Tundidor, I.; Seijo-Vila, M.; Blasco-Benito, S.; Rubert-Hernández, M.; Moreno-Bueno, G.; Bindila, L.; de la Rosa, R.F.; Guzmán, M.; Sánchez, C.; Pérez-Gómez, E. "Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation.". Cell Death Discov. 10(1): 12. (2024). (PMID: 38184644).
Ostrowska-Lesko, M.; Rajtak, A.; Moreno-Bueno, G.; Bobinski, M. "Scientific and clinical relevance of non-cellular tumor microenvironment components in ovarian cancer chemotherapy resistance.". Biochim Biophys Acta Rev Cancer. 1879(1): 189036. (2023). (PMID: 38042260).
Colomo, S.; Ros-Pardo, D.; Oltra, S.S.; Gomez-Puertas, P.; Sarrio, D.; Moreno-Bueno, G. "Structural and functional insights into GSDMB isoforms complex roles in pathogenesis.". Cell Cycle. (): 1-14. (2023). (PMID: 38037340).
Sarrio, D.; Colomo, S.; Moreno-Bueno, G. "Gasdermin-B (GSDMB) takes center stage in antibacterial defense, inflammatory diseases, and cancer.". FEBS J. (): . (2023). (PMID: 37997534).
Lores, S.; Gámez-Chiachio, M.; Cascallar, M.; Ramos-Nebot, C.; Hurtado, P.; Alijas, S.; López López, R.; Piñeiro, R.; Moreno-Bueno, G.; de la Fuente, M. "Correction: Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment.". Biomater Sci. 11(12): 4397. (2023). (PMID: 37255382).
Lores, S.; Gámez-Chiachio, M.; Cascallar, M.; Ramos-Nebot, C.; Hurtado, P.; Alijas, S.; López López, R.; Piñeiro, R.; Moreno-Bueno, G.; de la Fuente, M. "Effectiveness of a novel gene nanotherapy based on putrescine for cancer treatment.". Biomater Sci. 11(12): 4210-4225. (2023). (PMID: 36790445).
Tundidor, I.; Seijo-Vila, M.; Blasco-Benito, S.; Rubert-Hernández, M.; Adámez, S.; Andradas, C.; Manzano, S.; Álvarez-López, I.; Sarasqueta, C.; Villa-Morales, M.; González-Lois, C.; Ramírez-Medina, E.; Almoguera, B.; Sánchez-López, A.J.; Bindila, L.; Hamann, S.; Arnold, N.; Röcken, C.; Heras-Murillo, I.; Sancho, D.; Moreno-Bueno, G.; Caffarel, M.M.; Guzmán, M.; Sánchez, C.; Pérez-Gómez, E. "Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer.". Nat Commun. 14(1): 3130. (2023). (PMID: 37253733).
Mendoza, G.; González-Pastor, R.; Sánchez, J.M.; Arce-Cerezo, A.; Quintanilla, M.; Moreno-Bueno, G.; Pujol, A.; Belmar-López, C.; de Martino, A.; Riu, E.; Rodriguez, T.A.; Martin-Duque, P. "The E1a Adenoviral Gene Upregulates the Yamanaka Factors to Induce Partial Cellular Reprogramming.". Cells. 12(9): . (2023). (PMID: 37174738).
Sarrio, D.; Rojo-Sebastián, A.; Teijo, A.; Pérez-López, M.; Díaz-Martín, E.; Martínez, L.; Morales, S.; García-Sanz, P.; Palacios, J.; Moreno-Bueno, G. "Gasdermin-B Pro-Tumor Function in Novel Knock-in Mouse Models Depends on the in vivo Biological Context.". Front Cell Dev Biol. 10(): 813929. (2022). (PMID: 35281099).
Mota, A.; Oltra, S.S.; Selenica, P.; Moiola, C.P.; Casas-Arozamena, C.; López-Gil, C.; Diaz, E.; Gatius, S.; Ruiz-Miro, M.; Calvo, A.; Rojo-Sebastián, A.; Hurtado, P.; Piñeiro, R.; Colas, E.; Gil-Moreno, A.; Reis-Filho, J.S.; Muinelo-Romay, L.; Abal, M.; Matias-Guiu, X.; Weigelt, B.; Moreno-Bueno, G. "Intratumor genetic heterogeneity and clonal evolution to decode endometrial cancer progression.". Oncogene. (): . (2022). (PMID: 35145232).
García-Estevez, L.; González-Martínez, S.; Moreno-Bueno, G. "The Leptin Axis and Its Association With the Adaptive Immune System in Breast Cancer.". Front Immunol. 12(): 784823. (2021). (PMID: 34868066).
García-Estévez, L.; Cortés, J.; Pérez, S.; Calvo, I.; Gallegos, I.; Moreno-Bueno, G. "Obesity and Breast Cancer: A Paradoxical and Controversial Relationship Influenced by Menopausal Status.". Front Oncol. 11(): 705911. (2021). (PMID: 34485137).
Grilli, G.; Hermida-Prado, F.; Álvarez-Fernández, M.; Allonca, E.; Álvarez-González, M.; Astudillo, A.; Moreno-Bueno, G.; Cano, A.; García-Pedrero, J.M.; Rodrigo, J.P. "Impact of notch signaling on the prognosis of patients with head and neck squamous cell carcinoma.". Oral Oncol.. 110(): 105003. (2020). (PMID: 32932170).
Mota, A.; S Oltra, S.; Moreno-Bueno, G. "Insight updating of the molecular hallmarks in ovarian carcinoma.". EJC Suppl. 15(): 16-26. (2020). (PMID: 33240439).
Abreu, M.; Cabezas-Sainz, P.; Alonso-Alconada, L.; Ferreirós, A.; Mondelo-Macía, P.; Lago-Lestón, R.M.; Abalo, A.; Díaz, E.; Palacios-Zambrano, S.; Rojo-Sebastian, A.; López-López, R.; Sánchez, L.; Moreno-Bueno, G.; Muinelo-Romay, L. "Circulating Tumor Cells Characterization Revealed TIMP1 as a Potential Therapeutic Target in Ovarian Cancer.". Cells. 9(5): . (2020). (PMID: 32423054).
Majem, B.; Parrilla, A.; Jiménez, C.; Suárez-Cabrera, L.; Barber, M.; Marín, A.; Castellví, J.; Tamayo, G.; Moreno-Bueno, G.; Ponce, J.; Matias-Guiu, X.; Alameda, F.; Romero, I.; Sánchez, J.L.; Pérez-Benavente, A.; Moran, S.; Esteller, M.; Reventós, J.; Rigau, M.; Gil-Moreno, A.; Segura, M.F.; Santamaría, A. "MicroRNA-654-5p suppresses ovarian cancer development impacting on MYC, WNT and AKT pathways.". Oncogene. 38(32): 6035-6050. (2019). (PMID: 31278368).
Vázquez-Ríos, A.J.; Molina-Crespo, Á.; Bouzo, B.L.; López-López, R.; Moreno-Bueno, G.; de la Fuente, M. "Exosome-mimetic nanoplatforms for targeted cancer drug delivery.". J Nanobiotechnology. 17(1): 85. (2019). (PMID: 31319859).
Molina-Crespo, Á.; Cadete, A.; Sarrio, D.; Gámez-Chiachio, M.; Martinez, L.; Chao, K.; Olivera, A.; Gonella, A.; Díaz, E.; Palacios, J.; Dhal, P.K.; Besev, M.; Rodríguez-Serrano, M.; García Bermejo, M.L.; Triviño, J.C.; Cano, A.; García-Fuentes, M.; Herzberg, O.; Torres, D.; Alonso, M.J.; Moreno-Bueno, G. "Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness.". Clin. Cancer Res.. (): . (2019). (PMID: 31064780).
Garcia-Estevez, L.; Moreno-Bueno, G. "Updating the role of obesity and cholesterol in breast cancer.". Breast Cancer Res.. 21(1): 35. (2019). (PMID: 30823902).
Blasco-Benito, S.; Moreno, E.; Seijo-Vila, M.; Tundidor, I.; Andradas, C.; Caffarel, M.M.; Caro-Villalobos, M.; Urigüen, L.; Diez-Alarcia, R.; Moreno-Bueno, G.; Hernández, L.; Manso, L.; Homar-Ruano, P.; McCormick, P.J.; Bibic, L.; Bernadó-Morales, C.; Arribas, J.; Canals, M.; Casadó, V.; Canela, E.I.; Guzmán, M.; Pérez-Gómez, E.; Sánchez, C. "Therapeutic targeting of HER2-CB2R heteromers in HER2-positive breast cancer.". Proc. Natl. Acad. Sci. U.S.A.. 116(9): 3863-3872. (2019). (PMID: 30733293).
Calvo-Sánchez, M.I.; Fernández-Martos, S.; Carrasco, E.; Moreno-Bueno, G.; Bernabéu, C.; Quintanilla, M.; Espada, J. "A role for the Tgf-β/Bmp co-receptor Endoglin in the molecular oscillator that regulates the hair follicle cycle.". J Mol Cell Biol. 11(1): 39-52. (2019). (PMID: 30239775).
Suárez-Cabrera, C.; de la Peña, B.; González, L.L.; Page, A.; Martínez-Fernández, M.; Casanova, M.L.; Paramio, J.M.; Rojo-Sebastián, A.; Moreno-Bueno, G.; Maroto, A.; Ramírez, Á.; Navarro, M. "The Ras-related gene ERAS is involved in human and murine breast cancer.". Sci Rep. 8(1): 13038. (2018). (PMID: 30158566).
Rincón-Fernández, D.; Culler, M.D.; Tsomaia, N.; Moreno-Bueno, G.; Luque, R.M.; Gahete, M.D.; Castaño, J.P. "In1-ghrelin splicing variant is associated with reduced disease-free survival of breast cancer patients and increases malignancy of breast cancer cells lines.". Carcinogenesis. 39(3): 447-457. (2018). (PMID: 29272342).
Figueras, A.; Alsina-Sanchís, E.; Lahiguera, Á.; Abreu, M.; Muinelo-Romay, L.; Moreno-Bueno, G.; Casanovas, O.; Graupera, M.; Matias-Guiu, X.; Vidal, A.; Villanueva, A.; Viñals, F. "A Role for CXCR4 in Peritoneal and Hematogenous Ovarian Cancer Dissemination.". Mol. Cancer Ther.. 17(2): 532-543. (2018). (PMID: 29146630).
Rodríguez-Ubreva, J.; Català-Moll, F.; Obermajer, N.; Álvarez-Errico, D.; Ramirez, R.N.; Company, C.; Vento-Tormo, R.; Moreno-Bueno, G.; Edwards, R.P.; Mortazavi, A.; Kalinski, P.; Ballestar, E. "Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells.". Cell Rep. 21(1): 154-167. (2017). (PMID: 28978469).
Mota, A.; Colás, E.; García-Sanz, P.; Campoy, I.; Rojo-Sebastián, A.; Gatius, S.; García, Á.; Chiva, L.; Alonso, S.; Gil-Moreno, A.; González-Tallada, X.; Díaz-Feijoo, B.; Vidal, A.; Ziober-Malinowska, P.; Bobiński, M.; López-López, R.; Abal, M.; Reventós, J.; Matias-Guiu, X.; Moreno-Bueno, G. "Genetic analysis of uterine aspirates improves the diagnostic value and captures the intra-tumor heterogeneity of endometrial cancers.". Mod. Pathol.. 30(1): 134-145. (2017). (PMID: 27586201).
Gahete, M.D.; Rincón-Fernández, D.; Durán-Prado, M.; Hergueta-Redondo, M.; Ibáñez-Costa, A.; Rojo-Sebastián, A.; Gracia-Navarro, F.; Culler, M.D.; Casanovas, O.; Moreno-Bueno, G.; Luque, R.M.; Castaño, J.P. "The truncated somatostatin receptor sst5TMD4 stimulates the angiogenic process and is associated to lymphatic metastasis and disease-free survival in breast cancer patients.". Oncotarget. 7(37): 60110-60122. (2016). (PMID: 27507050).
Serra-Musach, J.; Mateo, F.; Capdevila-Busquets, E.; de Garibay, G.R.; Zhang, X.; Guha, R.; Thomas, C.J.; Grueso, J.; Villanueva, A.; Jaeger, S.; Heyn, H.; Vizoso, M.; Pérez, H.; Cordero, A.; Gonzalez-Suarez, E.; Esteller, M.; Moreno-Bueno, G.; Tjärnberg, A.; Lázaro, C.; Serra, V.; Arribas, J.; Benson, M.; Gustafsson, M.; Ferrer, M.; Aloy, P.; Pujana, M.À. "Cancer network activity associated with therapeutic response and synergism.". Genome Med. 8(1): 88. (2016). (PMID: 27553366).
RESULTS The effects of drug classes were associated with CNAs formed by different cell lines. CNAs also differentiate target families and effector pathways. Proteins that occupy a central position in the network largely contribute to CNA. Known key cancer-associated biological processes, signaling pathways, and master regulators also contribute to CNA. Moreover, the major cancer drivers frequently mediate CNA and therapeutic differences. Cell-based assays centered on these differences and using uncorrelated drug effects reveals novel synergistic combinations for the treatment of breast cancer dependent on PI3K-mTOR signaling.
CONCLUSIONS Cancer therapeutic responses can be predicted on the basis of a systems-level analysis of molecular interactions and gene expression. Fundamental cancer processes, pathways, and drivers contribute to this feature, which can also be exploited to predict precise synergistic drug combinations.
Adrados, I.; Larrasa-Alonso, J.; Galarreta, A.; López-Antona, I.; Menéndez, C.; Abad, M.; Gil, J.; Moreno-Bueno, G.; Palmero, I. "The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes.". Oncogene. 35(27): 3485-3494. (2016). (PMID: 26500063).
Santacana, M.; Coronado, P.; Matias-Guiu, X.; Romero, I.; Casado, A.; Gil-Moreno, A.; Dosil, M.A.; Mota, A.; Moreno-Bueno, G.; Dolcet, X.; Llombart-Cussac, A.; Poveda, A. "Biological Effects of Temsirolimus on the mTOR Pathway in Endometrial Carcinoma: A Pharmacodynamic Phase II Study.". Int. J. Gynecol. Cancer. (): . (2016). (PMID: 27258723).
Nuñez, O.; Román, A.; Johnson, S.R.; Inoue, Y.; Hirose, M.; Casanova, Á.; de Garibay, G.R.; Herranz, C.; Bueno-Moreno, G.; Boni, J.; Mateo, F.; Petit, A.; Climent, F.; Soler, T.; Vidal, A.; Sánchez-Mut, J.V.; Esteller, M.; López, J.I.; García, N.; Gumà, A.; Ortega, R.; Plà, M.J.; Campos, M.; Ansótegui, E.; Molina-Molina, M.; Valenzuela, C.; Ussetti, P.; Laporta, R.; Ancochea, J.; Xaubet, A.; Pollán, M.; Pujana, M.A. "Study of breast cancer incidence in patients of lymphangioleiomyomatosis.". Breast Cancer Res. Treat.. 156(1): 195-201. (2016). (PMID: 26951504).
Romero-Pérez, L.; Garcia-Sanz, P.; Mota, A.; Leskelä, S.; Hergueta-Redondo, M.; Díaz-Martín, J.; López-García, M.A.; Castilla, M.A.; Martínez-Ramírez, A.; Soslow, R.A.; Matias-Guiu, X.; Moreno-Bueno, G.; Palacios, J. "A role for the transducer of the Hippo pathway, TAZ, in the development of aggressive types of endometrial cancer.". Mod. Pathol.. 28(11): 1492-1503. (2015). (PMID: 26381823).
Castellana, B.; Aasen, T.; Moreno-Bueno, G.; Dunn, S.E.; Ramón y Cajal, S. "Interplay between YB-1 and IL-6 promotes the metastatic phenotype in breast cancer cells.". Oncotarget. 6(35): 38239-38256. (2015). (PMID: 26512918).
Canesin, G.; Cuevas, E.P.; Santos, V.; López-Menéndez, C.; Moreno-Bueno, G.; Huang, Y.; Csiszar, K.; Portillo, F.; Peinado, H.; Lyden, D.; Cano, A. "Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization.". Oncogene. 34(8): 951-964. (2015). (PMID: 24632622).
Díaz-López, A.; Díaz-Martín, J.; Moreno-Bueno, G.; Cuevas, E.P.; Santos, V.; Olmeda, D.; Portillo, F.; Palacios, J.; Cano, A. "Zeb1 and Snail1 engage miR-200f transcriptional and epigenetic regulation during EMT.". Int. J. Cancer. 136(4): E62-73. (2015). (PMID: 25178837).
Santacana, M.; Maiques, O.; Valls, J.; Gatius, S.; Abó, A.I.; López-García, M.Á.; Mota, A.; Reventós, J.; Moreno-Bueno, G.; Palacios, J.; Bartosch, C.; Dolcet, X.; Matias-Guiu, X. "A 9-protein biomarker molecular signature for predicting histologic type in endometrial carcinoma by immunohistochemistry.". Hum. Pathol.. 45(12): 2394-2403. (2014). (PMID: 25282036).
Garcia-Sanz, P.; Quintanilla, A.; Lafita, M.C.; Moreno-Bueno, G.; García-Gutierrez, L.; Tabor, V.; Varela, I.; Shiio, Y.; Larsson, L.G.; Portillo, F.; Leon, J. "Sin3b interacts with Myc and decreases Myc levels.". J. Biol. Chem.. 289(32): 22221-22236. (2014). (PMID: 24951594).
Llauradó, M.; Majem, B.; Altadill, T.; Lanau, L.; Castellví, J.; Sánchez-Iglesias, J.L.; Cabrera, S.; De la Torre, J.; Díaz-Feijoo, B.; Pérez-Benavente, A.; Colás, E.; Olivan, M.; Doll, A.; Alameda, F.; Matias-Guiu, X.; Moreno-Bueno, G.; Carey, M.S.; Del Campo, J.M.; Gil-Moreno, A.; Reventós, J.; Rigau, M. "MicroRNAs as prognostic markers in ovarian cancer.". Mol. Cell. Endocrinol.. 390(1-2): 73-84. (2014). (PMID: 24747602).
Moreno, A.; Soleto, I.; García-Sanz, P.; Moreno-Bueno, G.; Palmero, I. "ING4 regulates a secretory phenotype in primary fibroblasts with dual effects on cell proliferation and tumor growth.". Oncogene. 33(15): 1945-1953. (2014). (PMID: 23604125).
Díaz-López, A.; Moreno-Bueno, G.; Cano, A. "Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives.". Cancer Manag Res. 6(): 205-216. (2014). (PMID: 24812525).
Romero-Pérez, L.; Castilla, M.Á.; López-García, M.Á.; Díaz-Martín, J.; Biscuola, M.; Ramiro-Fuentes, S.; Oliva, E.; Matias-Guiu, X.; Prat, J.; Cano, A.; Moreno-Bueno, G.; Palacios, J. "Molecular events in endometrial carcinosarcomas and the role of high mobility group AT-hook 2 in endometrial carcinogenesis.". Hum. Pathol.. 44(2): 244-254. (2013). (PMID: 22974476).
Ocaña, O.H.; Córcoles, R.; Fabra, A.; Moreno-Bueno, G.; Acloque, H.; Vega, S.; Barrallo-Gimeno, A.; Cano, A.; Nieto, M.A. "Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1.". Cancer Cell. 22(6): 709-724. (2012). (PMID: 23201163).
Cano, A.; Santamaría, P.G.; Moreno-Bueno, G. "LOXL2 in epithelial cell plasticity and tumor progression.". Future Oncol. 8(9): 1095-1108. (2012). (PMID: 23030485).
Durán-Prado, M.; Gahete, M.D.; Hergueta-Redondo, M.; Martínez-Fuentes, A.J.; Córdoba-Chacón, J.; Palacios, J.; Gracia-Navarro, F.; Moreno-Bueno, G.; Malagón, M.M.; Luque, R.M.; Castaño, J.P. "The new truncated somatostatin receptor variant sst5TMD4 is associated to poor prognosis in breast cancer and increases malignancy in MCF-7 cells.". Oncogene. 31(16): 2049-2061. (2012). (PMID: 21927030).
Gahete, M.D.; Córdoba-Chacón, J.; Hergueta-Redondo, M.; Martínez-Fuentes, A.J.; Kineman, R.D.; Moreno-Bueno, G.; Luque, R.M.; Castaño, J.P. "A novel human ghrelin variant (In1-ghrelin) and ghrelin-O-acyltransferase are overexpressed in breast cancer: potential pathophysiological relevance.". PLoS ONE. 6(8): e23302. (2011). (PMID: 21829727).
Llobet, D.; Eritja, N.; Domingo, M.; Bergada, L.; Mirantes, C.; Santacana, M.; Pallares, J.; Macià, A.; Yeramian, A.; Encinas, M.; Moreno-Bueno, G.; Palacios, J.; Lewis, R.E.; Matias-Guiu, X.; Dolcet, X. "KSR1 is overexpressed in endometrial carcinoma and regulates proliferation and TRAIL-induced apoptosis by modulating FLIP levels.". Am. J. Pathol.. 178(4): 1529-1543. (2011). (PMID: 21435442).
Abad, M.; Moreno, A.; Palacios, A.; Narita, M.; Blanco, F.; Moreno-Bueno, G.; Narita, M.; Palmero, I. "The tumor suppressor ING1 contributes to epigenetic control of cellular senescence.". Aging Cell. 10(1): 158-171. (2011). (PMID: 21078114).
Castilla, M.Á.; Moreno-Bueno, G.; Romero-Pérez, L.; Van De Vijver, K.; Biscuola, M.; López-García, M.Á.; Prat, J.; Matías-Guiu, X.; Cano, A.; Oliva, E.; Palacios, J. "Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma.". J. Pathol.. 223(1): 72-80. (2011). (PMID: 21125666).
Castilla, M.A.; Moreno-Bueno, G.; Romero-Pérez, L.; De Vijver, K.V.; Biscuola, M.; López-García, M.A.; Prat, J.; Matías-Guiu, X.; Cano, A.; Oliva, E.; Palacios, J. "Micro-RNA signature of the epithelial-mesenchymal transition in endometrial carcinosarcoma.". J. Pathol.. (): . (2010). (PMID: 21038317).
Caffarel, M.M.; Andradas, C.; Mira, E.; Pérez-Gómez, E.; Cerutti, C.; Moreno-Bueno, G.; Flores, J.M.; García-Real, I.; Palacios, J.; Mañes, S.; Guzmán, M.; Sánchez, C. "Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition.". Mol. Cancer. 9(): 196. (2010). (PMID: 20649976).
Geyer, J.T.; López-García, M.A.; Sánchez-Estevez, C.; Sarrió, D.; Moreno-Bueno, G.; Franceschetti, I.; Palacios, J.; Oliva, E. "Pathogenetic pathways in ovarian endometrioid adenocarcinoma: a molecular study of 29 cases.". Am. J. Surg. Pathol.. 33(8): 1157-1163. (2009). (PMID: 19542870).
Fernandez-Marcos, P.J.; Abu-Baker, S.; Joshi, J.; Galvez, A.; Castilla, E.A.; Cañamero, M.; Collado, M.; Saez, C.; Moreno-Bueno, G.; Palacios, J.; Leitges, M.; Serrano, M.; Moscat, J.; Diaz-Meco, M.T. "Simultaneous inactivation of Par-4 and PTEN in vivo leads to synergistic NF-kappaB activation and invasive prostate carcinoma.". Proc. Natl. Acad. Sci. U.S.A.. 106(31): 12962-12967. (2009). (PMID: 19470463).
CONCLUSIONS Our results show the power of aCGH analysis in unraveling the genetic profiles of specific subgroups of cancer and for the identification of novel therapeutic targets.
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Sarrió, D.; Palacios, J.; Hergueta-Redondo, M.; Gómez-López, G.; Cano, A.; Moreno-Bueno, G. "Functional characterization of E- and P-cadherin in invasive breast cancer cells.". BMC Cancer. 9(): 74. (2009). (PMID: 19257890).
Fabre-Guillevin, E.; Malo, M.; Cartier-Michaud, A.; Peinado, H.; Moreno-Bueno, G.; Vallée, B.; Lawrence, D.A.; Palacios, J.; Cano, A.; Barlovatz-Meimon, G.; Charrière-Bertrand, C. "PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.". Breast Cancer Res.. 10(6): R100. (2008). (PMID: 19055748).
Moreno-Bueno, G.; Portillo, F.; Cano, A. "Transcriptional regulation of cell polarity in EMT and cancer.". Oncogene. 27(55): 6958-6969. (2008). (PMID: 19029937).
Durán, M.C.; Vega, F.; Moreno-Bueno, G.; Artiga, M.J.; Sanchez, L.; Palacios, J.; Ridley, A.; Timms, J.F. "Characterisation of tumoral markers correlated with ErbB2 (HER2/Neu) overexpression and metastasis in breast cancer.". Proteomics Clin Appl. 2(9): 1313-1326. (2008). (PMID: 21136925).
Turbiner, J.; Moreno-Bueno, G.; Dahiya, S.; Sánchez-Estevez, C.; Hardisson, D.; Prat, J.; Oliva, E.; Palacios, J. "Clinicopathological and molecular analysis of endometrial carcinoma associated with tamoxifen.". Mod. Pathol.. 21(8): 925-936. (2008). (PMID: 18500270).
Caffarel, M.M.; Moreno-Bueno, G.; Cerutti, C.; Palacios, J.; Guzman, M.; Mechta-Grigoriou, F.; Sanchez, C. "JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells.". Oncogene. 27(37): 5033-5044. (2008). (PMID: 18454173).
Olmeda, D.; Montes, A.; Moreno-Bueno, G.; Flores, J.M.; Portillo, F.; Cano, A. "Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines.". Oncogene. 27(34): 4690-4701. (2008). (PMID: 18408755).
Sarrió, D.; Rodriguez-Pinilla, S.M.; Hardisson, D.; Cano, A.; Moreno-Bueno, G.; Palacios, J. "Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype.". Cancer Res.. 68(4): 989-997. (2008). (PMID: 18281472).
Olmeda, D.; Moreno-Bueno, G.; Flores, J.M.; Fabra, A.; Portillo, F.; Cano, A. "SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells.". Cancer Res.. 67(24): 11721-11731. (2007). (PMID: 18089802).
Hernández-Vargas, H.; von Kobbe, C.; Sánchez-Estévez, C.; Julián-Tendero, M.; Palacios, J.; Moreno-Bueno, G. "Inhibition of paclitaxel-induced proteasome activation influences paclitaxel cytotoxicity in breast cancer cells in a sequence-dependent manner.". Cell Cycle. 6(21): 2662-2668. (2007). (PMID: 17912036).
Rodríguez-Pinilla, S.M.; Sarrió, D.; Honrado, E.; Moreno-Bueno, G.; Hardisson, D.; Calero, F.; Benítez, J.; Palacios, J. "Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas.". J. Clin. Pathol.. 60(9): 1006-1012. (2007). (PMID: 17105822).
Hernández-Vargas, H.; Palacios, J.; Moreno-Bueno, G. "Molecular profiling of docetaxel cytotoxicity in breast cancer cells: uncoupling of aberrant mitosis and apoptosis.". Oncogene. 26(20): 2902-2913. (2007). (PMID: 17099726).
Hernández-Vargas, H.; Rodríguez-Pinilla, S.M.; Julián-Tendero, M.; Sánchez-Rovira, P.; Cuevas, C.; Antón, A.; Ríos, M.J.; Palacios, J.; Moreno-Bueno, G. "Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance.". Breast Cancer Res. Treat.. 102(2): 157-172. (2007). (PMID: 17039268).
Rodriguez-Pinilla, S.M.; Sarrio, D.; Moreno-Bueno, G.; Rodriguez-Gil, Y.; Martinez, M.A.; Hernandez, L.; Hardisson, D.; Reis-Filho, J.S.; Palacios, J. "Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer.". Mod. Pathol.. 20(4): 474-481. (2007). (PMID: 17334350).
Rodríguez-Pinilla, S.M.; Rodríguez-Gil, Y.; Moreno-Bueno, G.; Sarrió, D.; Martín-Guijarro, M.d.e.l. .C.; Hernandez, L.; Palacios, J. "Sporadic invasive breast carcinomas with medullary features display a basal-like phenotype: an immunohistochemical and gene amplification study.". Am. J. Surg. Pathol.. 31(4): 501-508. (2007). (PMID: 17414096).
Hernández-Vargas, H.; Palacios, J.; Moreno-Bueno, G. "Telling cells how to die: docetaxel therapy in cancer cell lines.". Cell Cycle. 6(7): 780-783. (2007). (PMID: 17377494).
Moreno-Bueno, G.; Fernandez-Marcos, P.J.; Collado, M.; Tendero, M.J.; Rodriguez-Pinilla, S.M.; Garcia-Cao, I.; Hardisson, D.; Diaz-Meco, M.T.; Moscat, J.; Serrano, M.; Palacios, J. "Inactivation of the candidate tumor suppressor par-4 in endometrial cancer.". Cancer Res.. 67(5): 1927-1934. (2007). (PMID: 17332319).
Molina-Arcas, M.; Moreno-Bueno, G.; Cano-Soldado, P.; Hernández-Vargas, H.; Casado, F.J.; Palacios, J.; Pastor-Anglada, M. "Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5'-DFUR in breast cancer MCF7 cells.". Biochem. Pharmacol.. 72(12): 1646-1656. (2006). (PMID: 16965766).
Moreno-Bueno, G.; Cubillo, E.; Sarrió, D.; Peinado, H.; Rodríguez-Pinilla, S.M.; Villa, S.; Bolós, V.; Jordá, M.; Fabra, A.; Portillo, F.; Palacios, J.; Cano, A. "Genetic profiling of epithelial cells expressing E-cadherin repressors reveals a distinct role for Snail, Slug, and E47 factors in epithelial-mesenchymal transition.". Cancer Res.. 66(19): 9543-9556. (2006). (PMID: 17018611).
Hernández-Vargas, H.; Ballestar, E.; Carmona-Saez, P.; von Kobbe, C.; Bañón-Rodríguez, I.; Esteller, M.; Moreno-Bueno, G.; Palacios, J. "Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53.". Int. J. Cancer. 119(5): 1164-1175. (2006). (PMID: 16557594).
Sarrió, D.; Moreno-Bueno, G.; Sánchez-Estévez, C.; Bañón-Rodríguez, I.; Hernández-Cortés, G.; Hardisson, D.; Palacios, J. "Expression of cadherins and catenins correlates with distinct histologic types of ovarian carcinomas.". Hum. Pathol.. 37(8): 1042-1049. (2006). (PMID: 16867867).
Moreno-Bueno, G.; Sanchez-Estevez, C.; Palacios, J.; Hardisson, D.; Shiozawa, T. "Low frequency of BRAF mutations in endometrial and in cervical carcinomas.". Clin. Cancer Res.. 12(12): 3865; author reply 3865-6. (2006). (PMID: 16778116).
Oliva, E.; Sarrió, D.; Brachtel, E.F.; Sánchez-Estévez, C.; Soslow, R.A.; Moreno-Bueno, G.; Palacios, J. "High frequency of beta-catenin mutations in borderline endometrioid tumours of the ovary.". J Pathol. 208(5): 708-713. (2006). (PMID: 16429393).
Brachtel, E.F.; Sánchez-Estevez, C.; Moreno-Bueno, G.; Prat, J.; Palacios, J.; Oliva, E. "Distinct molecular alterations in complex endometrial hyperplasia (CEH) with and without immature squamous metaplasia (squamous morules).". Am J Surg Pathol. 29(10): 1322-1329. (2005). (PMID: 16160475).
Matar, P.; Rojo, F.; Cassia, R.; Moreno-Bueno, G.; Di Cosimo, S.; Tabernero, J.; Guzmán, M.; Rodriguez, S.; Arribas, J.; Palacios, J.; Baselga, J. "Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting.". Clin. Cancer Res.. 10(19): 6487-6501. (2004). (PMID: 15475436).
Moreno-Bueno, G.; Rodríguez-Perales, S.; Sánchez-Estévez, C.; Marcos, R.; Hardisson, D.; Cigudosa, J.C.; Palacios, J. "Molecular alterations associated with cyclin D1 overexpression in endometrial cancer.". Int. J. Cancer. 110(2): 194-200. (2004). (PMID: 15069681).
Sarrió, D.; Pérez-Mies, B.; Hardisson, D.; Moreno-Bueno, G.; Suárez, A.; Cano, A.; Martín-Pérez, J.; Gamallo, C.; Palacios, J. "Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions.". Oncogene. 23(19): 3272-3283. (2004). (PMID: 15077190).
Moreno-Bueno, G.; Hardisson, D.; Prat, J.; Matías-Guiu, J.; Palacios, J. "Re: Scholten et al. Nuclear beta-catenin is a molecular feature of type I endometrial carcinoma. J Pathol 2003; 201: 460-465.". J. Pathol.. 202(4): 511-512. (2004). (PMID: 15095279).
Cassia, R.; Moreno-Bueno, G.; Rodríguez-Perales, S.; Hardisson, D.; Cigudosa, J.C.; Palacios, J. "Cyclin E gene (CCNE) amplification and hCDC4 mutations in endometrial carcinoma.". J. Pathol.. 201(4): 589-595. (2003). (PMID: 14648662).
Hardisson, D.; Moreno-Bueno, G.; Sánchez, L.; Sarrió, D.; Suárez, A.; Calero, F.; Palacios, J. "Tissue microarray immunohistochemical expression analysis of mismatch repair (hMLH1 and hMSH2 genes) in endometrial carcinoma and atypical endometrial hyperplasia: relationship with microsatellite instability.". Mod. Pathol.. 16(11): 1148-1158. (2003). (PMID: 14614055).
Moreno-Bueno, G.; Sánchez-Estévez, C.; Cassia, R.; Rodríguez-Perales, S.; Díaz-Uriarte, R.; Domínguez, O.; Hardisson, D.; Andujar, M.; Prat, J.; Matias-Guiu, X.; Cigudosa, J.C.; Palacios, J. "Differential gene expression profile in endometrioid and nonendometrioid endometrial carcinoma: STK15 is frequently overexpressed and amplified in nonendometrioid carcinomas.". Cancer Res.. 63(18): 5697-5702. (2003). (PMID: 14522886).
Sarrió, D.; Moreno-Bueno, G.; Hardisson, D.; Sánchez-Estévez, C.; Guo, M.; Herman, J.G.; Gamallo, C.; Esteller, M.; Palacios, J. "Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability.". Int. J. Cancer. 106(2): 208-215. (2003). (PMID: 12800196).
Moreno-Bueno, G.; Hardisson, D.; Sarrió, D.; Sánchez, C.; Cassia, R.; Prat, J.; Herman, J.G.; Esteller, M.; Matías-Guiu, X.; Palacios, J. "Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia.". J. Pathol.. 199(4): 471-478. (2003). (PMID: 12635138).
Moreno-Bueno, G.; Hardisson, D.; Sánchez, C.; Sarrió, D.; Cassia, R.; García-Rostán, G.; Prat, J.; Guo, M.; Herman, J.G.; Matías-Guiu, X.; Esteller, M.; Palacios, J. "Abnormalities of the APC/beta-catenin pathway in endometrial cancer.". Oncogene. 21(52): 7981-7990. (2002). (PMID: 12439748).
Blanco, M.J.; Moreno-Bueno, G.; Sarrio, D.; Locascio, A.; Cano, A.; Palacios, J.; Nieto, M.A. "Correlation of Snail expression with histological grade and lymph node status in breast carcinomas.". Oncogene. 21(20): 3241-3246. (2002). (PMID: 12082640).
Gras, E.; Catasus, L.; Argüelles, R.; Moreno-Bueno, G.; Palacios, J.; Gamallo, C.; Matias-Guiu, X.; Prat, J. "Microsatellite instability, MLH-1 promoter hypermethylation, and frameshift mutations at coding mononucleotide repeat microsatellites in ovarian tumors.". Cancer. 92(11): 2829-2836. (2001). (PMID: 11753956).
Moreno-Bueno, G.; Gamallo, C.; Pérez-Gallego, L.; Contreras, F.; Palacios, J. "beta-catenin expression in pilomatrixomas. Relationship with beta-catenin gene mutations and comparison with beta-catenin expression in normal hair follicles.". Br. J. Dermatol.. 145(4): 576-581. (2001). (PMID: 11703283).
Rodríguez-Salas, N.; Palacios, J.; Moreno, G.; de Castro, J.; González-Barón, M.; Gamallo, C. "Correlation of p53 oncoprotein expression with chemotherapy response in small cell lung carcinomas.". Lung Cancer. 34(1): 67-74. (2001). (PMID: 11557115).
Pérez-Gallego, L.; Moreno-Bueno, G.; Sarrió, D.; Suárez, A.; Gamallo, C.; Palacios, J. "Human papillomavirus-16 E6 variants in cervical squamous intraepithelial lesions from HIV-negative and HIV-positive women.". Am. J. Clin. Pathol.. 116(1): 143-148. (2001). (PMID: 11447745).
Gamallo, C.; Moreno-Bueno, G.; Sarrió, D.; Calero, F.; Hardisson, D.; Palacios, J. "The prognostic significance of P-cadherin in infiltrating ductal breast carcinoma.". Mod. Pathol.. 14(7): 650-654. (2001). (PMID: 11454996).
Moreno-Bueno, G.; Gamallo, C.; Pérez-Gallego, L.; de Mora, J.C.; Suárez, A.; Palacios, J. "beta-Catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas.". Diagn. Mol. Pathol.. 10(2): 116-122. (2001). (PMID: 11385321).
Palacios, J.; Catasús, L.; Moreno-Bueno, G.; Matias-Guiu, X.; Prat, J.; Gamallo, C. "Beta- and gamma-catenin expression in endometrial carcinoma. Relationship with clinicopathological features and microsatellite instability.". Virchows Arch.. 438(5): 464-469. (2001). (PMID: 11407474).
Rodríguez-Salas, N.; Palacios, J.; de Castro, J.; Moreno, G.; González-Barón, M.; Gamallo, C. "Beta-catenin expression pattern in small cell lung cancer: correlation with clinical and evolutive features.". Histol. Histopathol.. 16(2): 353-358. (2001). (PMID: 11332690).
de Castro, J.; Gamallo, C.; Palacios, J.; Moreno-Bueno, G.; Rodríguez, N.; Feliu, J.; González-Barón, M. "beta-catenin expression pattern in primary oesophageal squamous cell carcinoma. Relationship with clinicopathologic features and clinical outcome.". Virchows Arch.. 437(6): 599-604. (2000). (PMID: 11193470).
Moreno-Bueno, G.; Calés, C.; Behrens, M.M.; Fernández-Renart, M. "Isolation and characterization of casein kinase I from Dictyostelium discoideum.". Biochem. J.. 349(Pt 2): 527-537. (2000). (PMID: 10880352).
Gamallo, C.; Palacios, J.; Moreno, G.; Calvo de Mora, J.; Suárez, A.; Armas, A. "beta-catenin expression pattern in stage I and II ovarian carcinomas : relationship with beta-catenin gene mutations, clinicopathological features, and clinical outcome.". Am. J. Pathol.. 155(2): 527-536. (1999). (PMID: 10433945).
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