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Institute
The Instituto de Investigaciones Biomédicas Sols-Morreale (IIBM), a joint center from the "Consejo Superior de Investigaciones Científicas (CSIC) and he Universidad Autónoma de Madrid (UAM). Actually, IIBM is one of the most important Biomedical Research Centers in Spain. The scientific aims are distributed according to the 3 Research Areas of the Institute Physiopathology, Metabolism and Cell Signalling, and Cancer Biology, besides teaching is a very important part of our activities.
Latest Publications
Cave, DD, Di Domenico, A, Fantuz, M, Ciotola, M, Mangini, M, Buonaiuto, S, Corrado, B, Corona, M, Saracino, F, Andolfi, G, Di Biase, I, Cucciardi, A, Carrer, A, Sainz, B , Pirozzi, T, Re, DL, Colonna, V, Minchiotti, G, De Luca, AC, Lonardo, E. (2025). TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis. Cell Death Dis. 16(1): 592 (PMID: 40770187) (doi:10.1038/s41419-025-07859-8) 
Vázquez, P , Escalona-Garrido, C , Pescador, N , Hitos, AB , González-Moreno, D , de Benito-Bueno, Á , Sierra-Filardi, E, Boya, P, Montero-Pedrazuela, A , Guadaño-Ferraz, A , Valverde, ÁM . (2025). Sirtuin 1 overexpression in mice preserves insulin and thermogenic responses in subcutaneous inguinal white adipose tissue under proinflammatory conditions. J Physiol Biochem. (PMID: 40760244) (doi:10.1007/s13105-025-01109-3) García-Yagüe, ÁJ , Cueto-Díaz, EJ, Escoll, M , Okunishi, I, Hayes, JD, Rodríguez-Franco, MI, Rojo, AI , Cuadrado, A . (2025). Dual targeting of Keap1 and Gsk-3 by hexaraphane in the regulation of transcription factor Nrf2. Free Radic Biol Med. (PMID: 40752636) (doi:10.1016/j.freeradbiomed.2025.07.051) 
Cave, DD, Di Domenico, A, Fantuz, M, Ciotola, M, Mangini, M, Buonaiuto, S, Corrado, B, Corona, M, Saracino, F, Andolfi, G, Di Biase, I, Cucciardi, A, Carrer, A, Sainz, B , Pirozzi, T, Re, DL, Colonna, V, Minchiotti, G, De Luca, AC, Lonardo, E. (2025). TGF-β1-mediated downregulation of L1CAM in pancreatic ductal adenocarcinoma drives upregulation of collagen 17A1 and MMP2, facilitating tumor invasiveness and metastasis. Cell Death Dis. 16(1): 592 (PMID: 40770187) (doi:10.1038/s41419-025-07859-8) Vázquez, P , Escalona-Garrido, C , Pescador, N , Hitos, AB , González-Moreno, D , de Benito-Bueno, Á , Sierra-Filardi, E, Boya, P, Montero-Pedrazuela, A , Guadaño-Ferraz, A , Valverde, ÁM . (2025). Sirtuin 1 overexpression in mice preserves insulin and thermogenic responses in subcutaneous inguinal white adipose tissue under proinflammatory conditions. J Physiol Biochem. (PMID: 40760244) (doi:10.1007/s13105-025-01109-3) García-Yagüe, ÁJ , Cueto-Díaz, EJ, Escoll, M , Okunishi, I, Hayes, JD, Rodríguez-Franco, MI, Rojo, AI , Cuadrado, A . (2025). Dual targeting of Keap1 and Gsk-3 by hexaraphane in the regulation of transcription factor Nrf2. Free Radic Biol Med. (PMID: 40752636) (doi:10.1016/j.freeradbiomed.2025.07.051) 
News
Change of website
Change of website - Follow IIBM news The IIBM has changed the main website. To follow the current news, we invite you to follow them on the new portal .
One more year the IIBM participates in the Spanish Biology Olympiad
The IIBM is very committed to encourage the passion for research of outstanding students For the second consecutive year, the IIBM hosts finalists in the...
Eloísa del Pino, president of CSIC, visits the IIBM
The IIBM welcomes with enthusiasm the CSIC Presidency team on its 101st visit to the CSIC's Institutes The president of the CSIC,...
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These nodes supply a range of scientific services, facilities and equipment shared at IIBM to provide internal and external researchers with technical support and advice.
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