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spacerTrabajos Publicados por Jose Luis Orgaz Bueno
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  1. Maiques, O.; Sallan, M.C.; Laddach, R.; Pandya, P.; Varela, A.; Crosas-Molist, E.; Barcelo, J.; Courbot, O.; Liu, Y.; Graziani, V.; Arafat, Y.; Sewell, J.; Rodriguez-Hernandez, I.; Fanshawe, B.; Jung-Garcia, Y.; Imbert, P.R.; Grasset, E.M.; Albrengues, J.; Santacana, M.; Macià, A.; Tarragona, J.; Matias-Guiu, X.; Marti, R.M.; Tsoka, S.; Gaggioli, C.; Orgaz, J.L.; Fruhwirth, G.O.; Wallberg, F.; Betteridge, K.; Reyes-Aldasoro, C.C.; Haider, S.; Braun, A.; Karagiannis, S.N.; Elosegui-Artola, A.; Sanz-Moreno, V. "Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis.". Nat Commun. 16(1): 1394. (2025). (PMID: 39952917).
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  2. Orgaz, J.L. "Creating a path during melanoma amoeboid migration: When too crowded, start worrying.". Dev Cell. 59(18): 2395-2397. (2024). (PMID: 39317164).
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  3. Samain, R.; Maiques, O.; Monger, J.; Lam, H.; Candido, J.; George, S.; Ferrari, N.; KohIhammer, L.; Lunetto, S.; Varela, A.; Orgaz, J.L.; Vilardell, F.; Olsina, J.J.; Matias-Guiu, X.; Sarker, D.; Biddle, A.; Balkwill, F.R.; Eyles, J.; Wilkinson, R.W.; Kocher, H.M.; Calvo, F.; Wells, C.M.; Sanz-Moreno, V. "CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells.". Sci Adv. 9(42): eadi0244. (2023). (PMID: 37851808).
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  4. Barreno, A.; Orgaz, J.L. "Cytoskeletal Remodelling as an Achilles' Heel for Therapy Resistance in Melanoma.". Cells. 11(3): . (2022). (PMID: 35159327).
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  5. Crosas-Molist, E.; Samain, R.; Kohlhammer, L.; Orgaz, J.; George, S.; Maiques, O.; Barcelo, J.; Sanz-Moreno, V. "RhoGTPase Signalling in Cancer Progression and Dissemination.". Physiol Rev. (): . (2021). (PMID: 34541899).
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  6. Maiques, O.; Fanshawe, B.; Crosas-Molist, E.; Rodriguez-Hernandez, I.; Volpe, A.; Cantelli, G.; Boehme, L.; Orgaz, J.L.; Mardakheh, F.K.; Sanz-Moreno, V.; Fruhwirth, G.O. "A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma.". Br J Cancer. (): . (2021). (PMID: 34172930).
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  7. Rodriguez-Hernandez, I.; Maiques, O.; Kohlhammer, L.; Cantelli, G.; Perdrix-Rosell, A.; Monger, J.; Fanshawe, B.; Bridgeman, V.L.; Karagiannis, S.N.; Penin, R.M.; Marcolval, J.; Marti, R.M.; Matias-Guiu, X.; Fruhwirth, G.O.; Orgaz, J.L.; Malanchi, I.; Sanz-Moreno, V. "WNT11-FZD7-DAAM1 signalling supports tumour initiating abilities and melanoma amoeboid invasion.". Nat Commun. 11(1): 5315. (2020). (PMID: 33082334).
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  8. Farrugia, A.J.; Rodríguez, J.; Orgaz, J.L.; Lucas, M.; Sanz-Moreno, V.; Calvo, F. "CDC42EP5/BORG3 modulates SEPT9 to promote actomyosin function, migration, and invasion.". J Cell Biol. 219(9): . (2020). (PMID: 32798219).
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  9. Orgaz, J.L.; Sanz-Moreno, V. "What does not kill you makes you stronger: surviving anti-cancer therapies by cytoskeletal remodeling and Myosin II reactivation.". Mol Cell Oncol. 7(3): 1735911. (2020). (PMID: 32391428).
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  10. Orgaz, J.L.; Crosas-Molist, E.; Sadok, A.; Perdrix-Rosell, A.; Maiques, O.; Rodriguez-Hernandez, I.; Monger, J.; Mele, S.; Georgouli, M.; Bridgeman, V.; Karagiannis, P.; Lee, R.; Pandya, P.; Boehme, L.; Wallberg, F.; Tape, C.; Karagiannis, S.N.; Malanchi, I.; Sanz-Moreno, V. "Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance.". Cancer Cell. 37(1): 85-103.e9. (2020). (PMID: 31935375).
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  11. Georgouli, M.; Herraiz, C.; Crosas-Molist, E.; Fanshawe, B.; Maiques, O.; Perdrix, A.; Pandya, P.; Rodriguez-Hernandez, I.; Ilieva, K.M.; Cantelli, G.; Karagiannis, P.; Mele, S.; Lam, H.; Josephs, D.H.; Matias-Guiu, X.; Marti, R.M.; Nestle, F.O.; Orgaz, J.L.; Malanchi, I.; Fruhwirth, G.O.; Karagiannis, S.N.; Sanz-Moreno, V. "Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.". Cell. 176(4): 757-774.e23. (2019). (PMID: 30712866).
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  12. Maiques, O.; Barceló, C.; Panosa, A.; Pijuan, J.; Orgaz, J.L.; Rodriguez-Hernandez, I.; Matas-Nadal, C.; Tell, G.; Vilella, R.; Fabra, A.; Puig, S.; Sanz-Moreno, V.; Matias-Guiu, X.; Canti, C.; Herreros, J.; Marti, R.M.; Macià, A. "T-type calcium channels drive migration/invasion in BRAFV600E melanoma cells through Snail1.". Pigment Cell Melanoma Res. 31(4): 484-495. (2018). (PMID: 29385656).
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  13. Pandya, P.; Orgaz, J.L.; Sanz-Moreno, V. "Actomyosin contractility and collective migration: may the force be with you.". Curr Opin Cell Biol. 48(): 87-96. (2017). (PMID: 28715714).
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  14. Pandya, P.; Orgaz, J.L.; Sanz-Moreno, V. "Modes of invasion during tumour dissemination.". Mol Oncol. 11(1): 5-27. (2017). (PMID: 28085224).
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  15. Herraiz, C.; Calvo, F.; Pandya, P.; Cantelli, G.; Rodriguez-Hernandez, I.; Orgaz, J.L.; Kang, N.; Chu, T.; Sahai, E.; Sanz-Moreno, V. "Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination.". J Natl Cancer Inst. 108(1): . (2016). (PMID: 26464464).
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  16. Cantelli, G.; Orgaz, J.L.; Rodriguez-Hernandez, I.; Karagiannis, P.; Maiques, O.; Matias-Guiu, X.; Nestle, F.O.; Marti, R.M.; Karagiannis, S.N.; Sanz-Moreno, V. "TGF-β-Induced Transcription Sustains Amoeboid Melanoma Migration and Dissemination.". Curr Biol. 25(22): 2899-2914. (2015). (PMID: 26526369).
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  17. Jiménez Cuenca, B.; Fernández-Barral, A.; Orgaz, J.L. "Microphthalmia-Associated Transcription Factor: A Central Regulator of Pigment Epithelium-Derived Factor Controlling Human Melanoma Progression.". Am. J. Pathol.. 185(7): 2069-2070. (2015). (PMID: 26093986).
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  18. Aguilera, Ó.; González-Sancho, J.M.; Zazo, S.; Rincón, R.; Fernández, A.F.; Tapia, O.; Canals, F.; Morte, B.; Calvanese, V.; Orgaz, J.L.; Niell, N.; Aguilar, S.; Freije, J.M.; Graña, O.; Pisano, D.G.; Borrero, A.; Martínez-Useros, J.; Jiménez, B.; Fraga, M.F.; García-Foncillas, J.; López-Otín, C.; Lafarga, M.; Rojo, F.; Muñoz, A. "Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer.". Oncotarget. 6(8): 5903-5917. (2015). (PMID: 25788273).
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  19. Orgaz, J.L.; Pandya, P.; Dalmeida, R.; Karagiannis, P.; Sanchez-Laorden, B.; Viros, A.; Albrengues, J.; Nestle, F.O.; Ridley, A.J.; Gaggioli, C.; Marais, R.; Karagiannis, S.N.; Sanz-Moreno, V. "Diverse matrix metalloproteinase functions regulate cancer amoeboid migration.". Nat Commun. 5(): 4255. (2014). (PMID: 24963846).
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  20. Fernández-Barral, A.; Orgaz, J.L.; Baquero, P.; Ali, Z.; Moreno, A.; Tiana, M.; Gómez, V.; Riveiro-Falkenbach, E.; Cañadas, C.; Zazo, S.; Bertolotto, C.; Davidson, I.; Rodríguez-Peralto, J.L.; Palmero, I.; Rojo, F.; Jensen, L.D.; del Peso, L.; Jiménez, B. "Regulatory and functional connection of microphthalmia-associated transcription factor and anti-metastatic pigment epithelium derived factor in melanoma.". Neoplasia. 16(6): 529-542. (2014). (PMID: 25030625).
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  21. Orgaz, J.L.; Herraiz, C.; Sanz-Moreno, V. "Rho GTPases modulate malignant transformation of tumor cells.". Small GTPases. 5(): e29019. (2014). (PMID: 25036871).
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  22. Baquero, P.; Sánchez-Hernández, I.; Jiménez-Mora, E.; Orgaz, J.L.; Jiménez, B.; Chiloeches, A. "(V600E)BRAF promotes invasiveness of thyroid cancer cells by decreasing E-cadherin expression through a Snail-dependent mechanism.". Cancer Lett.. 335(1): 232-241. (2013). (PMID: 23435375).
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  23. Ruiz-Ontañon, P.; Orgaz, J.L.; Aldaz, B.; Elosegui-Artola, A.; Martino, J.; Berciano, M.T.; Montero, J.A.; Grande, L.; Nogueira, L.; Diaz-Moralli, S.; Esparís-Ogando, A.; Vazquez-Barquero, A.; Lafarga, M.; Pandiella, A.; Cascante, M.; Segura, V.; Martinez-Climent, J.A.; Sanz-Moreno, V.; Fernandez-Luna, J.L. "Cellular plasticity confers migratory and invasive advantages to a population of glioblastoma-initiating cells that infiltrate peritumoral tissue.". Stem Cells. 31(6): 1075-1085. (2013). (PMID: 23401361).
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  24. Orgaz, J.L.; Sanz-Moreno, V. "Emerging molecular targets in melanoma invasion and metastasis.". Pigment Cell Melanoma Res. 26(1): 39-57. (2013). (PMID: 23095214).
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  25. Fernández-Barral, A.; Orgaz, J.L.; Gomez, V.; del Peso, L.; Calzada, M.J.; Jiménez, B. "Hypoxia negatively regulates antimetastatic PEDF in melanoma cells by a hypoxia inducible factor-independent, autophagy dependent mechanism.". PLoS ONE. 7(3): e32989. (2012). (PMID: 22457728).
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  26. Orgaz, J.L.; Benguria, A.; Sanchez-Martinez, C.; Ladhani, O.; Volpert, O.V.; Jimenez, B. "Changes in the gene expression profile of A375 human melanoma cells induced by overexpression of multifunctional pigment epithelium-derived factor.". Melanoma Res.. 21(4): 285-297. (2011). (PMID: 21673604).
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  27. Ladhani, O.; Sánchez-Martinez, C.; Orgaz, J.L.; Jimenez, B.; Volpert, O.V. "Pigment epithelium-derived factor blocks tumor extravasation by suppressing amoeboid morphology and mesenchymal proteolysis.". Neoplasia. 13(7): 633-642. (2011). (PMID: 21750657).
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  28. Moncho-Amor, V.; Ibañez de Cáceres, I.; Bandres, E.; Martínez-Poveda, B.; Orgaz, J.L.; Sánchez-Pérez, I.; Zazo, S.; Rovira, A.; Albanell, J.; Jiménez, B.; Rojo, F.; Belda-Iniesta, C.; García-Foncillas, J.; Perona, R. "DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer.". Oncogene. 30(6): 668-678. (2011). (PMID: 20890299).
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  29. Moreno, A.; Palacios, A.; Orgaz, J.L.; Jimenez, B.; Blanco, F.J.; Palmero, I. "Functional impact of cancer-associated mutations in the tumor suppressor protein ING4.". Carcinogenesis. 31(11): 1932-1938. (2010). (PMID: 20705953).
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  30. Orgaz, J.L.; Ladhani, O.; Hoek, K.S.; Fernández-Barral, A.; Mihic, D.; Aguilera, O.; Seftor, E.A.; Bernad, A.; Rodríguez-Peralto, J.L.; Hendrix, M.J.; Volpert, O.V.; Jiménez, B. "'Loss of pigment epithelium-derived factor enables migration, invasion and metastatic spread of human melanoma'.". Oncogene. 28(47): 4147-4161. (2009). (PMID: 19767774).
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  31. Orgaz, J.L.; Martínez-Poveda, B.; Fernández-García, N.I.; Jiménez, B. "Following up tumour angiogenesis: from the basic laboratory to the clinic.". Clin Transl Oncol. 10(8): 468-477. (2008). (PMID: 18667377).
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