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PUBLICACIONES

 

 

spacerTrabajos Publicados por Antonio Castrillo Viguera
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  1. Sánchez-García, S.; Povo-Retana, A.; Marin, S.; Madurga, S.; Fariñas, M.; Aleixandre, N.; Castrillo, A.; de la Rosa, J.V.; Alvarez-Lucena, C.; Landauro-Vera, R.; Prieto, P.; Cascante, M.; Boscá, L. "Immunometabolic Effect of Nitric Oxide on Human Macrophages Challenged With the SARS-CoV2-Induced Cytokine Storm. A Fluxomic Approach.". Adv Healthc Mater. (): e2401688. (2024). (PMID: 39502019).
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  2. Domínguez-Luis, M.J.; Castro-Hernández, J.; Santos-Concepción, S.; Díaz-Martín, A.; Arce-Franco, M.; Pérez-González, N.; Díaz, M.; Castrillo, A.; Salido, E.; Machado, J.D.; Gumá, M.; Corr, M.; Díaz-González, F. "Modulation of the K/BxN arthritis mouse model and the effector functions of human fibroblast-like synoviocytes by liver X receptors.". Eur J Immunol. (): e2451136. (2024). (PMID: 39148175).
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  3. Hernández-Hernández, I.; De La Rosa, J.V.; Martín-Rodríguez, P.; Díaz-Sarmiento, M.; Recio, C.; Guerra, B.; Fernández-Pérez, L.; León, T.E.; Torres, R.; Font-Díaz, J.; Roig, A.; de Mora, F.; Boscá, L.; Díaz, M.; Valledor, A.F.; Castrillo, A.; Tabraue, C. "Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation.". Cell Mol Life Sci. 81(1): 287. (2024). (PMID: 38970705).
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  4. Vladimir de la Rosa, J.; Tabraue, C.; Huang, Z.; Orizaola, M.C.; Martin-Rodríguez, P.; Steffensen, K.R.; Zapata, J.M.; Boscá, L.; Tontonoz, P.; Alemany, S.; Treuter, E.; Castrillo, A. "Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses.". Adv Sci (Weinh). (): e2307201. (2024). (PMID: 38549193).
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  5. Fernández-Pérez, L.; Guerra, B.; Recio, C.; Cabrera-Galván, J.J.; García, I.; De La Rosa, J.V.; Castrillo, A.; Iglesias-Gato, D.; Díaz, M. "Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver.". Front Endocrinol (Lausanne). 14(): 1266150. (2023). (PMID: 38144555).
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  6. Povo-Retana, A.; Fariñas, M.; Landauro-Vera, R.; Mojena, M.; Alvarez-Lucena, C.; Fernández-Moreno, M.A.; Castrillo, A.; de la Rosa Medina, J.V.; Sánchez-García, S.; Foguet, C.; Mas, F.; Marin, S.; Cascante, M.; Boscá, L. "Immunometabolic actions of trabectedin and lurbinectedin on human macrophages: relevance for their anti-tumor activity.". Front Immunol. 14(): 1211068. (2023). (PMID: 37675104).
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  7. Fernández-García, V.; González-Ramos, S.; Martín-Sanz, P.; Castrillo, A.; Boscá, L. "Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis.". Pharmacol Res. 183(): 106386. (2022). (PMID: 35933006).
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  8. Fernández-García, V.; González-Ramos, S.; Avendaño-Ortiz, J.; Martín-Sanz, P.; Gómez-Coronado, D.; Delgado, C.; Castrillo, A.; Boscá, L. "High-fat diet activates splenic NOD1 and enhances neutrophil recruitment and neutrophil extracellular traps release in the spleen of ApoE-deficient mice.". Cell Mol Life Sci. 79(8): 396. (2022). (PMID: 35789437).
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  9. López-Mateo, I.; Rodríguez-Muñoz, D.; de La Rosa, J.V.; Castrillo, A.; Alemany, S.; Aranda, A. "Regulation of metabolic and transcriptional responses by the thyroid hormone in cellular models of murine macrophages.". Front Immunol. 13(): 923727. (2022). (PMID: 35935955).
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  10. Fernández-García, V.; González-Ramos, S.; Avendaño-Ortiz, J.; Martín-Sanz, P.; Delgado, C.; Castrillo, A.; Boscá, L. "NOD1 splenic activation confers ferroptosis protection and reduces macrophage recruitment under pro-atherogenic conditions.". Biomed Pharmacother. 148(): 112769. (2022). (PMID: 35247718).
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  11. González de la Aleja, A.; Herrero, C.; Torres-Torresano, M.; de la Rosa, J.V.; Alonso, B.; Capa-Sardón, E.; Muller, I.B.; Jansen, G.; Puig-Kröger, A.; Vega, M.A.; Castrillo, A.; Corbí, Á.L. "Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages.". Front Immunol. 13(): 835478. (2022). (PMID: 35280993).
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  12. Ramírez, C.M.; Torrecilla-Parra, M.; Pardo-Marqués, V.; de-Frutos, M.F.; Pérez-García, A.; Tabraue, C.; de la Rosa, J.V.; Martín-Rodriguez, P.; Díaz-Sarmiento, M.; Nuñez, U.; Orizaola, M.C.; Través, P.G.; Camps, M.; Boscá, L.; Castrillo, A. "Crosstalk Between LXR and Caveolin-1 Signaling Supports Cholesterol Efflux and Anti-Inflammatory Pathways in Macrophages.". Front Endocrinol (Lausanne). 12(): 635923. (2021). (PMID: 34122329).
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  13. Font-Díaz, J.; Jiménez-Panizo, A.; Caelles, C.; Vivanco, M.D.; Pérez, P.; Aranda, A.; Estébanez-Perpiñá, E.; Castrillo, A.; Ricote, M.; Valledor, A.F. "Nuclear receptors: lipid and hormone sensors with essential roles in the control of cancer development.". Semin Cancer Biol. (): . (2020). (PMID: 33309851).
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  14. Carbó, J.M.; León, T.E.; Font-Díaz, J.; De la Rosa, J.V.; Castrillo, A.; Picard, F.R.; Staudenraus, D.; Huber, M.; Cedó, L.; Escolà-Gil, J.C.; Campos, L.; Bakiri, L.; Wagner, E.F.; Caelles, C.; Stratmann, T.; Van Ginderachter, J.A.; Valledor, A.F. "Pharmacological activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment.". Cancer Res. (): . (2020). (PMID: 33361391).
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  15. Fernández-García, V.; González-Ramos, S.; Martín-Sanz, P.; Castrillo, A.; Boscá, L. "Contribution of Extramedullary Hematopoiesis to Atherosclerosis. The Spleen as a Neglected Hub of Inflammatory Cells.". Front Immunol. 11(): 586527. (2020). (PMID: 33193412).
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  16. Sánchez, Á.; Orizaola, M.C.; Rodríguez-Muñoz, D.; Aranda, A.; Castrillo, A.; Alemany, S. "Stress erythropoiesis in atherogenic mice.". Sci Rep. 10(1): 18469. (2020). (PMID: 33116141).
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  17. Nicolás-Ávila, J.A.; Lechuga-Vieco, A.V.; Esteban-Martínez, L.; Sánchez-Díaz, M.; Díaz-García, E.; Santiago, D.J.; Rubio-Ponce, A.; Li, J.L.; Balachander, A.; Quintana, J.A.; Martínez-de-Mena, R.; Castejón-Vega, B.; Pun-García, A.; Través, P.G.; Bonzón-Kulichenko, E.; García-Marqués, F.; Cussó, L.; A-González, N.; González-Guerra, A.; Roche-Molina, M.; Martin-Salamanca, S.; Crainiciuc, G.; Guzmán, G.; Larrazabal, J.; Herrero-Galán, E.; Alegre-Cebollada, J.; Lemke, G.; Rothlin, C.V.; Jimenez-Borreguero, L.J.; Reyes, G.; Castrillo, A.; Desco, M.; Muñoz-Cánoves, P.; Ibáñez, B.; Torres, M.; Ng, L.G.; Priori, S.G.; Bueno, H.; Vázquez, J.; Cordero, M.D.; Bernal, J.A.; Enríquez, J.A.; Hidalgo, A. "A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.". Cell. (): . (2020). (PMID: 32937105).
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  18. González-Ramos, S.; Paz-García, M.; Fernández-García, V.; Portune, K.J.; Acosta-Medina, E.F.; Sanz, Y.; Castrillo, A.; Martín-Sanz, P.; Obregon, M.J.; Boscá, L. "NOD1 deficiency promotes an imbalance of thyroid hormones and microbiota homeostasis in mice fed high fat diet.". Sci Rep. 10(1): 12317. (2020). (PMID: 32704052).
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  19. de la Rosa, J.V.; Ramón-Vázquez, A.; Tabraue, C.; Castrillo, A. "Analysis of LXR Nuclear Receptor Cistrome Through ChIP-Seq Data Bioinformatics.". Methods Mol. Biol.. 1951(): 99-9109. (2019). (PMID: 30825147).
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  20. Ramón-Vázquez, A.; de la Rosa, J.V.; Tabraue, C.; Castrillo, A. "Bone Marrow-Derived Macrophage Immortalization of LXR Nuclear Receptor-Deficient Cells.". Methods Mol. Biol.. 1951(): 75-85. (2019). (PMID: 30825145).
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  21. Tabraue, C.; Lara, P.C.; De Mirecki-Garrido, M.; De La Rosa, J.V.; López-Blanco, F.; Fernández-Pérez, L.; Boscá, L.; Castrillo, A. "LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation.". Int. J. Radiat. Oncol. Biol. Phys.. 104(4): 913-923. (2019). (PMID: 30922944).
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  22. Keiran, N.; Ceperuelo-Mallafré, V.; Calvo, E.; Hernández-Alvarez, M.I.; Ejarque, M.; Núñez-Roa, C.; Horrillo, D.; Maymó-Masip, E.; Rodríguez, M.M.; Fradera, R.; de la Rosa, J.V.; Jorba, R.; Megia, A.; Zorzano, A.; Medina-Gómez, G.; Serena, C.; Castrillo, A.; Vendrell, J.; Fernández-Veledo, S. "SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.". Nat. Immunol.. 20(5): 581-592. (2019). (PMID: 30962591).
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  23. Ramón-Vázquez, A.; de la Rosa, J.V.; Tabraue, C.; Lopez, F.; Díaz-Chico, B.N.; Bosca, L.; Tontonoz, P.; Alemany, S.; Castrillo, A. "Common and Differential Transcriptional Actions of Nuclear Receptors LXRα and LXRβ in macrophages.". Mol. Cell. Biol.. (): . (2019). (PMID: 30602495).
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  24. Kourtzelis, I.; Li, X.; Mitroulis, I.; Grosser, D.; Kajikawa, T.; Wang, B.; Grzybek, M.; von Renesse, J.; Czogalla, A.; Troullinaki, M.; Ferreira, A.; Doreth, C.; Ruppova, K.; Chen, L.S.; Hosur, K.; Lim, J.H.; Chung, K.J.; Grossklaus, S.; Tausche, A.K.; Joosten, L.A.B.; Moutsopoulos, N.M.; Wielockx, B.; Castrillo, A.; Korostoff, J.M.; Coskun, Ü.; Hajishengallis, G.; Chavakis, T. "DEL-1 promotes macrophage efferocytosis and clearance of inflammation.". Nat. Immunol.. 20(1): 40-49. (2019). (PMID: 30455459).
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  25. Salmerón, M.L.; Quintana-Aguiar, J.; De La Rosa, J.V.; López-Blanco, F.; Castrillo, A.; Gallardo, G.; Tabraue, C. "Phenalenone-photodynamic therapy induces apoptosis on human tumor cells mediated by caspase-8 and p38-MAPK activation.". Mol. Carcinog.. 57(11): 1525-1539. (2018). (PMID: 30035337).
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  26. A-Gonzalez, N.; Castrillo, A. "Origin and specialization of splenic macrophages.". Cell. Immunol.. 330(): 151-158. (2018). (PMID: 29779612).
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  27. Gage, M.C.; Bécares, N.; Louie, R.; Waddington, K.E.; Zhang, Y.; Tittanegro, T.H.; Rodríguez-Lorenzo, S.; Jathanna, A.; Pourcet, B.; Pello, O.M.; De la Rosa, J.V.; Castrillo, A.; Pineda-Torra, I. "Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation.". Proc. Natl. Acad. Sci. U.S.A.. 115(28): E6556-E6565. (2018). (PMID: 29950315).
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  28. Beceiro, S.; Pap, A.; Czimmerer, Z.; Sallam, T.; Guillén, J.A.; Gallardo, G.; Hong, C.; A-Gonzalez, N.; Tabraue, C.; Diaz, M.; Lopez, F.; Matalonga, J.; Valledor, A.F.; Dominguez, P.; Ardavin, C.; Delgado-Martin, C.; Partida-Sanchez, S.; Rodriguez-Fernandez, J.L.; Nagy, L.; Tontonoz, P.; Castrillo, A. "Liver X Receptor Nuclear Receptors Are Transcriptional Regulators of Dendritic Cell Chemotaxis.". Mol. Cell. Biol.. 38(10): . (2018). (PMID: 29507185).
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  29. Sallam, T.; Jones, M.; Thomas, B.J.; Wu, X.; Gilliland, T.; Qian, K.; Eskin, A.; Casero, D.; Zhang, Z.; Sandhu, J.; Salisbury, D.; Rajbhandari, P.; Civelek, M.; Hong, C.; Ito, A.; Liu, X.; Daniel, B.; Lusis, A.J.; Whitelegge, J.; Nagy, L.; Castrillo, A.; Smale, S.; Tontonoz, P. "Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA.". Nat. Med.. 24(3): 304-312. (2018). (PMID: 29431742).
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  30. Nieto, C.; Bragado, R.; Municio, C.; Sierra-Filardi, E.; Alonso, B.; Escribese, M.M.; Domínguez-Andrés, J.; Ardavín, C.; Castrillo, A.; Vega, M.A.; Puig-Kröger, A.; Corbí, A.L. "The Activin A-Peroxisome Proliferator-Activated Receptor Gamma Axis Contributes to the Transcriptome of GM-CSF-Conditioned Human Macrophages.". Front Immunol. 9(): 31. (2018). (PMID: 29434585).
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  31. Zhang, L.; Rajbhandari, P.; Priest, C.; Sandhu, J.; Wu, X.; Temel, R.; Castrillo, A.; de Aguiar Vallim, T.Q.; Sallam, T.; Tontonoz, P. "Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP.". Elife. 6(): . (2017). (PMID: 29068315).
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  32. Brito-Casillas, Y.; Díaz-Sarmiento, M.; García-Arencibia, M.; Carranza, C.; Castrillo, A.; Fernández-Pérez, L.; Zumbado-Peña, M.; González, J.F.; Wägner, A.M.; Florin, D. "Outbreak and Eradication of Tropical Rat Mite (Acari: Macronyssidae) in a European Animal Facility.". J. Med. Entomol.. (): . (2017). (PMID: 29045705).
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  33. A-Gonzalez, N.; Quintana, J.A.; García-Silva, S.; Mazariegos, M.; González de la Aleja, A.; Nicolás-Ávila, J.A.; Walter, W.; Adrover, J.M.; Crainiciuc, G.; Kuchroo, V.K.; Rothlin, C.V.; Peinado, H.; Castrillo, A.; Ricote, M.; Hidalgo, A. "Phagocytosis imprints heterogeneity in tissue-resident macrophages.". J. Exp. Med.. 214(5): 1281-1296. (2017). (PMID: 28432199).
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  34. Cuevas, V.D.; Anta, L.; Samaniego, R.; Orta-Zavalza, E.; Vladimir de la Rosa, J.; Baujat, G.; Domínguez-Soto, Á.; Sánchez-Mateos, P.; Escribese, M.M.; Castrillo, A.; Cormier-Daire, V.; Vega, M.A.; Corbí, Á.L. "MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis.". J. Immunol.. 198(5): 2070-2081. (2017). (PMID: 28093525).
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  35. Matalonga, J.; Glaria, E.; Bresque, M.; Escande, C.; Carbó, J.M.; Kiefer, K.; Vicente, R.; León, T.E.; Beceiro, S.; Pascual-García, M.; Serret, J.; Sanjurjo, L.; Morón-Ros, S.; Riera, A.; Paytubi, S.; Juarez, A.; Sotillo, F.; Lindbom, L.; Caelles, C.; Sarrias, M.R.; Sancho, J.; Castrillo, A.; Chini, E.N.; Valledor, A.F. "The Nuclear Receptor LXR Limits Bacterial Infection of Host Macrophages through a Mechanism that Impacts Cellular NAD Metabolism.". Cell Rep. 18(5): 1241-1255. (2017). (PMID: 28147278).
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  36. Ito, A.; Hong, C.; Oka, K.; Salazar, J.V.; Diehl, C.; Witztum, J.L.; Diaz, M.; Castrillo, A.; Bensinger, S.J.; Chan, L.; Tontonoz, P. "Cholesterol Accumulation in CD11c(+) Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease.". Immunity. 45(6): 1311-1326. (2016). (PMID: 28002731).
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  37. Rodríguez, M.; Márquez, S.; de la Rosa, J.V.; Alonso, S.; Castrillo, A.; Sánchez Crespo, M.; Fernández, N. "Fungal pattern receptors down-regulate the inflammatory response by a cross-inhibitory mechanism independent of IL-10 production.". Immunology. (): . (2016). (PMID: 27709605).
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  38. Pourcet, B.; Gage, M.C.; León, T.E.; Waddington, K.E.; Pello, O.M.; Steffensen, K.R.; Castrillo, A.; Valledor, A.F.; Pineda-Torra, I. "The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms.". Sci Rep. 6(): 25481. (2016). (PMID: 27149934).
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  39. Domínguez-Soto, A.; de las Casas-Engel, M.; Bragado, R.; Medina-Echeverz, J.; Aragoneses-Fenoll, L.; Martín-Gayo, E.; van Rooijen, N.; Berraondo, P.; Toribio, M.L.; Moro, M.A.; Cuartero, I.; Castrillo, A.; Sancho, D.; Sánchez-Torres, C.; Bruhns, P.; Sánchez-Ramón, S.; Corbí, A.L. "Intravenous immunoglobulin promotes antitumor responses by modulating macrophage polarization.". J. Immunol.. 193(10): 5181-5189. (2014). (PMID: 25326025).
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  40. Través, P.G.; Pimentel-Santillana, M.; Rico, D.; Rodriguez, N.; Miethke, T.; Castrillo, A.; Theodorakis, E.A.; Martín-Sanz, P.; Palladino, M.A.; Boscá, L. "Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB.". Chem. Biol.. 21(8): 955-966. (2014). (PMID: 25065531).
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  41. A-Gonzalez, N.; Guillen, J.A.; Gallardo, G.; Diaz, M.; de la Rosa, J.V.; Hernandez, I.H.; Casanova-Acebes, M.; Lopez, F.; Tabraue, C.; Beceiro, S.; Hong, C.; Lara, P.C.; Andujar, M.; Arai, S.; Miyazaki, T.; Li, S.; Corbi, A.L.; Tontonoz, P.; Hidalgo, A.; Castrillo, A. "The nuclear receptor LXRα controls the functional specialization of splenic macrophages.". Nat. Immunol.. 14(8): 831-839. (2013). (PMID: 23770640).
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  42. Valbuena-Diez, A.C.; Blanco, F.J.; Oujo, B.; Langa, C.; Gonzalez-Nuñez, M.; Llano, E.; Pendas, A.M.; Díaz, M.; Castrillo, A.; Lopez-Novoa, J.M.; Bernabeu, C. "Oxysterol-induced soluble endoglin release and its involvement in hypertension.". Circulation. 126(22): 2612-2624. (2012). (PMID: 23110859).
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  43. Hong, C.; Kidani, Y.; A-Gonzalez, N.; Phung, T.; Ito, A.; Rong, X.; Ericson, K.; Mikkola, H.; Beaven, S.W.; Miller, L.S.; Shao, W.H.; Cohen, P.L.; Castrillo, A.; Tontonoz, P.; Bensinger, S.J. "Coordinate regulation of neutrophil homeostasis by liver X receptors in mice.". J. Clin. Invest.. 122(1): 337-347. (2012). (PMID: 22156197).
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  44. A-González, N.; Castrillo, A. "Liver X receptors as regulators of macrophage inflammatory and metabolic pathways.". Biochim. Biophys. Acta. 1812(8): 982-994. (2011). (PMID: 21193033).
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  45. Ruiz-García, A.; Monsalve, E.; Novellasdemunt, L.; Navarro-Sabaté, A.; Manzano, A.; Rivero, S.; Castrillo, A.; Casado, M.; Laborda, J.; Bartrons, R.; Díaz-Guerra, M.J. "Cooperation of adenosine with macrophage Toll-4 receptor agonists leads to increased glycolytic flux through the enhanced expression of PFKFB3 gene.". J. Biol. Chem.. 286(22): 19247-19258. (2011). (PMID: 21464136).
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  46. Köröskényi, K.; Duró, E.; Pallai, A.; Sarang, Z.; Kloor, D.; Ucker, D.S.; Beceiro, S.; Castrillo, A.; Chawla, A.; Ledent, C.A.; Fésüs, L.; Szondy, Z. "Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation.". J. Immunol.. 186(12): 7144-7155. (2011). (PMID: 21593381).
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  47. A-Gonzalez, N.; Bensinger, S.J.; Hong, C.; Beceiro, S.; Bradley, M.N.; Zelcer, N.; Deniz, J.; Ramirez, C.; Díaz, M.; Gallardo, G.; de Galarreta, C.R.; Salazar, J.; Lopez, F.; Edwards, P.; Parks, J.; Andujar, M.; Tontonoz, P.; Castrillo, A. "Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.". Immunity. 31(2): 245-258. (2009). (PMID: 19646905).
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  48. Morales, J.R.; Ballesteros, I.; Deniz, J.M.; Hurtado, O.; Vivancos, J.; Nombela, F.; Lizasoain, I.; Castrillo, A.; Moro, M.A. "Activation of liver X receptors promotes neuroprotection and reduces brain inflammation in experimental stroke.". Circulation. 118(14): 1450-1459. (2008). (PMID: 18794391).
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  49. Gallardo-Soler, A.; Gómez-Nieto, C.; Campo, M.L.; Marathe, C.; Tontonoz, P.; Castrillo, A.; Corraliza, I. "Arginase I induction by modified lipoproteins in macrophages: a peroxisome proliferator-activated receptor-gamma/delta-mediated effect that links lipid metabolism and immunity.". Mol Endocrinol. 22(6): 1394-1402. (2008). (PMID: 18323470).
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  50. Traves, P.G.; Hortelano, S.; Zeini, M.; Chao, T.H.; Lam, T.; Neuteboom, S.T.; Theodorakis, E.A.; Palladino, M.A.; Castrillo, A.; Bosca, L. "Selective activation of liver X receptors by acanthoic acid-related diterpenes.". Mol. Pharmacol.. 71(6): 1545-1553. (2007). (PMID: 17329499).
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  51. Oliva, J.L.; Zarich, N.; Martínez, N.; Jorge, R.; Castrillo, A.; Azañedo, M.; García-Vargas, S.; Gutiérrez-Eisman, S.; Juarranz, A.; Boscá, L.; Gutkind, J.S.; Rojas, J.M. "The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.". J. Biol. Chem.. 279(32): 33480-33491. (2004). (PMID: 15181015).
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  52. Oliva, J.L.; Pérez-Sala, D.; Castrillo, A.; Martínez, N.; Cañada, F.J.; Boscá, L.; Rojas, J.M. "The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.". Proc. Natl. Acad. Sci. U.S.A.. 100(8): 4772-4777. (2003). (PMID: 12684535).
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  53. Callejas, N.A.; Fernández-Martínez, A.; Castrillo, A.; Boscá, L.; Martín-Sanz, P. "Selective inhibitors of cyclooxygenase-2 delay the activation of nuclear factor kappa B and attenuate the expression of inflammatory genes in murine macrophages treated with lipopolysaccharide.". Mol. Pharmacol.. 63(3): 671-677. (2003). (PMID: 12606776).
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  54. Castrillo, A.; Través, P.G.; Martín-Sanz, P.; Parkinson, S.; Parker, P.J.; Boscá, L. "Potentiation of protein kinase C zeta activity by 15-deoxy-delta(12,14)-prostaglandin J(2) induces an imbalance between mitogen-activated protein kinases and NF-kappa B that promotes apoptosis in macrophages.". Mol. Cell. Biol.. 23(4): 1196-1208. (2003). (PMID: 12556480).
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  55. Millán, O.; Ballester, A.; Castrillo, A.; Oliva, J.L.; Través, P.G.; Rojas, J.M.; Boscá, L. "H-Ras-specific activation of NF-kappaB protects NIH 3T3 cells against stimulus-dependent apoptosis.". Oncogene. 22(4): 477-483. (2003). (PMID: 12555061).
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  56. Hortelano, S.; Zeini, M.; Castrillo, A.; Alvarez, A.M.; Boscá, L. "Induction of apoptosis by nitric oxide in macrophages is independent of apoptotic volume decrease.". Cell Death Differ.. 9(6): 643-650. (2002). (PMID: 12032673).
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  57. Molina-Holgado, E.; Arévalo-Martín, A.; Castrillo, A.; Boscá, L.; Vela, J.M.; Guaza, C. "Interleukin-4 and interleukin-10 modulate nuclear factor kappaB activity and nitric oxide synthase-2 expression in Theiler's virus-infected brain astrocytes.". J. Neurochem.. 81(6): 1242-1252. (2002). (PMID: 12068072).
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  58. Madrigal, J.L.; Hurtado, O.; Moro, M.A.; Lizasoain, I.; Lorenzo, P.; Castrillo, A.; Boscá, L.; Leza, J.C. "The increase in TNF-alpha levels is implicated in NF-kappaB activation and inducible nitric oxide synthase expression in brain cortex after immobilization stress.". Neuropsychopharmacology. 26(2): 155-163. (2002). (PMID: 11790511).
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  59. Castrillo, A.; Pennington, D.J.; Otto, F.; Parker, P.J.; Owen, M.J.; Boscá, L. "Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.". J. Exp. Med.. 194(9): 1231-1242. (2001). (PMID: 11696589).
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  60. Hortelano, S.; García-Martín, M.L.; Cerdán, S.; Castrillo, A.; Alvarez, A.M.; Boscá, L. "Intracellular water motion decreases in apoptotic macrophages after caspase activation.". Cell Death Differ.. 8(10): 1022-1028. (2001). (PMID: 11598800).
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  61. Castrillo, A.; Mojena, M.; Hortelano, S.; Boscá, L. "Peroxisome proliferator-activated receptor-gamma-independent inhibition of macrophage activation by the non-thiazolidinedione agonist L-796,449. Comparison with the effects of 15-deoxy-delta(12,14)-prostaglandin J(2).". J. Biol. Chem.. 276(36): 34082-34088. (2001). (PMID: 11438523).
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  62. Castrillo, A.; de Las Heras, B.; Hortelano, S.; Rodriguez, B.; Villar, A.; Bosca, L. "Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK.". J. Biol. Chem.. 276(19): 15854-15860. (2001). (PMID: 11278990).
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  63. Mojena, M.; Hortelano, S.; Castrillo, A.; Diaz-Guerra, M.J.; Garcia-Barchino, M.J.; Saez, G.T.; Bosca, L. "Protection by nitric oxide against liver inflammatory injury in animals carrying a nitric oxide synthase-2 transgene.". FASEB J.. 15(3): 583-585. (2001). (PMID: 11259374).
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  64. Madrigal, J.L.; Moro, M.A.; Lizasoain, I.; Lorenzo, P.; Castrillo, A.; Boscá, L.; Leza, J.C. "Inducible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mechanisms.". J. Neurochem.. 76(2): 532-538. (2001). (PMID: 11208916).
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  65. Hortelano, S.; Castrillo, A.; Alvarez, A.M.; Boscá, L. "Contribution of cyclopentenone prostaglandins to the resolution of inflammation through the potentiation of apoptosis in activated macrophages.". J. Immunol.. 165(11): 6525-6531. (2000). (PMID: 11086094).
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  66. Cárdenas, A.; Moro, M.A.; Hurtado, O.; Leza, J.C.; Lorenzo, P.; Castrillo, A.; Bodelón, O.G.; Boscá, L.; Lizasoain, I. "Implication of glutamate in the expression of inducible nitric oxide synthase after oxygen and glucose deprivation in rat forebrain slices.". J. Neurochem.. 74(5): 2041-2048. (2000). (PMID: 10800947).
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  67. Castrillo, A.; Díaz-Guerra, M.J.; Hortelano, S.; Martín-Sanz, P.; Boscá, L. "Inhibition of IkappaB kinase and IkappaB phosphorylation by 15-deoxy-Delta(12,14)-prostaglandin J(2) in activated murine macrophages.". Mol. Cell. Biol.. 20(5): 1692-1698. (2000). (PMID: 10669746).
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  68. Castrillo, A.; Bodelón, O.G.; Boscá, L. "Inhibitory effect of IGF-I on type 2 nitric oxide synthase expression in Ins-1 cells and protection against activation-dependent apoptosis: involvement of phosphatidylinositol 3-kinase.". Diabetes. 49(2): 209-217. (2000). (PMID: 10868937).
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  69. de las Heras, B.; Navarro, A.; Díaz-Guerra, M.J.; Bermejo, P.; Castrillo, A.; Boscá, L.; Villar, A. "Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol.". Br. J. Pharmacol.. 128(3): 605-612. (1999). (PMID: 10516639).
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  70. Díaz-Guerra, M.J.; Castrillo, A.; Martín-Sanz, P.; Boscá, L. "Negative regulation by protein tyrosine phosphatase of IFN-gamma-dependent expression of inducible nitric oxide synthase.". J. Immunol.. 162(11): 6776-6783. (1999). (PMID: 10352298).
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  71. Díaz-Guerra, M.J.; Castrillo, A.; Martín-Sanz, P.; Boscá, L. "Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages.". J. Immunol.. 162(10): 6184-6190. (1999). (PMID: 10229863).
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  72. Callejas, N.A.; Castrillo, A.; Boscá, L.; Martín-Sanz, P. "Inhibition of prostaglandin synthesis up-regulates cyclooxygenase-2 induced by lipopolysaccharide and peroxisomal proliferators.". J. Pharmacol. Exp. Ther.. 288(3): 1235-1241. (1999). (PMID: 10027864).
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