alvarez-Dolado, M.; Muñoz, A. "1,25-Dihydroxyvitamin D3 inhibits tenascin-C expression in mammary epithelial cells.". FEBS Lett.. 426(2): 225-228. (1998). (PMID: 9599013).
    spacer

  132. García-Fernández, L.F.; Urade, Y.; Hayaishi, O.; Bernal, J.; Muñoz, A. "Identification of a thyroid hormone response element in the promoter region of the rat lipocalin-type prostaglandin D synthase (beta-trace) gene.". Brain Res. Mol. Brain Res.. 55(2): 321-330. (1998). (PMID: 9582446).
    spacer

  133. Caelles, C.; González-Sancho, J.M.; Muñoz, A. "Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway.". Genes Dev.. 11(24): 3351-3364. (1997). (PMID: 9407028).
    spacer

  134. Muñoz, A.; Bernal, J. "Biological activities of thyroid hormone receptors.". Eur. J. Endocrinol.. 137(5): 433-445. (1997). (PMID: 9405018).
    spacer

  135. García-Fernández, L.F.; Rausell, E.; Urade, Y.; Hayaishi, O.; Bernal, J.; Muñoz, A. "Hypothyroidism alters the expression of prostaglandin D2 synthase/beta trace in specific areas of the developing rat brain.". Eur. J. Neurosci.. 9(8): 1566-1573. (1997). (PMID: 9283811).
    spacer

  136. López-Barahona, M.; Iglesias, T.; García-Higuera, I.; Mayor, F.; Zaballos, A.; Bernal, J.; Muñoz, A. "Post-transcriptional induction of beta 1-adrenergic receptor by retinoic acid, but not triiodothyronine, in C6 glioma cells expressing thyroid hormone receptors.". Eur. J. Endocrinol.. 135(6): 709-715. (1996). (PMID: 9025717).
    spacer

  137. Iglesias, T.; Caubín, J.; Stunnenberg, H.G.; Zaballos, A.; Bernal, J.; Muñoz, A. "Thyroid hormone-dependent transcriptional repression of neural cell adhesion molecule during brain maturation.". EMBO J.. 15(16): 4307-4316. (1996). (PMID: 8861959).
    spacer

  138. Llanos, S.; Iglesias, T.; Riese, H.H.; Garrido, T.; Caelles, C.; Muñoz, A. "v-erbA oncogene induces invasiveness and anchorage-independent growth in cultured glial cells by mechanisms involving platelet-derived growth factor.". Cell Growth Differ.. 7(3): 373-382. (1996). (PMID: 8838867).
    spacer

  139. Iglesias, T.; Caubín, J.; Zaballos, A.; Bernal, J.; Muñoz, A. "Identification of the mitochondrial NADH dehydrogenase subunit 3 (ND3) as a thyroid hormone regulated gene by whole genome PCR analysis.". Biochem. Biophys. Res. Commun.. 210(3): 995-991000. (1995). (PMID: 7763274).
    spacer

  140. Iglesias, T.; Llanos, S.; López-Barahona, M.; Seliger, B.; Rodríguez-Peña, A.; Bernal, J.; Muñoz, A. "Induction of platelet-derived growth factor B/c-sis by the v-erbA oncogene in glial cells.". Oncogene. 10(6): 1103-1110. (1995). (PMID: 7700635).
    spacer

  141. López-Barahona, M.; Fialka, I.; González-Sancho, J.M.; Asunción, M.; González, M.; Iglesias, T.; Bernal, J.; Beug, H.; Muñoz, A. "Thyroid hormone regulates stromelysin expression, protease secretion and the morphogenetic potential of normal polarized mammary epithelial cells.". EMBO J.. 14(6): 1145-1155. (1995). (PMID: 7720705).
    spacer

  142. Iñiguez, M.A.; Morte, B.; Rodriguez-Peña, A.; Muñoz, A.; Gerendasy, D.; Sutcliffe, J.G.; Bernal, J. "Characterization of the promoter region and flanking sequences of the neuron-specific gene RC3 (neurogranin).". Brain Res. Mol. Brain Res.. 27(2): 205-214. (1994). (PMID: 7898304).
    spacer

  143. Alvarez-Dolado, M.; Iglesias, T.; Rodríguez-Peña, A.; Bernal, J.; Muñoz, A. "Expression of neurotrophins and the trk family of neurotrophin receptors in normal and hypothyroid rat brain.". Brain Res. Mol. Brain Res.. 27(2): 249-257. (1994). (PMID: 7898308).
    spacer

  144. Caubín, J.; Iglesias, T.; Bernal, J.; Muñoz, A.; Márquez, G.; Barbero, J.L.; Zaballos, A. "Isolation of genomic DNA fragments corresponding to genes modulated in vivo by a transcription factor.". Nucleic Acids Res.. 22(20): 4132-4138. (1994). (PMID: 7937138).
    spacer

  145. Iglesias, T.; Llanos, S.; López-Barahona, M.; Pérez-Aranda, A.; Rodríguez-Peña, A.; Bernal, J.; Höhne, A.; Seliger, B.; Muñoz, A. "c-erbA and v-erbA modulate growth and gene expression of a mouse glial precursor cell line.". Cell Growth Differ.. 5(7): 697-704. (1994). (PMID: 7947384).
    spacer

  146. López-Barahona, M.; Miñano, M.; Mira, E.; Iglesias, T.; Stunnenberg, H.G.; Rodríguez-Peña, A.; Bernal, J.; Muñoz, A. "Retinoic acid posttranscriptionally up-regulates proteolipid protein gene expression in C6 glioma cells.". J. Biol. Chem.. 268(34): 25617-25623. (1993). (PMID: 7503983).
    spacer

  147. García-Fernández, L.F.; Iñiguez, M.A.; Rodríguez-Peña, A.; Muñoz, A.; Bernal, J. "Brain-specific prostaglandin D2 synthetase mRNA is dependent on thyroid hormone during rat brain development.". Biochem. Biophys. Res. Commun.. 196(1): 396-401. (1993). (PMID: 8216319).
    spacer

  148. Iñiguez, M.A.; Rodriguez-Peña, A.; Ibarrola, N.; Aguilera, M.; Muñoz, A.; Bernal, J. "Thyroid hormone regulation of RC3, a brain-specific gene encoding a protein kinase-C substrate.". Endocrinology. 133(2): 467-473. (1993). (PMID: 8344193).
    spacer

  149. Muñoz, A.; Wrighton, C.; Seliger, B.; Bernal, J.; Beug, H. "Thyroid hormone receptor/c-erbA: control of commitment and differentiation in the neuronal/chromaffin progenitor line PC12.". J. Cell Biol.. 121(2): 423-438. (1993). (PMID: 8385673).
    spacer

  150. Rodriguez-Peña, A.; Ibarrola, N.; Iñiguez, M.A.; Muñoz, A.; Bernal, J. "Neonatal hypothyroidism affects the timely expression of myelin-associated glycoprotein in the rat brain.". J. Clin. Invest.. 91(3): 812-818. (1993). (PMID: 7680668).
    spacer

  151. Bernal, J.; Rodriguez-Pena, A.; Iniguez, M.A.; Ibarrola, N.; Munoz, A. "Influence of thyroid hormone on brain gene expression.". Acta Med. Austriaca. 19 Suppl 1(): 32-35. (1992). (PMID: 1519449).
    spacer

  152. Muñoz, A.; Rodriguez-Peña, A.; Perez-Castillo, A.; Ferreiro, B.; Sutcliffe, J.G.; Bernal, J. "Effects of neonatal hypothyroidism on rat brain gene expression.". Mol. Endocrinol.. 5(2): 273-280. (1991). (PMID: 1710032).
    spacer

  153. Fuerstenberg, S.; Beug, H.; Introna, M.; Khazaie, K.; Muñoz, A.; Ness, S.; Nordström, K.; Sap, J.; Stanley, I.; Zenke, M. "Ectopic expression of the erythrocyte band 3 anion exchange protein, using a new avian retrovirus vector.". J. Virol.. 64(12): 5891-5902. (1990). (PMID: 2173771).
    spacer

  154. Zenke, M.; Muñoz, A.; Sap, J.; Vennström, B.; Beug, H. "v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA.". Cell. 61(6): 1035-1049. (1990). (PMID: 1972036).
    spacer

  155. Forrest, D.; Muñoz, A.; Raynoschek, C.; Vennström, B.; Beug, H. "Requirement for the C-terminal domain of the v-erbA oncogene protein for biological function and transcriptional repression.". Oncogene. 5(3): 309-316. (1990). (PMID: 1969136).
    spacer

  156. Muñoz, A.; Höppner, W.; Sap, J.; Brady, G.; Nordström, K.; Seitz, H.J.; Vennström, B. "The chicken c-erbA alpha-product induces expression of thyroid hormone-responsive genes in 3,5,3'-triiodothyronine receptor-deficient rat hepatoma cells.". Mol. Endocrinol.. 4(2): 312-320. (1990). (PMID: 2158623).
    spacer

  157. Sap, J.; Muñoz, A.; Schmitt, J.; Stunnenberg, H.; Vennström, B. "Repression of transcription mediated at a thyroid hormone response element by the v-erb-A oncogene product.". Nature. 340(6230): 242-244. (1989). (PMID: 2569164).
    spacer

  158. Muñoz, A.; Zenke, M.; Gehring, U.; Sap, J.; Beug, H.; Vennström, B. "Characterization of the hormone-binding domain of the chicken c-erbA/thyroid hormone receptor protein.". EMBO J.. 7(1): 155-159. (1988). (PMID: 3359993).
    spacer

  159. Sap, J.; Muñoz, A.; Damm, K.; Goldberg, Y.; Ghysdael, J.; Leutz, A.; Beug, H.; Vennström, B. "The c-erb-A protein is a high-affinity receptor for thyroid hormone.". Nature. 324(6098): 635-640. (1987). (PMID: 2879242).
    spacer

  160. Muñoz, A.; García, R.A.; Pérez-Aranda, A. "Potentiation by levamisole, methisoprinol, and adenine or adenosine of the inhibitory activity of human interferon against encephalomyocarditis virus.". Antimicrob. Agents Chemother.. 30(1): 192-195. (1986). (PMID: 2428301).
    spacer

  161. Muñoz, A.; Perez-Aranda, A.; Barbero, J.L. "Cloning and expression of human interleukin 2 in Streptomyces lividans using the Escherichia coli consensus promoter.". Biochem. Biophys. Res. Commun.. 133(2): 511-519. (1985). (PMID: 3910038).
    spacer

  162. Muñoz, A.; Castrillo, J.L.; Carrasco, L. "Modification of membrane permeability during Semliki Forest virus infection.". Virology. 146(2): 203-212. (1985). (PMID: 4049733).
    spacer

  163. Muñoz, A.; Alonso, M.A.; Carrasco, L. "The regulation of translation in reovirus-infected cells.". J. Gen. Virol.. 66 ( Pt 10)(): 2161-2170. (1985). (PMID: 2995553).
    spacer

  164. Muñoz, A.; Alonso, M.A.; Carrasco, L. "Synthesis of heat-shock proteins in HeLa cells: inhibition by virus infection.". Virology. 137(1): 150-159. (1984). (PMID: 6089412).
    spacer

  165. Muñoz, A.; Carrasco, L. "Formation of non-infective herpesvirus particles in cultured cells treated with human interferon.". J. Gen. Virol.. 65 ( Pt 6)(): 1069-1078. (1984). (PMID: 6327892).
    spacer

  166. Muñoz, A.; Carrasco, L. "Action of human lymphoblastoid interferon on HeLa cells infected with RNA-containing animal viruses.". J. Gen. Virol.. 65 ( Pt 2)(): 377-390. (1984). (PMID: 6319580).
    spacer

  167. Muñoz, A.; Carrasco, L. "Effect of interferon treatment on blockade of protein synthesis induced by poliovirus infection.". Eur. J. Biochem.. 137(3): 623-629. (1983). (PMID: 6198175).
    spacer

  168. Muñoz, A.; Harvey, R.; Carrasco, L. "Cellular RNA is not degraded in interferon-treated HeLa cells after poliovirus infection.". FEBS Lett.. 160(1-2): 87-92. (1983). (PMID: 6309570).
    spacer

  169. Muñoz, A.; Carrasco, L.; Fresno, M. "Enhancement of susceptibility of HSV-1-infected cells to natural killer lysis by interferon.". J. Immunol.. 131(2): 783-787. (1983). (PMID: 6190939).
    spacer

  170. Muñoz, A.; Carrasco, L. "Reversal by hypotonic medium of the antiviral state induced by lymphoblastoid interferon in human HeLa cells.". Intervirology. 16(2): 106-113. (1981). (PMID: 6173348).
    spacer

  171. Muñoz, A.; Carrasco, L. "Protein synthesis and membrane integrity in interferon-treated HeLa cells infected with encephalomyocarditis virus.". J. Gen. Virol.. 56(Pt 1): 153-162. (1981). (PMID: 6170728).
    spacer

 

 

 

 

 

Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
Tel +(34) 91 585 4400 // Fax +(34) 91 558 4401
Email:Info