Cazalla, E.; Cuadrado, A.; García-Yagüe, Á.J. "Role of the transcription factor NRF2 in maintaining the integrity of the Blood-Brain Barrier.". Fluids Barriers CNS. 21(1): 93. (2024). (PMID: 39574123).
García-Yagüe, Á.J.; Cuadrado, A. "Mechanisms of NURR1 Regulation: Consequences for Its Biological Activity and Involvement in Pathology.". Int J Mol Sci. 24(15): . (2023). (PMID: 37569656).
García-Yagüe, Á.J.; Lastres-Becker, I.; Stefanis, L.; Vassilatis, D.K.; Cuadrado, A. "α-Synuclein Induces the GSK-3-Mediated Phosphorylation and Degradation of NURR1 and Loss of Dopaminergic Hallmarks.". Mol Neurobiol. (): . (2021). (PMID: 34609698).
Galán-Ganga, M.; García-Yagüe, Á.J.; Lastres-Becker, I. "Role of MSK1 in the Induction of NF-κB by the Chemokine CX3CL1 in Microglial Cells.". Cell. Mol. Neurobiol.. 39(3): 331-340. (2019). (PMID: 30830503).
Castro-Sánchez, S.; García-Yagüe, Á.J.; Kügler, S.; Lastres-Becker, I. "CX3CR1-deficient microglia shows impaired signalling of the transcription factor NRF2: Implications in tauopathies.". Redox Biol. 22(): 101118. (2019). (PMID: 30769286).
Rojo, A.I.; Pajares, M.; García-Yagüe, A.J.; Buendia, I.; Van Leuven, F.; Yamamoto, M.; López, M.G.; Cuadrado, A. "Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy.". Redox Biol. 18(): 173-180. (2018). (PMID: 30029164).
Castro-Sánchez, S.; García-Yagüe, Á.J.; López-Royo, T.; Casarejos, M.; Lanciego, J.L.; Lastres-Becker, I. "Cx3cr1-deficiency exacerbates alpha-synuclein-A53T induced neuroinflammation and neurodegeneration in a mouse model of Parkinson's disease.". Glia. 66(8): 1752-1762. (2018). (PMID: 29624735).
Pajares, M.; Jiménez-Moreno, N.; García-Yagüe, Á.J.; Escoll, M.; de Ceballos, M.L.; Van Leuven, F.; Rábano, A.; Yamamoto, M.; Rojo, A.I.; Cuadrado, A. "Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.". Autophagy. 12(10): 1902-1916. (2016). (PMID: 27427974).
Lastres-Becker, I.; García-Yagüe, A.J.; Scannevin, R.H.; Casarejos, M.J.; Kügler, S.; Rábano, A.; Cuadrado, A. "Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease.". Antioxid. Redox Signal.. 25(2): 61-77. (2016). (PMID: 27009601).
Innamorato, N.G.; Rojo, A.I.; García-Yagüe, A.J.; Yamamoto, M.; de Ceballos, M.L.; Cuadrado, A. "The transcription factor Nrf2 is a therapeutic target against brain inflammation.". J. Immunol.. 181(1): 680-689. (2008). (PMID: 18566435).
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