Marañón, P.; Isaza, S.C.; Rey, E.; Rada, P. ; García-García, Y.; Dear, J.W.; García-Monzón, C.; Valverde, Á.M. ; Egea, J.; González-Rodríguez, Á. "BMP6 participates in the molecular mechanisms involved in APAP hepatotoxicity."
Rojo, A.I. ; Buttari, B.; Cadenas, S.; Carlos, A.R.; Cuadrado, A. ; Falcão, A.S.; López, M.G.; Georgiev, M.I.; Grochot-Przeczek, A.; Gumeni, S.; Jiménez-Villegas, J. ; Horbanczuk, J.O.; Konu, O.; Lastres-Becker, I. ; Levonen, A.L.; Maksimova, V.; Michaeloudes, C.; Mihaylova, L.V.; Mickael, M.E.; Milisav, I.; Miova, B.; Rada, P. ; Santos, M.; Seabra, M.C.; Strac, D.S.; Tenreiro, S.; Trougakos, I.P.; Dinkova-Kostova, A.T. "Corrigendum to "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases" [Redox Biol. 79 (2025) 103464]."
Rojo, A.I. ; Buttari, B.; Cadenas, S.; Carlos, A.R.; Cuadrado, A. ; Falcão, A.S.; López, M.G.; Georgiev, M.I.; Grochot-Przeczek, A.; Gumeni, S.; Jimenez-Villegas, J.; Horbanczuk, J.O.; Konu, O.; Lastres-Becker, I. ; Levonen, A.L.; Maksimova, V.; Michaeloudes, C.; Mihaylova, L.V.; Mickael, M.E.; Milisav, I.; Miova, B.; Rada, P. ; Santos, M.; Seabra, M.C.; Strac, D.S.; Tenreiro, S.; Trougakos, I.P.; Dinkova-Kostova, A.T. "Model organisms for investigating the functional involvement of NRF2 in non-communicable diseases."
Valdecantos, M.P. ; Ruiz, L. ; Folgueira, C.; Rada, P. ; Gomez-Santos, B.; Solas, M.; Hitos, A.B. ; Field, J.; Francisco, V. ; Escalona-Garrido, C. ; Zagmutt, S.; Calderon-Dominguez, M.; Mera, P.; Garcia-Martinez, I. ; Maymó-Masip, E.; Grajales, D. ; Alen, R. ; Mora, A.; Sáinz, N.; Vides-Urrestarazu, I.; Vilarrasa, N.; Arbones-Mainar, J.M.; Zaragoza, C.; Moreno-Aliaga, M.J.; Aspichueta, P.; Fernández-Veledo, S.; Vendrell, J.; Serra, D.; Herrero, L.; Schreiber, R.; Zechner, R.; Sabio, G.; Hornigold, D.; Rondinone, C.M.; Jermutus, L.; Grimsby, J.; Valverde, Á.M. "The dual GLP-1/glucagon receptor agonist G49 mimics bariatric surgery effects by inducing metabolic rewiring and inter-organ crosstalk."
Rada, P. ; Carceller-López, E. ; Hitos, A.B. ; Gómez-Santos, B.; Fernández-Hernández, C.; Rey, E.; Pose-Utrilla, J. ; García-Monzón, C.; González-Rodríguez, Á. ; Sabio, G.; García, A.; Aspichueta, P.; Iglesias, T. ; Valverde, Á.M. "Protein Kinase D2 modulates hepatic insulin sensitivity in male mice."
Zhang, M.; Barroso, E.; Peña, L.; Rada, P. ; Valverde, Á.M. ; Wahli, W.; Palomer, X.; Vázquez-Carrera, M. "PPARβ/δ attenuates hepatic fibrosis by reducing SMAD3 phosphorylation and p300 levels via AMPK in hepatic stellate cells."
Ferreira, V. ; Folgueira, C.; Montes-San Lorenzo, Á. ; Rodríguez-López, A.; Gonzalez-Iglesias, E.; Zubiaur, P.; Abad-Santos, F.; Sabio, G.; Rada, P. ; Valverde, Á.M. "Estrogens prevent the hypothalamus-periphery crosstalk induced by olanzapine intraperitoneal treatment in female mice: Effects on brown/beige adipose tissues and liver."
Marañón, P.; Rey, E.; Isaza, S.C.; Wu, H.; Rada, P. ; Choya-Foces, C.; Martínez-Ruiz, A.; Martín, M.Á.; Ramos, S.; García-Monzón, C.; Cubero, F.J.; Valverde, Á.M. ; González-Rodríguez, Á. "Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury."
Jurado-Aguilar, J.; Barroso, E.; Bernard, M.; Zhang, M.; Peyman, M.; Rada, P. ; Valverde, Á.M. ; Wahli, W.; Palomer, X.; Vázquez-Carrera, M. "GDF15 activates AMPK and inhibits gluconeogenesis and fibrosis in the liver by attenuating the TGF-β1/SMAD3 pathway."
Peyman, M.; Barroso, E.; Turcu, A.L.; Estrany, F.; Smith, D.; Jurado-Aguilar, J.; Rada, P. ; Morisseau, C.; Hammock, B.D.; Valverde, Á.M. ; Palomer, X.; Galdeano, C.; Vázquez, S.; Vázquez-Carrera, M. "Soluble epoxide hydrolase-targeting PROTAC activates AMPK and inhibits endoplasmic reticulum stress."
Zhang, M.; Barroso, E.; Ruart, M.; Peña, L.; Peyman, M.; Aguilar-Recarte, D.; Montori-Grau, M.; Rada, P. ; Cugat, C.; Montironi, C.; Zarei, M.; Jurado-Aguilar, J.; Camins, A.; Balsinde, J.; Valverde, Á.M. ; Wahli, W.; Palomer, X.; Vázquez-Carrera, M. "Elafibranor upregulates the EMT-inducer S100A4 via PPARβ/δ."
Marsal-Beltran, A.; Rodríguez-Castellano, A.; Astiarraga, B.; Calvo, E.; Rada, P. ; Madeira, A.; Rodríguez-Peña, M.M.; Llauradó, G.; Núñez-Roa, C.; Gómez-Santos, B.; Maymó-Masip, E.; Bosch, R.; Frutos, M.D.; Moreno-Navarrete, J.M.; Ramos-Molina, B.; Aspichueta, P.; Joven, J.; Fernández-Real, J.M.; Quer, J.C.; Valverde, Á.M. ; Pardo, A.; Vendrell, J.; Ceperuelo-Mallafré, V.; Fernández-Veledo, S. "Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD."
Ferreira, V. ; Folgueira, C.; García-Altares, M.; Guillén, M. ; Ruíz-Rosario, M.; DiNunzio, G.; Garcia-Martinez, I. ; Alen, R. ; Bookmeyer, C.; Jones, J.G.; Cigudosa, J.C.; López-Larrubia, P. ; Correig-Blanchar, X.; Davis, R.J.; Sabio, G.; Rada, P. ; Valverde, Á.M. "Hypothalamic JNK1-hepatic fatty acid synthase axis mediates a metabolic rewiring that prevents hepatic steatosis in male mice treated with olanzapine via intraperitoneal: Additional effects of PTP1B inhibition."
Frutos, M.F.; Pardo-Marqués, V.; Torrecilla-Parra, M.; Rada, P. ; Pérez-García, A.; Martín-Martín, Y.; de la Peña, G.; Gómez, A.; Toledano-Zaragoza, A.; Gómez-Coronado, D.; Casarejos, M.J.; Solís, J.M.; Rotllán, N.; Pastor, Ó.; Ledesma, M.D.; Valverde, Á.M. ; Busto, R.; Ramírez, C.M. ""MiR-7 controls cholesterol biosynthesis through posttranscriptional regulation of DHCR24 expression"."
Aguilar-Recarte, D.; Barroso, E.; Zhang, M.; Rada, P. ; Pizarro-Delgado, J.; Peña, L.; Palomer, X.; Valverde, Á.M. ; Wahli, W.; Vázquez-Carrera, M. "A positive feedback loop between AMPK and GDF15 promotes metformin antidiabetic effects."
Ferreira, V. ; Folgueira, C.; Guillén, M. ; Zubiaur, P.; Navares, M.; Sarsenbayeva, A.; López-Larrubia, P. ; Eriksson, J.W.; Pereira, M.J.; Abad-Santos, F.; Sabio, G.; Rada, P. ; Valverde, Á.M. "Modulation of hypothalamic AMPK phosphorylation by olanzapine controls energy balance and body weight."
Navarro Del Hierro, J.; Cantero-Bahillo, E.; Fernández-Felipe, M.T.; García-Risco, M.R.; Fornari, T.; Rada, P. ; Doblado, L. ; Ferreira, V. ; Hitos, A.B. ; Valverde, Á.M. ; Monsalve, M. ; Martin, D. "Effects of a Mealworm (Tenebrio molitor ) Extract on Metabolic Syndrome-Related Pathologies: In Vitro Insulin Sensitivity, Inflammatory Response, Hypolipidemic Activity and Oxidative Stress."
Barahona, I. ; Rada, P. ; Calero-Pérez, S. ; Grillo-Risco, R.; Pereira, L.; Soler-Vázquez, M.C.; LaIglesia, L.M.; Moreno-Aliaga, M.J.; Herrero, L.; Serra, D.; García-Monzon, C.; González-Rodriguez, Á. ; Balsinde, J.; García-García, F.; Valdecantos, M.P. ; Valverde, Á.M. "Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics."
Rada, P. ; Lamballe, F.; Carceller-López, E. ; Hitos, A.B. ; Sequera, C.; Maina, F.; Valverde, Á.M. "Enhanced Wild-Type MET Receptor Levels in Mouse Hepatocytes Attenuates Insulin-Mediated Signaling."
Brea, R. ; Valdecantos, P. ; Rada, P. ; Alen, R. ; García-Monzón, C.; Boscá, L. ; Fuertes-Agudo, M.; Casado, M.; Martín-Sanz, P. ; Valverde, Á.M. "Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress."
Rada, P. ; González-Rodríguez, Á. ; García-Monzón, C.; Valverde, Á.M. "Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?"
Garcia-Martinez, I. ; Alen, R. ; Rada, P. ; Valverde, A.M. "Insights Into Extracellular Vesicles as Biomarker of NAFLD Pathogenesis."
Forno, F.; Maatuf, Y.; Boukeileh, S.; Dipta, P.; Mahameed, M.; Darawshi, O.; Ferreira, V. ; Rada, P. ; Garcia-Martinez, I. ; Gross, E.; Priel, A.; Martinez Valverde, A. ; Tirosh, B. "Aripiprazole cytotoxicity coincides with activation of the unfolded protein response in human hepatic cells."
García-Ruiz, I. ; Blanes Ruiz, N. ; Rada, P. ; Pardo, V. ; Ruiz, L. ; Blas-García, A.; Valdecantos, M.P. ; Grau Sanz, M.; Solís Herruzo, J.A.; Valverde, Á.M. "Protein tyrosine phosphatase 1b deficiency protects against hepatic fibrosis by modulating nadph oxidases."
Villar-Lorenzo, A. ; Rada, P. ; Rey, E.; Marañón, P.; Arroba, A.I. ; Santamaría, B. ; Sáiz, J.; Rupérez, F.J.; Barbas, C.; García-Monzón, C.; Valverde, Á.M. ; González-Rodríguez, Á. "Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury."
Rius-Pérez, S.; Tormos, A.M.; Pérez, S.; Finamor, I.; Rada, P. ; Valverde, Á.M. ; Nebreda, A.R.; Sastre, J.; Taléns-Visconti, R. "p38α deficiency restrains liver regeneration after partial hepatectomy triggering oxidative stress and liver injury."
Rada, P. ; Mosquera, A. ; Muntané, J.; Ferrandiz, F.; Rodriguez-Mañas, L.; de Pablo, F.; González-Canudas, J.; Valverde, Á.M. "Differential effects of metformin glycinate and hydrochloride in glucose production, AMPK phosphorylation and insulin sensitivity in hepatocytes from non-diabetic and diabetic mice."
Cruces-Sande, M.; Vila-Bedmar, R.; Arcones, A.C.; González-Rodríguez, Á. ; Rada, P. ; Gutiérrez-de-Juan, V.; Vargas-Castrillón, J.; Iruzubieta, P.; Sánchez-González, C.; Formentini, L.; Crespo, J.; García-Monzón, C.; Martínez-Chantar, M.L.; Valverde, Á.M. ; Mayor, F.; Murga, C. "Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans."
Mojena, M. ; Pimentel-Santillana, M. ; Povo-Retana, A. ; Fernández-García, V. ; González-Ramos, S. ; Rada, P. ; Tejedor, A.; Rico, D.; Martín-Sanz, P. ; Valverde, A.M. ; Boscá, L. "Protection against gamma-radiation injury by protein tyrosine phosphatase 1B."
Zarei, M.; Barroso, E.; Palomer, X.; Dai, J.; Rada, P. ; Quesada-López, T.; Escolà-Gil, J.C.; Cedó, L.; Zali, M.R.; Molaei, M.; Dabiri, R.; Vázquez, S.; Pujol, E.; Valverde, Á.M. ; Villarroya, F.; Liu, Y.; Wahli, W.; Vázquez-Carrera, M. "Hepatic regulation of VLDL receptor by PPARβ/δ and FGF21 modulates non-alcoholic fatty liver disease."
González-Rodríguez, Á. ; Valdecantos, M.P. ; Rada, P. ; Addante, A.; Barahona, I. ; Rey, E.; Pardo, V. ; Ruiz, L. ; Laiglesia, L.M.; Moreno-Aliaga, M.J.; García-Monzón, C.; Sánchez, A.; Valverde, Á.M. "Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis."
Rojo, A.I. ; Pajares, M. ; Rada, P. ; Nuñez, A.; Nevado-Holgado, A.J.; Killik, R.; Van Leuven, F.; Ribe, E.; Lovestone, S.; Yamamoto, M.; Cuadrado, A. "NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology."
Rada, P. ; Pardo, V. ; Mobasher, M.; Garcia, I.; Ruiz, L. ; Gonzalez Rodriguez, A.; Sánchez Ramos, C.; Muntané, J.; Alemany, S. ; James, L.P.; Simpson, K.J.; Monsalve, M. ; Valdecantos, M.P. ; Valverde, A. "SIRT1 CONTROLS ACETAMINOPHEN HEPATOTOXICITY BY MODULATING INFLAMMATION AND OXIDATIVE STRESS."
Tormos, A.M.; Rius-Pérez, S.; Jorques, M.; Rada, P. ; Ramirez, L.; Valverde, Á.M. ; Nebreda, Á.R.; Sastre, J.; Taléns-Visconti, R. "p38α regulates actin cytoskeleton and cytokinesis in hepatocytes during development and aging."
González-Rodríguez, Á. ; Santamaría, B. ; Mas-Gutierrez, J.A.; Rada, P. ; Fernández-Millán, E.; Pardo, V. ; Álvarez, C.; Cuadrado, A. ; Ros, M.; Serrano, M.; Valverde, Á.M. "Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner."
Rada, P. ; Rojo, A.I. ; Offergeld, A.; Feng, G.J.; Velasco-Martín, J.P.; González-Sancho, J.M. ; Valverde, Á.M. ; Dale, T.; Regadera, J.; Cuadrado, A. "WNT-3A regulates an Axin1/NRF2 complex that regulates antioxidant metabolism in hepatocytes."
Rojo, A.I. ; Rada, P. ; Mendiola, M. ; Ortega-Molina, A.; Wojdyla, K.; Rogowska-Wrzesinska, A.; Hardisson, D.; Serrano, M.; Cuadrado, A. "The PTEN/NRF2 axis promotes human carcinogenesis."
García-Yagüe, Á.J. ; Rada, P. ; Rojo, A.I. ; Lastres-Becker, I. ; Cuadrado, A. "Nuclear import and export signals control the subcellular localization of Nurr1 protein in response to oxidative stress."
Rada, P. ; Rojo, A.I. ; Evrard-Todeschi, N.; Innamorato, N.G. ; Cotte, A.; Jaworski, T.; Tobón-Velasco, J.C.; Devijver, H.; García-Mayoral, M.F.; Van Leuven, F.; Hayes, J.D.; Bertho, G.; Cuadrado, A. "Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis."
Rojo, A.I. ; Medina-Campos, O.N.; Rada, P. ; Zúñiga-Toalá, A.; López-Gazcón, A.; Espada, S. ; Pedraza-Chaverri, J.; Cuadrado, A. "Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3."
Rada, P. ; Rojo, A.I. ; Chowdhry, S.; McMahon, M.; Hayes, J.D.; Cuadrado, A. "SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner."
Rojo, A.I. ; Rada, P. ; Egea, J.; Rosa, A.O.; López, M.G.; Cuadrado, A. "Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death."
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