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PUBLICACIONES

 

 

spacerTrabajos Publicados por Agueda González Rodríguez
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  1. Rada, P.; Carceller-López, E.; Hitos, A.B.; Gómez-Santos, B.; Fernández-Hernández, C.; Rey, E.; Pose-Utrilla, J.; García-Monzón, C.; González-Rodríguez, Á.; Sabio, G.; García, A.; Aspichueta, P.; Iglesias, T.; Valverde, Á.M. "Protein Kinase D2 modulates hepatic insulin sensitivity in male mice.". Mol Metab. (): 102045. (2024). (PMID: 39401614).
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  2. Brea, R.; Casanova, N.; Alvarez-Lucena, C.; Fuertes-Agudo, M.; Luque-Tevar, M.; Cucarella, C.; Capitani, M.C.; Marinochi, M.V.; Fusini, M.E.; Lahoz, A.; Nogueroles, M.L.; Fraile, J.; Ronco, M.T.; Boscá, L.; González-Rodríguez, Á.; García-Monzón, C.; Martín-Sanz, P.; Casado, M.; Francés, D.E. "Beneficial effects of hepatic cyclooxygenase-2 expression against cholestatic injury after common bile duct ligation in mice.". Liver Int. (): . (2024). (PMID: 38847511).
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  3. Gallego-Durán, R.; Ampuero, J.; Maya-Miles, D.; Pastor-Ramírez, H.; Montero-Vallejo, R.; Rivera-Esteban, J.; Álvarez-Amor, L.; Pareja, M.J.; Rico, M.C.; Millán, R.; Robles-Frías, M.J.; Aller, R.; Rojas, Á.; Muñoz-Hernández, R.; Gil-Gómez, A.; Gato, S.; García-Lozano, M.; Arias-Loste, M.T.; Abad, J.; Calleja, J.L.; Andrade, R.J.; Crespo, J.; González-Rodríguez, Á.; García-Monzón, C.; Andreola, F.; Pericás, J.M.; Jalan, R.; Martín-Bermudo, F.; Romero-Gómez, M. "Fibroblast growth factor 21 is a hepatokine involved in MASLD progression.". United European Gastroenterol J. (): . (2024). (PMID: 38894596).
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  4. Aroca-Esteban, J.; Souza-Neto, F.V.; Aguilar-Latorre, C.; Tribaldo-Torralbo, A.; González-López, P.; Ruiz-Simón, R.; Álvarez-Villareal, M.; Ballesteros, S.; de Ceniga, M.V.; Landete, P.; González-Rodríguez, Á.; Martín-Ventura, J.L.; de Las Heras, N.; Escribano, Ó.; Gómez-Hernández, A. "Potential protective role of let-7d-5p in atherosclerosis progression reducing the inflammatory pathway regulated by NF-κB and vascular smooth muscle cells proliferation.". Biochim Biophys Acta Mol Basis Dis. (): 167327. (2024). (PMID: 38945455).
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  5. Fernández-García, C.E.; Gallego-Galiana, J.; Solís-Muñoz, P.A.; Del Pozo-Maroto, E.; Domínguez-Alcón, L.; Tobar-Izquierdo, M.; Sáez, A.; Rodríguez de Cía, J.; Magaña-Sánchez, A.; Real-Martínez, Y.; García-Buey, L.; González-Moreno, L.; Caldas-Álvarez, M.; Cardeñoso-Domingo, L.M.; González-Gamarra, A.; Salvador-Calvo, A.; González-Rodríguez, Á.; García-Monzón, C. "Hospital-based screening outperforms primary care screening as a means of achieving hepatitis C virus micro-elimination.". Infect Dis Now. (): 104855. (2024). (PMID: 38309646).
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  6. Marañón, P.; Rey, E.; Isaza, S.C.; Wu, H.; Rada, P.; Choya-Foces, C.; Martínez-Ruiz, A.; Martín, M.Á.; Ramos, S.; García-Monzón, C.; Cubero, F.J.; Valverde, Á.M.; González-Rodríguez, Á. "Inhibition of ALK3-mediated signalling pathway protects against acetaminophen-induced liver injury.". Redox Biol. 71(): 103088. (2024). (PMID: 38401290).
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  7. Fernández-Ginés, R.; Encinar, J.A.; Escoll, M.; Carnicero-Senabre, D.; Jiménez-Villegas, J.; García-Yagüe, Á.J.; González-Rodríguez, Á.; Garcia-Martinez, I.; M Valverde, Á.; Rojo, A.I.; Cuadrado, A. "Specific targeting of the NRF2/β-TrCP axis promotes beneficial effects in NASH.". Redox Biol. 69(): 103027. (2024). (PMID: 38184999).
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  8. Solís-Muñoz, P.; de la Flor-Robledo, M.; Fernández-García, C.E.; González-Rodríguez, Á.; García-Monzón, C. "Editorial: mitochondrial respiratory chain activity-a potential link with disease severity and treatment response in alcoholic hepatitis. Authors' reply.". Aliment Pharmacol Ther. 57(10): 1159-1160. (2023). (PMID: 37094312).
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  9. Marañón, P.; Isaza, S.C.; Fernández-García, C.E.; Rey, E.; Gallego-Durán, R.; Montero-Vallejo, R.; de Cía, J.R.; Ampuero, J.; Valverde, Á.M.; Romero-Gómez, M.; García-Monzón, C.; González-Rodríguez, Á. "Circulating bone morphogenetic protein 8A is a novel biomarker to predict advanced liver fibrosis.". Biomark Res. 11(1): 46. (2023). (PMID: 37106416).
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  10. Solís-Muñoz, P.; de la Flor-Robledo, M.; García-Ruíz, I.; Fernández-García, C.E.; González-Rodríguez, Á.; Shah, N.; Bataller, R.; Heneghan, M.; García-Monzón, C.; Solís-Herruzo, J.A. "Mitochondrial respiratory chain activity is associated with severity, corticosteroid response and prognosis of alcoholic hepatitis.". Aliment Pharmacol Ther. (): . (2023). (PMID: 36864659).
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  11. Landete, P.; Fernández-García, C.E.; Muñoz, J.M.; Friera, A.; Ancochea, J.; González-Rodríguez, Á.; García-Monzón, C. "Sleep apnea-COPD overlap syndrome is associated with larger left carotid atherosclerotic plaques.". Front Cardiovasc Med. 10(): 1104377. (2023). (PMID: 37025690).
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  12. Barahona, I.; Rada, P.; Calero-Pérez, S.; Grillo-Risco, R.; Pereira, L.; Soler-Vázquez, M.C.; LaIglesia, L.M.; Moreno-Aliaga, M.J.; Herrero, L.; Serra, D.; García-Monzon, C.; González-Rodriguez, Á.; Balsinde, J.; García-García, F.; Valdecantos, M.P.; Valverde, Á.M. "Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics.". Cell Death Differ. (): . (2022). (PMID: 35681014).
    spacer -/- mice with NAFLD opens therapeutic perspectives to ensure OC viability and plasticity under lipotoxic liver damage.')" value="Abstract">

  13. Marañón, P.; Fernández-García, C.E.; Isaza, S.C.; Rey, E.; Gallego-Durán, R.; Montero-Vallejo, R.; de Cía, J.R.; Ampuero, J.; Romero-Gómez, M.; García-Monzón, C.; González-Rodríguez, Á. "Bone morphogenetic protein 2 is a new molecular target linked to non-alcoholic fatty liver disease with potential value as non-invasive screening tool.". Biomark Res. 10(1): 35. (2022). (PMID: 35614516).
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  14. de Toro-Martín, J.; Fernández-Marcelo, T.; González-Rodríguez, Á.; Escrivá, F.; Valverde, Á.M.; Álvarez, C.; Fernández-Millán, E. "Defective liver glycogen autophagy related to hyperinsulinemia in intrauterine growth-restricted newborn wistar rats.". Sci Rep. 10(1): 17651. (2020). (PMID: 33077861).
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  15. Rada, P.; González-Rodríguez, Á.; García-Monzón, C.; Valverde, Á.M. "Understanding lipotoxicity in NAFLD pathogenesis: is CD36 a key driver?". Cell Death Dis. 11(9): 802. (2020). (PMID: 32978374).
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  16. Villar-Lorenzo, A.; Rada, P.; Rey, E.; Marañón, P.; Arroba, A.I.; Santamaría, B.; Sáiz, J.; Rupérez, F.J.; Barbas, C.; García-Monzón, C.; Valverde, Á.M.; González-Rodríguez, Á. "Insulin receptor substrate 2 (IRS2) deficiency delays liver fibrosis associated with cholestatic injury.". Dis Model Mech. 12(7): . (2019). (PMID: 31262748).
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  17. Cruces-Sande, M.; Vila-Bedmar, R.; Arcones, A.C.; González-Rodríguez, Á.; Rada, P.; Gutiérrez-de-Juan, V.; Vargas-Castrillón, J.; Iruzubieta, P.; Sánchez-González, C.; Formentini, L.; Crespo, J.; García-Monzón, C.; Martínez-Chantar, M.L.; Valverde, Á.M.; Mayor, F.; Murga, C. "Involvement of G protein-coupled receptor kinase 2 (GRK2) in the development of non-alcoholic steatosis and steatohepatitis in mice and humans.". Biochim Biophys Acta Mol Basis Dis. (): . (2018). (PMID: 30261289).
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  18. González-Rodríguez, Á.; Valdecantos, M.P.; Rada, P.; Addante, A.; Barahona, I.; Rey, E.; Pardo, V.; Ruiz, L.; Laiglesia, L.M.; Moreno-Aliaga, M.J.; García-Monzón, C.; Sánchez, A.; Valverde, Á.M. "Dual role of protein tyrosine phosphatase 1B in the progression and reversion of non-alcoholic steatohepatitis.". Mol Metab. 7(): 132-146. (2018). (PMID: 29126873).
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  19. Valdecantos, M.P.; Pardo, V.; Ruiz, L.; Castro-Sánchez, L.; Lanzón, B.; Fernández-Millán, E.; García-Monzón, C.; Arroba, A.I.; González-Rodríguez, Á.; Escrivá, F.; Álvarez, C.; Rupérez, F.J.; Barbas, C.; Konkar, A.; Naylor, J.; Hornigold, D.; Santos, A.D.; Bednarek, M.; Grimsby, J.; Rondinone, C.M.; Valverde, Á.M. "A novel glucagon-like peptide 1/glucagon receptor dual agonist improves steatohepatitis and liver regeneration in mice.". Hepatology. 65(3): 950-968. (2017). (PMID: 27880981).
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  20. Villar-Lorenzo, A.; Ardiles, A.E.; Arroba, A.I.; Hernández-Jiménez, E.; Pardo, V.; López-Collazo, E.; Jiménez, I.A.; Bazzocchi, I.L.; González-Rodríguez, Á.; Valverde, Á.M. "Friedelane-type triterpenoids as selective anti-inflammatory agents by regulation of differential signaling pathways in LPS-stimulated macrophages.". Toxicol. Appl. Pharmacol.. 313(): 57-67. (2016). (PMID: 27751938).
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  21. Zarei, M.; Barroso, E.; Leiva, R.; Barniol-Xicota, M.; Pujol, E.; Escolano, C.; Vázquez, S.; Palomer, X.; Pardo, V.; González-Rodríguez, Á.; Valverde, Á.M.; Quesada-López, T.; Villarroya, F.; Wahli, W.; Vázquez-Carrera, M. "Heme-Regulated eIF2α Kinase Modulates Hepatic FGF21 and Is Activated by PPARβ/δ Deficiency.". Diabetes. 65(10): 3185-3199. (2016). (PMID: 27486236).
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  22. Baquedano, E.; Burgos-Ramos, E.; Canelles, S.; González-Rodríguez, A.; Chowen, J.A.; Argente, J.; Barrios, V.; Valverde, A.M.; Frago, L.M. "Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model.". Dis Model Mech. 9(5): 573-583. (2016). (PMID: 27013528).
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  23. López-Luque, J.; Caballero-Díaz, D.; Martinez-Palacián, A.; Roncero, C.; Moreno-Càceres, J.; García-Bravo, M.; Grueso, E.; Fernández, A.; Crosas-Molist, E.; García-Álvaro, M.; Addante, A.; Bertran, E.; Valverde, A.M.; González-Rodríguez, Á.; Herrera, B.; Montoliu, L.; Serrano, T.; Segovia, J.C.; Fernández, M.; Ramos, E.; Sánchez, A.; Fabregat, I. "Dissecting the role of epidermal growth factor receptor catalytic activity during liver regeneration and hepatocarcinogenesis.". Hepatology. 63(2): 604-619. (2016). (PMID: 26313466).
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  24. Santamaria, B.; Marquez, E.; Lay, A.; Carew, R.M.; González-Rodríguez, Á.; Welsh, G.I.; Ni, L.; Hale, L.J.; Ortiz, A.; Saleem, M.A.; Brazil, D.P.; Coward, R.J.; Valverde, Á.M. "IRS2 and PTEN are key molecules in controlling insulin sensitivity in podocytes.". Biochim. Biophys. Acta. 1853(12): 3224-3234. (2015). (PMID: 26384875).
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  25. Gonzalez-Rodriguez, A.; Valverde, A.M. "RNA Interference as a Therapeutic Strategy for the Treatment of Liver Diseases.". Curr. Pharm. Des.. 21(31): 4574-4586. (2015). (PMID: 26486144).
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  26. González-Rodríguez, Á.; Santamaría, B.; Mas-Gutierrez, J.A.; Rada, P.; Fernández-Millán, E.; Pardo, V.; Álvarez, C.; Cuadrado, A.; Ros, M.; Serrano, M.; Valverde, Á.M. "Resveratrol treatment restores peripheral insulin sensitivity in diabetic mice in a sirt1-independent manner.". Mol Nutr Food Res. 59(8): 1431-1442. (2015). (PMID: 25808216).
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  27. Francés, D.E.; Motiño, O.; Agrá, N.; González-Rodríguez, Á.; Fernández-Álvarez, A.; Cucarella, C.; Mayoral, R.; Castro-Sánchez, L.; García-Casarrubios, E.; Boscá, L.; Carnovale, C.E.; Casado, M.; Valverde, Á.M.; Martín-Sanz, P. "Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity, and insulin resistance.". Diabetes. 64(5): 1522-1531. (2015). (PMID: 25422106).
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  28. Pardo, V.; González-Rodríguez, Á.; Muntané, J.; Kozma, S.C.; Valverde, Á.M. "Role of hepatocyte S6K1 in palmitic acid-induced endoplasmic reticulum stress, lipotoxicity, insulin resistance and in oleic acid-induced protection.". Food Chem. Toxicol.. (): . (2015). (PMID: 25846498).
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  29. Pardo, V.; Gonzalez-Rodriguez, A.; Guijas, C.; Balsinde, J.; Valverde, A.M. "Opposite Cross-Talk by Oleate and Palmitate on Insulin Signaling in Hepatocytes through Macrophage Activation.". J. Biol. Chem.. (): . (2015). (PMID: 25792746).
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  30. Mobasher, M.A.; de Toro-Martín, J.; González-Rodríguez, Á.; Ramos, S.; Letzig, L.G.; James, L.P.; Muntané, J.; Álvarez, C.; Valverde, Á.M. "Essential role of protein-tyrosine phosphatase 1B in the modulation of insulin signaling by acetaminophen in hepatocytes.". J. Biol. Chem.. 289(42): 29406-29419. (2014). (PMID: 25204659).
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  31. González-Rodríguez, Á.; Reibert, B.; Amann, T.; Constien, R.; Rondinone, C.M.; Valverde, Á.M. "In vivo siRNA delivery of Keap1 modulates death and survival signaling pathways and attenuates concanavalin-A-induced acute liver injury in mice.". Dis Model Mech. 7(9): 1093-1100. (2014). (PMID: 24997191).
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  32. Arroba, A.I.; Revuelta-Cervantes, J.; Menes, L.; González-Rodríguez, Á.; Pardo, V.; de la Villa, P.; Burks, D.J.; Valverde, Á.M. "Loss of protein tyrosine phosphatase 1B increases IGF-I receptor tyrosine phosphorylation but does not rescue retinal defects in IRS2-deficient mice.". Invest. Ophthalmol. Vis. Sci.. 54(6): 4215-4225. (2013). (PMID: 23702782).
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  33. Sanz-Garcia, C.; Ferrer-Mayorga, G.; González-Rodríguez, Á.; Valverde, A.M.; Martín-Duce, A.; Velasco-Martín, J.P.; Regadera, J.; Fernández, M.; Alemany, S. "Sterile inflammation in acetaminophen-induced liver injury is mediated by Cot/tpl2.". J. Biol. Chem.. 288(21): 15342-15351. (2013). (PMID: 23572518).
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  34. Valverde, A.M.; Miranda, S.; García-Ramírez, M.; González-Rodriguez, Á.; Hernández, C.; Simó, R. "Proapoptotic and survival signaling in the neuroretina at early stages of diabetic retinopathy.". Mol. Vis.. 19(): 47-53. (2013). (PMID: 23335850).
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  35. Ardiles, A.E.; González-Rodríguez, A.; Núñez, M.J.; Perestelo, N.R.; Pardo, V.; Jiménez, I.A.; Valverde, A.M.; Bazzocchi, I.L. "Studies of naturally occurring friedelane triterpenoids as insulin sensitizers in the treatment type 2 diabetes mellitus.". Phytochemistry. 84(): 116-124. (2012). (PMID: 22925829).
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  36. Miranda, S.; González-Rodríguez, Á.; García-Ramírez, M.; Revuelta-Cervantes, J.; Hernández, C.; Simó, R.; Valverde, Á.M. "Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions.". J. Cell. Physiol.. 227(6): 2352-2362. (2012). (PMID: 21826649).
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  37. Ortiz, C.; Caja, L.; Bertran, E.; Gonzalez-Rodriguez, Á.; Valverde, Á.M.; Fabregat, I.; Sancho, P. "Protein-tyrosine phosphatase 1B (PTP1B) deficiency confers resistance to transforming growth factor-β (TGF-β)-induced suppressor effects in hepatocytes.". J. Biol. Chem.. 287(19): 15263-15274. (2012). (PMID: 22427664).
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  38. González-Rodríguez, A.; Más-Gutierrez, J.A.; Mirasierra, M.; Fernandez-Pérez, A.; Lee, Y.J.; Ko, H.J.; Kim, J.K.; Romanos, E.; Carrascosa, J.M.; Ros, M.; Vallejo, M.; Rondinone, C.M.; Valverde, A.M. "Essential role of protein tyrosine phosphatase 1B in obesity-induced inflammation and peripheral insulin resistance during aging.". Aging Cell. 11(2): 284-296. (2012). (PMID: 22221695).
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  39. Burgos-Ramos, E.; González-Rodríguez, A.; Canelles, S.; Baquedano, E.; Frago, L.M.; Revuelta-Cervantes, J.; Gómez-Ambrosi, J.; Frühbeck, G.; Chowen, J.A.; Argente, J.; Valverde, A.M.; Barrios, V. "Differential insulin receptor substrate-1 (IRS1)-related modulation of neuropeptide Y and proopiomelanocortin expression in nondiabetic and diabetic IRS2-/- mice.". Endocrinology. 153(3): 1129-1140. (2012). (PMID: 22210743).
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  40. Murillo-Cuesta, S.; Camarero, G.; González-Rodríguez, A.; De La Rosa, L.R.; Burks, D.J.; Avendaño, C.; Valverde, A.M.; Varela-Nieto, I. "Insulin receptor substrate 2 (IRS2)-deficient mice show sensorineural hearing loss that is delayed by concomitant protein tyrosine phosphatase 1B (PTP1B) loss of function.". Mol. Med.. 18(): 260-269. (2012). (PMID: 22160220).
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  41. Valverde, A.M.; González-Rodríguez, A. "IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling.". Arch. Physiol. Biochem.. 117(3): 105-115. (2011). (PMID: 21401320).
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  42. Revuelta-Cervantes, J.; Mayoral, R.; Miranda, S.; González-Rodríguez, A.; Fernández, M.; Martín-Sanz, P.; Valverde, A.M. "Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.". Am. J. Pathol.. 178(4): 1591-1604. (2011). (PMID: 21406170).
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  43. García-Monzón, C.; Lo Iacono, O.; Mayoral, R.; González-Rodríguez, A.; Miquilena-Colina, M.E.; Lozano-Rodríguez, T.; García-Pozo, L.; Vargas-Castrillón, J.; Casado, M.; Boscá, L.; Valverde, A.M.; Martín-Sanz, P. "Hepatic insulin resistance is associated with increased apoptosis and fibrogenesis in nonalcoholic steatohepatitis and chronic hepatitis C.". J. Hepatol.. 54(1): 142-152. (2011). (PMID: 20888662).
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  44. Escrivá, F.; González-Rodriguez, A.; Fernández-Millán, E.; Rondinone, C.M.; Alvarez, C.; Valverde, A.M. "PTP1B deficiency enhances liver growth during suckling by increasing the expression of insulin-like growth factor-I.". J. Cell. Physiol.. 225(1): 214-222. (2010). (PMID: 20506299).
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  45. Miranda, S.; González-Rodríguez, A.; Revuelta-Cervantes, J.; Rondinone, C.M.; Valverde, A.M. "Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.". Cell. Signal.. 22(4): 645-659. (2010). (PMID: 20026400).
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  46. González-Rodríguez, A.; Mas Gutierrez, J.A.; Sanz-González, S.; Ros, M.; Burks, D.J.; Valverde, A.M. "Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice.". Diabetes. 59(3): 588-599. (2010). (PMID: 20028942).
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  47. Mayoral, R.; Valverde, A.M.; Llorente Izquierdo, C.; González-Rodríguez, A.; Boscá, L.; Martín-Sanz, P. "Impairment of transforming growth factor beta signaling in caveolin-1-deficient hepatocytes: role in liver regeneration.". J. Biol. Chem.. 285(6): 3633-3642. (2010). (PMID: 19966340).
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  48. Fernandez-Marcos, P.J.; Pantoja, C.; Gonzalez-Rodriguez, A.; Martin, N.; Flores, J.M.; Valverde, A.M.; Hara, E.; Serrano, M. "Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1.". PLoS ONE. 5(1): e8744. (2010). (PMID: 20090907).
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  49. González-Rodriguez, A.; Alba, J.; Zimmerman, V.; Kozma, S.C.; Valverde, A.M. "S6K1 deficiency protects against apoptosis in hepatocytes.". Hepatology. 50(1): 216-229. (2009). (PMID: 19437488).
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  50. González-Rodriguez, A.; Nevado, C.; Escrivá, F.; Sesti, G.; Rondinone, C.M.; Benito, M.; Valverde, A.M. "PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.". Am. J. Physiol. Gastrointest. Liver Physiol.. 295(2): G338-47. (2008). (PMID: 18535291).
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  51. González-Rodriguez, A.; Escribano, O.; Alba, J.; Rondinone, C.M.; Benito, M.; Valverde, A.M. "Levels of protein tyrosine phosphatase 1B determine susceptibility to apoptosis in serum-deprived hepatocytes.". J. Cell. Physiol.. 212(1): 76-88. (2007). (PMID: 17323378).
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  52. Gonzalez-Rodriguez, A.; Clampit, J.E.; Escribano, O.; Benito, M.; Rondinone, C.M.; Valverde, A.M. "Developmental switch from prolonged insulin action to increased insulin sensitivity in protein tyrosine phosphatase 1B-deficient hepatocytes.". Endocrinology. 148(2): 594-608. (2007). (PMID: 17068137).
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Instituto de Investigaciones Biomédicas "Alberto Sols"
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