INVESTIGACIÓN

 
  • Grupos de Investigación
  • Unidades de Investigación
  • Memoria Cientifíca
  • Publicaciones
espacio

 

PUBLICACIONES

 

 

spacerTrabajos Publicados por Jorge Martín Pérez
spacer
  1. Mayoral-Varo, V.; Sánchez-Bailón, M.P.; Calcabrini, A.; García-Hernández, M.; Frezza, V.; Martín, M.E.; González, V.M.; Martín-Pérez, J. "The Relevance of the SH2 Domain for c-Src Functionality in Triple-Negative Breast Cancer Cells.". Cancers (Basel). 13(3): . (2021). (PMID: 33530373).
    spacer

  2. Alcalá, S.; Mayoral-Varo, V.; Ruiz-Cañas, L.; López-Gil, J.C.; Heeschen, C.; Martín-Pérez, J.; Sainz, B. "Correction: Alcalá, S., et al. Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells. Int. J. Mol. Sci. 2020, 21, 7437.". Int J Mol Sci. 21(23): . (2020). (PMID: 33287468).
    spacer

  3. Alcalá, S.; Mayoral-Varo, V.; Ruiz-Cañas, L.; López-Gil, J.C.; Heeschen, C.; Martín-Pérez, J.; Sainz, B. "Targeting SRC Kinase Signaling in Pancreatic Cancer Stem Cells.". Int J Mol Sci. 21(20): . (2020). (PMID: 33050159).
    spacer

  4. Mayoral-Varo, V.; Calcabrini, A.; Sánchez-Bailón, M.P.; Martínez-Costa, Ó.H.; González-Páramos, C.; Ciordia, S.; Hardisson, D.; Aragón, J.J.; Fernández-Moreno, M.Á.; Martín-Pérez, J. "c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells.". PLoS ONE. 15(7): e0235850. (2020). (PMID: 32673341).
    spacer

  5. Espada, J.; Martín-Pérez, J. "An Update on Src Family of Nonreceptor Tyrosine Kinases Biology.". Int Rev Cell Mol Biol. 331(): 83-8122. (2017). (PMID: 28325216).
    spacer

  6. Mayoral-Varo, V.; Calcabrini, A.; Sánchez-Bailón, M.P.; Martín-Pérez, J. "miR205 inhibits stem cell renewal in SUM159PT breast cancer cells.". PLoS ONE. 12(11): e0188637. (2017). (PMID: 29182685).
    spacer

  7. da Silva, I.L.; Montero-Montero, L.; Martín-Villar, E.; Martin-Pérez, J.; Sainz, B.; Renart, J.; Toscano Simões, R.; Soares Veloso, É.; Salviano Teixeira, C.; de Oliveira, M.C.; Ferreira, E.; Quintanilla, M. "Reduced expression of the murine HLA-G homolog Qa-2 is associated with malignancy, epithelial-mesenchymal transition and stemness in breast cancer cells.". Sci Rep. 7(1): 6276. (2017). (PMID: 28740236).
    spacer

  8. Sánchez-Bailón, M.P.; Calcabrini, A.; Mayoral-Varo, V.; Molinari, A.; Wagner, K.U.; Losada, J.P.; Ciordia, S.; Albar, J.P.; Martín-Pérez, J. "Cyr61 as mediator of Src signaling in triple negative breast cancer cells.". Oncotarget. 6(15): 13520-13538. (2015). (PMID: 25980494).
    spacer

  9. Martín-Pérez, J.; García-Martínez, J.M.; Sánchez-Bailón, M.P.; Mayoral-Varo, V.; Calcabrini, A. "Role of SRC family kinases in prolactin signaling.". Adv. Exp. Med. Biol.. 846(): 163-188. (2015). (PMID: 25472538).
    spacer

  10. Torres-Ayuso, P.; Daza-Martín, M.; Martín-Pérez, J.; Ávila-Flores, A.; Mérida, I. "Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.". Oncotarget. 5(20): 9710-9726. (2014). (PMID: 25339152).
    spacer

  11. Nunes-Xavier, C.E.; Martín-Pérez, J.; Elson, A.; Pulido, R. "Protein tyrosine phosphatases as novel targets in breast cancer therapy.". Biochim. Biophys. Acta. 1836(2): 211-226. (2013). (PMID: 23756181).
    spacer

  12. Mobasher, M.A.; González-Rodriguez, A.; Santamaría, B.; Ramos, S.; Martín, M.Á.; Goya, L.; Rada, P.; Letzig, L.; James, L.P.; Cuadrado, A.; Martín-Pérez, J.; Simpson, K.J.; Muntané, J.; Valverde, A.M. "Protein tyrosine phosphatase 1B modulates GSK3β/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity.". Cell Death Dis. 4(): e626. (2013). (PMID: 23661004).
    spacer

  13. Gómez-Casares, M.T.; García-Alegria, E.; López-Jorge, C.E.; Ferrándiz, N.; Blanco, R.; Alvarez, S.; Vaqué, J.P.; Bretones, G.; Caraballo, J.M.; Sánchez-Bailón, P.; Delgado, M.D.; Martín-Perez, J.; Cigudosa, J.C.; León, J. "MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27(KIP1.).". Oncogene. 32(17): 2239-2246. (2013). (PMID: 22710719).
    spacer

  14. Sánchez-Bailón, M.P.; Calcabrini, A.; Gómez-Domínguez, D.; Morte, B.; Martín-Forero, E.; Gómez-López, G.; Molinari, A.; Wagner, K.U.; Martín-Pérez, J. "Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells.". Cell. Signal.. 24(6): 1276-1286. (2012). (PMID: 22570868).
    spacer

  15. Tárrega, C.; Nunes-Xavier, C.; Cejudo-Marín, R.; Martín-Pérez, J.; Pulido, R. "Studying the regulation of MAP Kinase by MAP Kinase phosphatases in vitro and in cell systems.". Methods Mol. Biol.. 661(): 305-321. (2010). (PMID: 20811991).
    spacer

  16. García-Martínez, J.M.; Calcabrini, A.; González, L.; Martín-Forero, E.; Agulló-Ortuño, M.T.; Simon, V.; Watkin, H.; Anderson, S.M.; Roche, S.; Martín-Pérez, J. "A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling.". Cell. Signal.. 22(3): 415-426. (2010). (PMID: 19892015).
    spacer

  17. MacPherson, M.R.; Molina, P.; Souchelnytskyi, S.; Wernstedt, C.; Martin-Pérez, J.; Portillo, F.; Cano, A. "Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.". Mol. Biol. Cell. 21(2): 244-253. (2010). (PMID: 19923321).
    spacer

  18. González, L.; Zambrano, A.; Lazaro-Trueba, I.; Lopéz, E.; González, J.J.; Martín-Pérez, J.; Aranda, A. "Activation of the unliganded estrogen receptor by prolactin in breast cancer cells.". Oncogene. 28(10): 1298-1308. (2009). (PMID: 19169277).
    spacer

  19. Ferrandiz, N.; Martin-Perez, J.; Blanco, R.; Donertas, D.; Weber, A.; Eilers, M.; Dotto, P.; Delgado, M.D.; Leon, J. "HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.". DNA Repair (Amst.). 8(3): 390-399. (2009). (PMID: 19150257).
    spacer

  20. Calcabrini, A.; García-Martínez, J.M.; González, L.; Tendero, M.J.; Ortuño, M.T.; Crateri, P.; Lopez-Rivas, A.; Arancia, G.; González-Porqué, P.; Martín-Pérez, J. "Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate.". Carcinogenesis. 27(8): 1699-1712. (2006). (PMID: 16624827).
    spacer

  21. González, L.; Agulló-Ortuño, M.T.; García-Martínez, J.M.; Calcabrini, A.; Gamallo, C.; Palacios, J.; Aranda, A.; Martín-Pérez, J. "Role of c-Src in human MCF7 breast cancer cell tumorigenesis.". J. Biol. Chem.. 281(30): 20851-20864. (2006). (PMID: 16728403).
    spacer

  22. Salinas, M.; Wang, J.; Rosa de Sagarra, M.; Martín, D.; Rojo, A.I.; Martin-Perez, J.; Ortiz de Montellano, P.R.; Cuadrado, A. "Protein kinase Akt/PKB phosphorylates heme oxygenase-1 in vitro and in vivo.". FEBS Lett.. 578(1-2): 90-94. (2004). (PMID: 15581622).
    spacer

  23. Domínguez-Cáceres, M.A.; García-Martínez, J.M.; Calcabrini, A.; González, L.; Porque, P.G.; León, J.; Martín-Pérez, J. "Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells.". Oncogene. 23(44): 7378-7390. (2004). (PMID: 15286700).
    spacer

  24. Sarrió, D.; Pérez-Mies, B.; Hardisson, D.; Moreno-Bueno, G.; Suárez, A.; Cano, A.; Martín-Pérez, J.; Gamallo, C.; Palacios, J. "Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions.". Oncogene. 23(19): 3272-3283. (2004). (PMID: 15077190).
    spacer

  25. Acosta, J.J.; Muñoz, R.M.; González, L.; Subtil-Rodríguez, A.; Dominguez-Caceres, M.A.; García-Martínez, J.M.; Calcabrini, A.; Lazaro-Trueba, I.; Martín-Pérez, J. "Src mediates prolactin-dependent proliferation of T47D and MCF7 cells via the activation of focal adhesion kinase/Erk1/2 and phosphatidylinositol 3-kinase pathways.". Mol. Endocrinol.. 17(11): 2268-2282. (2003). (PMID: 12907754).
    spacer

  26. García-Martínez, J.M.; Fresno Vara, J.A.; Lastres, P.; Bernabéu, C.; Betés, P.O.; Martín-Pérez, J. "Effect of metamizol on promyelocytic and terminally differentiated granulocytic cells. Comparative analysis with acetylsalicylic acid and diclofenac.". Biochem. Pharmacol.. 65(2): 209-217. (2003). (PMID: 12504796).
    spacer

  27. Fresno Vara, J.A.; Cáceres, M.A.; Silva, A.; Martín-Pérez, J. "Src family kinases are required for prolactin induction of cell proliferation.". Mol. Biol. Cell. 12(7): 2171-2183. (2001). (PMID: 11452011).
    spacer

  28. Fresno Vara, J.A.; Carretero, M.V.; Gerónimo, H.; Ballmer-Hofer, K.; Martín-Pérez, J. "Stimulation of c-Src by prolactin is independent of Jak2.". Biochem. J.. 345 Pt 1(): 17-24. (2000). (PMID: 10600634).
    spacer

  29. Morales, P.; Carretero, M.V.; Geronimo, H.; Copín, S.G.; Gaspar, M.L.; Marcos, M.A.; Martín-Pérez, J. "Influence of prolactin on the differentiation of mouse B-lymphoid precursors.". Cell Growth Differ.. 10(8): 583-590. (1999). (PMID: 10470858).
    spacer

  30. Benes, C.; Poitout, V.; Marie, J.C.; Martin-Perez, J.; Roisin, M.P.; Fagard, R. "Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.". Biochem. J.. 340 ( Pt 1)(): 219-225. (1999). (PMID: 10229678).
    spacer

  31. Velasco, J.A.; Acebrón, A.; Zannini, M.; Martín-Pérez, J.; Di Lauro, R.; Santisteban, P. "Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.". Endocrinology. 139(6): 2796-2802. (1998). (PMID: 9607786).
    spacer

  32. Zannini, M.; Acebron, A.; De Felice, M.; Arnone, M.I.; Martin-Pérez, J.; Santisteban, P.; Di Lauro, R. "Mapping and functional role of phosphorylation sites in the thyroid transcription factor-1 (TTF-1).". J. Biol. Chem.. 271(4): 2249-2254. (1996). (PMID: 8567686).
    spacer

  33. Berlanga, J.J.; Fresno Vara, J.A.; Martín-Pérez, J.; García-Ruiz, J.P. "Prolactin receptor is associated with c-src kinase in rat liver.". Mol. Endocrinol.. 9(11): 1461-1467. (1995). (PMID: 8584023).
    spacer

  34. Lerga, A.; Belandia, B.; Delgado, M.D.; Cuadrado, M.A.; Richard, C.; Ortiz, J.M.; Martín-Perez, J.; León, J. "Down-regulation of c-Myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells.". Biochem. Biophys. Res. Commun.. 215(3): 889-895. (1995). (PMID: 7488057).
    spacer

  35. Lastres, P.; Martín-Perez, J.; Langa, C.; Bernabéu, C. "Phosphorylation of the human-transforming-growth-factor-beta-binding protein endoglin.". Biochem. J.. 301 ( Pt 3)(): 765-768. (1994). (PMID: 8053900).
    spacer

  36. Belandia, B.; Brautigan, D.; Martín-Pérez, J. "Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus.". Mol. Cell. Biol.. 14(1): 200-206. (1994). (PMID: 8264587).
    spacer

  37. Martin-Perez, J.; Bar-Zvi, D.; Branton, D.; Erikson, R.L. "Transformation by Rous sarcoma virus induces clathrin heavy chain phosphorylation.". J. Cell Biol.. 109(2): 577-584. (1989). (PMID: 2547803).
    spacer

  38. Martin-Pérez, J.; Thomas, G. "Phosphopeptide analysis of 40 S ribosomal protein S6.". Meth. Enzymol.. 146(): 369-375. (1987). (PMID: 3683210).
    spacer

  39. Martin-Pérez, J.; Rudkin, B.B.; Siegmann, M.; Thomas, G. "Activation of ribosomal protein S6 phosphorylation during meiotic maturation of Xenopus laevis oocytes: in vitro ordered appearance of S6 phosphopeptides.". EMBO J.. 5(4): 725-731. (1986). (PMID: 3709523).
    spacer

  40. del Pozo, E.; Martin-Perez, J. "Effect of dopamine receptor stimulation on the inhibition of LH pulsatility by a met-enkephaline (FK 33-824).". Acta Neurochir (Wien). 75(1-4): 88-90. (1985). (PMID: 2986425).
    spacer

  41. Martin-Pérez, J.; Siegmann, M.; Thomas, G. "EGF, PGF2 alpha and insulin induce the phosphorylation of identical S6 peptides in swiss mouse 3T3 cells: effect of cAMP on early sites of phosphorylation.". Cell. 36(2): 287-294. (1984). (PMID: 6319014).
    spacer

  42. Martin-Pérez, J.; Thomas, G. "Ordered phosphorylation of 40S ribosomal protein S6 after serum stimulation of quiescent 3T3 cells.". Proc. Natl. Acad. Sci. U.S.A.. 80(4): 926-930. (1983). (PMID: 6573662).
    spacer

  43. Thomas, G.; Martin-Pérez, J.; Siegmann, M.; Otto, A.M. "The effect of serum, EGF, PGF2 alpha and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis.". Cell. 30(1): 235-242. (1982). (PMID: 6751557).
    spacer

  44. del Pozo, E.; Martin-Perez, J.; Stadelmann, A.; Girard, J.; Brownell, J. "Inhibitory action of a met-enkephalin on ACTH release in man.". J. Clin. Invest.. 65(6): 1531-1534. (1980). (PMID: 6251114).
    spacer

  45. del Pozo, E.; Kleinstein, J.; Brun del Re, R.; Derrer, F.; Martin-Perez, J. "Failure of oxytocin and lysine-vasopressin to stimulate prolactin release in humans.". Horm. Metab. Res.. 12(1): 26-28. (1980). (PMID: 7188925).
    spacer

 

 

 

 

 

Instituto de Investigaciones Biomédicas "Alberto Sols"
C/Arturo Duperier 4. 28029 Madrid. (Spain)
Tel +(34) 91 585 4400 // Fax +(34) 91 558 4401
Email:Info