Aranda, A. "MicroRNAs and thyroid hormone action.". Mol Cell Endocrinol. (): 111175. (2021). (PMID: 33515639).
Font-Díaz, J.; Jiménez-Panizo, A.; Caelles, C.; Vivanco, M.D.; Pérez, P.; Aranda, A.; Estébanez-Perpiñá, E.; Castrillo, A.; Ricote, M.; Valledor, A.F. "Nuclear receptors: lipid and hormone sensors with essential roles in the control of cancer development.". Semin Cancer Biol. (): . (2020). (PMID: 33309851).
López-Mateo, I.; Alonso-Merino, E.; Suárez-Cabrera, C.; Park, J.W.; Cheng, S.Y.; Alemany, S.; Paramio, J.M.; Aranda, A. "The thyroid hormone receptor β inhibits self-renewal capacity of breast cancer stem cells.". Thyroid. (): . (2019). (PMID: 31760908).
Prieto, I.; Zambrano, A.; Laso, J.; Aranda, A.; Samper, E.; Monsalve, M. "Early induction of senescence and immortalization in PGC-1α-deficient mouse embryonic fibroblasts.". Free Radic. Biol. Med.. 138(): 23-32. (2019). (PMID: 31029787).
Ruiz-Llorente, L.; Contreras-Jurado, C.; Martínez-Fernández, M.; Paramio, J.M.; Aranda, A. "The thyroid hormone receptors regulate the expression of microRNAs with key roles in skin homeostasis.". Thyroid. (): . (2018). (PMID: 29742977).
Sánchez, Á.; Relaño, C.; Carrasco, A.; Contreras-Jurado, C.; Martín-Duce, A.; Aranda, A.; Alemany, S. "Map3k8 controls granulocyte colony-stimulating factor production and neutrophil precursor proliferation in lipopolysaccharide-induced emergency granulopoiesis.". Sci Rep. 7(1): 5010. (2017). (PMID: 28694430).
Bernardo, A.R.; Cosgaya, J.M.; Aranda, A.; Jiménez-Lara, A.M. "Pro-apoptotic signaling induced by Retinoic acid and dsRNA is under the control of Interferon Regulatory Factor-3 in breast cancer cells.". Apoptosis. (): . (2017). (PMID: 28409399).
Sanz-Garcia, C.; Sánchez, Á.; Contreras-Jurado, C.; Cales, C.; Barranquero, C.; Muñoz, M.; Merino, R.; Escudero, P.; Sanz, M.J.; Osada, J.; Aranda, A.; Alemany, S. "Map3k8 Modulates Monocyte State and Atherogenesis in ApoE-/- Mice.". Arterioscler. Thromb. Vasc. Biol.. 37(2): 237-246. (2017). (PMID: 27856455).
Martínez-Iglesias, O.; Olmeda, D.; Alonso-Merino, E.; Gómez-Rey, S.; González-López, A.M.; Luengo, E.; Soengas, M.S.; Palacios, J.; Regadera, J.; Aranda, A. "The nuclear corepressor 1 and the thyroid hormone receptor β suppress breast tumor lymphangiogenesis.". Oncotarget. (): . (2016). (PMID: 27806339).
Ruiz-Llorente, L.; Ardila-González, S.; Fanjul, L.F.; Martínez-Iglesias, O.; Aranda, A. "microRNAs 424 and 503 are mediators of the anti-proliferative and anti-invasive action of the thyroid hormone receptor beta.". Oncotarget. 5(10): 2918-2933. (2014). (PMID: 24796297).
Pascual, A.; Aranda, A. "Thyroid hormone receptors, cell growth and differentiation.". Biochim. Biophys. Acta. 1830(7): 3908-3916. (2013). (PMID: 22484490).
Bernardo, A.R.; Cosgaya, J.M.; Aranda, A.; Jiménez-Lara, A.M. "Synergy between RA and TLR3 promotes type I IFN-dependent apoptosis through upregulation of TRAIL pathway in breast cancer cells.". Cell Death Dis. 4(): e479. (2013). (PMID: 23370279).
Bedó, G.; Pascual, A.; Aranda, A. "Early thyroid hormone-induced gene expression changes in N2a-β neuroblastoma cells.". J. Mol. Neurosci.. 45(2): 76-86. (2011). (PMID: 20506002).
García-Carpizo, V.; Ruiz-Llorente, L.; Fraga, M.; Aranda, A. "The growing role of gene methylation on endocrine function.". J. Mol. Endocrinol.. 47(2): R75-89. (2011). (PMID: 21803863).
Lasa, M.; Gil-Araujo, B.; Palafox, M.; Aranda, A. "Thyroid hormone antagonizes tumor necrosis factor-alpha signaling in pituitary cells through the induction of dual specificity phosphatase 1.". Mol. Endocrinol.. 24(2): 412-422. (2010). (PMID: 20032197).
López-Fontal, R.; Zeini, M.; Través, P.G.; Gómez-Ferrería, M.; Aranda, A.; Sáez, G.T.; Cerdá, C.; Martín-Sanz, P.; Hortelano, S.; Boscá, L. "Mice lacking thyroid hormone receptor Beta show enhanced apoptosis and delayed liver commitment for proliferation after partial hepatectomy.". PLoS ONE. 5(1): e8710. (2010). (PMID: 20090848).
Jiménez-Lara, A.M.; Aranda, A.; Gronemeyer, H. "Retinoic acid protects human breast cancer cells against etoposide-induced apoptosis by NF-kappaB-dependent but cIAP2-independent mechanisms.". Mol. Cancer. 9(): 15. (2010). (PMID: 20102612).
Sánchez-Pacheco, A.; Martínez-Iglesias, O.; Méndez-Pertuz, M.; Aranda, A. "Residues K128, 132, and 134 in the thyroid hormone receptor-alpha are essential for receptor acetylation and activity.". Endocrinology. 150(11): 5143-5152. (2009). (PMID: 19819978).
González, L.; Zambrano, A.; Lazaro-Trueba, I.; Lopéz, E.; González, J.J.; Martín-Pérez, J.; Aranda, A. "Activation of the unliganded estrogen receptor by prolactin in breast cancer cells.". Oncogene. 28(10): 1298-1308. (2009). (PMID: 19169277).
Martínez-Iglesias, O.; Garcia-Silva, S.; Tenbaum, S.P.; Regadera, J.; Larcher, F.; Paramio, J.M.; Vennström, B.; Aranda, A. "Thyroid hormone receptor beta1 acts as a potent suppressor of tumor invasiveness and metastasis.". Cancer Res.. 69(2): 501-509. (2009). (PMID: 19147563).
Chiloeches, A.; Sánchez-Pacheco, A.; Gil-Araujo, B.; Aranda, A.; Lasa, M. "Thyroid hormone-mediated activation of the ERK/dual specificity phosphatase 1 pathway augments the apoptosis of GH4C1 cells by down-regulating nuclear factor-kappaB activity.". Mol. Endocrinol.. 22(11): 2466-2480. (2008). (PMID: 18755855).
Martínez-Iglesias, O.; Ruiz-Llorente, L.; Sánchez-Martínez, R.; García, L.; Zambrano, A.; Aranda, A. "Histone deacetylase inhibitors: mechanism of action and therapeutic use in cancer.". Clin Transl Oncol. 10(7): 395-398. (2008). (PMID: 18628067).
De los Santos, M.; Martínez-Iglesias, O.; Aranda, A. "Anti-estrogenic actions of histone deacetylase inhibitors in MCF-7 breast cancer cells.". Endocr. Relat. Cancer. 14(4): 1021-1028. (2007). (PMID: 18045953).
De los Santos, M.; Zambrano, A.; Sánchez-Pacheco, A.; Aranda, A. "Histone deacetylase inhibitors regulate retinoic acid receptor beta expression in neuroblastoma cells by both transcriptional and posttranscriptional mechanisms.". Mol. Endocrinol.. 21(10): 2416-2426. (2007). (PMID: 17622583).
De los Santos, M.; Zambrano, A.; Aranda, A. "Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells.". Mol. Cancer Ther.. 6(4): 1425-1432. (2007). (PMID: 17431121).
Castillo, A.I.; Sánchez-Martínez, R.; Jiménez-Lara, A.M.; Steinmeyer, A.; Zügel, U.; Aranda, A. "Characterization of vitamin D receptor ligands with cell-specific and dissociated activity.". Mol. Endocrinol.. 20(12): 3093-3104. (2006). (PMID: 16901972).
Sánchez-Martínez, R.; Castillo, A.I.; Steinmeyer, A.; Aranda, A. "The retinoid X receptor ligand restores defective signalling by the vitamin D receptor.". EMBO Rep.. 7(10): 1030-1034. (2006). (PMID: 16936639).
Shah, S.; Islam, M.N.; Dakshanamurthy, S.; Rizvi, I.; Rao, M.; Herrell, R.; Zinser, G.; Valrance, M.; Aranda, A.; Moras, D.; Norman, A.; Welsh, J.; Byers, S.W. "The molecular basis of vitamin D receptor and beta-catenin crossregulation.". Mol. Cell. 21(6): 799-809. (2006). (PMID: 16543149).
Scsucova, S.; Palacios, D.; Savignac, M.; Mellström, B.; Naranjo, J.R.; Aranda, A. "The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements.". Nucleic Acids Res.. 33(7): 2269-2279. (2005). (PMID: 15849313).
Cañón, E.; Cosgaya, J.M.; Scsucova, S.; Aranda, A. "Rapid effects of retinoic acid on CREB and ERK phosphorylation in neuronal cells.". Mol. Biol. Cell. 15(12): 5583-5592. (2004). (PMID: 15371543).
García-Silva, S.; Aranda, A. "The thyroid hormone receptor is a suppressor of ras-mediated transcription, proliferation, and transformation.". Mol. Cell. Biol.. 24(17): 7514-7523. (2004). (PMID: 15314161).
Nevado, J.; Tenbaum, S.P.; Aranda, A. "hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor.". Mol. Cell. Endocrinol.. 222(1-2): 41-51. (2004). (PMID: 15249124).
Castillo, A.I.; Sánchez-Martínez, R.; Moreno, J.L.; Martínez-Iglesias, O.A.; Palacios, D.; Aranda, A. "A permissive retinoid X receptor/thyroid hormone receptor heterodimer allows stimulation of prolactin gene transcription by thyroid hormone and 9-cis-retinoic acid.". Mol. Cell. Biol.. 24(2): 502-513. (2004). (PMID: 14701725).
Sánchez-Pacheco, A.; Aranda, A. "Binding of the thyroid hormone receptor to a negative element in the basal growth hormone promoter is associated with histone acetylation.". J. Biol. Chem.. 278(41): 39383-39391. (2003). (PMID: 12878587).
Méndez-Pertuz, M.; Sánchez-Pacheco, A.; Aranda, A. "The thyroid hormone receptor antagonizes CREB-mediated transcription.". EMBO J.. 22(12): 3102-3112. (2003). (PMID: 12805224).
Garcia-Silva, S.; Perez-Juste, G.; Aranda, A. "Cell cycle control by the thyroid hormone in neuroblastoma cells.". Toxicology. 181-182(): 179-182. (2002). (PMID: 12505306).
Aranda, A.; Pascual, A. "Nuclear hormone receptors and gene expression.". Physiol. Rev.. 81(3): 1269-1304. (2001). (PMID: 11427696).
Cosgaya, J.M.; Aranda, A. "Nerve growth factor activates the RARbeta2 promoter by a Ras-dependent mechanism.". J. Neurochem.. 76(3): 661-671. (2001). (PMID: 11158236).
Jimenez-Lara, A.M.; Aranda, A. "Interaction of vitamin D and retinoid receptors on regulation of gene expression.". Horm. Res.. 54(5-6): 301-305. (2000). (PMID: 11595822).
Tolón, R.M.; Castillo, A.I.; Jiménez-Lara, A.M.; Aranda, A. "Association with Ets-1 causes ligand- and AF2-independent activation of nuclear receptors.". Mol. Cell. Biol.. 20(23): 8793-8802. (2000). (PMID: 11073980).
López-Fernández, J.; Palacios, D.; Castillo, A.I.; Tolon, R.M.; Aranda, A.; Karin, M. "Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2.". J. Biol. Chem.. 275(28): 21653-21660. (2000). (PMID: 10801832).
Recio, J.A.; Martínez de la Mata, J.; Martín-Nieto, J.; Aranda, A. "Retinoic acid stimulates HIV-1 transcription in human neuroblastoma SH-SY5Y cells.". FEBS Lett.. 469(1): 118-122. (2000). (PMID: 10708768).
Pérez-Juste, G.; García-Silva, S.; Aranda, A. "An element in the region responsible for premature termination of transcription mediates repression of c-myc gene expression by thyroid hormone in neuroblastoma cells.". J. Biol. Chem.. 275(2): 1307-1314. (2000). (PMID: 10625678).
Perez-Juste, G.; Aranda, A. "Differentiation of neuroblastoma cells by phorbol esters and insulin-like growth factor 1 is associated with induction of retinoic acid receptor beta gene expression.". Oncogene. 18(39): 5393-5402. (1999). (PMID: 10498893).
Castillo, A.I.; Jimenez-Lara, A.M.; Tolon, R.M.; Aranda, A. "Synergistic activation of the prolactin promoter by vitamin D receptor and GHF-1: role of the coactivators, CREB-binding protein and steroid hormone receptor coactivator-1 (SRC-1).". Mol. Endocrinol.. 13(7): 1141-1154. (1999). (PMID: 10406465).
Jimenez-Lara, A.M.; Aranda, A. "The vitamin D receptor binds in a transcriptionally inactive form and without a defined polarity on a retinoic acid response element.". FASEB J.. 13(9): 1073-1081. (1999). (PMID: 10336890).
Jiménez-Lara, A.M.; Aranda, A. "Vitamin D represses retinoic acid-dependent transactivation of the retinoic acid receptor-beta2 promoter: the AF-2 domain of the vitamin D receptor is required for transrepression.". Endocrinology. 140(6): 2898-2907. (1999). (PMID: 10342883).
Jiménez-Lara, A.M.; Aranda, A. "Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity.". J. Biol. Chem.. 274(19): 13503-13510. (1999). (PMID: 10224118).
Perez-Juste, G.; Aranda, A. "The cyclin-dependent kinase inhibitor p27(Kip1) is involved in thyroid hormone-mediated neuronal differentiation.". J. Biol. Chem.. 274(8): 5026-5031. (1999). (PMID: 9988748).
Cosgaya, J.M.; Aranda, A. "The ras oncogene inhibits growth factor inducibility of early response genes, and promotes selectively expression of NGFI-A in a PC12 cell line.". FEBS Lett.. 445(2-3): 329-332. (1999). (PMID: 10094483).
Tolón, R.M.; Castillo, A.I.; Aranda, A. "Activation of the prolactin gene by peroxisome proliferator-activated receptor-alpha appears to be DNA binding-independent.". J. Biol. Chem.. 273(41): 26652-26661. (1998). (PMID: 9756906).
Palomino, T.; Barettino, D.; Aranda, A. "Role of GHF-1 in the regulation of the rat growth hormone gene promoter by thyroid hormone and retinoic acid receptors.". J. Biol. Chem.. 273(42): 27541-27547. (1998). (PMID: 9765286).
Palomino, T.; Sánchez-Pacheco, A.; Peña, P.; Aranda, A. "A direct protein-protein interaction is involved in the cooperation between thyroid hormone and retinoic acid receptors and the transcription factor GHF-1.". FASEB J.. 12(12): 1201-1209. (1998). (PMID: 9737723).
Cosgaya, J.M.; Aranda, A.; Cruces, J.; Martín-Blanco, E. "Neuronal differentiation of PC12 cells induced by engrailed homeodomain is DNA-binding specific and independent of MAP kinases.". J. Cell. Sci.. 111 ( Pt 16)(): 2377-2384. (1998). (PMID: 9683632).
Cosgaya, J.M.; Pérez-Juste, G.; Aranda, A. "Retinoic acid regulates selectively the expression of immediate early response genes in PC12 cells.". FEBS Lett.. 429(3): 254-258. (1998). (PMID: 9662427).
Castillo, A.I.; Tolon, R.M.; Aranda, A. "Insulin-like growth factor-1 stimulates rat prolactin gene expression by a Ras, ETS and phosphatidylinositol 3-kinase dependent mechanism.". Oncogene. 16(15): 1981-1991. (1998). (PMID: 9591782).
Sánchez-Pacheco, A.; Peña, P.; Palomino, T.; Güell, A.; Castrillo, J.L.; Aranda, A. "The transcription factor GHF-1, but not the splice variant GHF-2, cooperates with thyroid hormone and retinoic acid receptors to stimulate rat growth hormone gene expression.". FEBS Lett.. 422(1): 103-107. (1998). (PMID: 9475179).
Castillo, A.I.; Aranda, A. "Differential regulation of pituitary-specific gene expression by insulin-like growth factor 1 in rat pituitary GH4C1 and GH3 cells.". Endocrinology. 138(12): 5442-5451. (1997). (PMID: 9389530).
Recio, J.A.; Aranda, A. "Activation of the HIV-1 long terminal repeat by nerve growth factor.". J. Biol. Chem.. 272(43): 26807-26810. (1997). (PMID: 9341108).
Cosgaya, J.M.; Perez-Juste, G.; Castillo, A.I.; Aranda, A. "Growth factor ligands of tyrosine kinase receptors activate the Rous sarcoma virus promoter by a Ras- and Raf-dependent mechanism.". Gene. 188(2): 291-293. (1997). (PMID: 9133605).
Garcia-Villalba, P.; Jimenez-Lara, A.M.; Castillo, A.I.; Aranda, A. "Histone acetylation influences thyroid hormone and retinoic acid-mediated gene expression.". DNA Cell Biol.. 16(4): 421-431. (1997). (PMID: 9150429).
Cosgaya, J.M.; Recio, J.A.; Aranda, A. "Influence of Ras and retinoic acid on nerve growth factor induction of transin gene expression in PC12 cells.". Oncogene. 14(14): 1687-1696. (1997). (PMID: 9135070).
Cosgaya, J.M.; Perona, R.; Aranda, A. "Retinoic acid induces secretion of transforming growth factors by PC12 pheochromocytoma cells.". Oncogene. 14(5): 579-587. (1997). (PMID: 9053856).
Cosgaya, J.M.; Aranda, A. "Ras- and Raf-mediated regulation of transforming growth factor beta 1 gene expression by ligands of tyrosine kinase receptors in PC12 cells.". Oncogene. 12(12): 2651-2660. (1996). (PMID: 8700524).
Cosgaya, J.M.; Garcia-Villalba, P.; Perona, R.; Aranda, A. "Comparison of the effects of retinoic acid and nerve growth factor on PC12 cell proliferation, differentiation, and gene expression.". J. Neurochem.. 66(1): 89-98. (1996). (PMID: 8522994).
Garcia-Villalba, P.; Jimenez-Lara, A.M.; Aranda, A. "Vitamin D interferes with transactivation of the growth hormone gene by thyroid hormone and retinoic acid.". Mol. Cell. Biol.. 16(1): 318-327. (1996). (PMID: 8524311).
Cosgaya, J.M.; Aranda, A. "Nerve growth factor regulates transforming growth factor-beta 1 gene expression by both transcriptional and posttranscriptional mechanisms in PC12 cells.". J. Neurochem.. 65(6): 2484-2490. (1995). (PMID: 7595542).
Sánchez-Pacheco, A.; Palomino, T.; Aranda, A. "Retinoic acid induces expression of the transcription factor GHF-1/Pit-1 in pituitary prolactin- and growth hormone-producing cell lines.". Endocrinology. 136(12): 5391-5398. (1995). (PMID: 7588287).
Sanchez-Pacheco, A.; Palomino, T.; Aranda, A. "Negative regulation of expression of the pituitary-specific transcription factor GHF-1/Pit-1 by thyroid hormones through interference with promoter enhancer elements.". Mol. Cell. Biol.. 15(11): 6322-6330. (1995). (PMID: 7565785).
Perez, P.; Palomino, T.; Schönthal, A.; Aranda, A. "Determination of the promoter elements that mediate repression of c-fos gene transcription by thyroid hormone and retinoic acid receptors.". Biochem. Biophys. Res. Commun.. 205(1): 135-140. (1994). (PMID: 7999013).
Perez, P.; Schönthal, A.; Aranda, A. "Repression of c-fos gene expression by thyroid hormone and retinoic acid receptors.". J. Biol. Chem.. 268(31): 23538-23543. (1993). (PMID: 8226882).
García-Villalba, P.; Au-Fliegner, M.; Samuels, H.H.; Aranda, A. "Interaction of thyroid hormone and retinoic acid receptors on the regulation of the rat growth hormone gene promoter.". Biochem. Biophys. Res. Commun.. 191(2): 580-586. (1993). (PMID: 8384845).
Sanchez-Pacheco, A.; Perez, P.; Villa, A.; Pascual, A.; Aranda, A. "Nicotinamide analogs and DNA-damaging agents deplete thyroid hormone receptor and c-erbA mRNA levels in pituitary GH1 cells.". Mol. Cell. Endocrinol.. 91(1-2): 127-134. (1993). (PMID: 8386110).
Sánchez-Pacheco, A.; Aranda, A. "The thyroid hormone response element is required for activation of the growth hormone gene promoter by nicotinamide analogs.". FEBS Lett.. 312(1): 42-46. (1992). (PMID: 1426237).
Bedo, G.; Santisteban, P.; Jolin, T.; Aranda, A. "Expression of the growth hormone gene and the pituitary-specific transcription factor GHF-1 in diabetic rats.". Mol. Endocrinol.. 5(11): 1730-1739. (1991). (PMID: 1779974).